FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5924, 520 aa 1>>>pF1KB5924 520 - 520 aa - 520 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9969+/-0.000941; mu= 14.1488+/- 0.056 mean_var=64.3924+/-12.828, 0's: 0 Z-trim(104.2): 20 B-trim: 5 in 1/49 Lambda= 0.159829 statistics sampled from 7767 (7772) to 7767 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.239), width: 16 Scan time: 3.350 The best scores are: opt bits E(32554) CCDS9109.2 RIC8B gene_id:55188|Hs108|chr12 ( 520) 3369 785.9 0 CCDS81733.1 RIC8B gene_id:55188|Hs108|chr12 ( 536) 3145 734.2 8.6e-212 CCDS81734.1 RIC8B gene_id:55188|Hs108|chr12 ( 560) 3145 734.2 9e-212 CCDS65982.1 RIC8A gene_id:60626|Hs108|chr11 ( 531) 671 163.8 4.5e-40 CCDS7690.1 RIC8A gene_id:60626|Hs108|chr11 ( 537) 650 158.9 1.3e-38 >>CCDS9109.2 RIC8B gene_id:55188|Hs108|chr12 (520 aa) initn: 3369 init1: 3369 opt: 3369 Z-score: 4195.2 bits: 785.9 E(32554): 0 Smith-Waterman score: 3369; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KB5 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN 430 440 450 460 470 480 490 500 510 520 pF1KB5 AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD :::::::::::::::::::::::::::::::::::::::: CCDS91 AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD 490 500 510 520 >>CCDS81733.1 RIC8B gene_id:55188|Hs108|chr12 (536 aa) initn: 3165 init1: 3139 opt: 3145 Z-score: 3915.8 bits: 734.2 E(32554): 8.6e-212 Smith-Waterman score: 3145; 94.9% identity (97.1% similar) in 514 aa overlap (1-513:1-514) 10 20 30 40 50 60 pF1KB5 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN 430 440 450 460 470 480 490 500 510 520 pF1KB5 AKPKEELLKPMGLKP-DGTITPLEEALNQYSVIEETSSDTD :::. .:. .: . : . : ..: ... CCDS81 AKPNINLITGHLEEPMPNPIDEMTEEQKEYEAMKLVNMLDKLSRRADVKDLHQDGG 490 500 510 520 530 >>CCDS81734.1 RIC8B gene_id:55188|Hs108|chr12 (560 aa) initn: 3381 init1: 3139 opt: 3145 Z-score: 3915.5 bits: 734.2 E(32554): 9e-212 Smith-Waterman score: 3228; 92.6% identity (92.8% similar) in 552 aa overlap (1-512:1-552) 10 20 30 40 50 60 pF1KB5 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN 430 440 450 460 470 480 490 500 pF1KB5 AKP----------------------------------------KEELLKPMGLKPDGTIT ::: .:::::::::::::::: CCDS81 AKPNINLITGHLEEPMPNPIDEMTEEQKEYEAMKLVNMLDKLSREELLKPMGLKPDGTIT 490 500 510 520 530 540 510 520 pF1KB5 PLEEALNQYSVIEETSSDTD :::::::::::: CCDS81 PLEEALNQYSVIEETSSDTD 550 560 >>CCDS65982.1 RIC8A gene_id:60626|Hs108|chr11 (531 aa) initn: 1338 init1: 671 opt: 671 Z-score: 832.8 bits: 163.8 E(32554): 4.5e-40 Smith-Waterman score: 1316; 47.3% identity (73.3% similar) in 484 aa overlap (3-482:2-450) 10 20 30 40 50 pF1KB5 MDEERALY-IVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIP : ::. :..:: .: ..::.:...: .: :...... ::.: : . .:: . .: CCDS65 MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLP 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 TTCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLK . .: :. .::::::.. : : :.....: : : .. . :. . ... :..:::: CCDS65 PSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 CLCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIR ::::.:..: .::.:. : :..:: . . ..:.: .:.. :::::::::. :.::.: CCDS65 CLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 SQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPP--LSPQETDCAIEALKALFNV .:: ::.:. :::. :: .... : : : :: : :::. :.: ::.:::. CCDS65 QQLFQELKGVRLLTDTLELTLGV--TPE------GNPPPTLLPSQETERAMEILKVLFNI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 