FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5913, 504 aa 1>>>pF1KB5913 504 - 504 aa - 504 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6072+/-0.000917; mu= 16.0482+/- 0.055 mean_var=60.2981+/-12.065, 0's: 0 Z-trim(103.9): 22 B-trim: 0 in 0/51 Lambda= 0.165167 statistics sampled from 7608 (7616) to 7608 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.234), width: 16 Scan time: 3.120 The best scores are: opt bits E(32554) CCDS8934.1 SHMT2 gene_id:6472|Hs108|chr12 ( 504) 3343 805.3 0 CCDS53805.1 SHMT2 gene_id:6472|Hs108|chr12 ( 483) 3191 769.1 0 CCDS11196.1 SHMT1 gene_id:6470|Hs108|chr17 ( 483) 2033 493.2 2.7e-139 CCDS55837.1 SHMT2 gene_id:6472|Hs108|chr12 ( 494) 1917 465.5 5.9e-131 CCDS62112.1 SHMT1 gene_id:6470|Hs108|chr17 ( 345) 1457 355.9 4.2e-98 CCDS11197.1 SHMT1 gene_id:6470|Hs108|chr17 ( 444) 1256 308.0 1.4e-83 >>CCDS8934.1 SHMT2 gene_id:6472|Hs108|chr12 (504 aa) initn: 3343 init1: 3343 opt: 3343 Z-score: 4300.8 bits: 805.3 E(32554): 0 Smith-Waterman score: 3343; 100.0% identity (100.0% similar) in 504 aa overlap (1-504:1-504) 10 20 30 40 50 60 pF1KB5 MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS89 MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS89 QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS89 RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS89 KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS89 CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS89 PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS89 MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS89 PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ 430 440 450 460 470 480 490 500 pF1KB5 RLANLRQRVEQFARAFPMPGFDEH :::::::::::::::::::::::: CCDS89 RLANLRQRVEQFARAFPMPGFDEH 490 500 >>CCDS53805.1 SHMT2 gene_id:6472|Hs108|chr12 (483 aa) initn: 3191 init1: 3191 opt: 3191 Z-score: 4105.4 bits: 769.1 E(32554): 0 Smith-Waterman score: 3191; 100.0% identity (100.0% similar) in 483 aa overlap (22-504:1-483) 10 20 30 40 50 60 pF1KB5 MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL ::::::::::::::::::::::::::::::::::::::: CCDS53 MAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL 10 20 30 70 80 90 100 110 120 pF1KB5 QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB5 KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB5 CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB5 PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB5 MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB5 PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ 400 410 420 430 440 450 490 500 pF1KB5 RLANLRQRVEQFARAFPMPGFDEH :::::::::::::::::::::::: CCDS53 RLANLRQRVEQFARAFPMPGFDEH 460 470 480 >>CCDS11196.1 SHMT1 gene_id:6470|Hs108|chr17 (483 aa) initn: 2040 init1: 1950 opt: 2033 Z-score: 2614.1 bits: 493.2 E(32554): 2.7e-139 Smith-Waterman score: 2033; 66.1% identity (85.4% similar) in 460 aa overlap (47-503:24-482) 20 30 40 50 60 70 pF1KB5 GQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIAS . :.::: :.......:..:: ::::::: CCDS11 MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIAS 10 20 30 40 50 80 90 100 110 120 130 pF1KB5 ENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGV ::: :::.::::::::::::::::::.:::::.: .::.: :::.:::.:. ::: ::: CCDS11 ENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGV 60 70 80 90 100 110 140 150 160 170 180 190 pF1KB5 NVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYK :::::::::::.::::::..:: ::::::::::::::::.:.: :.:::::::::::::: CCDS11 NVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYK 120 130 140 150 160 170 200 210 220 230 240 250 pF1KB5 LNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHIS .:: :: :.:.:: .::::.:.::::::: :.: ..:::.:.. :: :.:.::::::: CCDS11 VNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHIS 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB5 GLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRIN ::::: :.::::.: .::::::::::: :.:.::::::::.::::::.:: :..:. :: CCDS11 GLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLIN 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB5 FAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGG ::::.:::::::::::.:::::::: : :. :. ::. : ::...:: : ::..:.:: CCDS11 SAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGG 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB5 TDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQF .::::.::::: :: ::.:::.::: ::. :::::::::::. :.:::::.:::::: . CCDS11 SDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGL 360 370 380 390 400 410 440 450 460 470 480 490 pF1KB5 REDDFRRVVDFIDEGVNIGLEVKSKT---AKLQDFKSFLLKDSETSQRLANLRQRVEQFA : ::..:. :: .:... :...: : : :..:: : :. . : ::..::.:: CCDS11 LEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQA-LREEVESFA 420 430 440 450 460 