Result of FASTA (omim) for
pF1KB5973
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5973, 519 aa
1>>>pF1KB5973 519 - 519 aa - 519 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5397+/-0.000352; mu= 10.6850+/- 0.022
mean_var=189.8986+/-38.393, 0's: 0 Z-trim(121.3): 120 B-trim: 1079 in 1/52
Lambda= 0.093071
statistics sampled from 37461 (37594) to 37461 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.441), width: 16
Scan time: 12.170
The best scores are: opt bits E(85289)
NP_057442 (OMIM: 606199) iroquois-class homeodomai ( 519) 3501 482.4 1.4e-135
NP_001265561 (OMIM: 606199) iroquois-class homeodo ( 519) 3501 482.4 1.4e-135
NP_001265563 (OMIM: 606199) iroquois-class homeodo ( 519) 3501 482.4 1.4e-135
NP_001265562 (OMIM: 606199) iroquois-class homeodo ( 545) 2589 359.9 1.1e-98
NP_001265564 (OMIM: 606199) iroquois-class homeodo ( 545) 2589 359.9 1.1e-98
XP_005256194 (OMIM: 606196) PREDICTED: iroquois-cl ( 445) 876 129.8 1.6e-29
NP_077311 (OMIM: 606196) iroquois-class homeodomai ( 446) 876 129.8 1.6e-29
NP_077312 (OMIM: 612985) iroquois-class homeodomai ( 501) 703 106.7 1.7e-22
XP_005256196 (OMIM: 612985) PREDICTED: iroquois-cl ( 529) 703 106.7 1.8e-22
NP_005844 (OMIM: 606195,611174) iroquois-class hom ( 483) 702 106.5 1.8e-22
NP_001239126 (OMIM: 606195,611174) iroquois-class ( 482) 694 105.4 3.9e-22
XP_011521111 (OMIM: 606195,611174) PREDICTED: iroq ( 413) 634 97.3 9.2e-20
NP_150366 (OMIM: 606198) iroquois-class homeodomai ( 471) 568 88.5 4.7e-17
XP_011512281 (OMIM: 606198) PREDICTED: iroquois-cl ( 471) 568 88.5 4.7e-17
NP_001127694 (OMIM: 606198) iroquois-class homeodo ( 471) 568 88.5 4.7e-17
XP_016865334 (OMIM: 606197) PREDICTED: iroquois-cl ( 449) 564 88.0 6.6e-17
NP_077313 (OMIM: 606197) iroquois-class homeodomai ( 480) 564 88.0 6.9e-17
XP_016871597 (OMIM: 601332) PREDICTED: homeobox pr ( 291) 266 47.8 5.4e-05
XP_016871596 (OMIM: 601332) PREDICTED: homeobox pr ( 295) 266 47.8 5.5e-05
NP_001229631 (OMIM: 601332) homeobox protein Mohaw ( 352) 266 47.8 6.2e-05
XP_016871594 (OMIM: 601332) PREDICTED: homeobox pr ( 352) 266 47.8 6.2e-05
XP_016871595 (OMIM: 601332) PREDICTED: homeobox pr ( 352) 266 47.8 6.2e-05
NP_775847 (OMIM: 601332) homeobox protein Mohawk [ ( 352) 266 47.8 6.2e-05
NP_001265611 (OMIM: 142946,602630) homeobox protei ( 275) 214 40.8 0.0066
NP_775299 (OMIM: 142946,602630) homeobox protein T ( 286) 210 40.2 0.0098
>>NP_057442 (OMIM: 606199) iroquois-class homeodomain pr (519 aa)
initn: 3501 init1: 3501 opt: 3501 Z-score: 2555.0 bits: 482.4 E(85289): 1.4e-135
Smith-Waterman score: 3501; 100.0% identity (100.0% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 SGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANV
430 440 450 460 470 480
490 500 510
pF1KB5 LTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
:::::::::::::::::::::::::::::::::::::::
NP_057 LTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
490 500 510
>>NP_001265561 (OMIM: 606199) iroquois-class homeodomain (519 aa)
initn: 3501 init1: 3501 opt: 3501 Z-score: 2555.0 bits: 482.4 E(85289): 1.4e-135
Smith-Waterman score: 3501; 100.0% identity (100.0% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 SGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANV
430 440 450 460 470 480
490 500 510
pF1KB5 LTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
:::::::::::::::::::::::::::::::::::::::
NP_001 LTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
490 500 510
>>NP_001265563 (OMIM: 606199) iroquois-class homeodomain (519 aa)
initn: 3501 init1: 3501 opt: 3501 Z-score: 2555.0 bits: 482.4 E(85289): 1.4e-135
Smith-Waterman score: 3501; 100.0% identity (100.0% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 SGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANV
430 440 450 460 470 480
490 500 510
pF1KB5 LTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
:::::::::::::::::::::::::::::::::::::::
NP_001 LTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
490 500 510
>>NP_001265562 (OMIM: 606199) iroquois-class homeodomain (545 aa)
