Result of FASTA (omim) for
pF1KB5891
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5891, 498 aa
1>>>pF1KB5891 498 - 498 aa - 498 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 17.3978+/-0.00053; mu= -35.2086+/- 0.033
mean_var=1009.4299+/-206.726, 0's: 0 Z-trim(125.9): 196 B-trim: 0 in 0/61
Lambda= 0.040368
statistics sampled from 50417 (50674) to 50417 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.823), E-opt: 0.2 (0.594), width: 16
Scan time: 11.660
The best scores are: opt bits E(85289)
NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome ( 498) 3525 220.6 8.6e-57
NP_001188333 (OMIM: 605875) wiskott-Aldrich syndro ( 281) 1841 122.2 1.9e-27
NP_001278894 (OMIM: 605068) wiskott-Aldrich syndro ( 499) 1690 113.7 1.3e-24
XP_011533191 (OMIM: 605068) PREDICTED: wiskott-Ald ( 502) 1590 107.9 7.2e-23
XP_011533192 (OMIM: 605068) PREDICTED: wiskott-Ald ( 502) 1590 107.9 7.2e-23
NP_006637 (OMIM: 605068) wiskott-Aldrich syndrome ( 502) 1590 107.9 7.2e-23
XP_016866929 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866933 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_011534537 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866932 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866930 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866928 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_016866931 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1245 87.8 8.7e-17
XP_011534535 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
NP_001020105 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1240 87.5 1.1e-16
XP_005267264 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
XP_011534536 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
NP_001020107 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1240 87.5 1.1e-16
XP_005267263 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
NP_003922 (OMIM: 605035) wiskott-Aldrich syndrome ( 559) 1240 87.5 1.1e-16
XP_016866927 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
XP_016866926 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
XP_005267260 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
NP_001020106 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1240 87.5 1.1e-16
XP_005267262 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1240 87.5 1.1e-16
XP_016857329 (OMIM: 606373,616193) PREDICTED: form (1102) 507 45.1 0.0012
XP_016857330 (OMIM: 606373,616193) PREDICTED: form (1102) 507 45.1 0.0012
XP_016857328 (OMIM: 606373,616193) PREDICTED: form (1159) 507 45.2 0.0013
XP_011542539 (OMIM: 606373,616193) PREDICTED: form (1360) 507 45.2 0.0014
XP_016857327 (OMIM: 606373,616193) PREDICTED: form (1384) 507 45.2 0.0014
XP_016857326 (OMIM: 606373,616193) PREDICTED: form (1417) 507 45.2 0.0015
NP_003932 (OMIM: 605056) neural Wiskott-Aldrich sy ( 505) 489 43.7 0.0015
NP_064450 (OMIM: 606373,616193) formin-2 isoform 2 (1722) 507 45.3 0.0017
NP_001292353 (OMIM: 606373,616193) formin-2 isofor (1726) 507 45.3 0.0017
NP_001026884 (OMIM: 610982,613237,614455) inverted (1240) 463 42.6 0.0078
NP_071934 (OMIM: 610982,613237,614455) inverted fo (1249) 463 42.6 0.0078
XP_005268062 (OMIM: 610982,613237,614455) PREDICTE (1272) 463 42.6 0.0079
XP_005268061 (OMIM: 610982,613237,614455) PREDICTE (1281) 463 42.6 0.008
XP_016877084 (OMIM: 610982,613237,614455) PREDICTE (1281) 463 42.6 0.008
NP_001300936 (OMIM: 124900,602121,616632) protein (1250) 462 42.6 0.0082
XP_011535875 (OMIM: 124900,602121,616632) PREDICTE (1250) 462 42.6 0.0082
XP_011535874 (OMIM: 124900,602121,616632) PREDICTE (1260) 462 42.6 0.0082
NP_001073280 (OMIM: 124900,602121,616632) protein (1263) 462 42.6 0.0082
NP_005210 (OMIM: 124900,602121,616632) protein dia (1272) 462 42.6 0.0083
>>NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome prot (498 aa)
initn: 3525 init1: 3525 opt: 3525 Z-score: 1140.6 bits: 220.6 E(85289): 8.6e-57
Smith-Waterman score: 3525; 100.0% identity (100.0% similar) in 498 aa overlap (1-498:1-498)
10 20 30 40 50 60
pF1KB5 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 FAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 FAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 SDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 SDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVE
430 440 450 460 470 480
490
pF1KB5 YSDSEDDSSEFDEDDWSD
::::::::::::::::::
NP_008 YSDSEDDSSEFDEDDWSD
490
>>NP_001188333 (OMIM: 605875) wiskott-Aldrich syndrome p (281 aa)
initn: 1841 init1: 1841 opt: 1841 Z-score: 613.7 bits: 122.2 E(85289): 1.9e-27
Smith-Waterman score: 1841; 99.3% identity (99.6% similar) in 276 aa overlap (1-276:1-276)
10 20 30 40 50 60
pF1KB5 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP
:::::::::::::::::::::::::::::::::: .
