Result of FASTA (omim) for
pF1KB5907
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5907, 504 aa
1>>>pF1KB5907 504 - 504 aa - 504 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.4668+/-0.000508; mu= -1.8559+/- 0.031
mean_var=221.4123+/-45.808, 0's: 0 Z-trim(115.7): 97 B-trim: 883 in 2/53
Lambda= 0.086193
statistics sampled from 26190 (26287) to 26190 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.308), width: 16
Scan time: 9.080
The best scores are: opt bits E(85289)
NP_000252 (OMIM: 137750,601652) myocilin precursor ( 504) 3319 426.1 1.2e-118
NP_001269541 (OMIM: 605366) noelin isoform 5 [Homo ( 458) 757 107.5 8.6e-23
NP_055094 (OMIM: 605366) noelin isoform 1 precurso ( 467) 757 107.5 8.7e-23
NP_001269540 (OMIM: 605366) noelin isoform 4 precu ( 485) 757 107.5 9e-23
NP_477518 (OMIM: 607567) noelin-3 isoform 2 precur ( 458) 676 97.4 9.2e-20
NP_001275750 (OMIM: 607567) noelin-3 isoform 1 pre ( 478) 676 97.4 9.6e-20
NP_001275752 (OMIM: 607567) noelin-3 isoform 3 [Ho ( 383) 673 97.0 1e-19
XP_016855729 (OMIM: 607567) PREDICTED: noelin-3 is ( 383) 673 97.0 1e-19
XP_016863431 (OMIM: 616417) PREDICTED: adhesion G (1235) 616 90.2 3.7e-17
NP_001309175 (OMIM: 616417) adhesion G protein-cou (1240) 616 90.2 3.7e-17
XP_016863430 (OMIM: 616417) PREDICTED: adhesion G (1299) 616 90.2 3.8e-17
XP_016863429 (OMIM: 616417) PREDICTED: adhesion G (1308) 616 90.2 3.8e-17
NP_001269644 (OMIM: 615899) olfactomedin-like prot ( 438) 605 88.6 4.1e-17
XP_016863428 (OMIM: 616417) PREDICTED: adhesion G (1442) 616 90.3 4.2e-17
NP_056051 (OMIM: 616417) adhesion G protein-couple (1469) 616 90.3 4.2e-17
XP_016863427 (OMIM: 616417) PREDICTED: adhesion G (1510) 616 90.3 4.3e-17
XP_011530093 (OMIM: 616417) PREDICTED: adhesion G (1515) 616 90.3 4.3e-17
XP_016863426 (OMIM: 616417) PREDICTED: adhesion G (1518) 616 90.3 4.3e-17
XP_016863425 (OMIM: 616417) PREDICTED: adhesion G (1524) 616 90.3 4.3e-17
XP_016863424 (OMIM: 616417) PREDICTED: adhesion G (1528) 616 90.3 4.4e-17
XP_016863423 (OMIM: 616417) PREDICTED: adhesion G (1532) 616 90.3 4.4e-17
XP_016863422 (OMIM: 616417) PREDICTED: adhesion G (1534) 616 90.3 4.4e-17
NP_001309331 (OMIM: 616417) adhesion G protein-cou (1537) 616 90.3 4.4e-17
XP_016863421 (OMIM: 616417) PREDICTED: adhesion G (1537) 616 90.3 4.4e-17
XP_011530090 (OMIM: 616417) PREDICTED: adhesion G (1543) 616 90.3 4.4e-17
XP_016863420 (OMIM: 616417) PREDICTED: adhesion G (1580) 616 90.3 4.5e-17
XP_016863418 (OMIM: 616417) PREDICTED: adhesion G (1586) 616 90.3 4.5e-17
XP_016863419 (OMIM: 616417) PREDICTED: adhesion G (1586) 616 90.3 4.5e-17
XP_006717052 (OMIM: 615899) PREDICTED: olfactomedi ( 616) 605 88.7 5.4e-17
NP_872293 (OMIM: 615899) olfactomedin-like protein ( 652) 605 88.7 5.6e-17
NP_001284635 (OMIM: 607018) adhesion G protein-cou (1123) 583 86.1 5.8e-16
XP_016856287 (OMIM: 607018) PREDICTED: adhesion G (1163) 583 86.1 6e-16
