FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5924, 520 aa 1>>>pF1KB5924 520 - 520 aa - 520 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7890+/-0.00041; mu= 15.3521+/- 0.025 mean_var=66.2598+/-12.993, 0's: 0 Z-trim(111.0): 27 B-trim: 0 in 0/51 Lambda= 0.157561 statistics sampled from 19477 (19489) to 19477 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.229), width: 16 Scan time: 10.280 The best scores are: opt bits E(85289) NP_060627 (OMIM: 609147) synembryn-B isoform 4 [Ho ( 520) 3369 775.1 0 NP_001317076 (OMIM: 609147) synembryn-B isoform 3 ( 536) 3145 724.2 2.4e-208 NP_001317074 (OMIM: 609147) synembryn-B isoform 1 ( 560) 3145 724.2 2.5e-208 XP_016875038 (OMIM: 609147) PREDICTED: synembryn-B ( 504) 3093 712.4 8.1e-205 XP_011536831 (OMIM: 609147) PREDICTED: synembryn-B ( 524) 3093 712.4 8.4e-205 XP_011536830 (OMIM: 609147) PREDICTED: synembryn-B ( 540) 2869 661.5 1.8e-189 NP_001317075 (OMIM: 609147) synembryn-B isoform 2 ( 544) 2869 661.5 1.8e-189 XP_011536828 (OMIM: 609147) PREDICTED: synembryn-B ( 564) 2869 661.5 1.9e-189 XP_016873596 (OMIM: 609146) PREDICTED: synembryn-A ( 421) 671 161.8 3.7e-39 NP_001273063 (OMIM: 609146) synembryn-A isoform 2 ( 531) 671 161.8 4.6e-39 XP_005253109 (OMIM: 609146) PREDICTED: synembryn-A ( 535) 671 161.8 4.6e-39 NP_068751 (OMIM: 609146) synembryn-A isoform 1 [Ho ( 537) 650 157.0 1.3e-37 >>NP_060627 (OMIM: 609147) synembryn-B isoform 4 [Homo s (520 aa) initn: 3369 init1: 3369 opt: 3369 Z-score: 4137.0 bits: 775.1 E(85289): 0 Smith-Waterman score: 3369; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KB5 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN 430 440 450 460 470 480 490 500 510 520 pF1KB5 AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD :::::::::::::::::::::::::::::::::::::::: NP_060 AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD 490 500 510 520 >>NP_001317076 (OMIM: 609147) synembryn-B isoform 3 [Hom (536 aa) initn: 3165 init1: 3139 opt: 3145 Z-score: 3861.6 bits: 724.2 E(85289): 2.4e-208 Smith-Waterman score: 3145; 94.9% identity (97.1% similar) in 514 aa overlap (1-513:1-514) 10 20 30 40 50 60 pF1KB5 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN 430 440 450 460 470 480 490 500 510 520 pF1KB5 AKPKEELLKPMGLKP-DGTITPLEEALNQYSVIEETSSDTD :::. .:. .: . : . : ..: ... NP_001 AKPNINLITGHLEEPMPNPIDEMTEEQKEYEAMKLVNMLDKLSRRADVKDLHQDGG 490 500 510 520 530 >>NP_001317074 (OMIM: 609147) synembryn-B isoform 1 [Hom (560 aa) initn: 3381 init1: 3139 opt: 3145 Z-score: 3861.3 bits: 724.2 E(85289): 2.5e-208 Smith-Waterman score: 3228; 92.6% identity (92.8% similar) in 552 aa overlap (1-512:1-552) 10 20 30 40 50 60 pF1KB5 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN 430 440 450 460 470 480 490 500 pF1KB5 AKP----------------------------------------KEELLKPMGLKPDGTIT ::: .:::::::::::::::: NP_001 AKPNINLITGHLEEPMPNPIDEMTEEQKEYEAMKLVNMLDKLSREELLKPMGLKPDGTIT 490 500 510 520 530 540 510 520 pF1KB5 PLEEALNQYSVIEETSSDTD :::::::::::: NP_001 PLEEALNQYSVIEETSSDTD 550 560 >>XP_016875038 (OMIM: 609147) PREDICTED: synembryn-B iso (504 aa) initn: 3093 init1: 3093 opt: 3093 Z-score: 3798.1 bits: 712.4 E(85289): 8.1e-205 Smith-Waterman score: 3221; 96.9% identity (96.9% similar) in 520 aa overlap (1-520:1-504) 10 20 30 40 50 60 pF1KB5 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT :::::::::::::::::::::::::::: :::::::::::::::: XP_016 MDEERALYIVRAGEAGAIERVLRDYSDK----------------KLCEGIFKVLIKDIPT 10 20 30 40 70 80 90 100 110 120 pF1KB5 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB5 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB5 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN 410 420 430 440 450 460 490 500 510 520 pF1KB5 AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD :::::::::::::::::::::::::::::::::::::::: XP_016 AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD 470 480 490 500 >>XP_011536831 (OMIM: 609147) PREDICTED: synembryn-B iso (524 aa) initn: 3089 init1: 3089 opt: 3093 Z-score: 