FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5987, 570 aa 1>>>pF1KB5987 570 - 570 aa - 570 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3361+/-0.000503; mu= 12.9721+/- 0.031 mean_var=93.0630+/-18.726, 0's: 0 Z-trim(110.5): 142 B-trim: 396 in 1/52 Lambda= 0.132949 statistics sampled from 18696 (18857) to 18696 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.221), width: 16 Scan time: 9.890 The best scores are: opt bits E(85289) NP_001161401 (OMIM: 602626) interleukin-1 receptor ( 570) 3810 741.9 1.3e-213 NP_002173 (OMIM: 602626) interleukin-1 receptor ac ( 570) 3810 741.9 1.3e-213 NP_001161400 (OMIM: 602626) interleukin-1 receptor ( 570) 3810 741.9 1.3e-213 NP_001161403 (OMIM: 602626) interleukin-1 receptor ( 687) 3291 642.4 1.4e-183 XP_016861837 (OMIM: 602626) PREDICTED: interleukin ( 376) 2431 477.3 3.8e-134 NP_608273 (OMIM: 602626) interleukin-1 receptor ac ( 356) 2401 471.5 2e-132 NP_001161402 (OMIM: 602626) interleukin-1 receptor ( 356) 2401 471.5 2e-132 XP_016861836 (OMIM: 602626) PREDICTED: interleukin ( 385) 2401 471.6 2.1e-132 NP_059112 (OMIM: 300277) X-linked interleukin-1 re ( 686) 1140 229.8 2.2e-59 XP_016884892 (OMIM: 300277) PREDICTED: X-linked in ( 686) 1140 229.8 2.2e-59 NP_055086 (OMIM: 300143,300206) interleukin-1 rece ( 696) 963 195.9 3.7e-49 XP_016884729 (OMIM: 300143,300206) PREDICTED: inte ( 696) 963 195.9 3.7e-49 XP_005264096 (OMIM: 604494) PREDICTED: interleukin ( 540) 619 129.8 2.2e-29 NP_001269328 (OMIM: 604494) interleukin-18 recepto ( 385) 589 124.0 8.8e-28 XP_011529207 (OMIM: 300277) PREDICTED: X-linked in ( 562) 586 123.5 1.8e-27 NP_003846 (OMIM: 604494) interleukin-18 receptor 1 ( 541) 578 122.0 5e-27 XP_016860670 (OMIM: 604494) PREDICTED: interleukin ( 386) 548 116.1 2e-25 NP_003845 (OMIM: 604512) interleukin-1 receptor-li ( 575) 545 115.7 4.3e-25 XP_005264093 (OMIM: 604512) PREDICTED: interleukin ( 575) 545 115.7 4.3e-25 XP_011510396 (OMIM: 604512) PREDICTED: interleukin ( 595) 545 115.7 4.4e-25 XP_005264092 (OMIM: 604512) PREDICTED: interleukin ( 603) 545 115.7 4.4e-25 XP_016860663 (OMIM: 604512) PREDICTED: interleukin ( 606) 545 115.7 4.5e-25 XP_011510394 (OMIM: 604512) PREDICTED: interleukin ( 617) 545 115.7 4.5e-25 NP_003844 (OMIM: 604509) interleukin-18 receptor a ( 599) 544 115.5 5.1e-25 XP_011510393 (OMIM: 604512) PREDICTED: interleukin ( 622) 535 113.8 1.7e-24 NP_001307907 (OMIM: 147810) interleukin-1 receptor ( 569) 534 113.5 1.8e-24 XP_005263991 (OMIM: 147810) PREDICTED: interleukin ( 569) 534 113.5 1.8e-24 XP_011509417 (OMIM: 147810) PREDICTED: interleukin ( 569) 534 113.5 1.8e-24 XP_016859478 (OMIM: 147810) PREDICTED: interleukin ( 569) 534 113.5 1.8e-24 XP_005263987 (OMIM: 147810) PREDICTED: interleukin ( 569) 534 113.5 1.8e-24 NP_001307909 (OMIM: 147810) interleukin-1 receptor ( 569) 534 113.5 1.8e-24 NP_000868 (OMIM: 147810) interleukin-1 receptor ty ( 569) 534 113.5 1.8e-24 NP_001307910 (OMIM: 147810) interleukin-1 receptor ( 569) 534 113.5 1.8e-24 XP_011509419 (OMIM: 147810) PREDICTED: interleukin ( 569) 534 113.5 1.8e-24 NP_001307911 (OMIM: 147810) interleukin-1 receptor ( 569) 534 113.5 1.8e-24 XP_011509420 (OMIM: 147810) PREDICTED: interleukin ( 569) 534 113.5 1.8e-24 XP_011509418 (OMIM: 147810) PREDICTED: interleukin ( 569) 534 113.5 1.8e-24 XP_011510389 (OMIM: 604509) PREDICTED: interleukin ( 457) 485 104.1 1e-21 XP_011510390 (OMIM: 604509) PREDICTED: interleukin ( 457) 485 104.1 1e-21 XP_016860672 (OMIM: 604494) PREDICTED: interleukin ( 291) 479 102.8 1.6e-21 XP_016860673 (OMIM: 604494) PREDICTED: interleukin ( 291) 479 102.8 1.6e-21 XP_016884730 (OMIM: 300143,300206) PREDICTED: inte ( 570) 465 100.3 1.8e-20 XP_016860671 (OMIM: 604494) PREDICTED: interleukin ( 292) 