XP_016856286 (OMIM: 607018) PREDICTED: adhesion G (1173) 583 86.1 6e-16
NP_001284634 (OMIM: 607018) adhesion G protein-cou (1177) 583 86.1 6e-16
XP_016856284 (OMIM: 607018) PREDICTED: adhesion G (1181) 583 86.1 6.1e-16
XP_016856285 (OMIM: 607018) PREDICTED: adhesion G (1186) 583 86.1 6.1e-16
XP_016856283 (OMIM: 607018) PREDICTED: adhesion G (1191) 583 86.1 6.1e-16
XP_016856282 (OMIM: 607018) PREDICTED: adhesion G (1225) 583 86.1 6.2e-16
NP_001284633 (OMIM: 607018) adhesion G protein-cou (1403) 583 86.2 7e-16
NP_036434 (OMIM: 607018) adhesion G protein-couple (1403) 583 86.2 7e-16
XP_016856281 (OMIM: 607018) PREDICTED: adhesion G (1408) 583 86.2 7e-16
NP_001317574 (OMIM: 607018) adhesion G protein-cou (1416) 583 86.2 7e-16
XP_016856279 (OMIM: 607018) PREDICTED: adhesion G (1421) 583 86.2 7.1e-16
XP_005270725 (OMIM: 607018) PREDICTED: adhesion G (1446) 583 86.2 7.2e-16
XP_016856278 (OMIM: 607018) PREDICTED: adhesion G (1446) 583 86.2 7.2e-16
XP_016856277 (OMIM: 607018) PREDICTED: adhesion G (1451) 583 86.2 7.2e-16
XP_005270723 (OMIM: 607018) PREDICTED: adhesion G (1459) 583 86.2 7.2e-16
XP_016856276 (OMIM: 607018) PREDICTED: adhesion G (1459) 583 86.2 7.2e-16
XP_016856275 (OMIM: 607018) PREDICTED: adhesion G (1463) 583 86.2 7.2e-16
XP_016856274 (OMIM: 607018) PREDICTED: adhesion G (1463) 583 86.2 7.2e-16
>>NP_000252 (OMIM: 137750,601652) myocilin precursor [Ho (504 aa)
initn: 3319 init1: 3319 opt: 3319 Z-score: 2251.4 bits: 426.1 E(85289): 1.2e-118
Smith-Waterman score: 3319; 100.0% identity (100.0% similar) in 504 aa overlap (1-504:1-504)
10 20 30 40 50 60
pF1KB5 MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 CPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 RRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 GDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 YDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 PGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 IRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYN
430 440 450 460 470 480
490 500
pF1KB5 PLEKKLFAWDNLNMVTYDIKLSKM
::::::::::::::::::::::::
NP_000 PLEKKLFAWDNLNMVTYDIKLSKM
490 500
>>NP_001269541 (OMIM: 605366) noelin isoform 5 [Homo sap (458 aa)
initn: 751 init1: 464 opt: 757 Z-score: 530.2 bits: 107.5 E(85289): 8.6e-23
Smith-Waterman score: 760; 32.7% identity (65.6% similar) in 407 aa overlap (110-501:53-449)
80 90 100 110 120 130
pF1KB5 TQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELE
::.:. . . . ::. ........ .:
NP_001 RVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIE
30 40 50 60 70 80
140 150 160 170 180 190
pF1KB5 TAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGS
. :: . .:. ..... . .. . :: .:..:: .. . : : . :
NP_001 VLDRRTQRDLQYVEKMENQMKGLESKFKQVEESHKQHLARQFKAIKAKM-DELRPLIPVL
90 100 110 120 130 140
200 210 220 230 240
pF1KB5 REVSTWNLDTLAFQELKSELTEVPASRILKESPSGY---------------LRSGEGDTG
.: .. .: :.: ..:: : :.: ..: ::. .