3797.9 bits: 712.4 E(85289): 8.4e-205 Smith-Waterman score: 3093; 98.4% identity (99.6% similar) in 485 aa overlap (36-520:40-524) 10 20 30 40 50 60 pF1KB5 ALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPTTCQVS ..:... .::::::::::::::::::::: XP_011 GTVKEKCLPGSNIFFLLPALGSKSPISEVKDTTNNQVIQKLCEGIFKVLIKDIPTTCQVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 FNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEET 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 VLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKE 430 440 450 460 470 480 490 500 510 520 pF1KB5 ELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD ::::::::::::::::::::::::::::::::::: XP_011 ELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD 490 500 510 520 >>XP_011536830 (OMIM: 609147) PREDICTED: synembryn-B iso (540 aa) initn: 2883 init1: 2857 opt: 2869 Z-score: 3522.5 bits: 661.5 E(85289): 1.8e-189 Smith-Waterman score: 2869; 92.9% identity (96.5% similar) in 479 aa overlap (36-513:40-518) 10 20 30 40 50 60 pF1KB5 ALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPTTCQVS ..:... .::::::::::::::::::::: XP_011 GTVKEKCLPGSNIFFLLPALGSKSPISEVKDTTNNQVIQKLCEGIFKVLIKDIPTTCQVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 FNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEET 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 VLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_011 EFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPNI 430 440 450 460 470 480 490 500 510 520 pF1KB5 ELLKPMGLKP-DGTITPLEEALNQYSVIEETSSDTD .:. .: . : . : ..: ... XP_011 NLITGHLEEPMPNPIDEMTEEQKEYEAMKLVNMLDKLSRRADVKDLHQDGG 490 500 510 520 530 540 >>NP_001317075 (OMIM: 609147) synembryn-B isoform 2 [Hom (544 aa) initn: 3267 init1: 2863 opt: 2869 Z-score: 3522.4 bits: 661.5 E(85289): 1.8e-189 Smith-Waterman score: 3080; 89.7% identity (89.9% similar) in 552 aa overlap (1-512:1-536) 10 20 30 40 50 60 pF1KB5 MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT :::::::::::::::::::::::::::: :::::::::::::::: NP_001 MDEERALYIVRAGEAGAIERVLRDYSDK----------------KLCEGIFKVLIKDIPT 10 20 30 40 70 80 90 100 110 120 pF1KB5 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB5 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB5 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN 410 420 430 440 450 460 490 500 pF1KB5 AKP----------------------------------------KEELLKPMGLKPDGTIT ::: .:::::::::::::::: NP_001 AKPNINLITGHLEEPMPNPIDEMTEEQKEYEAMKLVNMLDKLSREELLKPMGLKPDGTIT 470 480 490 500 510 520 510 520 pF1KB5 PLEEALNQYSVIEETSSDTD :::::::::::: NP_001 PLEEALNQYSVIEETSSDTD 530 540 >>XP_011536828 (OMIM: 609147) PREDICTED: synembryn-B iso (564 aa) initn: 3099 init1: 2857 opt: 2869 Z-score: 3522.2 bits: 661.5 E(85289): 1.9e-189 Smith-Waterman score: 2952; 90.5% identity (91.9% similar) in 517 aa overlap (36-512:40-556) 10 20 30 40 50 60 pF1KB5 ALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPTTCQVS ..:... .::::::::::::::::::::: XP_011 GTVKEKCLPGSNIFFLLPALGSKSPISEVKDTTNNQVIQKLCEGIFKVLIKDIPTTCQVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 FNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEET 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 VLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKP-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPNI 430 440 450 460 470 480 490 500 pF1KB5 --------------------------------------KEELLKPMGLKPDGTITPLEEA .::::::::::::::::::::: XP_011 NLITGHLEEPMPNPIDEMTEEQKEYEAMKLVNMLDKLSREELLKPMGLKPDGTITPLEEA 490 500 510 520 530 540 510 520 pF1KB5 LNQYSVIEETSSDTD ::::::: XP_011 LNQYSVIEETSSDTD 550 560 >>XP_016873596 (OMIM: 609146) PREDICTED: synembryn-A iso (421 aa) initn: 1145 init1: 671 opt: 671 Z-score: 824.0 bits: 161.8 E(85289): 3.7e-39 Smith-Waterman score: 1120; 52.0% identity (74.8% similar) in 373 aa overlap (113-482:3-340) 90 100 110 120 130 140 pF1KB5 VTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKCLCNIVFNSQMAQQLSLELNLAA :..::::::::.:..: .::.:. : :.. XP_016 