FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5952, 547 aa 1>>>pF1KB5952 547 - 547 aa - 547 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5233+/-0.000934; mu= 18.2511+/- 0.056 mean_var=88.4393+/-17.785, 0's: 0 Z-trim(107.8): 60 B-trim: 278 in 2/50 Lambda= 0.136380 statistics sampled from 9716 (9775) to 9716 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.675), E-opt: 0.2 (0.3), width: 16 Scan time: 3.070 The best scores are: opt bits E(32554) CCDS12235.1 ICAM3 gene_id:3385|Hs108|chr19 ( 547) 3657 729.9 1.9e-210 CCDS82290.1 ICAM3 gene_id:3385|Hs108|chr19 ( 470) 3133 626.7 1.9e-179 CCDS12233.1 ICAM5 gene_id:7087|Hs108|chr19 ( 924) 1586 322.6 1.3e-87 CCDS12231.1 ICAM1 gene_id:3383|Hs108|chr19 ( 532) 1577 320.6 2.9e-87 CCDS11657.1 ICAM2 gene_id:3384|Hs108|chr17 ( 275) 419 92.5 6.9e-19 >>CCDS12235.1 ICAM3 gene_id:3385|Hs108|chr19 (547 aa) initn: 3657 init1: 3657 opt: 3657 Z-score: 3891.6 bits: 729.9 E(32554): 1.9e-210 Smith-Waterman score: 3657; 100.0% identity (100.0% similar) in 547 aa overlap (1-547:1-547) 10 20 30 40 50 60 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 CTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 CTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG 490 500 510 520 530 540 pF1KB5 EEPSRAE ::::::: CCDS12 EEPSRAE >>CCDS82290.1 ICAM3 gene_id:3385|Hs108|chr19 (470 aa) initn: 3133 init1: 3133 opt: 3133 Z-score: 3335.3 bits: 626.7 E(32554): 1.9e-179 Smith-Waterman score: 3133; 100.0% identity (100.0% similar) in 470 aa overlap (78-547:1-470) 50 60 70 80 90 100 pF1KB5 SLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITG :::::::::::::::::::::::::::::: CCDS82 MGWAAFNLSNVTGNSRILCSVYCNGSQITG 10 20 30 110 120 130 140 150 160 pF1KB5 SSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAV 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB5 EEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 EEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVA 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB5 PRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB5 GAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 GAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLD 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB5 GVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 GVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATC 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB5 PQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSS 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB5 RGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 RGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTY 400 410 420 430 440 450 530 540 pF1KB5 LPLTSMQPTEAMGEEPSRAE :::::::::::::::::::: CCDS82 LPLTSMQPTEAMGEEPSRAE 460 470 >>CCDS12233.1 ICAM5 gene_id:7087|Hs108|chr19 (924 aa) initn: 1537 init1: 1206 opt: 1586 Z-score: 1686.3 bits: 322.6 E(32554): 1.3e-87 Smith-Waterman score: 1586; 51.6% identity (76.5% similar) in 473 aa overlap (15-480:16-488) 10 20 30 40 50 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQE-FLLRVEPQNPVLSAGGSLFVNCSTDCP :. : :. .. .:: : ..:. . ::::..::::.:: CCDS12 MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 SSEKIALETSLSKELVASGMGWAAFNLSNVT-GNSRILCSVYCNGSQITGSSNITVYRLP :. .::::: .. . :. : : .: .. ... .: : . . . : ... : CCDS12 RPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 ERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEP-----AE .:::: :::::::::.:::: :.: ..::.:::..::: .:: :. . :: : CCDS12 DRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 VTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLE .:::::: :.:::: ::::.:::..:.::::: :.::::.:::: : :::.:::.:: CCDS12 LTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 VETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREI : . ::.::::::::::::.:::::::: :. : .::...::::::: :.:::::.. CCDS12 VGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 VCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAA ::::::::: ::.:::.:..:: .:...::::.. ::. :::.: :::.. :::.::::: CCDS12 VCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 APGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLK .:::::::::::::.:: :::::.:::.:::: : .: :..:::::.:..: . ::. CCDS12 VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 WKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYT : . ...:.:.::::: : ..: . .. . .:. :. . .:::.:.:....:. . CCDS12 WPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAV 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 LVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTS :.. .: CCDS12 KDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLL 490 500 510 520 530 540 >>CCDS12231.1 ICAM1 gene_id:3383|Hs108|chr19 (532 aa) initn: 1491 init1: 1403 opt: 1577 Z-score: 1680.0 bits: 320.6 E(32554): 2.9e-87 Smith-Waterman score: 1577; 46.8% identity (74.1% similar) in 532 aa overlap (4-530:1-523) 10 20 30 40 50 60 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS :.:: : :.. : :: . . : :.. .: :::..:.:::.: . CCDS12 MAPSSPRPALPALLVLLGALFPGPGNAQ--TSVSPSKVILPRGGSVLVTCSTSCDQP 10 20 30 40 50 70 80 90 100 110 pF1KB5 EKIALETSL-SKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPER . ...:: : .:::. : . ...:::: .:. .: : .: :... .::: ::: CCDS12 KLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPER 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 VELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLA ::::::: :::::.:.::::::: :.::..::::::: :.::.:.::: ::::::.:::. CCDS12 VELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 SRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPV :: ::: ::::::::..:::: :: ::::: ::.:::::.:::.::.:: :::.:. : CCDS12 RRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 DCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLG :.::::::.:::::.:::::: :: :: .:...: :.... :..::.....: : :: CCDS12 VCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 GERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQ .. .:. ...:..:: .: : :..: . ::. :::.: : :..:::.:::: : :: CCDS12 NQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQ 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 LQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRH : :.:: :.:::: ::::::: :...:.:.. .:::::::..:. :: . : ..... CCDS12 LLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQ 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 VLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDI . .::: ::: :::.:::.:. .:.: :. .::: :.: :..:. : :.... CCDS12 TPMCQAWGNPLPELKCLKDGTF-PLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNV 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 EAGSSHFVPVFVAVLLTLGVVTIVLALM----YVFREHQRSGSYHVREESTYLPLTSMQP . : . :..:. ....... :.. .... .:.... . :. CCDS12 ------LSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQ 480 490 500 510 520 540 pF1KB5 TEAMGEEPSRAE CCDS12 ATPP 530 >>CCDS11657.1 ICAM2 gene_id:3384|Hs108|chr17 (275 aa) initn: 428 init1: 302 opt: 419 Z-score: 452.5 bits: 92.5 E(32554): 6.9e-19 Smith-Waterman score: 419; 36.0% identity (63.1% similar) in 214 aa overlap (18-226:16-225) 10 20 30 40 50 60 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS :.:: :: . . : ..:.:.. .. ::: ::::: : . CCDS11 MSSFGYRTLTVALFTLICC---PGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQP 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV : .:::::.: :. : . .::.. .. . : :.:.: . .::..::. :..: CCDS11 EVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQV 60 70 80 90 100 110 130 140 150 160 170 pF1KB5 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQP---AVEEPAEVTATV :. : ::..::..:.: : :::. :.: .: : . :. : :.::: CCDS11 ILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 --LASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVET :.:.: ::: . ::.. .: ..: . :::..:. . ::. ..: CCDS11 NSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE-PVSDSQMVIIVTVVSVL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 SWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCN CCDS11 LSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP 240 250 260 270 547 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:37:46 2016 done: Fri Nov 4 21:37:47 2016 Total Scan time: 3.070 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]