NP_001 EEYKADAKLVLQFKEEVQNLTSVLNE--LQEEIGAYDYDELQSRVSNLEERLRACMQKLA
150 160 170 180 190
250 260 270 280 290 300
pF1KB5 CGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLI
::.:. ...:.:..:. . ..: :: :: : .. .: .: .. : : :: .
NP_001 CGKLTGISDPVTVKTSGS---RFGSWMTDP--LAPEGDNRVWYMDGYHNN-RFVREYKSM
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB5 SQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG
.::. : ::.: .:: :::.::.::. .:. .::..:.:::. . . ::
NP_001 VDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTRSLDYAG
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB5 YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQ
:.... :.:::..:::: :::.:::..:.:.. : ::.:.:.: .:. :::.:. :.
NP_001 YNNMYHYAWGGHSDIDLMVDESGLWAVYATNQNAGNIVVSRLDPVSLQTLQTWNTSYPKR
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB5 SVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEK
:...:::::::::....: :. . :..::.:... . . :::.:.:.. ::.:::: ..
NP_001 SAGEAFIICGTLYVTNGY-SGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDR
380 390 400 410 420 430
490 500
pF1KB5 KLFAWDNLNMVTYDIKLSKM
:.::.: ... :.. :
NP_001 ALYAWNNGHQILYNVTLFHVIRSDEL
440 450
>>NP_055094 (OMIM: 605366) noelin isoform 1 precursor [H (467 aa)
initn: 777 init1: 464 opt: 757 Z-score: 530.1 bits: 107.5 E(85289): 8.7e-23
Smith-Waterman score: 760; 32.7% identity (65.6% similar) in 407 aa overlap (110-501:62-458)
80 90 100 110 120 130
pF1KB5 TQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELE
::.:. . . . ::. ........ .:
NP_055 QVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB5 TAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGS
. :: . .:. ..... . .. . :: .:..:: .. . : : . :
NP_055 VLDRRTQRDLQYVEKMENQMKGLESKFKQVEESHKQHLARQFKAIKAKM-DELRPLIPVL
100 110 120 130 140 150
200 210 220 230 240
pF1KB5 REVSTWNLDTLAFQELKSELTEVPASRILKESPSGY---------------LRSGEGDTG
.: .. .: :.: ..:: : :.: ..: ::. .
NP_055 EEYKADAKLVLQFKEEVQNLTSVLNE--LQEEIGAYDYDELQSRVSNLEERLRACMQKLA
160 170 180 190 200
250 260 270 280 290 300
pF1KB5 CGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLI
::.:. ...:.:..:. . ..: :: :: : .. .: .: .. : : :: .
NP_055 CGKLTGISDPVTVKTSGS---RFGSWMTDP--LAPEGDNRVWYMDGYHNN-RFVREYKSM
210 220 230 240 250 260
310 320 330 340 350 360
pF1KB5 SQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG
.::. : ::.: .:: :::.::.::. .:. .::..:.:::. . . ::
NP_055 VDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTRSLDYAG
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB5 YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQ
:.... :.:::..:::: :::.:::..:.:.. : ::.:.:.: .:. :::.:. :.
NP_055 YNNMYHYAWGGHSDIDLMVDESGLWAVYATNQNAGNIVVSRLDPVSLQTLQTWNTSYPKR
330 340 350 360 370 380
430 440 450 460 470 480
pF1KB5 SVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEK
:...:::::::::....: :. . :..::.:... . . :::.:.:.. ::.:::: ..
NP_055 SAGEAFIICGTLYVTNGY-SGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDR
390 400 410 420 430 440
490 500
pF1KB5 KLFAWDNLNMVTYDIKLSKM
:.::.: ... :.. :
NP_055 ALYAWNNGHQILYNVTLFHVIRSDEL
450 460
>>NP_001269540 (OMIM: 605366) noelin isoform 4 precursor (485 aa)
initn: 751 init1: 464 opt: 757 Z-score: 529.8 bits: 107.5 E(85289): 9e-23
Smith-Waterman score: 760; 32.7% identity (65.6% similar) in 407 aa overlap (110-501:80-476)
80 90 100 110 120 130
pF1KB5 TQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELE
::.:. . . . ::. ........ .:
NP_001 GVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIE
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB5 TAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGS
. :: . .:. ..... . .. . :: .:..:: .. . : : . :
NP_001 VLDRRTQRDLQYVEKMENQMKGLESKFKQVEESHKQHLARQFKAIKAKM-DELRPLIPVL
110 120 130 140 150 160
200 210 220 230 240
pF1KB5 REVSTWNLDTLAFQELKSELTEVPASRILKESPSGY---------------LRSGEGDTG
.: .. .: :.: ..:: : :.: ..: ::. .