454 98.0 4.3e-20 NP_001307912 (OMIM: 147810) interleukin-1 receptor ( 425) 433 94.1 9.7e-19 XP_006712883 (OMIM: 604512) PREDICTED: interleukin ( 529) 429 93.4 2e-18 XP_016860664 (OMIM: 604512) PREDICTED: interleukin ( 508) 428 93.2 2.2e-18 XP_016860668 (OMIM: 604512) PREDICTED: interleukin ( 424) 426 92.8 2.5e-18 XP_016860667 (OMIM: 604512) PREDICTED: interleukin ( 424) 426 92.8 2.5e-18 XP_006712885 (OMIM: 604512) PREDICTED: interleukin ( 444) 426 92.8 2.6e-18 XP_016860666 (OMIM: 604512) PREDICTED: interleukin ( 443) 425 92.6 2.9e-18 >>NP_001161401 (OMIM: 602626) interleukin-1 receptor acc (570 aa) initn: 3810 init1: 3810 opt: 3810 Z-score: 3956.1 bits: 741.9 E(85289): 1.3e-213 Smith-Waterman score: 3810; 100.0% identity (100.0% similar) in 570 aa overlap (1-570:1-570) 10 20 30 40 50 60 pF1KB5 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK 490 500 510 520 530 540 550 560 570 pF1KB5 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV :::::::::::::::::::::::::::::: NP_001 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV 550 560 570 >>NP_002173 (OMIM: 602626) interleukin-1 receptor access (570 aa) initn: 3810 init1: 3810 opt: 3810 Z-score: 3956.1 bits: 741.9 E(85289): 1.3e-213 Smith-Waterman score: 3810; 100.0% identity (100.0% similar) in 570 aa overlap (1-570:1-570) 10 20 30 40 50 60 pF1KB5 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK 490 500 510 520 530 540 550 560 570 pF1KB5 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV :::::::::::::::::::::::::::::: NP_002 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV 550 560 570 >>NP_001161400 (OMIM: 602626) interleukin-1 receptor acc (570 aa) initn: 3810 init1: 3810 opt: 3810 Z-score: 3956.1 bits: 741.9 E(85289): 1.3e-213 Smith-Waterman score: 3810; 100.0% identity (100.0% similar) in 570 aa overlap (1-570:1-570) 10 20 30 40 50 60 pF1KB5 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK 490 500 510 520 530 540 550 560 570 pF1KB5 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV :::::::::::::::::::::::::::::: NP_001 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV 550 560 570 >>NP_001161403 (OMIM: 602626) interleukin-1 receptor acc (687 aa) initn: 3266 init1: 3169 opt: 3291 Z-score: 3416.9 bits: 642.4 E(85289): 1.4e-183 Smith-Waterman score: 3291; 86.1% identity (94.5% similar) in 567 aa overlap (1-567:1-565) 10 20 30 40 50 60 pF1KB5 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL :::::::::::::::::::::::::::: ... ...:::.:::..:::::.:: . . .. NP_001 VLLTLRGVLENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVTEKSISM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK ::.: :. . : .. ..:.:.:. ... . :. ..: . ..:::::::. ..::: NP_001 LEFKLGVMCQNSIAT-KLIVVEYRPLEHPHPGILQLKESV-SFVSWKGEKSKHSGSKFWK 490 500 510 520 530 550 560 570 pF1KB5 QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV :..:.:... :. .:. : :.. NP_001 ALRLALPLRSLSASSGWNESCSSQSDISLDHVQRRRSRLKEPPELQSSERAAGSPPAPGT 540 550 560 570 580 590 >>XP_016861837 (OMIM: 602626) PREDICTED: interleukin-1 r (376 aa) initn: 2431 init1: 2431 opt: 2431 Z-score: 2529.4 bits: 477.3 E(85289): 3.8e-134 Smith-Waterman score: 2431; 100.0% identity (100.0% similar) in 376 aa overlap (195-570:1-376) 170 180 190 200 210 220 pF1KB5 GYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFH :::::::::::::::::::::::::::::: XP_016 MNLSFLIALISNNGNYTCVVTYPENGRTFH 10 20 30 230 240 250 260 270 280 pF1KB5 LTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTI 40 50 60 70 80 90 290 300 310 320 330 340 pF1KB5 DGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKA 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB5 AKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKE 160 170 180 190 200 210 410 420 