FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5909, 504 aa 1>>>pF1KB5909 504 - 504 aa - 504 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3243+/-0.000445; mu= 14.5015+/- 0.028 mean_var=173.4687+/-36.973, 0's: 0 Z-trim(114.6): 429 B-trim: 652 in 1/55 Lambda= 0.097379 statistics sampled from 23954 (24539) to 23954 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.288), width: 16 Scan time: 8.490 The best scores are: opt bits E(85289) NP_055317 (OMIM: 608330) pre-mRNA-processing facto ( 504) 3297 476.2 9.6e-134 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 405 69.6 1.4e-11 NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 405 69.6 1.4e-11 NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 405 69.9 2e-11 NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 405 69.9 2e-11 NP_008882 (OMIM: 601787) transcription initiation ( 800) 397 69.0 5.6e-11 NP_758440 (OMIM: 614784,615973) POC1 centriolar pr ( 478) 382 66.7 1.8e-10 NP_001186706 (OMIM: 614784,615973) POC1 centriolar ( 436) 368 64.6 6.5e-10 NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 353 62.4 2.4e-09 XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 353 62.4 2.4e-09 NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 353 62.4 2.4e-09 XP_016860391 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 341 60.7 7.5e-09 XP_011510137 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 341 60.7 7.5e-09 XP_016860389 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 341 60.7 7.5e-09 XP_016860390 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 341 60.7 7.5e-09 XP_016860387 (OMIM: 612173) PREDICTED: sperm-assoc ( 390) 341 60.8 8.5e-09 XP_011531865 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 338 60.1 8.5e-09 XP_011531867 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 338 60.1 8.5e-09 XP_011531866 (OMIM: 614783,614813) PREDICTED: POC1 ( 246) 338 60.1 8.5e-09 XP_016860385 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 341 60.9 1e-08 XP_016860386 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 341 60.9 1e-08 XP_011510125 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 341 61.0 1e-08 XP_011510124 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 341 61.0 1e-08 XP_011510123 (OMIM: 612173) PREDICTED: sperm-assoc ( 537) 341 61.0 1e-08 XP_011510121 (OMIM: 612173) PREDICTED: sperm-assoc ( 577) 341 61.0 1.1e-08 XP_011510116 (OMIM: 612173) PREDICTED: sperm-assoc ( 600) 341 61.0 1.1e-08 NP_078808 (OMIM: 612173) sperm-associated antigen ( 631) 341 61.0 1.1e-08 NP_005877 (OMIM: 602703,616212) katanin p80 WD40 r ( 655) 332 59.8 2.8e-08 XP_016878353 (OMIM: 602703,616212) PREDICTED: kata ( 655) 332 59.8 2.8e-08 XP_016878352 (OMIM: 602703,616212) PREDICTED: kata ( 655) 332 59.8 2.8e-08 XP_006721186 (OMIM: 602703,616212) PREDICTED: kata ( 658) 332 59.8 2.8e-08 XP_016878351 (OMIM: 602703,616212) PREDICTED: kata ( 672) 332 59.8 2.8e-08 XP_005255829 (OMIM: 602703,616212) PREDICTED: kata ( 672) 332 59.8 2.8e-08 XP_016878350 (OMIM: 602703,616212) PREDICTED: kata ( 672) 332 59.8 2.8e-08 XP_016878349 (OMIM: 602703,616212) PREDICTED: kata ( 675) 332 59.8 2.8e-08 XP_011521112 (OMIM: 602703,616212) PREDICTED: kata ( 675) 332 59.8 2.8e-08 XP_006721184 (OMIM: 602703,616212) PREDICTED: kata ( 675) 332 59.8 2.8e-08 XP_006721185 (OMIM: 602703,616212) PREDICTED: kata ( 675) 332 59.8 2.8e-08 XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD re ( 540) 324 58.6 5.4e-08 NP_001013433 (OMIM: 606278) F-box/WD repeat-contai ( 589) 324 58.6 5.7e-08 NP_060785 (OMIM: 606278) F-box/WD repeat-containin ( 627) 324 58.7 5.9e-08 XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 324 58.7 6.2e-08 XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 324 58.7 6.2e-08 XP_016863851 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 324 58.7 6.4e-08 NP_361014 (OMIM: 606278) F-box/WD repeat-containin ( 707) 324 58.7 6.4e-08 XP_011530387 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 324 58.7 6.4e-08 XP_011530385 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 324 58.7 6.4e-08 XP_011530386 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 324 58.7 6.4e-08 NP_001269467 (OMIM: 139380,613065,616973) guanine ( 240) 307 55.7 1.7e-07 NP_001269468 (OMIM: 139380,613065,616973) guanine ( 340) 307 55.9 2.1e-07 >>NP_055317 (OMIM: 608330) pre-mRNA-processing factor 19 (504 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 2522.1 bits: 476.2 E(85289): 9.6e-134 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 504 aa overlap (1-504:1-504) 10 20 30 40 50 60 pF1KB5 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 IRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 TVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG 430 440 450 460 470 480 490 500 pF1KB5 VAFGHHAKFIASTGMDRSLKFYSL :::::::::::::::::::::::: NP_055 VAFGHHAKFIASTGMDRSLKFYSL 490 500 >>NP_001309196 (OMIM: 607795,615922) U4/U6 small nuclear (279 aa) initn: 410 init1: 204 opt: 405 Z-score: 329.2 bits: 69.6 E(85289): 1.4e-11 Smith-Waterman score: 405; 27.1% identity (60.5% similar) in 258 aa overlap (256-502:22-276) 230 240 250 260 270 280 pF1KB5 ALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVF----- .: ::.::. .: ..::::.. . . NP_001 MLSFVFDRSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDV 10 20 30 40 50 290 300 310 320 330 pF1KB5 ---SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT : . :.....::. . : ...: :. . : .: .: .. :. : . :... NP_001 NLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEA 60 70 80 90 100 110 340 350 360 370 380 390 pF1KB5 GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITS . . . .. : . :: :: . ::: .:. ..:::. . . :: : . NP_001 QEEILHQEGHSMG--VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 120 130 140 150 160 400 410 420 430 440 450 pF1KB5 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ-SGTYLALGGTD : :: :::..::.. :.. :.::::. . :. .:. : .. :. :..: :. : NP_001 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNL-VTGVKFEPIHGNFLLTGAYD 170 180 190 200 210 220 460 470 480 490 500 pF1KB5 --VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL ..:. :. . .. : : . :. .. ...::. ..::..:.. NP_001 NTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 230 240 250 260 270 >>NP_001309195 (OMIM: 607795,615922) U4/U6 small nuclear (279 aa) initn: 410 init1: 204 opt: 405 Z-score: 329.2 bits: 69.6 E(85289): 1.4e-11 Smith-Waterman score: 405; 27.1% identity (60.5% similar) in 258 aa overlap (256-502:22-276) 230 240 250 260 270 280 pF1KB5 ALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVF----- .: ::.::. .: ..::::.. . . NP_001 MLSFVFDRSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDV 10 20 30 40 50 290 300 310 320 330 pF1KB5 ---SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT : . :.....::. . : ...: :. . : .: .: .. :. : . :... NP_001 NLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEA 60 70 80 90 100 110 340 350 360 370 380 390 pF1KB5 GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITS . . . .. : . :: :: . ::: .:. ..:::. . . :: : . NP_001 QEEILHQEGHSMG--VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 120 130 140 150 160 400 410 420 430 440 450 pF1KB5 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ-SGTYLALGGTD : :: :::..::.. :.. :.::::. . :. .:. : .. :. :..: :. : NP_001 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNL-VTGVKFEPIHGNFLLTGAYD 170 180 190 200 210 220 460 470 480 490 500 pF1KB5 --VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL ..:. :. . .. : : . :. .. ...::. ..::..:.. NP_001 NTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 230 240 250 260 270 >>NP_001231855 (OMIM: 607795,615922) U4/U6 small nuclear (521 aa) initn: 410 init1: 204 opt: 405 Z-score: 326.2 bits: 69.9 E(85289): 2e-11 Smith-Waterman score: 405; 27.1% identity (60.5% similar) in 258 aa overlap (256-502:264-518) 230 240 250 260 270 280 pF1KB5 ALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVF----- .: ::.::. .: ..::::.. . . NP_001 SYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDV 240 250 260 270 280 290 290 300 310 320 330 pF1KB5 ---SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT : . :.....::. . : ...: :. . : .: .: .. :. : . :... NP_001 NLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEA 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB5 GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITS . . . .. : . :: :: . ::: .:. ..:::. . . :: : . NP_001 QEEILHQEGHSMG--VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB5 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ-SGTYLALGGTD : :: :::..::.. :.. :.::::. . :. .:. : .. :. :..: :. : NP_001 