NP_001 EEYKADAKLVLQFKEEVQNLTSVLNE--LQEEIGAYDYDELQSRVSNLEERLRACMQKLA
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB5 CGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLI
::.:. ...:.:..:. . ..: :: :: : .. .: .: .. : : :: .
NP_001 CGKLTGISDPVTVKTSGS---RFGSWMTDP--LAPEGDNRVWYMDGYHNN-RFVREYKSM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB5 SQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG
.::. : ::.: .:: :::.::.::. .:. .::..:.:::. . . ::
NP_001 VDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTRSLDYAG
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB5 YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQ
:.... :.:::..:::: :::.:::..:.:.. : ::.:.:.: .:. :::.:. :.
NP_001 YNNMYHYAWGGHSDIDLMVDESGLWAVYATNQNAGNIVVSRLDPVSLQTLQTWNTSYPKR
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB5 SVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEK
:...:::::::::....: :. . :..::.:... . . :::.:.:.. ::.:::: ..
NP_001 SAGEAFIICGTLYVTNGY-SGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDR
410 420 430 440 450
490 500
pF1KB5 KLFAWDNLNMVTYDIKLSKM
:.::.: ... :.. :
NP_001 ALYAWNNGHQILYNVTLFHVIRSDEL
460 470 480
>>NP_477518 (OMIM: 607567) noelin-3 isoform 2 precursor (458 aa)
initn: 645 init1: 443 opt: 676 Z-score: 475.7 bits: 97.4 E(85289): 9.2e-20
Smith-Waterman score: 695; 31.5% identity (60.8% similar) in 467 aa overlap (40-501:38-448)
10 20 30 40 50 60
pF1KB5 SFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMS
:.: .::: : :..:... :
NP_477 LNLLLLSLFAGLDPSKTQISPKEGWQVYSSAQDPDGRCICT--VVAPEQNLC--------
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 VIHNLQRDSSTQRLD--LEATKARLSSLESLLHQLTLD-QAARPQETQ-EGLQRELGTLR
.::.....: :: .. .:.: : . : : . .::: .::. .. ..
NP_477 -----SRDAKSRQLRQLLEKVQNMSQSIEVLNLRTQRDFQYVLKMETQMKGLKAKFRQIE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 RERDQLETQT-RELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQ
.: : :. .::. ...:: :::. : :. . . ..:. :
NP_477 DDRKTLMTKHFQELKEKMDELLPLIPVLEQYKTD--------AKLITQFKEEIRNLS---
120 130 140 150 160
190 200 210 220 230 240
pF1KB5 CPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTG
:: : .: .. . ..::.. :.: : ::.
NP_477 ---------AVLTGIQE----EIGAYDYEELHQ--------RVL--SLETRLRDCMKKLT
170 180 190
250 260 270 280 290 300
pF1KB5 CGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLI
::.:. . :.:..:. : ..:.:: :: . .. .: .:. :. . : :: :
NP_477 CGKLMKITGPVTVKTSGT---RFGAWMTDPLASE--KNNRVWYMDSY-TNNKIVREYKSI
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB5 SQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG
..:..: :... :: .:. :::.:::::. .: .:.: .. : :.. . ::
NP_477 ADFVSGAESRTYNLPFKWAGTNHVVYNGSLYFNKYQSNIIIKYSFDMGRVLAQRSLEYAG
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB5 YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQ
.:. .::.:::..:::: .:: :::..:.:.. : ::.:.:: ..::. ..: :. :.