initn: 2589 init1: 2589 opt: 2589 Z-score: 1892.9 bits: 359.9 E(85289): 1.1e-98
Smith-Waterman score: 3439; 95.2% identity (95.2% similar) in 545 aa overlap (1-519:1-545)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
70 80 90 100 110 120
130 140 150
pF1KB5 AYYPYEPALGQYPYDR--------------------------YGTMDSGTRRKNATRETT
:::::::::::::::: ::::::::::::::::::
NP_001 AYYPYEPALGQYPYDRIKRLGGHPHKGIGLDLSGLGRSPGSLYGTMDSGTRRKNATRETT
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB5 STLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKC
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB5 ADEKRPYAEGEEEEGGEEEAREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADEKRPYAEGEEEEGGEEEAREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB5 LKPPFHSLDGGLERVPAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKPPFHSLDGGLERVPAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGP
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB5 EPLPGAEGGPQVCEAKLGFVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPLPGAEGGPQVCEAKLGFVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB5 LKRQGPAAPAAVSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKRQGPAAPAAVSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLN
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB5 QAWATAKGALLDPGPLGRSLGAGANVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAWATAKGALLDPGPLGRSLGAGANVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGG
490 500 510 520 530 540
pF1KB5 KPFCA
:::::
NP_001 KPFCA
>>NP_001265564 (OMIM: 606199) iroquois-class homeodomain (545 aa)
initn: 2589 init1: 2589 opt: 2589 Z-score: 1892.9 bits: 359.9 E(85289): 1.1e-98
Smith-Waterman score: 3439; 95.2% identity (95.2% similar) in 545 aa overlap (1-519:1-545)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
70 80 90 100 110 120
130 140 150
pF1KB5 AYYPYEPALGQYPYDR--------------------------YGTMDSGTRRKNATRETT
:::::::::::::::: ::::::::::::::::::
NP_001 AYYPYEPALGQYPYDRIKRLGGHPHKGIGLDLSGLGRSPGSLYGTMDSGTRRKNATRETT
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB5 STLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKC
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB5 ADEKRPYAEGEEEEGGEEEAREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADEKRPYAEGEEEEGGEEEAREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACE
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB5 LKPPFHSLDGGLERVPAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKPPFHSLDGGLERVPAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGP
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB5 EPLPGAEGGPQVCEAKLGFVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPLPGAEGGPQVCEAKLGFVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB5 LKRQGPAAPAAVSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKRQGPAAPAAVSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLN
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB5 QAWATAKGALLDPGPLGRSLGAGANVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAWATAKGALLDPGPLGRSLGAGANVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGG
490 500 510 520 530 540
pF1KB5 KPFCA
:::::
NP_001 KPFCA
>>XP_005256194 (OMIM: 606196) PREDICTED: iroquois-class (445 aa)
initn: 765 init1: 452 opt: 876 Z-score: 651.0 bits: 129.8 E(85289): 1.6e-29
Smith-Waterman score: 973; 44.1% identity (66.4% similar) in 440 aa overlap (1-431:1-407)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::.:.::.:: .: ::: ...: .::::: :...: . ... . : :.::::..:
XP_005 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
10 20 30 40 50 60
70 80 90 100 110
pF1KB5 RHELNSAAALGVYGGPYGGS---QGYGNYVTYGSEASAFY-SLN-SFDSKDGSGSAHGGL
: :: .::::.::.::... :.: .:. :. : ..: .:: ... :...:: ..:
XP_005 RPEL--GAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSL
70 80 90 100 110
120 130 140 150 160 170
pF1KB5 APAAAAYYPYEPALGQYPYDRYGTMD-SGT-RRKNATRETTSTLKAWLQEHRKNPYPTKG
: .: ::::: .:::: :.:::... ::. :::::::::::::::::.:::::::::::
XP_005 AQPGA-YYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEE
::::::::::::::::::::::::::::::::::: :.:: ..:.. :::::.