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNL-VTGVKFEPIHGNFLLTGAYD 420 430 440 450 460 470 460 470 480 490 500 pF1KB5 --VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL ..:. :. . .. : : . :. .. ...::. ..::..:.. NP_001 NTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 480 490 500 510 520 >>NP_004688 (OMIM: 607795,615922) U4/U6 small nuclear ri (522 aa) initn: 410 init1: 204 opt: 405 Z-score: 326.2 bits: 69.9 E(85289): 2e-11 Smith-Waterman score: 405; 27.1% identity (60.5% similar) in 258 aa overlap (256-502:265-519) 230 240 250 260 270 280 pF1KB5 ALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVF----- .: ::.::. .: ..::::.. . . NP_004 SYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDV 240 250 260 270 280 290 290 300 310 320 330 pF1KB5 ---SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT : . :.....::. . : ...: :. . : .: .: .. :. : . :... NP_004 NLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEA 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB5 GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITS . . . .. : . :: :: . ::: .:. ..:::. . . :: : . NP_004 QEEILHQEGHSMG--VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB5 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ-SGTYLALGGTD : :: :::..::.. :.. :.::::. . :. .:. : .. :. :..: :. : NP_004 INFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNL-VTGVKFEPIHGNFLLTGAYD 420 430 440 450 460 470 460 470 480 490 500 pF1KB5 --VQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL ..:. :. . .. : : . :. .. ...::. ..::..:.. NP_004 NTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 480 490 500 510 520 >>NP_008882 (OMIM: 601787) transcription initiation fact (800 aa) initn: 380 init1: 225 opt: 397 Z-score: 318.0 bits: 69.0 E(85289): 5.6e-11 Smith-Waterman score: 397; 30.2% identity (59.9% similar) in 242 aa overlap (248-485:527-758) 220 230 240 250 260 270 pF1KB5 SASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQD ..:... . : : ::. : .. : :... NP_008 WSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRN 500 510 520 530 540 550 280 290 300 310 320 330 pF1KB5 LVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQY---WAFSD ..:.: :.:.:.::. . .:. ..:. : .. : :..:.. :. :: . NP_008 YLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDH 560 570 580 590 600 610 340 350 360 370 380 390 pF1KB5 IQTGRVLT-KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG : :... ...: ..:..:::.. .::. : ...::. . . : : ::.: NP_008 YQPLRIFAGHLAD------VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 620 630 640 650 660 670 400 410 420 430 440 450 pF1KB5 PITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALG :: :..:: :: .:::.: :. : :::. . :. .. : :: :...: :: : NP_008 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD-TVCSLRFSRDGEILASG 680 690 700 710 720 460 470 480 490 500 pF1KB5 GTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL . : . . : : : . .: :: NP_008 SMDNTV---RLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFT 730 740 750 760 770 780 NP_008 RRNLVLAAGAYSPQ 790 800 >>NP_758440 (OMIM: 614784,615973) POC1 centriolar protei (478 aa) initn: 322 init1: 186 opt: 382 Z-score: 309.1 bits: 66.7 E(85289): 1.8e-10 Smith-Waterman score: 382; 29.3% identity (59.1% similar) in 276 aa overlap (224-496:21-291) 200 210 220 230 240 250 pF1KB5 VPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSS : .::: :. ... :.. : ..... . NP_758 MASATEDPVLERYFKGHKAAITSLDLSPNG-KQLATASWDTFLMLWNFKP 10 20 30 40 260 270 280 290 300 310 pF1KB5 EQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA-SCVQVVRAHESAVTGL . :: :::: : : .:. ::: : :.:.: .:. . . .:: . : .. NP_758 HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSV 50 60 70 80 90 100 320 330 340 350 360 370 pF1KB5 SLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDS .. : :..: ..:.:. .. : : .. .: . ::.: ::: .. . . :. NP_758 DFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHW--VRCAKFSPDGRLIVSCSEDK 110 120 130 140 150 160 380 390 400 410 420 430 pF1KB5 QIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQL ::::: .. : :: : . . :. .: .:.:..:..::.::.: : .. :. NP_758 TIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQV 170 180 190 200 210 220 440 450 460 470 480 490 pF1KB5 DNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTE--HSGLTTGVAFGHHAKFI .. :. . : ::.:: ...: . : : .: :.: . :.:.. .... NP_758 HSG-GVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELF 230 240 250 260 270 280 500 pF1KB5 ASTGMDRSLKFYSL :: : : NP_758 ASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEI 290 300 310 320 330 340 >>NP_001186706 (OMIM: 614784,615973) POC1 centriolar pro (436 aa) initn: 322 init1: 186 opt: 368 Z-score: 298.9 bits: 64.6 E(85289): 6.5e-10 Smith-Waterman score: 368; 31.1% identity (59.7% similar) in 238 aa overlap (262-496:16-249) 240 250 260 270 280 290 pF1KB5 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW :: :::: : : .:. ::: : :.:.: NP_001 MLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW 10 20 30 40 300 310 320 330 340 350 pF1KB5 SVPNA-SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG .:. . . .:: . : .... : :..: ..:.:. .. : : .. .: NP_001 -IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHW 50 60 70 80 90 100 360 370 380 390 400 410 pF1KB5 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATA . ::.: ::: .. . . :. ::::: .. : :: : . . :. .: .:.: NP_001 --VRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASA 110 120 130 140 150 160 420 430 440 450 460 470 pF1KB5 ADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILH ..:..::.::.: : .. :. .. :. . : ::.:: ...: . : : NP_001 GSDQTVKVWDVRVNKLLQHYQVHSG-GVNCISFHPSGNYLITASSDGTLKILDLLEGRLI 170 180 190 200 210 220 480 490 500 pF1KB5 FTE--HSGLTTGVAFGHHAKFIASTGMDRSLKFYSL .: :.: . :.:.. ....:: : : NP_001 YTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPP 230 240 250 260 270 280 >>NP_060058 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 458 init1: 229 opt: 353 Z-score: 288.8 bits: 62.4 E(85289): 2.4e-09 Smith-Waterman score: 375; 27.1% identity (65.7% similar) in 207 aa overlap (259-465:40-241) 230 240 250 260 270 280 pF1KB5 LCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATI :: :::: :.:: : :. . . :.: : : NP_060 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLI 10 20 30 40 50 60 290 300 310 320 330 340 pF1KB5 RIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET .::.. ... ... .:. ... .. . .. :.:.:::. . :...:. : . .. NP_060 KIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS 70 80 90 100 110 120 350 360 370 380 390 400 pF1KB5 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA . . : .:.:.. .. .:..: ...:::.: . ..:.:: :.... :...: .. NP_060 N--YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 130 140 150 160 170 180 410 420 430 440 450 460 pF1KB5 TAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEI ... :. ..:: . . .::: :.: :. . :. .: :. . : . : : NP_060 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL---KLWDYS 190 200 210 220 230 240 470 480 490 500 pF1KB5 LHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL NP_060 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 250 260 270 280 290 300 >>XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-conta (334 aa) initn: 458 init1: 229 opt: 353 Z-score: 288.8 bits: 62.4 E(85289): 2.4e-09 Smith-Waterman score: 375; 27.1% identity (65.7% similar) in 207 aa overlap (259-465:40-241) 230 240 250 260 270 280 pF1KB5 LCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATI :: :::: :.:: : :. . . :.: : : XP_005 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLI 10 20 30 40 50 60 290 300 310 320 330 340 pF1KB5 RIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET .::.. ... ... .:. ... .. . .. :.:.:::. . :...:. : . .. XP_005 KIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS 70 80 90 100 110 120 350 360 370 380 390 400 pF1KB5 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA . . : .:.:.. .. .:..: ...:::.: . ..:.:: :.... :...: .. XP_005 N--YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 130 140 150 160 170 180 410 420 430 440 450 460 pF1KB5 TAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEI ... :. ..:: . . .::: :.: :. . :. .: :. . : . : : XP_005 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL---KLWDYS 190 200 210 220 230 240 470 480 490 500 pF1KB5 LHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL XP_005 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 250 260 270 280 290 300 504 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:39:33 2016 done: Sat Nov 5 10:39:34 2016 Total Scan time: 8.490 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]