MDVVLESLKCLCNLVLSSPVAQMLAAEARLVV 10 20 30 150 160 170 180 190 200 pF1KB5 KLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYELQGLPLLTQILESAFSI :: . . ..:.: .:.. :::::::::. :.::.:.:: ::.:. :::. :: .... XP_016 KLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGV 40 50 60 70 80 90 210 220 230 240 250 pF1KB5 KWTDEYESAIDHNGPP--LSPQETDCAIEALKALFNVTVDSWKVH-KESDSHQFRVMAAV : : : :: : :::. :.: ::.:::.:.:: : . : :. .: .... XP_016 --TPE------GNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTL 100 110 120 130 140 260 270 280 290 300 310 pF1KB5 LRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEETAQEATTLDELPSNK ::::..:. . :.:::.:..:::::.:.:..:::::. ::. : . XP_016 LRHCVMIA-TAGDRTEEFHGHAVNLLGNLPLKCLDVLL-------------TLE--PHGD 150 160 170 180 320 330 340 350 360 370 pF1KB5 TAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTPVLSLLTECSRAHRN ..: . :.::..:..:: :.:::. : .:...::::.::::.: :: XP_016 STE-----------FMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRP 190 200 210 220 230 380 390 400 410 420 430 pF1KB5 IRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAAEFLFVLCKERVDSL ::::: ::::::::: .::::: .::::::::::.: ::..:::::::::.: : . XP_016 ARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRF 240 250 260 270 280 290 440 450 460 470 480 490 pF1KB5 LKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKEELLKPMGLKPDGTI .:::::::::::::::::.:::: .. :::::::::.:::.:: XP_016 IKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNP 300 310 320 330 340 350 500 510 520 pF1KB5 TPLEEALNQYSVIEETSSDTD XP_016 MEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPD 360 370 380 390 400 410 >>NP_001273063 (OMIM: 609146) synembryn-A isoform 2 [Hom (531 aa) initn: 1338 init1: 671 opt: 671 Z-score: 822.3 bits: 161.8 E(85289): 4.6e-39 Smith-Waterman score: 1316; 47.3% identity (73.3% similar) in 484 aa overlap (3-482:2-450) 10 20 30 40 50 pF1KB5 MDEERALY-IVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIP : ::. :..:: .: ..::.:...: .: :...... ::.: : . .:: . .: NP_001 MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLP 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 TTCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLK . .: :. .::::::.. : : :.....: : : .. . :. . ... :..:::: NP_001 PSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 CLCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIR ::::.:..: .::.:. : :..:: . . ..:.: .:.. :::::::::. :.::.: NP_001 CLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 SQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPP--LSPQETDCAIEALKALFNV .:: ::.:. :::. :: .... : : : :: : :::. :.: ::.:::. NP_001 QQLFQELKGVRLLTDTLELTLGV--TPE------GNPPPTLLPSQETERAMEILKVLFNI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 TVDSWKVH-KESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVL :.:: : . : :. .: ....::::..:. . :.:::.:..:::::.:.:..::::: NP_001 TLDSIKGEVDEEDAALYRHLGTLLRHCVMIA-TAGDRTEEFHGHAVNLLGNLPLKCLDVL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 ICPLTHEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKG . ::. : . ..: . :.::..:..:: :.:::. : NP_001 L-------------TLE--PHGDSTE-----------FMGVNMDVIRALLIFLEKRLHKT 300 310 320 360 370 380 390 400 410 pF1KB5 SSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHV .:...::::.::::.: :: ::::: ::::::::: .::::: .::::::::::. NP_001 HRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHL 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB5 DLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTE : ::..:::::::::.: : ..:::::::::::::::::.:::: .. :::::::::. NP_001 DTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTD 390 400 410 420 430 440 480 490 500 510 520 pF1KB5 EYKNAKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD :::.:: NP_001 EYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPR 450 460 470 480 490 500 520 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 04:48:24 2016 done: Mon Nov 7 04:48:25 2016 Total Scan time: 10.280 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]