430 440 450 460 pF1KB5 YDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRL 220 230 240 250 260 270 470 480 490 500 510 520 pF1KB5 LVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVI 280 290 300 310 320 330 530 540 550 560 570 pF1KB5 KWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV :::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV 340 350 360 370 >>NP_608273 (OMIM: 602626) interleukin-1 receptor access (356 aa) initn: 2401 init1: 2401 opt: 2401 Z-score: 2498.6 bits: 471.5 E(85289): 2e-132 Smith-Waterman score: 2401; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KB5 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_608 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_608 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_608 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_608 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_608 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL :::::::::::::::::::::::::::::::::::::::::::::::::: NP_608 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKGNRCGQ 310 320 330 340 350 370 380 390 400 410 420 pF1KB5 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF >>NP_001161402 (OMIM: 602626) interleukin-1 receptor acc (356 aa) initn: 2401 init1: 2401 opt: 2401 Z-score: 2498.6 bits: 471.5 E(85289): 2e-132 Smith-Waterman score: 2401; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KB5 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKGNRCGQ 310 320 330 340 350 370 380 390 400 410 420 pF1KB5 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF >>XP_016861836 (OMIM: 602626) PREDICTED: interleukin-1 r (385 aa) initn: 2401 init1: 2401 opt: 2401 Z-score: 2498.1 bits: 471.6 E(85289): 2.1e-132 Smith-Waterman score: 2401; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KB5 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKEFPSCCPGWS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF XP_016 TVARSRLSATSTSWVQMILLPQPPE 370 380 >>NP_059112 (OMIM: 300277) X-linked interleukin-1 recept (686 aa) initn: 978 init1: 267 opt: 1140 Z-score: 1187.2 bits: 229.8 E(85289): 2.2e-59 Smith-Waterman score: 1151; 36.2% identity (65.6% similar) in 588 aa overlap (1-562:7-577) 10 20 30 40 50 pF1KB5 MTLLWC-VVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHF ..:. : ::: . . . .. . : ::..: .. ... ::.:.:: :: . NP_059 MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVD-LKTYMALAGEPVRVKCALFYSY 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYT .. :::::.:.:: :.:: .. :::::: : : :.:::.: .::. . .:.: :: NP_059 IRTNYSTAQSTGLRLMWY--KNKGDLEEPIIF--SEVRMSKEEDSIWFHSAEAQDSGFYT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 CMLRNTTYCSKVAFPLEVVQKDS--CFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSV :.:::.::: ::.. : :....: :.:: .. ..: . ..:.::..: . :. NP_059 CVLRNSTYCMKVSMSLTVAENESGLCYNSRIRY-LEKSEVTKR-KEISCPDMDDFKKSDQ 120 130 140 150 160 170 180 190 200 210 220 pF1KB5 KPTITWYMGCYKIQNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTL .: ..:: : : . . ..: . : ..:: .. ..::::: . : .:. . :: NP_059 EPDVVWYKEC-KPKMWRSIIIQKGN-ALLIQEVQEEDGGNYTCELKY--EGKL--VRRTT 180 190 200 210 220 230 240 250 260 270 280 pF1KB5 TVKVVGSPKNAVP-PVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKK .::.. . : :.. :. : . . :. : ::: ..:.: .: ..: : NP_059 ELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 PDDITIDVTINES--ISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAK .... . .: ... : :.. .. . .:. :: .:.::... .:. : :. NP_059 IEELAGHIREGEIRLLKEHLGEKEVELALI-FDSVVEADLA-NYTCHVENRNGR--KHAS 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 VKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYD : . : .::: :.:: ::.:.:.:.:. : .:..:::: :::.::: :.:::: NP_059 VLLRKKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYD 350 360 370 380 390 400 410 420 430 440 450 pF1KB5 IYVSYAR---------NAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSF :.::.. : :::.:.: .: :::...:::: : .:: .:.: .. . NP_059 AYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRY 410 420 430 440 450 460 460 470 480 490 500 510 pF1KB5 IQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKET----KVKE ...::::..::.:.:.:. ...::.. :.:: :.:.:::.. .: .:. NP_059 VEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVES 470 480 490 500 510 520 520 530 540 550 560 pF1KB5 LKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKS---PRRSSSD--EQGLSYSSLK :::. .:..::::: ::. ...:::.: ::.::. :: : :::: NP_059 LKRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQP 530 540 550 560 570 580 570 pF1KB5 NV NP_059 IPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCN 590 600 610 620 630 640 >>XP_016884892 (OMIM: 300277) PREDICTED: X-linked interl (686 aa) initn: 978 init1: 267 opt: 1140 Z-score: 1187.2 bits: 229.8 E(85289): 2.2e-59 Smith-Waterman score: 1151; 36.2% identity (65.6% similar) in 588 aa overlap (1-562:7-577) 10 20 30 40 50 pF1KB5 MTLLWC-VVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHF ..:. : ::: . . . .. . : ::..: .. ... ::.:.:: :: . XP_016 MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVD-LKTYMALAGEPVRVKCALFYSY 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYT .. :::::.:.:: :.:: .. :::::: : : :.:::.: .::. . .:.: :: XP_016 IRTNYSTAQSTGLRLMWY--KNKGDLEEPIIF--SEVRMSKEEDSIWFHSAEAQDSGFYT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 CMLRNTTYCSKVAFPLEVVQKDS--CFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSV :.:::.::: ::.. : :....: :.:: .. ..: . ..:.::..: . :. XP_016 CVLRNSTYCMKVSMSLTVAENESGLCYNSRIRY-LEKSEVTKR-KEISCPDMDDFKKSDQ 120 130 140 150 160 170 180 190 200 210 220 pF1KB5 KPTITWYMGCYKIQNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTL .: ..:: : : . . ..: . : ..:: .. ..::::: . : .:. . :: XP_016 EPDVVWYKEC-KPKMWRSIIIQKGN-ALLIQEVQEEDGGNYTCELKY--EGKL--VRRTT 180 190 200 210 220 230 240 250 260 270 280 pF1KB5 TVKVVGSPKNAVP-PVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKK .::.. . : :.. :. : . . :. : ::: ..:.: .: ..: : XP_016 ELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 PDDITIDVTINES--ISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAK .... . .: ... : :.. .. . .:. :: .:.::... .:. : :. XP_016 IEELAGHIREGEIRLLKEHLGEKEVELALI-FDSVVEADLA-NYTCHVENRNGR--KHAS 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 VKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYD : . : .::: :.:: ::.:.:.:.:. : .:..:::: :::.::: :.:::: XP_016 VLLRKKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYD 350 360 370 380 390 400 410 420 430 440 450 pF1KB5 IYVSYAR---------NAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSF :.::.. : :::.:.: .: :::...:::: : .:: .:.: .. . XP_016 AYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRY 410 420 430 440 450 460 460 470 480 490 500 510 pF1KB5 IQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKET----KVKE ...::::..::.:.:.:. ...::.. :.:: :.:.:::.. .: .:. XP_016 VEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVES 470 480 490 500 510 520 520 530 540 550 560 pF1KB5 LKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKS---PRRSSSD--EQGLSYSSLK :::. .:..::::: ::. ...:::.: ::.::. :: : :::: XP_016 LKRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQP 530 540 550 560 570 580 570 pF1KB5 NV XP_016 IPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCN 590 600 610 620 630 640 570 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:35:24 2016 done: Sun Nov 6 17:35:26 2016 Total Scan time: 9.890 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]