TVDSWKVH-KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVL :.:: : . : :. .: ....::::..:. . :.:::.:..:::::.:.:..::::: CCDS65 TLDSIKGEVDEEDAALYRHLGTLLRHCVMIA-TAGDRTEEFHGHAVNLLGNLPLKCLDVL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 ICPLTHEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKG . ::. : . ..: . :.::..:..:: :.:::. : CCDS65 L-------------TLE--PHGDSTE-----------FMGVNMDVIRALLIFLEKRLHKT 300 310 320 360 370 380 390 400 410 pF1KB5 SSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHV .:...::::.::::.: :: ::::: ::::::::: .::::: .::::::::::. CCDS65 HRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHL 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB5 DLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTE : ::..:::::::::.: : ..:::::::::::::::::.:::: .. :::::::::. CCDS65 DTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTD 390 400 410 420 430 440 480 490 500 510 520 pF1KB5 EYKNAKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD :::.:: CCDS65 EYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPR 450 460 470 480 490 500 >>CCDS7690.1 RIC8A gene_id:60626|Hs108|chr11 (537 aa) initn: 1128 init1: 484 opt: 650 Z-score: 806.6 bits: 158.9 E(32554): 1.3e-38 Smith-Waterman score: 1295; 46.7% identity (72.4% similar) in 490 aa overlap (3-482:2-456) 10 20 30 40 50 pF1KB5 MDEERALY-IVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIP : ::. :..:: .: ..::.:...: .: :...... ::.: : . .:: . .: CCDS76 MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLP 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 TTCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLK . .: :. .::::::.. : : :.....: : : .. . :. . ... :..:::: CCDS76 PSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 CLCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIR ::::.:..: .::.:. : :..:: . . ..:.: .:.. :::::::::. :.::.: CCDS76 CLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 SQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPP--LSPQETDCAIEALKALFNV .:: ::.:. :::. :: .... : : : :: : :::. :.: ::.:::. CCDS76 QQLFQELKGVRLLTDTLELTLGV--TPE------GNPPPTLLPSQETERAMEILKVLFNI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 TVDSWKVH-KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVL :.:: : . : :. .: ....::::..:. . :.:::.:..:::::.:.:..::::: CCDS76 TLDSIKGEVDEEDAALYRHLGTLLRHCVMIA-TAGDRTEEFHGHAVNLLGNLPLKCLDVL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 ICPLTHEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKG . ::. : . ..: . :.::..:..:: :.:::. : CCDS76 L-------------TLE--PHGDSTE-----------FMGVNMDVIRALLIFLEKRLHKT 300 310 320 360 370 380 390 400 410 pF1KB5 SSYREGLTPVLSLLTECSRAHRNIRKFLK------DQVLPPLRDVTNRPEVGSTVRNKLV .:...::::.::::.: :: ::::: ::::::::: .::::: .::::: CCDS76 HRLKESVAPVLSVLTECARMHRPARKFLKAQGWPPPQVLPPLRDVRTRPEVGEMLRNKLV 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB5 RLMTHVDLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSED :::::.: ::..:::::::::.: : ..:::::::::::::::::.:::: .. :::: CCDS76 RLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSED 390 400 410 420 430 440 480 490 500 510 520 pF1KB5 EDTDTEEYKNAKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD :::::.:::.:: CCDS76 EDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQP 450 460 470 480 490 500 520 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 04:48:23 2016 done: Mon Nov 7 04:48:23 2016 Total Scan time: 3.350 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]