FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5905, 502 aa 1>>>pF1KB5905 502 - 502 aa - 502 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.0667+/-0.000697; mu= -20.3246+/- 0.040 mean_var=796.3591+/-186.075, 0's: 0 Z-trim(115.1): 117 B-trim: 513 in 1/49 Lambda= 0.045449 statistics sampled from 25178 (25272) to 25178 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.296), width: 16 Scan time: 6.690 The best scores are: opt bits E(85289) XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 3430 241.4 4.5e-63 XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 3430 241.4 4.5e-63 XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 3430 241.4 4.5e-63 XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 3430 241.4 4.5e-63 NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 3430 241.4 4.5e-63 NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 3430 241.4 4.5e-63 XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 3430 241.4 4.5e-63 NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 3430 241.4 4.5e-63 NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 3430 241.5 4.7e-63 NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 2520 181.8 4.3e-45 XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 2520 181.8 4.3e-45 XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 2520 181.8 4.3e-45 NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 1708 128.5 4.4e-29 NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 1695 127.7 7.9e-29 XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 1632 123.5 1.3e-27 XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 1632 123.5 1.3e-27 XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 1619 122.6 2.3e-27 NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 1616 122.5 2.9e-27 XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1600 121.5 6e-27 NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1600 121.5 6e-27 XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1600 121.5 6e-27 XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1600 121.5 6e-27 XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1600 121.5 6e-27 NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1600 121.5 6e-27 XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1600 121.5 6e-27 XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1600 121.5 6e-27 NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 1584 120.4 1.2e-26 NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 1573 119.6 1.9e-26 NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 1532 116.9 1.2e-25 XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 1492 114.2 6.6e-25 NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 1492 114.3 7.3e-25 NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 1434 110.6 1.1e-23 XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 1434 110.6 1.1e-23 NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 1434 110.6 1.1e-23 NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 1398 108.1 5.1e-23 XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 1216 96.2 2e-19 XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 1070 86.7 1.7e-16 XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 1070 86.7 1.7e-16 NP_064733 (OMIM: 601300) activin receptor type-1B ( 546) 1070 86.7 1.8e-16 XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 1030 83.9 9e-16 NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 1021 83.2 1.3e-15 NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 780 67.6 8e-11 NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 780 67.7 9.2e-11 NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 780 67.7 9.2e-11 XP_016863005 (OMIM: 602730,613751) PREDICTED: acti ( 511) 743 65.3 4.9e-10 NP_001097 (OMIM: 602730,613751) activin receptor t ( 512) 743 65.3 4.9e-10 XP_016863004 (OMIM: 602730,613751) PREDICTED: acti ( 518) 743 65.3 5e-10 XP_016863003 (OMIM: 602730,613751) PREDICTED: acti ( 526) 743 65.3 5e-10 XP_005265640 (OMIM: 602730,613751) PREDICTED: acti ( 533) 743 65.3 5.1e-10 XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 728 64.3 1e-09 >>XP_016864048 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.3 bits: 241.4 E(85289): 4.5e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 430 440 450 460 470 480 490 500 pF1KB5 RLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::: XP_016 RLTALRVKKTLAKMSESQDIKL 490 500 >>XP_016864049 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.3 bits: 241.4 E(85289): 4.5e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 430 440 450 460 470 480 490 500 pF1KB5 RLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::: XP_016 RLTALRVKKTLAKMSESQDIKL 490 500 >>XP_016864050 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.3 bits: 241.4 E(85289): 4.5e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 430 440 450 460 470 480 490 500 pF1KB5 RLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::: XP_016 RLTALRVKKTLAKMSESQDIKL 490 500 >>XP_011530503 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.3 bits: 241.4 E(85289): 4.5e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 430 440 450 460 470 480 490 500 pF1KB5 RLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::: XP_011 RLTALRVKKTLAKMSESQDIKL 490 500 >>NP_001243723 (OMIM: 112600,603248,609441,616849) bone (502 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.3 bits: 241.4 E(85289): 4.5e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 430 440 450 460 470 480 490 500 pF1KB5 RLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::: NP_001 RLTALRVKKTLAKMSESQDIKL 490 500 >>NP_001194 (OMIM: 112600,603248,609441,616849) bone mor (502 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.3 bits: 241.4 E(85289): 4.5e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 430 440 450 460 470 480 490 500 pF1KB5 RLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::: NP_001 RLTALRVKKTLAKMSESQDIKL 490 500 >>XP_016864047 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.3 bits: 241.4 E(85289): 4.5e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 430 440 450 460 470 480 490 500 pF1KB5 RLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::: XP_016 RLTALRVKKTLAKMSESQDIKL 490 500 >>NP_001243721 (OMIM: 112600,603248,609441,616849) bone (502 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.3 bits: 241.4 E(85289): 4.5e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 430 440 450 460 470 480 490 500 pF1KB5 RLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::: NP_001 RLTALRVKKTLAKMSESQDIKL 490 500 >>NP_001243722 (OMIM: 112600,603248,609441,616849) bone (532 aa) initn: 3430 init1: 3430 opt: 3430 Z-score: 1253.1 bits: 241.5 E(85289): 4.7e-63 Smith-Waterman score: 3430; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:31-532) 10 20 30 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVL :::::::::::::::::::::::::::::: NP_001 MGWLEELNWQLHIFLLILLSMHTRANFLDNMLLRSAGKLNVGTKKEDGESTAPTPRPKVL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 RCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 RSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRY 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB5 KRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQI 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB5 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB5 SWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAH 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 RDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRN 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB5 HFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLR 430 440 450 460 470 480 460 470 480 490 500 pF1KB5 PSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 490 500 510 520 530 >>NP_004320 (OMIM: 174900,601299,610069) bone morphogene (532 aa) initn: 2406 init1: 2040 opt: 2520 Z-score: 930.6 bits: 181.8 E(85289): 4.3e-45 Smith-Waterman score: 2520; 73.3% identity (88.2% similar) in 491 aa overlap (14-502:43-532) 10 20 30 40 pF1KB5 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSV :.:.: . :: :.: : :::.:.. NP_004 AYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAI 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECN :: : :.:.::..:::::.: ...:::. :::::::.:.: . ::.:::: . : :: NP_004 NNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECC-RTNLCN 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 KDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLII-LFCYFRY-KRQETRPRYSI . :.:::::. : :: :. .::::..:: . .... ::: .: : .: ::. NP_004 QYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNR 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 GLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMG :::::..:: ::::.:::.::::::::::::::::::::::::::.:.::::::::::: NP_004 DLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMG 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB5 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB5 HENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK ::::::::.:: .:::....::::::.. :::::::::..::::::::::::::::::.: NP_004 HENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK 320 330 340 350 360 370 350 360 370 380 390 400 pF1KB5 KNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMY :::.:::::::::::: :::::::.: :::::::::: :::::::::.:::: :::::.: NP_004 KNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIY 380 390 400 410 420 430 410 420 430 440 450 460 pF1KB5 SFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDE :::::.::.::::..:::::::::::...::::::::::::.::.:.::: :::.::: NP_004 SFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDE 440 450 460 470 480 490 470 480 490 500 pF1KB5 CLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL ::: . :::.:::::::::::::::.::::::: ::::.:. NP_004 CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 500 510 520 530 502 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:38:14 2016 done: Sat Nov 5 10:38:15 2016 Total Scan time: 6.690 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]