XP_005 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKA-------EGGEED
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 AREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAP
. ..:.. ...: . :.::::.:.. : : : . : : .:
XP_005 SLGCLTADTKEVT-ASQEARGLRLSDLEDLEEEEEEEEEAEDE----------EVVATAG
240 250 260 270
300 310 320 330 340 350
pF1KB5 DGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGF
: .. .:: .:: . .:: . ::: : : .: :.. . :. :
XP_005 DRLTEFRKGA--QSLPGPCAAAREGRLER-RECGLAAPRFSFNDPSGSEEADFLSAETGS
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB5 VPAGASAGLEAKPRIWSLAHTATAAAA--AATSLSQTEFPSCMLKRQGPAAPAAVSSAPA
:::::::::::::.:. : . . . : : :. :. : ::
XP_005 PRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARPRPRSPEC---RMIPGQP------PA
340 350 360 370 380
420 430 440 450 460 470
pF1KB5 TSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLG
.. ...:...: :. . :
XP_005 SARRLSVPRDSACDESSCIPKAFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEG
390 400 410 420 430 440
>>NP_077311 (OMIM: 606196) iroquois-class homeodomain pr (446 aa)
initn: 765 init1: 452 opt: 876 Z-score: 650.9 bits: 129.8 E(85289): 1.6e-29
Smith-Waterman score: 973; 44.1% identity (66.4% similar) in 440 aa overlap (1-431:1-407)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::.:.::.:: .: ::: ...: .::::: :...: . ... . : :.::::..:
NP_077 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
10 20 30 40 50 60
70 80 90 100 110
pF1KB5 RHELNSAAALGVYGGPYGGS---QGYGNYVTYGSEASAFY-SLN-SFDSKDGSGSAHGGL
: :: .::::.::.::... :.: .:. :. : ..: .:: ... :...:: ..:
NP_077 RPEL--GAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSL
70 80 90 100 110
120 130 140 150 160 170
pF1KB5 APAAAAYYPYEPALGQYPYDRYGTMD-SGT-RRKNATRETTSTLKAWLQEHRKNPYPTKG
: .: ::::: .:::: :.:::... ::. :::::::::::::::::.:::::::::::
NP_077 AQPGA-YYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEE
::::::::::::::::::::::::::::::::::: :.:: ..:.. :::::.
NP_077 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKA-------EGGEED
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 AREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAP
. ..:.. ...: . :.::::.:.. : : : . : : .:
NP_077 SLGCLTADTKEVT-ASQEARGLRLSDLEDLEEEEEEEEEAEDE----------EVVATAG
240 250 260 270
300 310 320 330 340 350
pF1KB5 DGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGF
: .. .:: .:: . .:: . ::: : : .: :.. . :. :
NP_077 DRLTEFRKGA--QSLPGPCAAAREGRLER-RECGLAAPRFSFNDPSGSEEADFLSAETGS
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB5 VPAGASAGLEAKPRIWSLAHTATAAAA--AATSLSQTEFPSCMLKRQGPAAPAAVSSAPA
:::::::::::::.:. : . . . : : :. :. : ::
NP_077 PRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARPRPRSPEC---RMIPGQP------PA
340 350 360 370 380
420 430 440 450 460 470
pF1KB5 TSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLG
.. ...:...: :. . :
NP_077 SARRLSVPRDSACDESSCIPKAFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
390 400 410 420 430 440
>>NP_077312 (OMIM: 612985) iroquois-class homeodomain pr (501 aa)
initn: 654 init1: 473 opt: 703 Z-score: 524.8 bits: 106.7 E(85289): 1.7e-22
Smith-Waterman score: 739; 36.7% identity (56.9% similar) in 534 aa overlap (1-519:1-465)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::.::.:: : : :. .. .. ::: . : .: .:.: :.: :..
