FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5908, 520 aa 1>>>pF1KB5908 520 - 520 aa - 520 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7718+/-0.000873; mu= 8.0229+/- 0.053 mean_var=154.6376+/-30.219, 0's: 0 Z-trim(112.2): 49 B-trim: 29 in 1/51 Lambda= 0.103138 statistics sampled from 12977 (13021) to 12977 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.4), width: 16 Scan time: 3.400 The best scores are: opt bits E(32554) CCDS43106.1 MITF gene_id:4286|Hs108|chr3 ( 520) 3424 521.3 1.1e-147 CCDS46865.1 MITF gene_id:4286|Hs108|chr3 ( 504) 3192 486.7 2.6e-137 CCDS54607.1 MITF gene_id:4286|Hs108|chr3 ( 468) 3082 470.3 2.1e-132 CCDS43107.1 MITF gene_id:4286|Hs108|chr3 ( 413) 2667 408.5 7.2e-114 CCDS2913.1 MITF gene_id:4286|Hs108|chr3 ( 419) 2645 405.3 7.1e-113 CCDS46866.2 MITF gene_id:4286|Hs108|chr3 ( 357) 2146 331.0 1.4e-90 CCDS14315.3 TFE3 gene_id:7030|Hs108|chrX ( 575) 1018 163.3 6.9e-40 CCDS5762.1 TFEC gene_id:22797|Hs108|chr7 ( 347) 972 156.3 5.3e-38 CCDS59076.1 TFEC gene_id:22797|Hs108|chr7 ( 280) 899 145.4 8.3e-35 CCDS34738.1 TFEC gene_id:22797|Hs108|chr7 ( 318) 899 145.4 9.1e-35 CCDS4858.1 TFEB gene_id:7942|Hs108|chr6 ( 476) 770 126.3 7.6e-29 CCDS64425.1 TFEB gene_id:7942|Hs108|chr6 ( 490) 770 126.3 7.8e-29 CCDS64424.1 TFEB gene_id:7942|Hs108|chr6 ( 391) 758 124.5 2.2e-28 CCDS74962.1 MITF gene_id:4286|Hs108|chr3 ( 91) 527 89.7 1.5e-18 >>CCDS43106.1 MITF gene_id:4286|Hs108|chr3 (520 aa) initn: 3424 init1: 3424 opt: 3424 Z-score: 2765.1 bits: 521.3 E(32554): 1.1e-147 Smith-Waterman score: 3424; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KB5 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 QQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 THLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 THLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PMAMLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PMAMLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 ILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 ILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 AKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 EQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 VLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 VLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILM 430 440 450 460 470 480 490 500 510 520 pF1KB5 DDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC :::::::::::::::::::::::::::::::::::::::: CCDS43 DDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC 490 500 510 520 >>CCDS46865.1 MITF gene_id:4286|Hs108|chr3 (504 aa) initn: 3192 init1: 3192 opt: 3192 Z-score: 2578.7 bits: 486.7 E(32554): 2.6e-137 Smith-Waterman score: 3192; 100.0% identity (100.0% similar) in 485 aa overlap (36-520:20-504) 10 20 30 40 50 60 pF1KB5 GIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLRQQLMR :::::::::::::::::::::::::::::: CCDS46 MEALRVQMFMPCSFESLYLSSAEHPGASKPPISSSSMTSRILLRQQLMR 10 20 30 40 70 80 90 100 110 120 pF1KB5 EQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 EQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLEN 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 PTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 PTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAML 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB5 TLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 TLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLM 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB5 DPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQ 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 KKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 KELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENC 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 SQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLS 410 420 430 440 450 460 490 500 510 520 pF1KB5 PVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC ::::::::::::::::::::::::::::::::::: CCDS46 PVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC 470 480 490 500 >>CCDS54607.1 MITF gene_id:4286|Hs108|chr3 (468 aa) initn: 3082 init1: 3082 opt: 3082 Z-score: 2490.7 bits: 470.3 E(32554): 2.1e-132 Smith-Waterman score: 3082; 100.0% identity (100.0% similar) in 468 aa overlap (53-520:1-468) 30 40 50 