FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5911, 504 aa 1>>>pF1KB5911 504 - 504 aa - 504 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9706+/-0.000317; mu= 11.9442+/- 0.020 mean_var=129.5165+/-25.775, 0's: 0 Z-trim(119.2): 27 B-trim: 244 in 1/55 Lambda= 0.112697 statistics sampled from 32912 (32939) to 32912 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.386), width: 16 Scan time: 11.010 The best scores are: opt bits E(85289) XP_016873517 (OMIM: 609059,610717) PREDICTED: pata ( 504) 3398 563.6 4.6e-160 NP_065109 (OMIM: 609059,610717) patatin-like phosp ( 504) 3398 563.6 4.6e-160 XP_006718328 (OMIM: 609059,610717) PREDICTED: pata ( 597) 2053 345.0 3.6e-94 XP_006718329 (OMIM: 609059,610717) PREDICTED: pata ( 597) 2053 345.0 3.6e-94 NP_079501 (OMIM: 609567) patatin-like phospholipas ( 481) 973 169.3 2.2e-41 NP_620169 (OMIM: 611589) patatin-like phospholipas ( 429) 927 161.8 3.5e-39 NP_001139189 (OMIM: 612121,615024) patatin-like ph ( 532) 774 137.0 1.3e-31 XP_011512821 (OMIM: 612121,615024) PREDICTED: pata ( 572) 774 137.0 1.4e-31 NP_775947 (OMIM: 612121,615024) patatin-like phosp ( 437) 592 107.4 8.9e-23 XP_011512822 (OMIM: 612121,615024) PREDICTED: pata ( 477) 592 107.4 9.6e-23 NP_004641 (OMIM: 300102) patatin-like phospholipas ( 253) 580 105.3 2.2e-22 NP_001135861 (OMIM: 300102) patatin-like phospholi ( 253) 580 105.3 2.2e-22 XP_011543890 (OMIM: 300102) PREDICTED: patatin-lik ( 253) 580 105.3 2.2e-22 XP_016866266 (OMIM: 612121,615024) PREDICTED: pata ( 541) 496 91.8 5.3e-18 XP_016866265 (OMIM: 612121,615024) PREDICTED: pata ( 581) 496 91.9 5.6e-18 NP_001171146 (OMIM: 611589) patatin-like phospholi ( 315) 417 78.8 2.5e-14 XP_011528261 (OMIM: 611589) PREDICTED: patatin-lik ( 289) 404 76.7 1e-13 NP_001166143 (OMIM: 300102) patatin-like phospholi ( 166) 391 74.4 2.9e-13 NP_001139188 (OMIM: 612121,615024) patatin-like ph ( 446) 314 62.2 3.7e-09 XP_016866267 (OMIM: 612121,615024) PREDICTED: pata ( 486) 314 62.2 3.9e-09 XP_016866268 (OMIM: 612121,615024) PREDICTED: pata ( 395) 238 49.8 1.7e-05 >>XP_016873517 (OMIM: 609059,610717) PREDICTED: patatin- (504 aa) initn: 3398 init1: 3398 opt: 3398 Z-score: 2994.6 bits: 563.6 E(85289): 4.6e-160 Smith-Waterman score: 3398; 100.0% identity (100.0% similar) in 504 aa overlap (1-504:1-504) 10 20 30 40 50 60 pF1KB5 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 GWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQ 430 440 450 460 470 480 490 500 pF1KB5 LAGPAPLLSTPAPEARPVIGALGL :::::::::::::::::::::::: XP_016 LAGPAPLLSTPAPEARPVIGALGL 490 500 >>NP_065109 (OMIM: 609059,610717) patatin-like phospholi (504 aa) initn: 3398 init1: 3398 opt: 3398 Z-score: 2994.6 bits: 563.6 E(85289): 4.6e-160 Smith-Waterman score: 3398; 100.0% identity (100.0% similar) in 504 aa overlap (1-504:1-504) 10 20 30 40 50 60 pF1KB5 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 GWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQ 430 440 450 460 470 480 490 500 pF1KB5 LAGPAPLLSTPAPEARPVIGALGL :::::::::::::::::::::::: NP_065 LAGPAPLLSTPAPEARPVIGALGL 490 500 >>XP_006718328 (OMIM: 609059,610717) PREDICTED: patatin- (597 aa) initn: 2113 init1: 2053 opt: 2053 Z-score: 1811.7 bits: 345.0 E(85289): 3.6e-94 Smith-Waterman score: 2053; 100.0% identity (100.0% similar) in 306 aa overlap (1-306:1-306) 10 20 30 40 50 60 pF1KB5 