470 500 pF1KB5 RAFPMPGFDEH ::.::. . CCDS11 SLFPLPGLPDF 480 >>CCDS55837.1 SHMT2 gene_id:6472|Hs108|chr12 (494 aa) initn: 3260 init1: 1917 opt: 1917 Z-score: 2464.6 bits: 465.5 E(32554): 5.9e-131 Smith-Waterman score: 3244; 98.0% identity (98.0% similar) in 504 aa overlap (1-504:1-494) 10 20 30 40 50 60 pF1KB5 MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV :::::::::::::::::: :::::::::::::::::::::::::::::::: CCDS55 KRISATSIFFESMPYKLN----------LALTARLFRPRLIIAGTSAYARLIDYARMREV 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB5 MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB5 PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ 420 430 440 450 460 470 490 500 pF1KB5 RLANLRQRVEQFARAFPMPGFDEH :::::::::::::::::::::::: CCDS55 RLANLRQRVEQFARAFPMPGFDEH 480 490 >>CCDS62112.1 SHMT1 gene_id:6470|Hs108|chr17 (345 aa) initn: 1470 init1: 1380 opt: 1457 Z-score: 1874.8 bits: 355.9 E(32554): 4.2e-98 Smith-Waterman score: 1457; 64.3% identity (83.8% similar) in 345 aa overlap (162-503:1-344) 140 150 160 170 180 190 pF1KB5 AQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFE ::::::::::::::.:.: :.::::::::: CCDS62 MGLDLPDGGHLTHGFMTDKKKISATSIFFE 10 20 30 200 210 220 230 240 250 pF1KB5 SMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLAD :::::.:: :: :.:.:: .::::.:.::::::: :.: ..:::.:.. :: :.:.:: CCDS62 SMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMAD 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB5 MAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTF :::::::::: :.::::.: .::::::::::: :.:.::::::::.::::::.:: :.. CCDS62 MAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNL 100 110 120 130 140 150 320 330 340 350 360 370 pF1KB5 EDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYS :. :: ::::.:::::::::::.:::::::: : :. :. ::. : ::...:: : ::. CCDS62 ESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYK 160 170 180 190 200 210 380 390 400 410 420 430 pF1KB5 LVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPAL .:.::.::::.::::: :: ::.:::.::: ::. :::::::::::. :.:::::.::: CCDS62 IVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPAL 220 230 240 250 260 270 440 450 460 470 480 pF1KB5 TSRQFREDDFRRVVDFIDEGVNIGLEVKSKT---AKLQDFKSFLLKDSETSQRLANLRQR ::: . : ::..:. :: .:... :...: : : :..:: : :. . : ::.. CCDS62 TSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQA-LREE 280 290 300 310 320 490 500 pF1KB5 VEQFARAFPMPGFDEH ::.:: ::.::. . CCDS62 VESFASLFPLPGLPDF 330 340 >>CCDS11197.1 SHMT1 gene_id:6470|Hs108|chr17 (444 aa) initn: 1816 init1: 1256 opt: 1256 Z-score: 1614.1 bits: 308.0 E(32554): 1.4e-83 Smith-Waterman score: 1752; 59.8% identity (77.6% similar) in 460 aa overlap (47-503:24-443) 20 30 40 50 60 70 pF1KB5 GQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIAS . :.::: :.......:..:: ::::::: CCDS11 MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIAS 10 20 30 40 50 80 90 100 110 120 130 pF1KB5 ENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGV ::: :::.::::::::::::::::::.:::::.: .::.: :::.:::.:. ::: ::: CCDS11 ENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGV 60 70 80 90 100 110 140 150 160 170 180 190 pF1KB5 NVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYK :::::::::::.::::::..:: ::::::::::::::::.:.: :.:::::::::::::: CCDS11 NVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYK 120 130 140 150 160 170 200 210 220 230 240 250 pF1KB5 LNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHIS .:: :: :.:.:: .::::.:.::::::: :.: ..:::.:.. :: :.:.::::::: CCDS11 VNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHIS 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB5 GLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRIN ::::: :.::::.: .::::::::::: :.:.::::::: CCDS11 GLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGV-------------------- 240 250 260 270 320 330 340 350 360 370 pF1KB5 FAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGG ::::::: : :. :. ::. : ::...:: : ::..:.:: CCDS11 -------------------AVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGG 280 290 300 310 380 390 400 410 420 430 pF1KB5 TDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQF .::::.::::: :: ::.:::.::: ::. :::::::::::. :.:::::.:::::: . CCDS11 SDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGL 320 330 340 350 360 370 440 450 460 470 480 490 pF1KB5 REDDFRRVVDFIDEGVNIGLEVKSKT---AKLQDFKSFLLKDSETSQRLANLRQRVEQFA : ::..:. :: .:... :...: : : :..:: : :. . : ::..::.:: CCDS11 LEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQA-LREEVESFA 380 390 400 410 420 430 500 pF1KB5 RAFPMPGFDEH ::.::. . CCDS11 SLFPLPGLPDF 440 504 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:32:22 2016 done: Sat Nov 5 15:32:23 2016 Total Scan time: 3.120 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]