NP_001 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFRFSAAQG
250 260 270 280
310 320 330 340 350 360
pF1KB5 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD
>>NP_001278894 (OMIM: 605068) wiskott-Aldrich syndrome p (499 aa)
initn: 1190 init1: 1190 opt: 1690 Z-score: 563.0 bits: 113.7 E(85289): 1.3e-24
Smith-Waterman score: 1690; 53.5% identity (71.5% similar) in 512 aa overlap (1-498:1-499)
10 20 30 40 50
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
:::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
NP_001 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
.: :..:: .:.::: ::::::: :::::: :: .:::.:::.:::.. ..::.: :
NP_001 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
: . :: : ::::: ::::::: :..::::::::::::::::::::::.: ::::...
NP_001 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 KEK-KDNPNRGN-VNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGC
.:: : ::::.. :: ::..:::::::. ::: ::. . .:: .: .::
NP_001 REKHKLNPNRNQQVNVRKVRTRKEEWERRKMGIEFMSDAKKLEQAGSAKEDRVPSGS--H
190 200 210 220 230
240 250 260 270 280 290
pF1KB5 VENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKRSSVV
. .: ::: :. . .: .::.. ..:: :: : .... :. .. ..
NP_001 ASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARHMALN
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 SPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSF
:..::: :: .: : . : : : :. : .. : :::: :: .
NP_001 RPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVI
300 310 320 330 340
360 370 380 390 400
pF1KB5 PP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPPPPPF
: . :..: : :: ::. : :: :: ::::: ::::::::: :
NP_001 PSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPG-
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB5 TGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDVVG
.. ...: ::.... . . . : .::::::::.:::.:.::..:.:::::: ::. ::
NP_001 SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVG
410 420 430 440 450 460
470 480 490
pF1KB5 NDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
::::::::::::::::::.::: ::::.::::
NP_001 NDVATILSRRIAVEYSDSDDDS-EFDENDWSD
470 480 490
>>XP_011533191 (OMIM: 605068) PREDICTED: wiskott-Aldrich (502 aa)
initn: 869 init1: 869 opt: 1590 Z-score: 531.5 bits: 107.9 E(85289): 7.2e-23
Smith-Waterman score: 1590; 50.6% identity (70.7% similar) in 516 aa overlap (1-498:1-502)
10 20 30 40 50
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
:::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
XP_011 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
.: :..:: .:.::: ::::::: :::::: :: .:::.:::.:::.. ..::.: :
XP_011 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
: . :: : ::::: ::::::: :..::::::::::::::::::::::.: ::::...
XP_011 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 KEKK-DNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIG--
..:. :. .: . :: ..:..::. : . .:. . ..:. : : . ..::..
XP_011 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKEL-RPDNRLSQSVYHGA--SSEGSLSPD
190 200 210 220 230
240 250 260 270 280 290
pF1KB5 ---CVENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKR
. .: ::: :. . .: .::.. ..:: :: : .... :. ..
XP_011 TRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARH
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 SSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPS
.. :..::: :: .: : . : : : :. : .. : ::::
XP_011 MALNRPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPP
300 310 320 330 340
360 370 380 390 400
pF1KB5 PPSFPP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPP
:: .: . :..: : :: ::. : :: :: ::::: :::::::::
XP_011 PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPP
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB5 PPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KR
: .. ...: ::.... . . . : .::::::::.:::.:.::..:.:::::: ::
XP_011 GPG-SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKR
410 420 430 440 450 460
470 480 490
pF1KB5 DVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
. ::::::::::::::::::::.::: ::::.::::
XP_011 EPVGNDVATILSRRIAVEYSDSDDDS-EFDENDWSD
470 480 490 500
>>XP_011533192 (OMIM: 605068) PREDICTED: wiskott-Aldrich (502 aa)
initn: 869 init1: 869 opt: 1590 Z-score: 531.5 bits: 107.9 E(85289): 7.2e-23
Smith-Waterman score: 1590; 50.6% identity (70.7% similar) in 516 aa overlap (1-498:1-502)
10 20 30 40 50
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
:::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
XP_011 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
.: :..:: .:.::: ::::::: :::::: :: .:::.:::.:::.. ..::.: :
XP_011 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
: . :: : ::::: ::::::: :..::::::::::::::::::::::.: ::::...