NP_477 FHNVYPYTWGGFSDIDLMADEIGLWAVYATNQNAGNIVISQLNQDTLEVMKSWSTGYPKR
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB5 SVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEK
:....:.::::::...:. .. : : ..:.: :. . :::.:.: . ::.::: ..
NP_477 SAGESFMICGTLYVTNSHLTG-AKVYYSYSTKTSTYEYTDIPFHNQYFHISMLDYNARDR
380 390 400 410 420 430
490 500
pF1KB5 KLFAWDNLNMVTYDIKLSKM
:.::.: ..: ... :
NP_477 ALYAWNNGHQVLFNVTLFHIIKTEDDT
440 450
>>NP_001275750 (OMIM: 607567) noelin-3 isoform 1 precurs (478 aa)
initn: 645 init1: 443 opt: 676 Z-score: 475.5 bits: 97.4 E(85289): 9.6e-20
Smith-Waterman score: 695; 31.5% identity (60.8% similar) in 467 aa overlap (40-501:58-468)
10 20 30 40 50 60
pF1KB5 SFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMS
:.: .::: : :..:... :
NP_001 SLVGLNTTRLSTPDTLTQISPKEGWQVYSSAQDPDGRCICT--VVAPEQNLC--------
30 40 50 60 70
70 80 90 100 110 120
pF1KB5 VIHNLQRDSSTQRLD--LEATKARLSSLESLLHQLTLD-QAARPQETQ-EGLQRELGTLR
.::.....: :: .. .:.: : . : : . .::: .::. .. ..
NP_001 -----SRDAKSRQLRQLLEKVQNMSQSIEVLNLRTQRDFQYVLKMETQMKGLKAKFRQIE
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB5 RERDQLETQT-RELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQ
.: : :. .::. ...:: :::. : :. . . ..:. :
NP_001 DDRKTLMTKHFQELKEKMDELLPLIPVLEQYKTD--------AKLITQFKEEIRNLS---
140 150 160 170 180
190 200 210 220 230 240
pF1KB5 CPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTG
:: : .: .. . ..::.. :.: : ::.
NP_001 ---------AVLTGIQE----EIGAYDYEELHQ--------RVL--SLETRLRDCMKKLT
190 200 210
250 260 270 280 290 300
pF1KB5 CGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLI
::.:. . :.:..:. : ..:.:: :: . .. .: .:. :. . : :: :
NP_001 CGKLMKITGPVTVKTSGT---RFGAWMTDPLASE--KNNRVWYMDSY-TNNKIVREYKSI
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB5 SQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG
..:..: :... :: .:. :::.:::::. .: .:.: .. : :.. . ::
NP_001 ADFVSGAESRTYNLPFKWAGTNHVVYNGSLYFNKYQSNIIIKYSFDMGRVLAQRSLEYAG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB5 YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQ
.:. .::.:::..:::: .:: :::..:.:.. : ::.:.:: ..::. ..: :. :.
NP_001 FHNVYPYTWGGFSDIDLMADEIGLWAVYATNQNAGNIVISQLNQDTLEVMKSWSTGYPKR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB5 SVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEK
:....:.::::::...:. .. : : ..:.: :. . :::.:.: . ::.::: ..
NP_001 SAGESFMICGTLYVTNSHLTG-AKVYYSYSTKTSTYEYTDIPFHNQYFHISMLDYNARDR
400 410 420 430 440 450
490 500
pF1KB5 KLFAWDNLNMVTYDIKLSKM
:.::.: ..: ... :
NP_001 ALYAWNNGHQVLFNVTLFHIIKTEDDT
460 470
>>NP_001275752 (OMIM: 607567) noelin-3 isoform 3 [Homo s (383 aa)
initn: 645 init1: 443 opt: 673 Z-score: 474.9 bits: 97.0 E(85289): 1e-19
Smith-Waterman score: 687; 31.4% identity (64.2% similar) in 388 aa overlap (120-501:6-373)
90 100 110 120 130 140
pF1KB5 ARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERD-----QLETQTRELETAYSN
:. .:: .:: ..::: . :.. . .
