FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5930, 538 aa 1>>>pF1KB5930 538 - 538 aa - 538 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2713+/-0.000309; mu= 15.5550+/- 0.019 mean_var=126.8461+/-25.945, 0's: 0 Z-trim(120.5): 84 B-trim: 979 in 2/59 Lambda= 0.113877 statistics sampled from 35677 (35782) to 35677 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.42), width: 16 Scan time: 10.780 The best scores are: opt bits E(85289) NP_851564 (OMIM: 147050,605383,615207) interleukin ( 538) 3838 641.7 1.6e-183 NP_068570 (OMIM: 147050,605383,615207) interleukin ( 538) 3838 641.7 1.6e-183 XP_016878746 (OMIM: 147050,605383,615207) PREDICTE ( 538) 3838 641.7 1.6e-183 XP_011544159 (OMIM: 147050,605383,615207) PREDICTE ( 560) 3838 641.8 1.7e-183 NP_851565 (OMIM: 147050,605383,615207) interleukin ( 560) 3838 641.8 1.7e-183 XP_011544160 (OMIM: 147050,605383,615207) PREDICTE ( 414) 2636 444.2 3.8e-124 NP_001333152 (OMIM: 146710) interleukin-2 receptor ( 551) 324 64.4 1e-09 NP_001333151 (OMIM: 146710) interleukin-2 receptor ( 551) 324 64.4 1e-09 NP_000869 (OMIM: 146710) interleukin-2 receptor su ( 551) 324 64.4 1e-09 XP_016885533 (OMIM: 300007) PREDICTED: interleukin ( 567) 229 48.8 5.2e-05 XP_016884984 (OMIM: 300007) PREDICTED: interleukin ( 567) 229 48.8 5.2e-05 XP_016884991 (OMIM: 300007) PREDICTED: interleukin ( 386) 226 48.2 5.5e-05 XP_016885540 (OMIM: 300007) PREDICTED: interleukin ( 386) 226 48.2 5.5e-05 XP_011543951 (OMIM: 300007) PREDICTED: interleukin ( 500) 226 48.3 6.6e-05 XP_016885536 (OMIM: 300007) PREDICTED: interleukin ( 500) 226 48.3 6.6e-05 XP_016884988 (OMIM: 300007) PREDICTED: interleukin ( 500) 226 48.3 6.6e-05 XP_016884987 (OMIM: 300007) PREDICTED: interleukin ( 500) 226 48.3 6.6e-05 XP_016885537 (OMIM: 300007) PREDICTED: interleukin ( 500) 226 48.3 6.6e-05 XP_016885535 (OMIM: 300007) PREDICTED: interleukin ( 500) 226 48.3 6.6e-05 XP_011529456 (OMIM: 300007) PREDICTED: interleukin ( 500) 226 48.3 6.6e-05 XP_016884986 (OMIM: 300007) PREDICTED: interleukin ( 500) 226 48.3 6.6e-05 NP_002177 (OMIM: 300007) interleukin-9 receptor is ( 521) 226 48.3 6.8e-05 XP_011543948 (OMIM: 300007) PREDICTED: interleukin ( 560) 226 48.3 7.2e-05 XP_011529454 (OMIM: 300007) PREDICTED: interleukin ( 560) 226 48.3 7.2e-05 XP_011529453 (OMIM: 300007) PREDICTED: interleukin ( 568) 226 48.3 7.3e-05 XP_011543947 (OMIM: 300007) PREDICTED: interleukin ( 568) 226 48.3 7.3e-05 NP_000112 (OMIM: 133100,133171) erythropoietin rec ( 508) 223 47.8 9.5e-05 XP_016878700 (OMIM: 147050,147781,609423) PREDICTE ( 304) 214 46.1 0.00018 NP_000386 (OMIM: 138981,614370) cytokine receptor ( 897) 201 44.4 0.0017 XP_005261397 (OMIM: 138981,614370) PREDICTED: cyto ( 903) 201 44.4 0.0017 NP_002176 (OMIM: 146661,608971) interleukin-7 rece ( 459) 184 41.4 0.0075 NP_001244336 (OMIM: 147050,147781,609423) interleu ( 810) 187 42.1 0.008 XP_011544129 (OMIM: 147050,147781,609423) PREDICTE ( 825) 187 42.1 0.0081 XP_011544128 (OMIM: 147050,147781,609423) PREDICTE ( 825) 187 42.1 0.0081 NP_000409 (OMIM: 147050,147781,609423) interleukin ( 825) 187 42.1 0.0081 XP_011544127 (OMIM: 147050,147781,609423) PREDICTE ( 825) 187 42.1 0.0081 NP_001244335 (OMIM: 147050,147781,609423) interleu ( 825) 187 42.1 0.0081 >>NP_851564 (OMIM: 147050,605383,615207) interleukin-21 (538 aa) initn: 3838 init1: 3838 opt: 3838 Z-score: 3415.7 bits: 641.7 E(85289): 1.6e-183 Smith-Waterman score: 3838; 100.0% identity (100.0% similar) in 538 aa overlap (1-538:1-538) 10 20 30 40 50 60 pF1KB5 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 EATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 APPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 APPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 RSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 LLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 LELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 LELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 SAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 AGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 AGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGS 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 PLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 PLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS 490 500 510 520 530 >>NP_068570 (OMIM: 147050,605383,615207) interleukin-21 (538 aa) initn: 3838 init1: 3838 opt: 3838 Z-score: 3415.7 bits: 641.7 E(85289): 1.6e-183 Smith-Waterman score: 3838; 100.0% identity (100.0% similar) in 538 aa overlap (1-538:1-538) 10 20 30 40 50 60 pF1KB5 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 EATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 APPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 APPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 LELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 SAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 AGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 AGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGS 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 PLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 PLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS 490 500 510 520 530 >>XP_016878746 (OMIM: 147050,605383,615207) PREDICTED: i (538 aa) initn: 3838 init1: 3838 opt: 3838 Z-score: 3415.7 bits: 641.7 E(85289): 1.6e-183 Smith-Waterman score: 3838; 100.0% identity (100.0% similar) in 538 aa overlap (1-538:1-538) 10 20 30 40 50 60 pF1KB5 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 APPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 LELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 AGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGS 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 PLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS 490 500 510 520 530 >>XP_011544159 (OMIM: 147050,605383,615207) PREDICTED: i (560 aa) initn: 3838 init1: 3838 opt: 3838 Z-score: 3415.5 bits: 641.8 E(85289): 1.7e-183 Smith-Waterman score: 3838; 100.0% identity (100.0% similar) in 538 aa overlap (1-538:23-560) 10 20 30 pF1KB5 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILE :::::::::::::::::::::::::::::::::::::: XP_011 MSCRCIFLMKHGERVGWPVGVSMPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 MWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 TDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYEL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB5 QYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB5 DPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFM 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB5 PLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 ELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDG 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB5 YPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGED 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB5 WAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRS 490 500 510 520 530 540 520 530 pF1KB5 YLRQWVVIPPPLSSPGPQAS :::::::::::::::::::: XP_011 YLRQWVVIPPPLSSPGPQAS 550 560 >>NP_851565 (OMIM: 147050,605383,615207) interleukin-21 (560 aa) initn: 3838 init1: 3838 opt: 3838 Z-score: 3415.5 bits: 641.8 E(85289): 1.7e-183 Smith-Waterman score: 3838; 100.0% identity (100.0% similar) in 538 aa overlap (1-538:23-560) 10 20 30 pF1KB5 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILE :::::::::::::::::::::::::::::::::::::: NP_851 MSCRCIFLMKHGERVGWPVGVSMPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 MWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 MWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 TDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 TDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYEL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB5 QYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 QYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB5 DPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 DPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFM 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB5 PLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 PLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 ELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 ELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDG 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB5 YPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 YPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGED 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB5 WAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 WAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRS 490 500 510 520 530 540 520 530 pF1KB5 YLRQWVVIPPPLSSPGPQAS :::::::::::::::::::: NP_851 YLRQWVVIPPPLSSPGPQAS 550 560 >>XP_011544160 (OMIM: 147050,605383,615207) PREDICTED: i (414 aa) initn: 2635 init1: 2635 opt: 2636 Z-score: 2349.9 bits: 444.2 E(85289): 3.8e-124 Smith-Waterman score: 2636; 99.2% identity (99.5% similar) in 373 aa overlap (167-538:42-414) 140 150 160 170 180 190 pF1KB5 SWRSDYEDPAFYMLKGKLQYELQYRNRGDPWA-VSPRRKLISVDSRSVSLLPLEFRKDSS : .:::::::::::::::::::::::::: XP_011 MYSTSWPTTFSVSTSQTSLATTPRSVAAFSWLRASPRRKLISVDSRSVSLLPLEFRKDSS 20 30 40 50 60 70 200 210 220 230 240 250 pF1KB5 YELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSL 80 90 100 110 120 130 260 270 280 290 300 310 pF1KB5 KTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLE 140 150 160 170 180 190 320 330 340 350 360 370 pF1KB5 VYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVS 200 210 220 230 240 250 380 390 400 410 420 430 pF1KB5 IDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGS 260 270 280 290 300 310 440 450 460 470 480 490 pF1KB5 PGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFV 320 330 340 350 360 370 500 510 520 530 pF1KB5 GSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS ::::::::::::::::::::::::::::::::::::::::::: XP_011 GSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS 380 390 400 410 >>NP_001333152 (OMIM: 146710) interleukin-2 receptor sub (551 aa) initn: 245 init1: 120 opt: 324 Z-score: 295.5 bits: 64.4 E(85289): 1e-09 Smith-Waterman score: 357; 25.1% identity (50.6% similar) in 514 aa overlap (5-471:8-478) 10 20 30 40 pF1KB5 MPRGWAAPLLLLLLQ--GGW------GCPDLVCYTDYLQTVICILEMWN----LHPS : :::.::: .: : ...:. . .. :. :. :. . NP_001 MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCV---WSQDGALQDT 10 20 30 40 50 50 60 70 80 90 pF1KB5 TLTL-TWQDQYEELKDEATSCSLHRSAHNATHATYTCHM-----DVFHFMADDIFSVNIT . . .: :. . .: : ...:...:.. : .. . :: .. . NP_001 SCQVHAWPDR----RRWNQTCELL----PVSQASWACNLILGAPDSQKLTTVDIVTLRVL 60 70 80 90 100 100 110 120 130 140 150 pF1KB5 DQSGNY--SQECGSFLLAESIKPAPPFNVTVTF--SGQYNISWRSDYEDPAFYMLKGKLQ . : . .: :... :... :. . . ::::. . : .... .:. NP_001 CREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQ---ASHYFERHLE 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB5 YELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWS .: . . : : .: :... ... . . :..::.:::. :. : ::: NP_001 FEARTLSPGHTWEEAP---LLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFT--TWS 170 180 190 200 210 220 220 230 240 250 260 pF1KB5 EWSDPVIFQTQSEELKEG---WNPHLLLLLLLVIVFIPAFWSL----KTHPLWRLWKKIW ::.:. :.:. : . : :::. : .. :: . : .: : : ::. NP_001 PWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGP-W--LKKVL 230 240 250 260 270 270 280 290 300 310 320 pF1KB5 A--VPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPA .:.: .:: : . .:: .::...:: .::. : .::. : ::: NP_001 KCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEI-SPLEVL--------- 280 290 300 310 320 330 340 350 360 370 380 pF1KB5 KRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI-DTVTVLDAE .: ..:.: :...: ::.:. . .:. : : .. : . . :.. . . NP_001 