FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5952, 547 aa 1>>>pF1KB5952 547 - 547 aa - 547 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8343+/-0.000413; mu= 16.5246+/- 0.025 mean_var=105.9487+/-21.138, 0's: 0 Z-trim(114.5): 108 B-trim: 615 in 1/54 Lambda= 0.124602 statistics sampled from 24231 (24352) to 24231 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.286), width: 16 Scan time: 10.380 The best scores are: opt bits E(85289) NP_002153 (OMIM: 146631) intercellular adhesion mo ( 547) 3657 668.6 1.3e-191 NP_001307535 (OMIM: 146631) intercellular adhesion ( 470) 3133 574.4 2.7e-163 NP_001307537 (OMIM: 146631) intercellular adhesion ( 286) 1882 349.3 9.4e-96 NP_001307534 (OMIM: 146631) intercellular adhesion ( 451) 1584 295.9 1.7e-79 NP_003250 (OMIM: 601852) intercellular adhesion mo ( 924) 1586 296.6 2.3e-79 XP_011526531 (OMIM: 601852) PREDICTED: intercellul ( 924) 1586 296.6 2.3e-79 NP_000192 (OMIM: 147840,611162) intercellular adhe ( 532) 1577 294.7 4.7e-79 XP_016882674 (OMIM: 601852) PREDICTED: intercellul ( 586) 516 104.0 1.3e-21 NP_001093258 (OMIM: 146630) intercellular adhesion ( 275) 419 86.3 1.3e-16 NP_001093256 (OMIM: 146630) intercellular adhesion ( 275) 419 86.3 1.3e-16 NP_001093259 (OMIM: 146630) intercellular adhesion ( 275) 419 86.3 1.3e-16 NP_001093257 (OMIM: 146630) intercellular adhesion ( 275) 419 86.3 1.3e-16 NP_000864 (OMIM: 146630) intercellular adhesion mo ( 275) 419 86.3 1.3e-16 NP_001535 (OMIM: 111250,614088) intercellular adhe ( 271) 255 56.8 1e-07 NP_001120645 (OMIM: 609743) cell adhesion molecule ( 398) 215 49.8 1.9e-05 NP_067012 (OMIM: 609743) cell adhesion molecule 3 ( 432) 215 49.8 2e-05 NP_001186763 (OMIM: 192225) vascular cell adhesion ( 677) 203 47.8 0.00013 NP_001069 (OMIM: 192225) vascular cell adhesion pr ( 739) 203 47.9 0.00013 NP_001034221 (OMIM: 111250,614088) intercellular a ( 272) 190 45.1 0.00033 >>NP_002153 (OMIM: 146631) intercellular adhesion molecu (547 aa) initn: 3657 init1: 3657 opt: 3657 Z-score: 3560.8 bits: 668.6 E(85289): 1.3e-191 Smith-Waterman score: 3657; 100.0% identity (100.0% similar) in 547 aa overlap (1-547:1-547) 10 20 30 40 50 60 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 CTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG 490 500 510 520 530 540 pF1KB5 EEPSRAE ::::::: NP_002 EEPSRAE >>NP_001307535 (OMIM: 146631) intercellular adhesion mol (470 aa) initn: 3133 init1: 3133 opt: 3133 Z-score: 3052.6 bits: 574.4 E(85289): 2.7e-163 Smith-Waterman score: 3133; 100.0% identity (100.0% similar) in 470 aa overlap (78-547:1-470) 50 60 70 80 90 100 pF1KB5 SLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITG :::::::::::::::::::::::::::::: NP_001 MGWAAFNLSNVTGNSRILCSVYCNGSQITG 10 20 30 110 120 130 140 150 160 pF1KB5 SSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAV 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB5 EEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVA 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB5 PRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB5 GAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLD 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB5 GVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATC 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB5 PQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSS 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB5 RGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTY 400 410 420 430 440 450 530 540 pF1KB5 LPLTSMQPTEAMGEEPSRAE :::::::::::::::::::: NP_001 LPLTSMQPTEAMGEEPSRAE 460 470 >>NP_001307537 (OMIM: 146631) intercellular adhesion mol (286 aa) initn: 1882 init1: 1882 opt: 1882 Z-score: 1840.1 bits: 349.3 E(85289): 9.4e-96 Smith-Waterman score: 1882; 100.0% identity (100.0% similar) in 286 aa overlap (262-547:1-286) 240 250 260 270 280 290 pF1KB5 EVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGARE :::::::::::::::::::::::::::::: NP_001 MLNATVMNHGDTLTATATATARADQEGARE 10 20 30 300 310 320 330 340 350 pF1KB5 IVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPA 40 50 60 70 80 90 360 370 380 390 400 410 pF1KB5 AAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHL 100 110 120 130 140 150 420 430 440 450 460 470 pF1KB5 KWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKY 160 170 180 190 200 210 480 490 500 510 520 530 pF1KB5 TLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLT 220 230 240 250 260 270 540 pF1KB5 SMQPTEAMGEEPSRAE :::::::::::::::: NP_001 SMQPTEAMGEEPSRAE 280 >>NP_001307534 (OMIM: 146631) intercellular adhesion mol (451 aa) initn: 1573 init1: 1573 opt: 1584 Z-score: 1548.0 bits: 295.9 E(85289): 1.7e-79 Smith-Waterman score: 2824; 82.3% identity (82.4% similar) in 547 aa overlap (1-547:1-451) 10 20 30 40 50 60 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVD :::::::::::::::::::::::::::::::::::: NP_001 RDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTF------------------------ 190 200 210 250 260 270 280 290 300 pF1KB5 CTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG NP_001 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KB5 ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL .::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ------------GFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQL 220 230 240 250 260 370 380 390 400 410 420 pF1KB5 QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHV 270 280 290 300 310 320 430 440 450 460 470 480 pF1KB5 LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE 330 340 350 360 370 380 490 500 510 520 530 540 pF1KB5 AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMG 390 400 410 420 430 440 pF1KB5 EEPSRAE ::::::: NP_001 EEPSRAE 450 >>NP_003250 (OMIM: 601852) intercellular adhesion molecu (924 aa) initn: 1537 init1: 1206 opt: 1586 Z-score: 1545.8 bits: 296.6 E(85289): 2.3e-79 Smith-Waterman score: 1586; 51.6% identity (76.5% similar) in 473 aa overlap (15-480:16-488) 10 20 30 40 50 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQE-FLLRVEPQNPVLSAGGSLFVNCSTDCP :. : :. .. .:: : ..:. . ::::..::::.:: NP_003 MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 SSEKIALETSLSKELVASGMGWAAFNLSNVT-GNSRILCSVYCNGSQITGSSNITVYRLP :. .::::: .. . :. : : .: .. ... .: : . . . : ... : NP_003 RPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 ERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEP-----AE .:::: :::::::::.:::: :.: ..::.:::..::: .:: :. . :: : NP_003 DRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 VTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLE .:::::: :.:::: ::::.:::..:.::::: :.::::.:::: : :::.:::.:: NP_003 LTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 VETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREI : . ::.::::::::::::.:::::::: :. : .::...::::::: :.:::::.. NP_003 VGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 VCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAA ::::::::: ::.:::.:..:: .:...::::.. ::. :::.: :::.. :::.::::: NP_003 VCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 APGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLK .:::::::::::::.:: :::::.:::.:::: : .: :..:::::.:..: . ::. NP_003 VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 WKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYT : . ...:.:.::::: : ..: . .. . .:. :. . .:::.:.:....:. . NP_003 WPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAV 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 LVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTS :.. .: NP_003 KDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLL 490 500 510 520 530 540 >>XP_011526531 (OMIM: 601852) PREDICTED: intercellular a (924 aa) initn: 1537 init1: 1206 opt: 1586 Z-score: 1545.8 bits: 296.6 E(85289): 2.3e-79 Smith-Waterman score: 1586; 51.6% identity (76.5% similar) in 473 aa overlap (15-480:16-488) 10 20 30 40 50 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQE-FLLRVEPQNPVLSAGGSLFVNCSTDCP :. : :. .. .:: : ..:. . ::::..::::.:: XP_011 MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 SSEKIALETSLSKELVASGMGWAAFNLSNVT-GNSRILCSVYCNGSQITGSSNITVYRLP :. .::::: .. . :. : : .: .. ... .: : . . . : ... : XP_011 RPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 ERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEP-----AE .:::: :::::::::.:::: :.: ..::.:::..::: .:: :. . :: : XP_011 DRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 VTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLE .:::::: :.:::: ::::.:::..:.::::: :.::::.:::: : :::.:::.:: XP_011 LTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 VETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREI : . ::.::::::::::::.:::::::: :. : .::...::::::: :.:::::.. XP_011 VGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 VCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAA ::::::::: ::.:::.:..:: .:...::::.. ::. :::.: :::.. :::.::::: XP_011 VCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 APGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLK .:::::::::::::.:: :::::.:::.:::: : .: :..:::::.:..: . ::. XP_011 VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 WKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYT : . ...:.:.::::: : ..: . .. . .:. :. . .:::.:.:....:. . XP_011 WPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAV 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 LVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTS :.. .: XP_011 KDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLL 490 500 510 520 530 540 >>NP_000192 (OMIM: 147840,611162) intercellular adhesion (532 aa) initn: 1491 init1: 1403 opt: 1577 Z-score: 1540.2 bits: 294.7 E(85289): 4.7e-79 Smith-Waterman score: 1577; 46.8% identity (74.1% similar) in 532 aa overlap (4-530:1-523) 10 20 30 40 50 60 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS :.:: : :.. : :: . . : :.. .: :::..:.:::.: . NP_000 MAPSSPRPALPALLVLLGALFPGPGNAQ--TSVSPSKVILPRGGSVLVTCSTSCDQP 10 20 30 40 50 70 80 90 100 110 pF1KB5 EKIALETSL-SKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPER . ...:: : .:::. : . ...:::: .:. .: : .: :... .::: ::: NP_000 KLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPER 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 VELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLA ::::::: :::::.:.::::::: :.::..::::::: :.::.:.::: ::::::.:::. NP_000 VELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 SRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPV :: ::: ::::::::..:::: :: ::::: ::.:::::.:::.::.:: :::.:. : NP_000 RRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 DCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLG :.::::::.:::::.:::::: :: :: .:...: :.... :..::.....: : :: NP_000 VCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 GERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQ .. .:. ...:..:: .: : :..: . ::. :::.: : :..:::.:::: : :: NP_000 NQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQ 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 LQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRH : :.:: :.:::: ::::::: :...:.:.. .:::::::..:. :: . : ..... NP_000 LLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQ 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 VLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDI . .::: ::: :::.:::.:. .:.: :. .::: :.: :..:. : :.... NP_000 TPMCQAWGNPLPELKCLKDGTF-PLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNV 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 EAGSSHFVPVFVAVLLTLGVVTIVLALM----YVFREHQRSGSYHVREESTYLPLTSMQP . : . :..:. ....... :.. .... .:.... . :. NP_000 ------LSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQ 480 490 500 510 520 540 pF1KB5 TEAMGEEPSRAE NP_000 ATPP 530 >>XP_016882674 (OMIM: 601852) PREDICTED: intercellular a (586 aa) initn: 508 init1: 508 opt: 516 Z-score: 508.9 bits: 104.0 E(85289): 1.3e-21 Smith-Waterman score: 516; 49.7% identity (79.2% similar) in 149 aa overlap (332-480:2-150) 310 320 330 340 350 360 pF1KB5 RREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQ :::.: :::.. :::.:::::.:::::::: XP_016 MVTVTCAAGAQALVTLEGVPAAVPGQPAQLQ 10 20 30 370 380 390 400 410 420 pF1KB5 LNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVL :::::.:: :::::.:::.:::: : .: :..:::::.:..: . ::. : . ...: XP_016 LNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTL 40 50 60 70 80 90 430 440 450 460 470 480 pF1KB5 QCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEA .:.::::: : ..: . .. . .:. :. . .:::.:.:....:. . :.. .: XP_016 RCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEY 100 110 120 130 140 150 490 500 510 520 530 540 pF1KB5 GSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGE XP_016 APALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREHAGT 160 170 180 190 200 210 >>NP_001093258 (OMIM: 146630) intercellular adhesion mol (275 aa) initn: 428 init1: 302 opt: 419 Z-score: 418.9 bits: 86.3 E(85289): 1.3e-16 Smith-Waterman score: 419; 36.0% identity (63.1% similar) in 214 aa overlap (18-226:16-225) 10 20 30 40 50 60 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS :.:: :: . . : ..:.:.. .. ::: ::::: : . NP_001 MSSFGYRTLTVALFTLICC---PGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQP 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV : .:::::.: :. : . .::.. .. . : :.:.: . .::..::. :..: NP_001 EVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQV 60 70 80 90 100 110 130 140 150 160 170 pF1KB5 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQP---AVEEPAEVTATV :. : ::..::..:.: : :::. :.: .: : . :. : :.::: NP_001 ILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 --LASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVET :.:.: ::: . ::.. .: ..: . :::..:. . ::. ..: NP_001 NSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE-PVSDSQMVIIVTVVSVL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 SWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCN NP_001 LSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP 240 250 260 270 >>NP_001093256 (OMIM: 146630) intercellular adhesion mol (275 aa) initn: 428 init1: 302 opt: 419 Z-score: 418.9 bits: 86.3 E(85289): 1.3e-16 Smith-Waterman score: 419; 36.0% identity (63.1% similar) in 214 aa overlap (18-226:16-225) 10 20 30 40 50 60 pF1KB5 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS :.:: :: . . : ..:.:.. .. ::: ::::: : . NP_001 MSSFGYRTLTVALFTLICC---PGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQP 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV : .:::::.: :. : . .::.. .. . : :.:.: . .::..::. :..: NP_001 EVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQV 60 70 80 90 100 110 130 140 150 160 170 pF1KB5 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQP---AVEEPAEVTATV :. : ::..::..:.: : :::. :.: .: : . :. : :.::: NP_001 ILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 --LASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVET :.:.: ::: . ::.. .: ..: . :::..:. . ::. ..: NP_001 NSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE-PVSDSQMVIIVTVVSVL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 SWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCN NP_001 LSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP 240 250 260 270 547 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:37:47 2016 done: Fri Nov 4 21:37:49 2016 Total Scan time: 10.380 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]