60 70 80 pF1KB5 TYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQA :::::::::::::::::::::::::::::: CCDS54 MTSRILLRQQLMREQMQEQERREQQQKLQA 10 20 30 90 100 110 120 130 140 pF1KB5 AQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 AQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQY 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB5 LSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 LSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQ 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB5 NRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 NRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLI 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB5 DLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 DLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNIN 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB5 DRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 DRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHL 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB5 LLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 LLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTL 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB5 DLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 DLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGAS 400 410 420 430 440 450 510 520 pF1KB5 KTSSRRSSMSMEETEHTC :::::::::::::::::: CCDS54 KTSSRRSSMSMEETEHTC 460 >>CCDS43107.1 MITF gene_id:4286|Hs108|chr3 (413 aa) initn: 2667 init1: 2667 opt: 2667 Z-score: 2157.7 bits: 408.5 E(32554): 7.2e-114 Smith-Waterman score: 2667; 99.8% identity (100.0% similar) in 403 aa overlap (118-520:11-413) 90 100 110 120 130 140 pF1KB5 QRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTL .::::::::::::::::::::::::::::: CCDS43 MLEMLEYNHYQVQTHLENPTKYHIQQAQRQQVKQYLSTTL 10 20 30 40 150 160 170 180 190 200 pF1KB5 ANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 ANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAES 50 60 70 80 90 100 210 220 230 240 250 260 pF1KB5 ECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 ECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGN 110 120 130 140 150 160 270 280 290 300 310 320 pF1KB5 QGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 QGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKE 170 180 190 200 210 220 330 340 350 360 370 380 pF1KB5 LGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 LGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQ 230 240 250 260 270 280 390 400 410 420 430 440 pF1KB5 ELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 ELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDG 290 300 310 320 330 340 450 460 470 480 490 500 pF1KB5 TITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 TITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSR 350 360 370 380 390 400 510 520 pF1KB5 RSSMSMEETEHTC ::::::::::::: CCDS43 RSSMSMEETEHTC 410 >>CCDS2913.1 MITF gene_id:4286|Hs108|chr3 (419 aa) initn: 1477 init1: 1477 opt: 2645 Z-score: 2140.0 bits: 405.3 E(32554): 7.1e-113 Smith-Waterman score: 2645; 98.3% identity (98.5% similar) in 409 aa overlap (118-520:11-419) 90 100 110 120 130 140 pF1KB5 QRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTL .::::::::::::::::::::::::::::: CCDS29 MLEMLEYNHYQVQTHLENPTKYHIQQAQRQQVKQYLSTTL 10 20 30 40 150 160 170 180 190 200 pF1KB5 ANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 ANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAES 50 60 70 80 90 100 210 220 230 240 250 260 pF1KB5 ECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 ECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGN 110 120 130 140 150 160 270 280 290 300 310 320 pF1KB5 QGLPPPGLTISNSCPANLPNIKRELT------ESEARALAKERQKKDNHNLIERRRRFNI :::::::::::::::::::::::::: :::::::::::::::::::::::::::: CCDS29 QGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNI 170 180 190 200 210 220 330 340 350 360 370 380 pF1KB5 NDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 NDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRH 230 240 250 260 270 280 390 400 410 420 430 440 pF1KB5 LLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 LLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTT 290 300 310 320 330 340 450 460 470 480 490 500 pF1KB5 LDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS29 LDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGA 350 360 370 380 390 400 510 520 pF1KB5 SKTSSRRSSMSMEETEHTC ::::::::::::::::::: CCDS29 SKTSSRRSSMSMEETEHTC 410 >>CCDS46866.2 MITF gene_id:4286|Hs108|chr3 (357 aa) initn: 2146 init1: 2146 opt: 2146 Z-score: 1739.7 bits: 331.0 E(32554): 1.4e-90 Smith-Waterman score: 2158; 85.9% identity (86.1% similar) in 403 aa overlap (118-520:11-357) 90 100 110 120 130 140 pF1KB5 QRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTL .:::::::::::::::::::: CCDS46 MLEMLEYNHYQVQTHLENPTKYHIQQAQRQQ--------- 10 20 30 150 160 170 180 190 200 pF1KB5 ANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAES ::::::::::::: CCDS46 -----------------------------------------------GFYKFEEQNRAES 40 210 220 230 240 250 260 pF1KB5 ECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGN 50 60 70 80 90 100 270 280 290 300 310 320 pF1KB5 QGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 QGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKE 110 120 130 140 150 160 330 340 350 360 370 380 pF1KB5 LGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQ 170 180 190 200 210 220 390 400 410 420 430 440 pF1KB5 ELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDG 230 240 250 260 270 280 450 460 470 480 490 500 pF1KB5 TITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 TITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSR 290 300 310 320 330 340 510 520 pF1KB5 RSSMSMEETEHTC ::::::::::::: CCDS46 RSSMSMEETEHTC 350 >>CCDS14315.3 TFE3 gene_id:7030|Hs108|chrX (575 aa) initn: 1398 init1: 824 opt: 1018 Z-score: 829.6 bits: 163.3 E(32554): 6.9e-40 Smith-Waterman score: 1476; 50.5% identity (68.8% similar) in 564 aa overlap (4-515:46-573) 10 20 30 pF1KB5 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPL- ::::: :.:. : .: ..:::::::: CCDS14 AEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIEL--ENVLDPDSFYELKSQPLP 20 30 40 50 60 70 40 50 60 70 pF1KB5 -KSS---------------SSAEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQ .:: :.. :.:. : ::: .::.:::::::: : :::::::. CCDS14 LRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRER 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB5 QQKLQAAQFMQQRVPVSQTPAINV-SVPT---TL--PSATQVPMEVLKVQTHLENPTKYH ... :: : . :. .:::.: .: . :: : .::: :::::::::::::.:: CCDS14 REQAAAAPFPS---PAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYH 140 150 160 170 180 190 140 150 160 170 180 pF1KB5 IQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMP-PV------PGSSAPNSPMA .:::.::::::::::::. : :.:.:. : :. . . .: : : .:::::::: CCDS14 LQQARRQQVKQYLSTTLGPKLASQALT-PPPGPASAQPLPAPEAAHTTGPTGSAPNSPMA 200 210 220 230 240 190 200 210 220 230 240 pF1KB5 MLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILG .::..:. ::: .:::::.:::::::::.:.:. CCDS14 LLTIGSSSEKE----------------------------IDDVIDEIISLESSYNDEMLS 250 260 270 280 250 260 270 280 290 300 pF1KB5 LMD---PALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARAL . .::. .::::::::.:.:..::. :..:.::::::.:::::::..:.::.:: CCDS14 YLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKAL 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB5 AKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQR ::::::::::::::::::::::::::::::::::.::.::::::::::::::::::::. CCDS14 LKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQK 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB5 EQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEP ::::.:.::.::..::.::: : :::::::.::. ::: . :. :: : .. . .: CCDS14 EQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKP 410 420 430 440 450 460 430 440 450 460 470 pF1KB5 ----VLENCSQDLLQHHADLTCTTTLDLTDGTITFNN---NLGTGTEANQAYSVPTKMGS . :. :. . . . .. .: .. . : ..: CCDS14 EQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLG- 470 480 490 500 510 520 480 490 500 510 520 pF1KB5 KLEDILMDD-----------TLSPV-GVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC ::::::.. .:::. ...:::::::::..::.::::::.:::: CCDS14 -LEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES 530 540 550 560 570 >>CCDS5762.1 TFEC gene_id:22797|Hs108|chr7 (347 aa) initn: 883 init1: 648 opt: 972 Z-score: 795.8 bits: 156.3 E(32554): 5.3e-38 Smith-Waterman score: 972; 57.9% identity (79.1% similar) in 