XP_011 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 KEKK-DNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIG--
..:. :. .: . :: ..:..::. : . .:. . ..:. : : . ..::..
XP_011 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKEL-RPDNRLSQSVYHGA--SSEGSLSPD
190 200 210 220 230
240 250 260 270 280 290
pF1KB5 ---CVENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKR
. .: ::: :. . .: .::.. ..:: :: : .... :. ..
XP_011 TRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARH
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 SSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPS
.. :..::: :: .: : . : : : :. : .. : ::::
XP_011 MALNRPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPP
300 310 320 330 340
360 370 380 390 400
pF1KB5 PPSFPP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPP
:: .: . :..: : :: ::. : :: :: ::::: :::::::::
XP_011 PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPP
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB5 PPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KR
: .. ...: ::.... . . . : .::::::::.:::.:.::..:.:::::: ::
XP_011 GPG-SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKR
410 420 430 440 450 460
470 480 490
pF1KB5 DVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
. ::::::::::::::::::::.::: ::::.::::
XP_011 EPVGNDVATILSRRIAVEYSDSDDDS-EFDENDWSD
470 480 490 500
>>NP_006637 (OMIM: 605068) wiskott-Aldrich syndrome prot (502 aa)
initn: 869 init1: 869 opt: 1590 Z-score: 531.5 bits: 107.9 E(85289): 7.2e-23
Smith-Waterman score: 1590; 50.6% identity (70.7% similar) in 516 aa overlap (1-498:1-502)
10 20 30 40 50
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
:::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
NP_006 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
.: :..:: .:.::: ::::::: :::::: :: .:::.:::.:::.. ..::.: :
NP_006 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
: . :: : ::::: ::::::: :..::::::::::::::::::::::.: ::::...
NP_006 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 KEKK-DNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIG--
..:. :. .: . :: ..:..::. : . .:. . ..:. : : . ..::..
NP_006 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKEL-RPDNRLSQSVYHGA--SSEGSLSPD
190 200 210 220 230
240 250 260 270 280 290
pF1KB5 ---CVENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKR
. .: ::: :. . .: .::.. ..:: :: : .... :. ..
NP_006 TRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARH
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 SSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPS
.. :..::: :: .: : . : : : :. : .. : ::::
NP_006 MALNRPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPP
300 310 320 330 340
360 370 380 390 400
pF1KB5 PPSFPP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPP
:: .: . :..: : :: ::. : :: :: ::::: :::::::::
NP_006 PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPP
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB5 PPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KR
: .. ...: ::.... . . . : .::::::::.:::.:.::..:.:::::: ::
NP_006 GPG-SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKR
410 420 430 440 450 460
470 480 490
pF1KB5 DVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
. ::::::::::::::::::::.::: ::::.::::
NP_006 EPVGNDVATILSRRIAVEYSDSDDDS-EFDENDWSD
470 480 490 500
>>XP_016866929 (OMIM: 605035) PREDICTED: wiskott-Aldrich (558 aa)
initn: 1082 init1: 896 opt: 1245 Z-score: 422.4 bits: 87.8 E(85289): 8.7e-17
Smith-Waterman score: 1486; 48.9% identity (65.8% similar) in 546 aa overlap (1-470:1-531)
10 20 30 40 50
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
:::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:.
XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
.:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.:
XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
. :::..:. ::::: ::::::::::.:::::.::::::::::::::::.: :::::..
XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
180 190 200 210 220
pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP
:. : :.. . :: . :..::.:. .: :..:. .: : ... :
XP_016 KNL-DRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
190 200 210 220 230
230 240 250 260 270
pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP
: : ...:: . : : . . ::: : : . . :
XP_016 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI
240 250 260 270 280 290
280 290 300 310 320
pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP
:. .: ..:. : .: :. : :::. ::: ::: : . . : . ::::
XP_016 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP
300 310 320 330 340 350
330 340 350 360 370
pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP--
:: ::::: ... .:..::::.: .. : :::: :: :: : :
XP_016 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC
360 370 380 390 400
380 390 400 410
pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ-
:.: :: : . : :::::::: ::: :: : : : : :
XP_016 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH
410 420 430 440 450 460
420 430 440 450 460
pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV
: .:: : :. . :.::..::::: :: :::.:.:::.:::::::: :..