NP_001 MSQSIEVLNLRTQRDFQYVLKMETQMKGLKAKFRQ
10 20 30
150 160 170 180 190 200
pF1KB5 LLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVST
. :...: . .. ..: .... . :. : . :. . ..:. .
NP_001 IEDDRKTL------MTKHFQELKEKMDELLPLIPVLE-----QYKTDAKLITQFKEEIRN
40 50 60 70 80
210 220 230 240 250 260
pF1KB5 WNLDTLAFQE-LKSELTEVPASRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETI
. ..:: . . : .:.: : ::. ::.:. . :.:..:. :
NP_001 LSAVLTGIQEEIGAYDYEELHQRVL--SLETRLRDCMKKLTCGKLMKITGPVTVKTSGT-
90 100 110 120 130 140
270 280 290 300 310 320
pF1KB5 TGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLE
..:.:: :: . .. .: .:. :. . : :: :..:..: :... ::
NP_001 --RFGAWMTDPLASE--KNNRVWYMDSY-TNNKIVREYKSIADFVSGAESRTYNLPFKWA
150 160 170 180 190
330 340 350 360 370 380
pF1KB5 STGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAV
.:. :::.:::::. .: .:.: .. : :.. . ::.:. .::.:::..:::: .
NP_001 GTNHVVYNGSLYFNKYQSNIIIKYSFDMGRVLAQRSLEYAGFHNVYPYTWGGFSDIDLMA
200 210 220 230 240 250
390 400 410 420 430 440
pF1KB5 DEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYT
:: :::..:.:.. : ::.:.:: ..::. ..: :. :.:....:.::::::...:.
NP_001 DEIGLWAVYATNQNAGNIVISQLNQDTLEVMKSWSTGYPKRSAGESFMICGTLYVTNSHL
260 270 280 290 300 310
450 460 470 480 490 500
pF1KB5 SADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSK
.. : : ..:.: :. . :::.:.: . ::.::: .. :.::.: ..: ... :
NP_001 TG-AKVYYSYSTKTSTYEYTDIPFHNQYFHISMLDYNARDRALYAWNNGHQVLFNVTLFH
320 330 340 350 360 370
pF1KB5 M
NP_001 IIKTEDDT
380
>>XP_016855729 (OMIM: 607567) PREDICTED: noelin-3 isofor (383 aa)
initn: 645 init1: 443 opt: 673 Z-score: 474.9 bits: 97.0 E(85289): 1e-19
Smith-Waterman score: 687; 31.4% identity (64.2% similar) in 388 aa overlap (120-501:6-373)
90 100 110 120 130 140
pF1KB5 ARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERD-----QLETQTRELETAYSN
:. .:: .:: ..::: . :.. . .
XP_016 MSQSIEVLNLRTQRDFQYVLKMETQMKGLKAKFRQ
10 20 30
150 160 170 180 190 200
pF1KB5 LLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVST
. :...: . .. ..: .... . :. : . :. . ..:. .
XP_016 IEDDRKTL------MTKHFQELKEKMDELLPLIPVLE-----QYKTDAKLITQFKEEIRN
40 50 60 70 80
210 220 230 240 250 260
pF1KB5 WNLDTLAFQE-LKSELTEVPASRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETI
. ..:: . . : .:.: : ::. ::.:. . :.:..:. :
XP_016 LSAVLTGIQEEIGAYDYEELHQRVL--SLETRLRDCMKKLTCGKLMKITGPVTVKTSGT-
90 100 110 120 130 140
270 280 290 300 310 320
pF1KB5 TGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLE
..:.:: :: . .. .: .:. :. . : :: :..:..: :... ::
XP_016 --RFGAWMTDPLASE--KNNRVWYMDSY-TNNKIVREYKSIADFVSGAESRTYNLPFKWA
150 160 170 180 190
330 340 350 360 370 380
pF1KB5 STGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAV
.:. :::.:::::. .: .:.: .. : :.. . ::.:. .::.:::..:::: .