NP_077 MSFPQLGYQYIR-P--LYPSERPGAAGGSGGSAGARGGLGAGA----------SELNASG
10 20 30 40
70 80 90 100 110
pF1KB5 RHELNSAAALGVYGGPYGGS------QGYGNYVTYGSEASAFYSLNS-FDSKDGSGSAHG
:... . .:::.::... :::: .. :..: : .:.. .. ::. : :
NP_077 --SLSNVLS-SVYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQH-
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 GLAPAAAAYYPY-EPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTK
::::: .:. .::. ::: .: : .: ::::::.::::::::.::::::::::
NP_077 ---PAAAAAFPHPHPAF--YPYGQYQFGDP-SRPKNATRESTSTLKAWLNEHRKNPYPTK
110 120 130 140 150
180 190 200 210 220 230
pF1KB5 GEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEE
:::::::::::::::::::::::::::::::::::: ::.. .: :. .::: ::
NP_077 GEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEE
160 170 180 190 200 210
240 250 260 270 280
pF1KB5 EAREEPLKSSKNAEPVGKEEKELE---LSDLDDFDPLEAEPPACELKPPFHSLDGGLERV
. .. . . : .: ::.. :.: :. . .. : : :: :. .:
NP_077 DEEDGKRELELEEEELGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRD
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 PAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEA
::.... . : . .. .: :: : : : : : : : ..:..
NP_077 GDLGLGPISDS----KNSDSEDSSEGL-ED--RPLPVLSLA---PAPPPVAVASPSLPSP
280 290 300 310 320
350 360 370 380 390 400
pF1KB5 KLGF---VPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPA-APAA
... .:: : :. ::.:::::.:::. : :. . : : ::.:
NP_077 PVSLDPCAPAPAPASALQKPKIWSLAETATSPDNPRRS-----PPGAGGSPPGAAVAPSA
330 340 350 360 370 380
410 420 430 440 450 460
pF1KB5 VSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALL
.. .::.. ..: : : ..:. .. :.. : : : :
NP_077 LQLSPAAAAAAA--H-----RLVSAPLGKFPAWTNRPFPGP-------------PPGPRL
390 400 410 420
470 480 490 500 510
pF1KB5 DPGPLGRSLGAGANVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
: : ::.. : ..: :. . : ::. :: : :. :: :.
NP_077 HPLSL---LGSAP-----PHLLGLPGAAGHPAAAAAFARP--AEPE-GGTDRCSALEVEK
430 440 450 460 470
NP_077 KLLKTAFQPVPRRPQNHLDAALVLSALSSS
480 490 500
>>XP_005256196 (OMIM: 612985) PREDICTED: iroquois-class (529 aa)
initn: 654 init1: 473 opt: 703 Z-score: 524.5 bits: 106.7 E(85289): 1.8e-22
Smith-Waterman score: 739; 36.7% identity (56.9% similar) in 534 aa overlap (1-519:1-465)
10 20 30 40 50 60
pF1KB5 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
::.::.:: : : :. .. .. ::: . : .: .:.: :.: :..
XP_005 MSFPQLGYQYIR-P--LYPSERPGAAGGSGGSAGARGGLGAGA----------SELNASG
10 20 30 40
70 80 90 100 110
pF1KB5 RHELNSAAALGVYGGPYGGS------QGYGNYVTYGSEASAFYSLNS-FDSKDGSGSAHG
:... . .:::.::... :::: .. :..: : .:.. .. ::. : :
XP_005 --SLSNVLS-SVYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQH-
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 GLAPAAAAYYPY-EPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTK
::::: .:. .::. ::: .: : .: ::::::.::::::::.::::::::::
XP_005 ---PAAAAAFPHPHPAF--YPYGQYQFGDP-SRPKNATRESTSTLKAWLNEHRKNPYPTK
110 120 130 140 150
180 190 200 210 220 230
pF1KB5 GEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEE
:::::::::::::::::::::::::::::::::::: ::.. .: :. .::: ::
XP_005 GEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEE
160 170 180 190 200 210
240 250 260 270 280
pF1KB5 EAREEPLKSSKNAEPVGKEEKELE---LSDLDDFDPLEAEPPACELKPPFHSLDGGLERV
. .. . . : .: ::.. :.: :. . .. : : :: :. .:
XP_005 DEEDGKRELELEEEELGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRD
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 PAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEA
::.... . : . .. .: :: : : : : : : : ..:..