XP_016 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER
470 480 490 500 510 520
470 480 490
pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
. ::::
XP_016 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE
530 540 550
>>XP_016866933 (OMIM: 605035) PREDICTED: wiskott-Aldrich (558 aa)
initn: 1082 init1: 896 opt: 1245 Z-score: 422.4 bits: 87.8 E(85289): 8.7e-17
Smith-Waterman score: 1486; 48.9% identity (65.8% similar) in 546 aa overlap (1-470:1-531)
10 20 30 40 50
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
:::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:.
XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
.:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.:
XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
. :::..:. ::::: ::::::::::.:::::.::::::::::::::::.: :::::..
XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
180 190 200 210 220
pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP
:. : :.. . :: . :..::.:. .: :..:. .: : ... :
XP_016 KNL-DRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
190 200 210 220 230
230 240 250 260 270
pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP
: : ...:: . : : . . ::: : : . . :
XP_016 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI
240 250 260 270 280 290
280 290 300 310 320
pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP
:. .: ..:. : .: :. : :::. ::: ::: : . . : . ::::
XP_016 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP
300 310 320 330 340 350
330 340 350 360 370
pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP--
:: ::::: ... .:..::::.: .. : :::: :: :: : :
XP_016 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC
360 370 380 390 400
380 390 400 410
pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ-
:.: :: : . : :::::::: ::: :: : : : : :
XP_016 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH
410 420 430 440 450 460
420 430 440 450 460
pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV
: .:: : :. . :.::..::::: :: :::.:.:::.:::::::: :..
XP_016 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER
470 480 490 500 510 520
470 480 490
pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
. ::::
XP_016 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE
530 540 550
>>XP_011534537 (OMIM: 605035) PREDICTED: wiskott-Aldrich (558 aa)
initn: 1082 init1: 896 opt: 1245 Z-score: 422.4 bits: 87.8 E(85289): 8.7e-17
Smith-Waterman score: 1486; 48.9% identity (65.8% similar) in 546 aa overlap (1-470:1-531)
10 20 30 40 50
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
:::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:.
XP_011 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
.:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.:
XP_011 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
. :::..:. ::::: ::::::::::.:::::.::::::::::::::::.: :::::..
XP_011 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
180 190 200 210 220
pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP
:. : :.. . :: . :..::.:. .: :..:. .: : ... :
XP_011 KNL-DRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
190 200 210 220 230
230 240 250 260 270
pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP
: : ...:: . : : . . ::: : : . . :
XP_011 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI
240 250 260 270 280 290
280 290 300 310 320
pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP
:. .: ..:. : .: :. : :::. ::: ::: : . . : . ::::
XP_011 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP
300 310 320 330 340 350
330 340 350 360 370
pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP--
:: ::::: ... .:..::::.: .. : :::: :: :: : :
XP_011 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC
360 370 380 390 400
380 390 400 410
pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ-
:.: :: : . : :::::::: ::: :: : : : : :
XP_011 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH
410 420 430 440 450 460
420 430 440 450 460
pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV
: .:: : :. . :.::..::::: :: :::.:.:::.:::::::: :..
XP_011 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER
470 480 490 500 510 520
470 480 490
pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
. ::::
XP_011 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE
530 540 550
>>XP_016866932 (OMIM: 605035) PREDICTED: wiskott-Aldrich (558 aa)
initn: 1082 init1: 896 opt: 1245 Z-score: 422.4 bits: 87.8 E(85289): 8.7e-17
Smith-Waterman score: 1486; 48.9% identity (65.8% similar) in 546 aa overlap (1-470:1-531)
10 20 30 40 50
pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
:::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:.
XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
.:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.:
XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
. :::..:. ::::: ::::::::::.:::::.::::::::::::::::.: :::::..
XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
180 190 200 210 220
pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP
:. : :.. . :: . :..::.:. .: :..:. .: : ... :
XP_016 KNL-DRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
190 200 210 220 230
230 240 250 260 270
pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP
: : ...:: . : : . . ::: : : . . :
XP_016 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI
240 250 260 270 280 290
280 290 300 310 320
pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP
:. .: ..:. : .: :. : :::. ::: ::: : . . : . ::::
XP_016 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP
300 310 320 330 340 350
330 340 350 360 370
pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP--
:: ::::: ... .:..::::.: .. : :::: :: :: : :
XP_016 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC
360 370 380 390 400
380 390 400 410
pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ-
:.: :: : . : :::::::: ::: :: : : : : :
XP_016 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH
410 420 430 440 450 460
420 430 440 450 460
pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV
: .:: : :. . :.::..::::: :: :::.:.:::.:::::::: :..
XP_016 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER
470 480 490 500 510 520
470 480 490
pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
. ::::
XP_016 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE
530 540 550
498 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 15:28:40 2016 done: Sat Nov 5 15:28:42 2016
Total Scan time: 11.660 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]