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVP :::::: XP_006 PARLNEGAHLGDGRGGGEAGGKEREERTVSRGGKPSGSWAPLPPLAADLPPTRSPAGGLR 310 320 330 340 350 360 >>XP_006718329 (OMIM: 609059,610717) PREDICTED: patatin- (597 aa) initn: 2113 init1: 2053 opt: 2053 Z-score: 1811.7 bits: 345.0 E(85289): 3.6e-94 Smith-Waterman score: 2053; 100.0% identity (100.0% similar) in 306 aa overlap (1-306:1-306) 10 20 30 40 50 60 pF1KB5 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVP :::::: XP_006 PARLNEGAHLGDGRGGGEAGGKEREERTVSRGGKPSGSWAPLPPLAADLPPTRSPAGGLR 310 320 330 340 350 360 >>NP_079501 (OMIM: 609567) patatin-like phospholipase do (481 aa) initn: 1172 init1: 957 opt: 973 Z-score: 864.1 bits: 169.3 E(85289): 2.2e-41 Smith-Waterman score: 1165; 42.8% identity (68.1% similar) in 458 aa overlap (1-429:1-456) 10 20 30 40 50 60 pF1KB5 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV :. :. :..::::::::: :.::.. :: :::: :. .: ..::::::: .....:. NP_079 MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR : .. . .. ..::.: .: .:::::: :..:. : : :::. :. ::..:::::: NP_079 PLEQTLQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISLTR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN :::::::..: : ::::...: ::: ::: : ::::::..::::::::.:::.:. . :. NP_079 VSDGENVLVSDFRSKDEVVDALVCSCFIPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ ::::::: :: ::::. .:::. .. .:. :... ::: ::.:. ::. :: :.: . NP_079 TITVSPFYGEYDICPKVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLR 190 200 210 220 230 240 250 260 270 280 pF1KB5 GYRDGLRFLQRNGLLNRPNPLL-----ALPP--ARPH--------GPEDKDQAV--ESAQ :: :..:::...:. :::.: : .. : : : .::. :: :. . NP_079 GYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDE 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 AEDY---SQLPGEDHILEHLPARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTL :. : :: .. ::. : :: :: : . .. . :.::.:. . .:.: :: NP_079 LLDHLRLSILPWDESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTL 310 320 330 340 350 360 350 360 370 380 390 pF1KB5 PLESALSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVM------RAKRKLGRHLPSRLP :.:::.... ::. ::::.:.:. :.. :... ..: :.. .. . : : NP_079 PVESAIAIVQRLVTWLPDMPDDVLWLQWVTSQVFTRVLMCLLPASRSQMPVSSQQAS--P 370 380 390 400 410 400 410 420 430 440 450 pF1KB5 EQVELRRVQSLPSVPLSCAAYR--EALP-GWMRNNLSLGDALAKWEECQRQLLLGLFCTN : : : .: : :: : . .:..:.. NP_079 CTPEQDWPCWTPCSPKGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGLSTFPSFSLE 420 430 440 450 460 470 460 470 480 490 500 pF1KB5 VAFPPEALRMRAPADPAPAPADPASPQHQLAGPAPLLSTPAPEARPVIGALGL NP_079 KSL 480 >>NP_620169 (OMIM: 611589) patatin-like phospholipase do (429 aa) initn: 914 init1: 787 opt: 927 Z-score: 824.3 bits: 161.8 E(85289): 3.5e-39 Smith-Waterman score: 928; 38.5% identity (64.8% similar) in 429 aa overlap (5-419:7-423) 10 20 30 40 50 pF1KB5 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVT : ::.::.: :.::...::.. :::..:: :. .: .:::.:.:::.:...: NP_620 MGFLEEEGRWNLSFSGAGYLGAHHVGATECLRQRAPRLLQGARRIYGSSSGALNAVSIVC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 GVCLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISL : . .... . . .. :. :::.. .. ... : .:: :.: :: :::::: NP_620 GKSVDFCCSHLLGMVGQLERLSLSILHPAYAPIEHVKQQLQDALPPDAHVLASQRLGISL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 TRVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYEL :: ::.: ... : . :::::: ::. ..: ::::::: ..: ::.::..:.:::. . NP_620 TRWPDGRNFLVTDFATCDELIQALVCTLYFPFYCGLIPPEFRGERYIDGALSNNLPFADC 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 KNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMC .::::::: : :::::..: :.::: : : :.:.. .:.. :.:: :. . : NP_620 PSTITVSPFHGTVDICPQSTSPNLHELNVFNFSFQISTENFFLGLICLIPPSLEVVADNC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 KQGYRDGLRFLQRNGLLNRPNPLLAL----PPARPHGPEDK--DQAVESAQAEDYSQLPG .::: :.::::.: :: ..: : .: ::: : : :: ... . .. ..: NP_620 RQGYLDALRFLERRGLTKEPV-LWTLVSKEPPAPADGNWDAGCDQRWKGGLSLNW-KVP- 250 260 270 280 290 300 310 320 330 340 pF1KB5 EDHI-------LEHLPARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESA :. .:.: .:. :: .::.. . . . . : .. : ...: :::.: NP_620 --HVQVKDVPNFEQLSPELEAALKKACTRDPSRWARFWHSGPGQVLTYLLLPCTLPFEYI 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 LSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKL-GRHLPSRLPEQVELRRVQS . ::. :::::: :. ::. .. . :.: .: : : : : ... NP_620 YFRSRRLVVWLPDVPADLWWMQGLLRNMALEVFSRTKAQLLG---PISPPAT---RVLET 360 370 380 390 400 410 420 430 440 450 460 pF1KB5 LPSVPLSCAAYREALPGWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAP : : . : .:: : NP_620 SPLQP-QIAPHREELGPTHQA 410 420 >>NP_001139189 (OMIM: 612121,615024) patatin-like phosph (532 aa) initn: 794 init1: 769 opt: 774 Z-score: 688.6 bits: 137.0 E(85289): 1.3e-31 Smith-Waterman score: 774; 44.2% identity (77.7% similar) in 260 aa overlap (9-265:15-273) 10 20 30 40 50 pF1KB5 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTAT .:::.: :::. : .:... ::. :: .. .: .. :.::::. :. NP_001 MEEQVFKGDPDTPHSISFSGSGFLSFYQAGAVDALRDLAPRMLETAHRFAGTSAGAVIAA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ALVTGVCLGEAGAKFIEVS-KEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGR . :. . : . ..:. :..: ::::: :: ..:...:.:: .::: ::.. ..:. NP_001 LAICGIEMDEY-LRVLNVGVAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKVTTGK 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 LGISLTRVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNL : .::::..:::::..:.:.::.:::.: :: :.:::::::::. .::::.:::.. NP_001 LHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 PLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLV : ..::.: :::..::::.: . .:..:. : :.::.:.:. :...:::::. .. NP_001 PCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 LREMCKQGYRDGLRFLQR-NGL-LNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLP :... .::.:.. .:.: :.. :: . . .: NP_001 LHDYYYRGYEDAVLYLRRLNAVYLNSSSKRVIFPRVEVYCQIELALGNECPERSQPSLRA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 GEDHILEHLPARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIR NP_001 RQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLA 300 310 320 330 340 350 >>XP_011512821 (OMIM: 612121,615024) PREDICTED: patatin- (572 aa) initn: 794 init1: 769 opt: 774 Z-score: 688.1 bits: 137.0 E(85289): 1.4e-31 Smith-Waterman score: 774; 44.2% identity (77.7% similar) in 260 aa overlap (9-265:15-273) 10 20 30 40 50 pF1KB5 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTAT .:::.: :::. : .:... ::. :: .. .: .. :.::::. :. XP_011 MEEQVFKGDPDTPHSISFSGSGFLSFYQAGAVDALRDLAPRMLETAHRFAGTSAGAVIAA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ALVTGVCLGEAGAKFIEVS-KEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGR . :. . : . ..:. :..: ::::: :: ..:...:.:: .::: ::.. ..:. XP_011 