XP_016 GTNHVVYNGSLYFNKYQSNIIIKYSFDMGRVLAQRSLEYAGFHNVYPYTWGGFSDIDLMA
200 210 220 230 240 250
390 400 410 420 430 440
pF1KB5 DEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYT
:: :::..:.:.. : ::.:.:: ..::. ..: :. :.:....:.::::::...:.
XP_016 DEIGLWAVYATNQNAGNIVISQLNQDTLEVMKSWSTGYPKRSAGESFMICGTLYVTNSHL
260 270 280 290 300 310
450 460 470 480 490 500
pF1KB5 SADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSK
.. : : ..:.: :. . :::.:.: . ::.::: .. :.::.: ..: ... :
XP_016 TG-AKVYYSYSTKTSTYEYTDIPFHNQYFHISMLDYNARDRALYAWNNGHQVLFNVTLFH
320 330 340 350 360 370
pF1KB5 M
XP_016 IIKTEDDT
380
>>XP_016863431 (OMIM: 616417) PREDICTED: adhesion G prot (1235 aa)
initn: 576 init1: 469 opt: 616 Z-score: 429.1 bits: 90.2 E(85289): 3.7e-17
Smith-Waterman score: 616; 39.0% identity (69.5% similar) in 246 aa overlap (268-504:156-394)
240 250 260 270 280 290
pF1KB5 SGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDP---KPTYPYTQETTWRIDTVGTD
:.: .:: . : : .: ::.
XP_016 YKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLT--
130 140 150 160 170 180
300 310 320 330 340 350
pF1KB5 VRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETV
::. ..:. : :. .. ::. ...:: :::.:.:.:. ..:......: :.
XP_016 -----EYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIK
190 200 210 220 230
360 370 380 390 400 410
pF1KB5 KAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELE
..: : .:.:: :: ::: .:::::::: ::::::.:.. .: ::.:.::: .:..:
XP_016 SGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIE
240 250 260 270 280 290
420 430 440 450 460
pF1KB5 QTWETNIRKQSVANAFIICGTLYTVSS-YTSAD--AT---VNFAYDTGTGISKTLTIPFK
::.: :.:..:::.::: ::.:.: : . : :: ... :.: . .. . .::
XP_016 GTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFP
300 310 320 330 340 350
470 480 490 500
pF1KB5 NRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM
: :.: . .:::: .. :..:.: ..: :.. .. .
XP_016 NSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSE
360 370 380 390 400 410
XP_016 LERPSVKGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDMTTH
420 430 440 450 460 470
>>NP_001309175 (OMIM: 616417) adhesion G protein-coupled (1240 aa)
initn: 576 init1: 469 opt: 616 Z-score: 429.1 bits: 90.2 E(85289): 3.7e-17
Smith-Waterman score: 616; 39.0% identity (69.5% similar) in 246 aa overlap (268-504:156-394)
240 250 260 270 280 290
pF1KB5 SGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDP---KPTYPYTQETTWRIDTVGTD
:.: .:: . : : .: ::.
NP_001 YKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLT--
130 140 150 160 170 180
300 310 320 330 340 350
pF1KB5 VRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETV
::. ..:. : :. .. ::. ...:: :::.:.:.:. ..:......: :.
NP_001 -----EYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIK
190 200 210 220 230
360 370 380 390 400 410
pF1KB5 KAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELE
..: : .:.:: :: ::: .:::::::: ::::::.:.. .: ::.:.::: .:..:
NP_001 SGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIE
240 250 260 270 280 290
420 430 440 450 460
pF1KB5 QTWETNIRKQSVANAFIICGTLYTVSS-YTSAD--AT---VNFAYDTGTGISKTLTIPFK
::.: :.:..:::.::: ::.:.: : . : :: ... :.: . .. . .::
NP_001 GTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFP
300 310 320 330 340 350
470 480 490 500
pF1KB5 NRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM
: :.: . .:::: .. :..:.: ..: :.. .. .
NP_001 NSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSE
360 370 380 390 400 410
NP_001 LERPSVKDISTTGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLD
420 430 440 450 460 470
504 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 15:31:15 2016 done: Sat Nov 5 15:31:16 2016
Total Scan time: 9.080 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]