FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5919, 505 aa 1>>>pF1KB5919 505 - 505 aa - 505 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.7587+/-0.000866; mu= -22.4733+/- 0.051 mean_var=993.5921+/-220.971, 0's: 0 Z-trim(112.9): 1396 B-trim: 0 in 0/53 Lambda= 0.040688 statistics sampled from 20467 (22075) to 20467 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.259), width: 16 Scan time: 7.920 The best scores are: opt bits E(85289) XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 3422 217.9 5.5e-56 XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 3422 217.9 5.5e-56 XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 3422 217.9 5.5e-56 XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 3422 217.9 5.5e-56 XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 3422 217.9 5.5e-56 NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 3422 217.9 5.5e-56 XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 3422 217.9 5.5e-56 XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 3422 217.9 5.5e-56 XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392) 2620 170.7 7.1e-42 XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1651 114.0 1.1e-24 XP_016866140 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1651 114.0 1.1e-24 NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 1651 114.0 1.1e-24 XP_016866142 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1651 114.0 1.1e-24 XP_016866139 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1651 114.0 1.1e-24 XP_016866143 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1651 114.0 1.1e-24 NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 1590 110.4 1.3e-23 NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 1590 110.4 1.3e-23 NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 1590 110.4 1.3e-23 NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 1590 110.4 1.3e-23 NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 1590 110.4 1.3e-23 NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 1590 110.4 1.3e-23 XP_011527315 (OMIM: 114500,190090,616937) PREDICTE ( 536) 1584 110.1 1.7e-23 NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1584 110.1 1.7e-23 NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1584 110.1 1.7e-23 XP_016883515 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1572 109.4 2.8e-23 XP_016883516 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1572 109.4 2.8e-23 XP_016883514 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1572 109.4 2.8e-23 XP_016883513 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1572 109.4 2.8e-23 XP_016868905 (OMIM: 165120) PREDICTED: tyrosine-pr ( 491) 1568 109.1 3.1e-23 NP_001104567 (OMIM: 165120) tyrosine-protein kinas ( 491) 1568 109.1 3.1e-23 NP_002341 (OMIM: 165120) tyrosine-protein kinase L ( 512) 1568 109.1 3.2e-23 XP_011539312 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 1566 109.0 3.5e-23 XP_006710515 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 1566 109.0 3.5e-23 NP_001036212 (OMIM: 164940) tyrosine-protein kinas ( 529) 1566 109.0 3.5e-23 NP_005239 (OMIM: 164940) tyrosine-protein kinase F ( 529) 1566 109.0 3.5e-23 NP_001036194 (OMIM: 164940) tyrosine-protein kinas ( 529) 1566 109.0 3.5e-23 XP_011515831 (OMIM: 165120) PREDICTED: tyrosine-pr ( 682) 1568 109.3 3.8e-23 NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 1512 105.8 3.1e-22 NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 1512 105.8 3.1e-22 XP_016881449 (OMIM: 164880) PREDICTED: tyrosine-pr ( 543) 1438 101.5 6.6e-21 NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 1438 101.5 6.6e-21 NP_001317394 (OMIM: 191305,613375) tyrosine-protei ( 434) 1431 100.9 7.7e-21 NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 1431 101.0 8.4e-21 NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 1419 100.4 1.4e-20 XP_005266947 (OMIM: 137025) PREDICTED: tyrosine-pr ( 534) 1419 100.4 1.4e-20 NP_005966 (OMIM: 602004) protein-tyrosine kinase 6 ( 451) 1271 91.6 5.3e-18 XP_011539313 (OMIM: 164940) PREDICTED: tyrosine-pr ( 460) 1227 89.0 3.2e-17 NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130) 1212 88.7 9.7e-17 NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149) 1212 88.7 9.8e-17 NP_001129473 (OMIM: 164690) Abelson tyrosine-prote ( 542) 1196 87.3 1.2e-16 >>XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-protei (505 aa) initn: 3422 init1: 3422 opt: 3422 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56 Smith-Waterman score: 3422; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KB5 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 430 440 450 460 470 480 490 500 pF1KB5 ETLRWKLEDYFETDSSYSDANNFIR ::::::::::::::::::::::::: XP_016 ETLRWKLEDYFETDSSYSDANNFIR 490 500 >>XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-protei (505 aa) initn: 3422 init1: 3422 opt: 3422 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56 Smith-Waterman score: 3422; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KB5 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 430 440 450 460 470 480 490 500 pF1KB5 ETLRWKLEDYFETDSSYSDANNFIR ::::::::::::::::::::::::: XP_011 ETLRWKLEDYFETDSSYSDANNFIR 490 500 >>XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-protei (505 aa) initn: 3422 init1: 3422 opt: 3422 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56 Smith-Waterman score: 3422; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KB5 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 430 440 450 460 470 480 490 500 pF1KB5 ETLRWKLEDYFETDSSYSDANNFIR ::::::::::::::::::::::::: XP_011 ETLRWKLEDYFETDSSYSDANNFIR 490 500 >>XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-protei (505 aa) initn: 3422 init1: 3422 opt: 3422 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56 Smith-Waterman score: 3422; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KB5 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 430 440 450 460 470 480 490 500 pF1KB5 ETLRWKLEDYFETDSSYSDANNFIR ::::::::::::::::::::::::: XP_005 ETLRWKLEDYFETDSSYSDANNFIR 490 500 >>XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-protei (505 aa) initn: 3422 init1: 3422 opt: 3422 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56 Smith-Waterman score: 3422; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KB5 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 430 440 450 460 470 480 490 500 pF1KB5 ETLRWKLEDYFETDSSYSDANNFIR ::::::::::::::::::::::::: XP_005 ETLRWKLEDYFETDSSYSDANNFIR 490 500 >>NP_002022 (OMIM: 606573) tyrosine-protein kinase FRK [ (505 aa) initn: 3422 init1: 3422 opt: 3422 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56 Smith-Waterman score: 3422; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KB5 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 430 440 450 460 470 480 490 500 pF1KB5 ETLRWKLEDYFETDSSYSDANNFIR ::::::::::::::::::::::::: NP_002 ETLRWKLEDYFETDSSYSDANNFIR 490 500 >>XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-protei (505 aa) initn: 3422 init1: 3422 opt: 3422 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56 Smith-Waterman score: 3422; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KB5 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 430 440 450 460 470 480 490 500 pF1KB5 ETLRWKLEDYFETDSSYSDANNFIR ::::::::::::::::::::::::: XP_005 ETLRWKLEDYFETDSSYSDANNFIR 490 500 >>XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-protei (505 aa) initn: 3422 init1: 3422 opt: 3422 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56 Smith-Waterman score: 3422; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KB5 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF 430 440 450 460 470 480 490 500 pF1KB5 ETLRWKLEDYFETDSSYSDANNFIR ::::::::::::::::::::::::: XP_011 ETLRWKLEDYFETDSSYSDANNFIR 490 500 >>XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-protei (392 aa) initn: 2620 init1: 2620 opt: 2620 Z-score: 872.8 bits: 170.7 E(85289): 7.1e-42 Smith-Waterman score: 2620; 100.0% identity (100.0% similar) in 390 aa overlap (116-505:3-392) 90 100 110 120 130 140 pF1KB5 EKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRES :::::::::::::::::::::::::::::: XP_011 MRWFFGAIGRSDAEKQLLYSENKTGSFLIRES 10 20 30 150 160 170 180 190 200 pF1KB5 ESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLG 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB5 KPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLK 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB5 PGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSK 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB5 IHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNED 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB5 IYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQM 280 290 300 310 320 330 450 460 470 480 490 500 pF1KB5 LAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR 340 350 360 370 380 390 >>XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-protei (537 aa) initn: 1114 init1: 423 opt: 1651 Z-score: 564.0 bits: 114.0 E(85289): 1.1e-24 Smith-Waterman score: 1651; 54.0% identity (78.0% similar) in 463 aa overlap (47-503:87-537) 20 30 40 50 60 70 pF1KB5 PCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLH ::::.::.::: .::::. :.:.:.:.. . XP_016 GGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSE 60 70 80 90 100 110 80 90 100 110 120 130 pF1KB5 EGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENK :: :: : : . ::::::::: :.::: :.:: .::.:::.::: : XP_016 GDWWEARSL---TTGET----GYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNP 120 130 140 150 160 140 150 160 170 180 190 pF1KB5 TGSFLIRESESQKGEFSLSVLD-----GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVS :.:::::::. :: .:::. : : ::::.:..::.::...: : : ::...:. XP_016 RGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQ 170 180 190 200 210 220 200 210 220 230 240 250 pF1KB5 HYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEG ::.. . ::: .: :: : .: ::: :: : ::: :.:.::.::::.::::::: : XP_016 HYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMG 230 240 250 260 270 280 260 270 280 290 300 310 pF1KB5 LWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRH ::..: ::.::::::.:.:..::.::::::.:.: ::.::::: . :.::::.:: : . XP_016 TWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMNK 290 300 310 320 330 340 320 330 340 350 360 370 pF1KB5 GSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVA ::: ..:.. : ..: . ::::::::.::::.: ::::::: . :.:::. : :.: XP_016 GSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIA 350 360 370 380 390 400 380 390 400 410 420 430 pF1KB5 DFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGK ::::::... ::: : .:. :.:.::::::: ..:.:::::::::::: :..: :. XP_016 DFGLARLIE-DNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGR 410 420 430 440 450 460 440 450 460 470 480 490 pF1KB5 MPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF .:: ::.. .:.... ..::.: :..:: .....:..::. .:.:::::: :. ::::: XP_016 VPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYF 470 480 490 500 510 520 500 pF1KB5 E-TDSSYSDANNFIR :. .:. ..:. XP_016 TATEPQYQPGENL 530 505 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:15:48 2016 done: Sat Nov 5 08:15:49 2016 Total Scan time: 7.920 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]