297 aa overlap (222-515:60-343) 200 210 220 230 240 250 pF1KB5 EKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQM .:.:::.:::..:::..:: : : : : CCDS57 HTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEE--G-ADSPLLM 30 40 50 60 70 80 260 270 280 290 300 pF1KB5 ANTLPVSGNLIDLY-GNQGLPPP--GLTISNSCPANLPNIKRELTESEARALAKERQKKD :: ::...:.: :.::. : ::: : :::..:: .:::.::...::::::::::: CCDS57 QRTL--SGSILDVYSGEQGISPINMGLT-SASCPSSLP-MKREITETDTRALAKERQKKD 90 100 110 120 130 140 310 320 330 340 350 360 pF1KB5 NHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKEL ::::::::::.::: :::::::::::::::::::::::::::::.::. ::.:::::.:: CCDS57 NHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRAREL 150 160 170 180 190 200 370 380 390 400 410 420 pF1KB5 ENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQD :.::::::.:::.:::::::::.:::.::: . : : . :: .. ::. :. : : CCDS57 EHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLG--TVDLGAHVTKQQSHPEQNSVD 210 220 230 240 250 260 430 440 450 460 470 480 pF1KB5 LLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVG :. .. . .: : .:.:.. :. :. ..:. : ..:. .:.:::.:: : CCDS57 YCQQ-LTVSQGPSPELCDQAIAFSDPLSYFTDL--SFSAALKEEQRLDGMLLDDTISPFG 270 280 290 300 310 490 500 510 520 pF1KB5 VTDPLLSSVSPGASKTSSRRSSMSMEETEHTC ::::::..::..:: ::::::.: .. CCDS57 -TDPLLSATSPAVSKESSRRSSFSSDDGDEL 320 330 340 >>CCDS59076.1 TFEC gene_id:22797|Hs108|chr7 (280 aa) initn: 814 init1: 648 opt: 899 Z-score: 738.4 bits: 145.4 E(32554): 8.3e-35 Smith-Waterman score: 899; 58.8% identity (80.5% similar) in 262 aa overlap (257-515:23-276) 230 240 250 260 270 280 pF1KB5 IDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLY-GNQGLPPP--GLTISNSCPA .::...:.: :.::. : ::: : :::. CCDS59 MMKEKEKTIAIVKVIDTSKLKLLSGSILDVYSGEQGISPINMGLT-SASCPS 10 20 30 40 50 290 300 310 320 330 340 pF1KB5 NLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWN .:: .:::.::...:::::::::::::::::::::.::: :::::::::::::::::::: CCDS59 SLP-MKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWN 60 70 80 90 100 110 350 360 370 380 390 400 pF1KB5 KGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPS :::::::::.::. ::.:::::.:::.::::::.:::.:::::::::.:::.::: . : CCDS59 KGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLAS 120 130 140 150 160 170 410 420 430 440 450 460 pF1KB5 TGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQ : . :: .. ::. :. : : :. .. . .: : .:.:.. :. :. . CCDS59 LG--TVDLGAHVTKQQSHPEQNSVDYCQQ-LTVSQGPSPELCDQAIAFSDPLSYFTDLS- 180 190 200 210 220 470 480 490 500 510 520 pF1KB5 AYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC .:. : ..:. .:.:::.:: : ::::::..::..:: ::::::.: .. CCDS59 -FSAALKEEQRLDGMLLDDTISPFG-TDPLLSATSPAVSKESSRRSSFSSDDGDEL 230 240 250 260 270 280 >>CCDS34738.1 TFEC gene_id:22797|Hs108|chr7 (318 aa) initn: 814 init1: 648 opt: 899 Z-score: 737.6 bits: 145.4 E(32554): 9.1e-35 Smith-Waterman score: 899; 58.8% identity (80.5% similar) in 262 aa overlap (257-515:61-314) 230 240 250 260 270 280 pF1KB5 IDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLY-GNQGLPPP--GLTISNSCPA .::...:.: :.::. : ::: : :::. CCDS34 TTLDSDAGLTENPLTKLLAIGKEDDNAQWHLSGSILDVYSGEQGISPINMGLT-SASCPS 40 50 60 70 80 290 300 310 320 330 340 pF1KB5 NLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWN .:: .:::.::...:::::::::::::::::::::.::: :::::::::::::::::::: CCDS34 SLP-MKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWN 90 100 110 120 130 140 350 360 370 380 390 400 pF1KB5 KGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPS :::::::::.::. ::.:::::.:::.::::::.:::.:::::::::.:::.::: . : CCDS34 KGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLAS 150 160 170 180 190 200 410 420 430 440 450 460 pF1KB5 TGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQ : . :: .. ::. :. : : :. .. . .: : .:.:.. :. :. . CCDS34 LG--TVDLGAHVTKQQSHPEQNSVDYCQQ-LTVSQGPSPELCDQAIAFSDPLSYFTDLS- 210 220 230 240 250 260 470 480 490 500 510 520 pF1KB5 AYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC .:. : ..:. .:.:::.:: : ::::::..::..:: ::::::.: .. CCDS34 -FSAALKEEQRLDGMLLDDTISPFG-TDPLLSATSPAVSKESSRRSSFSSDDGDEL 270 280 290 300 310 520 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:38:52 2016 done: Sat Nov 5 10:38:53 2016 Total Scan time: 3.400 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]