XP_005 GDLGLGPISDS----KNSDSEDSSEGL-ED--RPLPVLSLA---PAPPPVAVASPSLPSP
280 290 300 310 320
350 360 370 380 390 400
pF1KB5 KLGF---VPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPA-APAA
... .:: : :. ::.:::::.:::. : :. . : : ::.:
XP_005 PVSLDPCAPAPAPASALQKPKIWSLAETATSPDNPRRS-----PPGAGGSPPGAAVAPSA
330 340 350 360 370 380
410 420 430 440 450 460
pF1KB5 VSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALL
.. .::.. ..: : : ..:. .. :.. : : : :
XP_005 LQLSPAAAAAAA--H-----RLVSAPLGKFPAWTNRPFPGP-------------PPGPRL
390 400 410 420
470 480 490 500 510
pF1KB5 DPGPLGRSLGAGANVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA
: : ::.. : ..: :. . : ::. :: : :. :: :.
XP_005 HPLSL---LGSAP-----PHLLGLPGAAGHPAAAAAFARP--AEPE-GGTDRCSALEVEK
430 440 450 460 470
XP_005 KLLKTAFQPVPRRPRPRVLTPRAHPTVKPQHTHLQLDIILHCDTFLTIGPNPSRISPP
480 490 500 510 520
>>NP_005844 (OMIM: 606195,611174) iroquois-class homeodo (483 aa)
initn: 562 init1: 451 opt: 702 Z-score: 524.2 bits: 106.5 E(85289): 1.8e-22
Smith-Waterman score: 702; 38.9% identity (59.4% similar) in 406 aa overlap (39-422:11-394)
10 20 30 40 50 60
pF1KB5 PYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAA
:.:: : ::.: . ... : . . .
NP_005 MSYPQGYLYQPSASL-ALYSCPAYSTSVISGPRTDELGRS
10 20 30
70 80 90 100 110 120
pF1KB5 ALGVYGGPYGGSQ-------GYGNYVTYGSEASAFYSLNSFDSKDGSGSAHG-GLAPAAA
. : .::.:: ::.... ::.. .: . .:.: :: : :.: ..
NP_005 SSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAA-AAAAAFSSYVGSPYDHTPGMA-GSL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB5 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
.:.:: ::.::: . . ::::::..:.::::::.::::::::::::::::::
NP_005 GYHPYAAPLGSYPY------GDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAI
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB5 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
:::::::::::::::::::::::::::: :::. :: : ::. :.. ..:: :
NP_005 ITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDE-----EEEENIDLEKNDEDEPQK
160 170 180 190 200
250 260 270 280 290
pF1KB5 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSL-DGGLERVPAAPDGPVKE
...: : : : . . . :.. ::. : :: :. ... :. .: .
NP_005 PEDKGDPEGPEAGGAEQKAASGCERLQG-PPTPAGKETEGSLSDSDFKEPPS--EGRLDA
210 220 230 240 250 260
300 310 320 330 340 350
pF1KB5 ASGALRMS--LAAGGGAA-LDEDLERARSCLRSAAAGPEP----LPGAEGGPQVCEAKLG
.: : . :: .:: : :: . . : ::.: .: . :::.: ..
NP_005 LQGPPRTGGPSPAGPAAARLAED-PAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSP--
270 280 290 300 310 320
360 370 380 390 400
pF1KB5 FVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTE---FPSCMLKRQGPA---APAAV
: .. :::..::::. ::.. . . . .: : : : : . :.
NP_005 --PPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPGPIAGQALGGSRASP
330 340 350 360 370
410 420 430 440 450 460
pF1KB5 SSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLD
. ::. :::. : :
NP_005 APAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSH
380 390 400 410 420 430
519 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:49:16 2016 done: Sat Nov 5 10:49:18 2016
Total Scan time: 12.170 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]