ERDKVTQL-----LLQQDKVPEPA----SLSSNHSLTSCFTNQGYFFFHLPDALEIEACQ 330 340 350 360 370 390 400 410 420 430 pF1KB5 GPCTW-PCSCEDD-----GYPALDLDAGLEPSPGLED-----PLLDAGTTVLSCGCVSAG :. : : :: : :. . :.: : .: : : ..: . ... NP_001 VYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRD-DLLLFSPSLLGGP 380 390 400 410 420 430 440 450 460 470 480 490 pF1KB5 SPGLGGPLGSLL--DRLKPPLAD--GEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTF :: .: :: .:. : : . .:: : : .:: NP_001 SPPSTAPGGSGAGEERMPPSLQERVPRDW-DPQPLGPPTPGVPDLVDFQPPPELVLREAG 440 450 460 470 480 490 500 510 520 530 pF1KB5 DSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS NP_001 EEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV 500 510 520 530 540 550 >>NP_001333151 (OMIM: 146710) interleukin-2 receptor sub (551 aa) initn: 245 init1: 120 opt: 324 Z-score: 295.5 bits: 64.4 E(85289): 1e-09 Smith-Waterman score: 357; 25.1% identity (50.6% similar) in 514 aa overlap (5-471:8-478) 10 20 30 40 pF1KB5 MPRGWAAPLLLLLLQ--GGW------GCPDLVCYTDYLQTVICILEMWN----LHPS : :::.::: .: : ...:. . .. :. :. :. . NP_001 MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCV---WSQDGALQDT 10 20 30 40 50 50 60 70 80 90 pF1KB5 TLTL-TWQDQYEELKDEATSCSLHRSAHNATHATYTCHM-----DVFHFMADDIFSVNIT . . .: :. . .: : ...:...:.. : .. . :: .. . NP_001 SCQVHAWPDR----RRWNQTCELL----PVSQASWACNLILGAPDSQKLTTVDIVTLRVL 60 70 80 90 100 100 110 120 130 140 150 pF1KB5 DQSGNY--SQECGSFLLAESIKPAPPFNVTVTF--SGQYNISWRSDYEDPAFYMLKGKLQ . : . .: :... :... :. . . ::::. . : .... .:. NP_001 CREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQ---ASHYFERHLE 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB5 YELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWS .: . . : : .: :... ... . . :..::.:::. :. : ::: NP_001 FEARTLSPGHTWEEAP---LLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFT--TWS 170 180 190 200 210 220 220 230 240 250 260 pF1KB5 EWSDPVIFQTQSEELKEG---WNPHLLLLLLLVIVFIPAFWSL----KTHPLWRLWKKIW ::.:. :.:. : . : :::. : .. :: . : .: : : ::. NP_001 PWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGP-W--LKKVL 230 240 250 260 270 270 280 290 300 310 320 pF1KB5 A--VPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPA .:.: .:: : . .:: .::...:: .::. : .::. : ::: NP_001 KCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEI-SPLEVL--------- 280 290 300 310 320 330 340 350 360 370 380 pF1KB5 KRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI-DTVTVLDAE .: ..:.: :...: ::.:. . .:. : : .. : . . :.. . . NP_001 ERDKVTQL-----LLQQDKVPEPA----SLSSNHSLTSCFTNQGYFFFHLPDALEIEACQ 330 340 350 360 370 390 400 410 420 430 pF1KB5 GPCTW-PCSCEDD-----GYPALDLDAGLEPSPGLED-----PLLDAGTTVLSCGCVSAG :. : : :: : :. . :.: : .: : : ..: . ... NP_001 VYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRD-DLLLFSPSLLGGP 380 390 400 410 420 430 440 450 460 470 480 490 pF1KB5 SPGLGGPLGSLL--DRLKPPLAD--GEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTF :: .: :: .:. : : . .:: : : .:: NP_001 SPPSTAPGGSGAGEERMPPSLQERVPRDW-DPQPLGPPTPGVPDLVDFQPPPELVLREAG 440 450 460 470 480 490 500 510 520 530 pF1KB5 DSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS NP_001 EEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV 500 510 520 530 540 550 >>NP_000869 (OMIM: 146710) interleukin-2 receptor subuni (551 aa) initn: 245 init1: 120 opt: 324 Z-score: 295.5 bits: 64.4 E(85289): 1e-09 Smith-Waterman score: 357; 25.1% identity (50.6% similar) in 514 aa overlap (5-471:8-478) 10 20 30 40 pF1KB5 MPRGWAAPLLLLLLQ--GGW------GCPDLVCYTDYLQTVICILEMWN----LHPS : :::.::: .: : ...:. . .. :. :. :. . NP_000 MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCV---WSQDGALQDT 10 20 30 40 50 50 60 70 80 90 pF1KB5 TLTL-TWQDQYEELKDEATSCSLHRSAHNATHATYTCHM-----DVFHFMADDIFSVNIT . . .: :. . .: : ...:...:.. : .. . :: .. . NP_000 SCQVHAWPDR----RRWNQTCELL----PVSQASWACNLILGAPDSQKLTTVDIVTLRVL 60 70 80 90 100 100 110 120 130 140 150 pF1KB5 DQSGNY--SQECGSFLLAESIKPAPPFNVTVTF--SGQYNISWRSDYEDPAFYMLKGKLQ . : . .: :... :... :. . . ::::. . : .... .:. NP_000 CREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQ---ASHYFERHLE 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB5 YELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWS .: . . : : .: :... ... . . :..::.:::. :. : ::: NP_000 FEARTLSPGHTWEEAP---LLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFT--TWS 170 180 190 200 210 220 220 230 240 250 260 pF1KB5 EWSDPVIFQTQSEELKEG---WNPHLLLLLLLVIVFIPAFWSL----KTHPLWRLWKKIW ::.:. :.:. : . : :::. : .. :: . : .: : : ::. NP_000 PWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGP-W--LKKVL 230 240 250 260 270 270 280 290 300 310 320 pF1KB5 A--VPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPA .:.: .:: : . .:: .::...:: .::. : .::. : ::: NP_000 KCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEI-SPLEVL--------- 280 290 300 310 320 330 340 350 360 370 380 pF1KB5 KRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI-DTVTVLDAE .: ..:.: :...: ::.:. . .:. : : .. : . . :.. . . NP_000 ERDKVTQL-----LLQQDKVPEPA----SLSSNHSLTSCFTNQGYFFFHLPDALEIEACQ 330 340 350 360 370 390 400 410 420 430 pF1KB5 GPCTW-PCSCEDD-----GYPALDLDAGLEPSPGLED-----PLLDAGTTVLSCGCVSAG :. : : :: : :. . :.: : .: : : ..: . ... NP_000 VYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRD-DLLLFSPSLLGGP 380 390 400 410 420 430 440 450 460 470 480 490 pF1KB5 SPGLGGPLGSLL--DRLKPPLAD--GEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTF :: .: :: .:. : : . .:: : : .:: NP_000 SPPSTAPGGSGAGEERMPPSLQERVPRDW-DPQPLGPPTPGVPDLVDFQPPPELVLREAG 440 450 460 470 480 490 500 510 520 530 pF1KB5 DSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS NP_000 EEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV 500 510 520 530 540 550 >>XP_016885533 (OMIM: 300007) PREDICTED: interleukin-9 r (567 aa) initn: 195 init1: 108 opt: 229 Z-score: 211.0 bits: 48.8 E(85289): 5.2e-05 Smith-Waterman score: 293; 27.1% identity (51.9% similar) in 362 aa overlap (112-438:186-527) 90 100 110 120 130 140 pF1KB5 HMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFS-GQYNISWRS .: . .: :: .. ..: :. ..: XP_016 EAVLVPSDNFTITFHHCMSGREQVSLVDPEYLPRRHVKLDPPSDLQSNISSGHCILTWSI 160 170 180 190 200 210 150 160 170 180 190 pF1KB5 DYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLE-FRKDSSY--- . ::. . :.::: .... . : .. : ... .:. : :: :. : .. XP_016 S---PALEPMTTLLSYELAFKKQEEAWEAQHRDHIV-----GVTWLILEAFELDPGFIHE 220 230 240 250 260 200 210 220 230 240 pF1KB5 -ELQVRAGPMPGS-----SYQGTWSEWSDPVIFQTQSEE--LKEGWN-PHLLLLLLLVIV .:.:. . . . : : :::::.:: ::. ... : :. : :. . ... XP_016 ARLRVQMATLEDDVVEEERYTGQWSEWSQPVCFQAPQRQGPLIPPWGWPGNTLVAVSIFL 270 280 290 300 310 320 250 260 270 280 290 300 pF1KB5 FI--PAFWSLKTHPLWRLWKKIW--AVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLEL .. :.. .: : :. :.:. :::: ::.:::. .:.:. :.:: .: : XP_016 LLTGPTYLLFKLSP--RV-KRIFYQNVPSPAMFFQPLYSVHNGNFQTWMGAHGAGVLLSQ 330 340 350 360 370 380 310 320 330 340 350 pF1KB5 -------GPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQE------PAELVESDGVPKPS : : : . . .: : : : : . : : :: :..: : .: XP_016 DCAGTPQGALEPCVQEATALLTCGPAR-PWKSVALEEEQEGPGTRLPGNLSSEDVLPAGC 390 400 410 420 430 440 360 370 380 390 400 pF1KB5 FWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGP--CTWPCSCEDDGYPALDLDAG- .:. :: ..: .. .:. . :.:: . : ....: :: .: XP_016 TEWRVQTL---AYLPQED--WAPTSLTRPAPPDSEGSRSSSSSSSSNNNNYCALGCYGGW 450 460 470 480 490 410 420 430 440 450 460 pF1KB5 -LEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWG : :: . .. .:.:: .: :: XP_016 HLSALPG--NTQSSGPIPALACG-LSCDHQGLETQQGVAWVLAGHCQRPGLHEDLQGMLL 500 510 520 530 540 550 470 480 490 500 510 520 pF1KB5 GRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVI XP_016 PSVLSKARSWTF 560 538 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:37:24 2016 done: Sat Nov 5 15:37:25 2016 Total Scan time: 10.780 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]