FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5967, 518 aa 1>>>pF1KB5967 518 - 518 aa - 518 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8101+/-0.000862; mu= 7.6769+/- 0.052 mean_var=140.7649+/-28.051, 0's: 0 Z-trim(112.0): 34 B-trim: 0 in 0/52 Lambda= 0.108100 statistics sampled from 12833 (12866) to 12833 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.737), E-opt: 0.2 (0.395), width: 16 Scan time: 2.890 The best scores are: opt bits E(32554) CCDS9173.1 TBX5 gene_id:6910|Hs108|chr12 ( 518) 3605 573.6 1.8e-163 CCDS9174.1 TBX5 gene_id:6910|Hs108|chr12 ( 468) 3260 519.8 2.7e-147 CCDS82180.1 TBX4 gene_id:9496|Hs108|chr17 ( 546) 1720 279.7 6e-75 CCDS11629.1 TBX4 gene_id:9496|Hs108|chr17 ( 545) 1710 278.1 1.8e-74 CCDS9175.1 TBX3 gene_id:6926|Hs108|chr12 ( 723) 867 146.7 8.5e-35 CCDS13765.1 TBX1 gene_id:6899|Hs108|chr22 ( 372) 827 140.3 3.7e-33 CCDS43568.1 TBX20 gene_id:57057|Hs108|chr7 ( 447) 828 140.5 3.8e-33 CCDS13767.1 TBX1 gene_id:6899|Hs108|chr22 ( 495) 825 140.0 5.8e-33 CCDS11627.2 TBX2 gene_id:6909|Hs108|chr17 ( 712) 822 139.7 1.1e-32 CCDS13766.1 TBX1 gene_id:6899|Hs108|chr22 ( 398) 816 138.6 1.3e-32 CCDS10670.1 TBX6 gene_id:6911|Hs108|chr16 ( 436) 808 137.4 3.3e-32 CCDS81360.1 TBX15 gene_id:6913|Hs108|chr1 ( 602) 790 134.6 3e-31 CCDS31621.1 TBX10 gene_id:347853|Hs108|chr11 ( 385) 785 133.8 3.5e-31 CCDS30816.1 TBX15 gene_id:6913|Hs108|chr1 ( 496) 783 133.5 5.4e-31 CCDS34495.1 TBX18 gene_id:9096|Hs108|chr6 ( 607) 766 130.9 4e-30 CCDS5290.1 T gene_id:6862|Hs108|chr6 ( 435) 721 123.8 4e-28 CCDS14445.1 TBX22 gene_id:50945|Hs108|chrX ( 520) 695 119.8 7.7e-27 CCDS11514.1 TBX21 gene_id:30009|Hs108|chr17 ( 535) 685 118.2 2.3e-26 CCDS2646.1 EOMES gene_id:8320|Hs108|chr3 ( 686) 681 117.7 4.4e-26 CCDS59045.1 T gene_id:6862|Hs108|chr6 ( 377) 676 116.8 4.5e-26 CCDS55960.1 MGA gene_id:23269|Hs108|chr15 (2856) 686 118.8 8.5e-26 CCDS55959.1 MGA gene_id:23269|Hs108|chr15 (3065) 686 118.8 9.1e-26 CCDS33310.1 TBR1 gene_id:10716|Hs108|chr2 ( 682) 673 116.4 1e-25 CCDS63585.1 EOMES gene_id:8320|Hs108|chr3 ( 705) 645 112.1 2.2e-24 CCDS1272.1 TBX19 gene_id:9095|Hs108|chr1 ( 448) 632 109.9 6.1e-24 CCDS63584.1 EOMES gene_id:8320|Hs108|chr3 ( 410) 525 93.2 6e-19 CCDS9176.1 TBX3 gene_id:6926|Hs108|chr12 ( 743) 528 93.8 7.2e-19 >>CCDS9173.1 TBX5 gene_id:6910|Hs108|chr12 (518 aa) initn: 3605 init1: 3605 opt: 3605 Z-score: 3048.1 bits: 573.6 E(32554): 1.8e-163 Smith-Waterman score: 3605; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518) 10 20 30 40 50 60 pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 RELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 RELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 PRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 DMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 QQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 QQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 LPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 LPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPG 430 440 450 460 470 480 490 500 510 pF1KB5 TLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS :::::::::::::::::::::::::::::::::::::: CCDS91 TLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS 490 500 510 >>CCDS9174.1 TBX5 gene_id:6910|Hs108|chr12 (468 aa) initn: 3260 init1: 3260 opt: 3260 Z-score: 2758.0 bits: 519.8 E(32554): 2.7e-147 Smith-Waterman score: 3260; 100.0% identity (100.0% similar) in 468 aa overlap (51-518:1-468) 30 40 50 60 70 80 pF1KB5 DLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAG :::::::::::::::::::::::::::::: CCDS91 MEGIKVFLHERELWLKFHEVGTEMIITKAG 10 20 30 90 100 110 120 130 140 pF1KB5 RRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 RRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPD 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB5 SPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 SPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTA 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB5 FCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 FCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB5 STVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 STVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQI 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB5 YHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 YHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMY 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB5 ASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 ASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLA 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB5 GMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS91 GMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPH 400 410 420 430 440 450 510 pF1KB5 QYHSVHGVGMVPEWSDNS :::::::::::::::::: CCDS91 QYHSVHGVGMVPEWSDNS 460 >>CCDS82180.1 TBX4 gene_id:9496|Hs108|chr17 (546 aa) initn: 1484 init1: 1322 opt: 1720 Z-score: 1459.0 bits: 279.7 E(32554): 6e-75 Smith-Waterman score: 1772; 53.9% identity (71.2% similar) in 553 aa overlap (1-516:7-545) 10 20 30 40 pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPS------KSPSSP-----Q .....:.: ..: : . . :: ::.::. :: .: CCDS82 MLQDKGLSESEEAF---RAP-GPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVA 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 AAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILL :: ..: .:.::: :::.::: ::::.:::::::::::::::::::::::.::::::::: CCDS82 AAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 MDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN .:::::::::::: :::: :.::::::::::::::::::::::::::::::::::::::: CCDS82 IDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 HLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKIT :::::::::::::::::::::::::::::.::::::::::::::::.::.:::::::::: CCDS82 HLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKIT 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 QLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALST :::::::::::::::::: .: :..:.:::::::. .: .::.. : . . . : CCDS82 QLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLG 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 SSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKK . . ..:: :::. . ::: : . .: .. : .::: ::. . : : :. CCDS82 THQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRADGTRHLDLPCKR 300 310 320 330 340 350 350 360 370 380 390 pF1KB5 PYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDI- :.: .:: :: ..:: : .:: :. :: .: . :.::::..:.: : ...:. CCDS82 SYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLP 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB5 ----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGE ::: : :. :.: .:: :. .::: : .:::. ..::: .. ..: :. CCDS82 PPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGN 420 430 440 450 460 460 470 480 490 pF1KB5 GMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQPP--------EFLYSHGVPRTL- . :. .... : ::. :: . :: . .:: :::::. . CCDS82 AHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRE 470 480 490 500 510 520 500 510 pF1KB5 SPHQYHSVHGVGMVPEWSDNS : :::: :.: : .:.: CCDS82 SSLQYHS--GMGTVENWTDG 530 540 >>CCDS11629.1 TBX4 gene_id:9496|Hs108|chr17 (545 aa) initn: 1586 init1: 1297 opt: 1710 Z-score: 1450.6 bits: 278.1 E(32554): 1.8e-74 Smith-Waterman score: 1761; 53.9% identity (71.2% similar) in 553 aa overlap (1-516:7-544) 10 20 30 40 pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPS------KSPSSP-----Q .....:.: ..: : . . :: ::.::. :: .: CCDS11 MLQDKGLSESEEAF---RAP-GPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVA 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 AAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILL :: ..: .:.::: :::.::: ::::.:::::::::::::::::::::::.::::::::: CCDS11 AAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 MDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN .:::::::::::: :::: :.::::::::::::::::::::::::::::::::::::::: CCDS11 IDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 HLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKIT :::::::::::::::::::::::::::::.::::::::::::::::.::.:::::::::: CCDS11 HLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKIT 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 QLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALST :::::::::::::::::: .: :..:.:::::::. .: .::.. : . . . : CCDS11 QLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLG 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 SSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKK . . ..:: :::. . ::: : . .: .. : .::: ::.. : : :. CCDS11 THQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRDGT-RHLDLPCKR 300 310 320 330 340 350 350 360 370 380 390 pF1KB5 PYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDI- :.: .:: :: ..:: : .:: :. :: .: . :.::::..:.: : ...:. CCDS11 SYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLP 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB5 ----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGE ::: : :. :.: .:: :. .::: : .:::. ..::: .. ..: :. CCDS11 PPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGN 420 430 440 450 460 460 470 480 490 pF1KB5 GMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQPP--------EFLYSHGVPRTL- . :. .... : ::. :: . :: . .:: :::::. . CCDS11 AHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRE 470 480 490 500 510 520 500 510 pF1KB5 SPHQYHSVHGVGMVPEWSDNS : :::: :.: : .:.: CCDS11 SSLQYHS--GMGTVENWTDG 530 540 >>CCDS9175.1 TBX3 gene_id:6926|Hs108|chr12 (723 aa) initn: 833 init1: 634 opt: 867 Z-score: 738.2 bits: 146.7 E(32554): 8.5e-35 Smith-Waterman score: 867; 37.7% identity (60.7% similar) in 448 aa overlap (28-462:77-506) 10 20 30 40 50 pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVF : :.:: .. .. . :: CCDS91 PPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVH 50 60 70 80 90 100 60 70 80 90 100 110 pF1KB5 LHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFA :. .::: .::. ::::.:::.:::::: .::. .::. :.::::::::. ::: :::: CCDS91 LEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFH 110 120 130 140 150 160 120 130 140 150 160 170 pF1KB5 DNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMH ...: :.:::.: :: :.:.:::::::: .:: ..:.:.::::::: : : :::::: CCDS91 NSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMH 170 180 190 200 210 220 180 190 200 210 220 230 pF1KB5 KYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFR :::::.:::.: :. . ..: :..:::: :::::.::: :::::::.::::::::: CCDS91 KYQPRFHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR 230 240 250 260 270 280 240 250 260 270 280 290 pF1KB5 GSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGV . . . .. ... . . : . ... .:..: :::. :.. .. .: :. CCDS91 DTGNGRREKRKQLTLQSMRVFDERHKKENGTSDES--SSEQAAFNCFAQASSPAASTVGT 290 300 310 320 330 340 300 310 320 330 340 pF1KB5 SGPSQDLLPPPNPYPLPQEHSQIYH----C------TKRKEEECSTTDHPYKKPYMETSP :. .:: : . : :. : : : .:: : : : .. .. CCDS91 SN-LKDLCPSEGESDAEAE-SKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE 350 360 370 380 390 400 350 360 370 380 390 400 pF1KB5 SEEDS-FYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPS .:: .. :... :. :. : .: : . . . :. . CCDS91 RPRDSGRLDKASPDSRHSPATIS--SSTRGLGAEERRSPVREGTAPAKVEEARALPGKEA 410 420 430 440 450 410 420 430 440 450 460 pF1KB5 YSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQL--GEGMFQHQTSVAHQ .. :: : . .::...::: : :. . .. :. :. .: : .. : CCDS91 FAPLTVQT---------DAAAAHLAQGPL-PGLGFAPGLAGQQFFNGHPLFLHPSQFAMG 460 470 480 490 500 470 480 490 500 510 pF1KB5 PVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS CCDS91 GAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLA 510 520 530 540 550 560 >>CCDS13765.1 TBX1 gene_id:6899|Hs108|chr22 (372 aa) initn: 562 init1: 384 opt: 827 Z-score: 708.8 bits: 140.3 E(32554): 3.7e-33 Smith-Waterman score: 827; 47.6% identity (71.9% similar) in 288 aa overlap (28-307:89-367) 10 20 30 40 50 pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVF : .. .: .:.: . .: . :..: CCDS13 GAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAK-----VAGVSVQ 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB5 LHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFA :. . :: .:...:::::.:::::::::...::. :..: . :.::::.::.::.::..: CCDS13 LEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYA 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB5 --DNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNS ...: :.:::.:: :::.. :::::: ::.::.:.:::.::::::: :: ::::::: CCDS13 FHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNS 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB5 MHKYQPRLHIVKAD---ENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPF ::.::::.:.: .: ... .. .: : : :: :: : :::.::::.:::::: .::: CCDS13 MHRYQPRFHVVYVDPRKDSEKYAEEN--FKTFVFEETRFTAVTAYQNHRITQLKIASNPF 240 250 260 270 280 290 240 250 260 270 280 pF1KB5 AKGFRGSDDMELHRMSRMQSKEYPVVPR-STVRQKVASNHSPFSSESRALSTSSNL--GS ::::: : . : : :.. . :. ::: .: ..:. .. .:.: : CCDS13 AKGFRDCDPEDWPRNHR--PGALPLMSAFARSRNPVASPTQPSGTEKGLVTEGSGLQPGL 300 310 320 330 340 290 300 310 320 330 340 pF1KB5 QYQCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSE . : :..: :: CCDS13 LDVLLKPPSKKSESLRPPHCKDT 350 360 370 >>CCDS43568.1 TBX20 gene_id:57057|Hs108|chr7 (447 aa) initn: 534 init1: 364 opt: 828 Z-score: 708.5 bits: 140.5 E(32554): 3.8e-33 Smith-Waterman score: 828; 41.9% identity (67.6% similar) in 346 aa overlap (26-359:74-411) 10 20 30 40 50 pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIK : :.: . :..: . .. : : CCDS43 QFVEKSSCAQPLGELTSLDAHGEFGGGSGSSPSSSSLCTEPLIPTTP--IIPSEEMAKIA 50 60 70 80 90 100 60 70 80 90 100 110 pF1KB5 VFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYK :. .::: ::::.::::::::.::::::. .:. .:..:..:::.::::::.:..::. CCDS43 CSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYR 110 120 130 140 150 160 120 130 140 150 160 170 pF1KB5 FADNK--WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIIL .: .. : :.:::.: .:.::::::::: :: . ..:.:::.:.:::::.:: ::::: CCDS43 YAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIIL 170 180 190 200 210 220 180 190 200 210 220 230 pF1KB5 NSMHKYQPRLHIVKADENNG--FGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNP :::::::::.::.: .... .. :. : : .::::.: :::.:::. ::.:::..:: CCDS43 NSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNP 230 240 250 260 270 280 240 250 260 270 280 290 pF1KB5 FAKGFRGSDDM-ELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQ :::::: :. . ...: : . . :: .: ..... ...::. :. : :: CCDS43 FAKGFRDSSRLTDIERESVESLIQKHSYARSPIRT-YGGEEDVLGDESQ---TTPNRGSA 290 300 310 320 330 300 310 320 330 340 pF1KB5 YQCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYK---KPY----M . ...: : . . .: :. ... . :: . :: : CCDS43 FTTSDNLSLSSW--VSSSSSFPGFQHPQSLTALGTSTASIATPIPHPIQGSLPPYSRLGM 340 350 360 370 380 390 350 360 370 380 390 400 pF1KB5 ETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPS .:: : ...: : CCDS43 PLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV 400 410 420 430 440 >>CCDS13767.1 TBX1 gene_id:6899|Hs108|chr22 (495 aa) initn: 595 init1: 384 opt: 825 Z-score: 705.3 bits: 140.0 E(32554): 5.8e-33 Smith-Waterman score: 829; 40.3% identity (64.2% similar) in 372 aa overlap (28-393:89-441) 10 20 30 40 50 pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVF : .. .: .:.: . .: . :..: CCDS13 GAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAK-----VAGVSVQ 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB5 LHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFA :. . :: .:...:::::.:::::::::...::. :..: . :.::::.::.::.::..: CCDS13 LEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYA 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB5 --DNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNS ...: :.:::.:: :::.. :::::: ::.::.:.:::.::::::: :: ::::::: CCDS13 FHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNS 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB5 MHKYQPRLHIVKAD---ENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPF ::.::::.:.: .: ... .. .: : : :: :: : :::.::::.:::::: .::: CCDS13 MHRYQPRFHVVYVDPRKDSEKYAEEN--FKTFVFEETRFTAVTAYQNHRITQLKIASNPF 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB5 AKGFRGSDDMELHRMSRMQSKEYPVVPR-STVRQKVASNHSPFSSESRALSTSSNLGSQY ::::: : . : : . :.. . :. ::: .: ..:. : . .. CCDS13 AKGFRDCDPEDWPRNHRPGA--LPLMSAFARSRNPVASPTQPSGTEKDAAEARR----EF 300 310 320 330 340 300 310 320 330 340 350 pF1KB5 QCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEED : . : ::. : : .: :: ... . . : . :: . . CCDS13 QRDAG--GPAV-LGDPAHP---PQLLARVLSPSLPGAGGAGGLVPLPGAPGGRPSPPNPE 350 360 370 380 390 360 370 380 390 400 410 pF1KB5 SFYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCT .. .. :. .: . . :.: : :.:.: CCDS13 LRLEAPGASEPLHHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHGYHPHAHPHHHHHPV 400 410 420 430 440 450 420 430 440 450 460 470 pF1KB5 VTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCG CCDS13 SPAAAAAAAAAAAAAAANMYSSAGAAPPGSYDYCPR 460 470 480 490 >>CCDS11627.2 TBX2 gene_id:6909|Hs108|chr17 (712 aa) initn: 814 init1: 637 opt: 822 Z-score: 700.4 bits: 139.7 E(32554): 1.1e-32 Smith-Waterman score: 840; 37.9% identity (59.4% similar) in 456 aa overlap (55-509:106-519) 30 40 50 60 70 80 pF1KB5 DSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMF :: :. .::: .::..::::.:::.::::: CCDS11 HVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMF 80 90 100 110 120 130 90 100 110 120 130 140 pF1KB5 PSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPAT : .::.:.::. :.::::::::: ::: :::: ...: :.:::.: :: :.:.::::::: CCDS11 PPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB5 GAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTH : .:: . :.:.::::::: : : :::::::::::.:::.: :. . ..: :. CCDS11 GEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRA--NDILKLPYSTFRTY 200 210 220 230 240 250 210 220 230 240 250 260 pF1KB5 VFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVR ::::: :::::.::: :::::::.::::::::: . . .: .... ..: . CCDS11 VFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGN------GRREKRKQLTLPSLRLY 260 270 280 290 300 270 280 290 300 310 320 pF1KB5 QKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCT .. : .. ..:: :. :... :: .: :. : . CCDS11 EE----HCKPERDGAESDASS-------CD---PPPARE--PPTSPGAAPSPLR--LHRA 310 320 330 340 330 340 350 360 370 380 pF1KB5 KRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMYASSA . .:. :.. . : .: . . :: :.. :: . ..: : CCDS11 RAEEKSCAADSDP--EPERLSEERAGAPLGRSPAPDS----ASPTRLTEPERARERRSPE 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB5 PPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMAN .::. : : : . : .. . .. .:. :.: :. ... CCDS11 RGKEPAESGGD-----GPF--GLRSLEKERAEARRKDEGRKEAAEGKEQGLAP-LVVQTD 410 420 430 440 450 450 460 470 480 490 500 pF1KB5 HGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLS-PHQYH .:: :: : . . .: . :: : .: :.: .: .. :. ... : CCDS11 SASP-LGAGHLPGLAFSSHLHGQQFFGP-LGAGQPLFLHPGQFTMGPGAFSAMGMGHLLA 460 470 480 490 500 510 510 pF1KB5 SVHGVGMVPEWSDNS :: : : CCDS11 SVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLF 520 530 540 550 560 570 >>CCDS13766.1 TBX1 gene_id:6899|Hs108|chr22 (398 aa) initn: 547 init1: 384 opt: 816 Z-score: 699.1 bits: 138.6 E(32554): 1.3e-32 Smith-Waterman score: 816; 50.4% identity (74.6% similar) in 256 aa overlap (28-277:89-335) 10 20 30 40 50 pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVF : .. .: .:.: . .: . :..: CCDS13 GAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAK-----VAGVSVQ 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB5 LHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFA :. . :: .:...:::::.:::::::::...::. :..: . :.::::.::.::.::..: CCDS13 LEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYA 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB5 --DNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNS ...: :.:::.:: :::.. :::::: ::.::.:.:::.::::::: :: ::::::: CCDS13 FHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNS 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB5 MHKYQPRLHIVKAD---ENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPF ::.::::.:.: .: ... .. .: : : :: :: : :::.::::.:::::: .::: CCDS13 MHRYQPRFHVVYVDPRKDSEKYAEEN--FKTFVFEETRFTAVTAYQNHRITQLKIASNPF 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB5 AKGFRGSDDMELHRMSRMQSKEYPVVPR-STVRQKVASNHSPFSSESRALSTSSNLGSQY ::::: : . : : :.. . :. ::: .: ..: CCDS13 AKGFRDCDPEDWPRNHR--PGALPLMSAFARSRNPVASPTQPSGTEKGGHVLKDKEVKAE 300 310 320 330 340 300 310 320 330 340 350 pF1KB5 QCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEED CCDS13 TSRNTPEREVELLRDAGGCVNLGLPCPAECQPFNTQGLVAGRTAGDRLC 350 360 370 380 390 518 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:47:50 2016 done: Sat Nov 5 10:47:51 2016 Total Scan time: 2.890 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]