LAICGIEMDEY-LRVLNVGVAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKVTTGK 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 LGISLTRVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNL : .::::..:::::..:.:.::.:::.: :: :.:::::::::. .::::.:::.. XP_011 LHVSLTRLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 PLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLV : ..::.: :::..::::.: . .:..:. : :.::.:.:. :...:::::. .. XP_011 PCAFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 LREMCKQGYRDGLRFLQR-NGL-LNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLP :... .::.:.. .:.: :.. :: . . .: XP_011 LHDYYYRGYEDAVLYLRRLNAVYLNSSSKRVIFPRVEVYCQIELALGNECPERSQPSLRA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 GEDHILEHLPARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIR XP_011 RQASLEGATQPHKEWVPKGDGRGSHGPPVSQPVQTLEFTCESPVSAPVSPLEQPPAQPLA 300 310 320 330 340 350 >>NP_775947 (OMIM: 612121,615024) patatin-like phospholi (437 aa) initn: 632 init1: 590 opt: 592 Z-score: 529.9 bits: 107.4 E(85289): 8.9e-23 Smith-Waterman score: 592; 46.6% identity (80.9% similar) in 178 aa overlap (90-265:1-178) 60 70 80 90 100 110 pF1KB5 VCLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLT .:...:.:: .::: ::.. ..:.: .::: NP_775 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLT 10 20 30 120 130 140 150 160 170 pF1KB5 RVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELK :..:::::..:.:.::.:::.: :: :.:::::::::. .::::.:::.. : NP_775 RLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQPCAFWT 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB5 NTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCK ..::.: :::..::::.: . .:..:. : :.::.:.:. :...:::::. ..:... NP_775 DAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYY 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB5 QGYRDGLRFLQR-NGL-LNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHIL .::.:.. .:.: :.. :: . . .: NP_775 RGYEDAVLYLRRLNAVYLNSSSKRVIFPRVEVYCQIELALGNECPERSQPSLRARQASLE 160 170 180 190 200 210 >>XP_011512822 (OMIM: 612121,615024) PREDICTED: patatin- (477 aa) initn: 632 init1: 590 opt: 592 Z-score: 529.3 bits: 107.4 E(85289): 9.6e-23 Smith-Waterman score: 592; 46.6% identity (80.9% similar) in 178 aa overlap (90-265:1-178) 60 70 80 90 100 110 pF1KB5 VCLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLT .:...:.:: .::: ::.. ..:.: .::: XP_011 MVQMMRQFLYRVLPEDSYKVTTGKLHVSLT 10 20 30 120 130 140 150 160 170 pF1KB5 RVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELK :..:::::..:.:.::.:::.: :: :.:::::::::. .::::.:::.. : XP_011 RLTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIPPTYRGVRYIDGGFTGMQPCAFWT 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB5 NTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCK ..::.: :::..::::.: . .:..:. : :.::.:.:. :...:::::. ..:... XP_011 DAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLVILHDYYY 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB5 QGYRDGLRFLQR-NGL-LNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHIL .::.:.. .:.: :.. :: . . .: XP_011 RGYEDAVLYLRRLNAVYLNSSSKRVIFPRVEVYCQIELALGNECPERSQPSLRARQASLE 160 170 180 190 200 210 504 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:31:47 2016 done: Sat Nov 5 15:31:48 2016 Total Scan time: 11.010 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]