FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5995, 577 aa 1>>>pF1KB5995 577 - 577 aa - 577 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.4359+/-0.000535; mu= -4.7854+/- 0.034 mean_var=574.8918+/-121.933, 0's: 0 Z-trim(122.1): 106 B-trim: 1946 in 1/54 Lambda= 0.053491 statistics sampled from 39589 (39711) to 39589 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.466), width: 16 Scan time: 12.940 The best scores are: opt bits E(85289) NP_001316 (OMIM: 300907) cleavage stimulation fact ( 577) 3935 318.7 3.3e-86 NP_056050 (OMIM: 611968) cleavage stimulation fact ( 616) 2535 210.7 1.1e-53 NP_001293138 (OMIM: 300907) cleavage stimulation f ( 560) 2313 193.5 1.5e-48 NP_001293135 (OMIM: 300907) cleavage stimulation f ( 597) 2299 192.5 3.4e-48 NP_005841 (OMIM: 154400,605593) splicing factor 3B ( 424) 360 42.6 0.003 >>NP_001316 (OMIM: 300907) cleavage stimulation factor s (577 aa) initn: 3935 init1: 3935 opt: 3935 Z-score: 1668.8 bits: 318.7 E(85289): 3.3e-86 Smith-Waterman score: 3935; 100.0% identity (100.0% similar) in 577 aa overlap (1-577:1-577) 10 20 30 40 50 60 pF1KB5 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 GMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAAL 490 500 510 520 530 540 550 560 570 pF1KB5 IMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP ::::::::::::::::::::::::::::::::::::: NP_001 IMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP 550 560 570 >>NP_056050 (OMIM: 611968) cleavage stimulation factor s (616 aa) initn: 1812 init1: 1221 opt: 2535 Z-score: 1084.6 bits: 210.7 E(85289): 1.1e-53 Smith-Waterman score: 2777; 69.4% identity (80.8% similar) in 625 aa overlap (1-570:1-609) 10 20 30 40 50 60 pF1KB5 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG :..:.:::::.::::::::::::::::::::::::::::: ::::::::::::::::::: NP_056 MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS ::::::::::::::::::::::::::::::::::::::::::::: .::.:.::::. :. NP_056 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR ::::::::..:::::::::::::::::::::::: ::::::::::::::::::::::::: NP_056 PEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMR 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 IVDPEIALKILHRQTNIPTLIAGNPQ------PVHGAGPG--SGSNVSMNQQNPQAPQAQ :.:::::::::::. .. :: :. : : : ::: : :: .::::: ::: : NP_056 IMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 SLGGMHVNGAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSM :. :. :::::. .:::.:::: .:::: : :::::.:::.:: :.:::: ::: . NP_056 HLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 ERGQVPMQDPRAAMQRGSL-PANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPH ::::: :.:::: . :: . :...: :::::::::::::::::::::::::::::::::: NP_056 ERGQVQMSDPRAPIPRGPVTPGGLP-PRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPH 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 QGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGID :::::::. ::..::: ::.::::: .:: :..::::::.:::: :.::::::: NP_056 QGPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPMIDQRGLPMDGRGGRD----- 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 ARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPV .:.::.::::.. ..:.:.:: :.::. :::.:.::.:::.:::.. :::: NP_056 SRAMETRAMETE----------VLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPV 420 430 440 450 460 480 490 500 510 pF1KB5 PGPRGPIPSGMQGPSPINMGAV-VPQGSRQVPVM---------------QGTGMQGASIQ :. :::. .:.:::.:::.:: ::: :::: . ::::::::.:: NP_056 PSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQ 470 480 490 500 510 520 520 530 540 pF1KB5 GG------------------------------SQPGGFSPGQNQVTPQDHEKAALIMQVL :: :::..:::::.::::::.:::::::::: NP_056 GGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVL 530 540 550 560 570 580 550 560 570 pF1KB5 QLTADQIAMLPPEQRQSILILKEQIQKSTGAP ::::::::::::::::::::::::: NP_056 QLTADQIAMLPPEQRQSILILKEQIQKSTGAS 590 600 610 >>NP_001293138 (OMIM: 300907) cleavage stimulation facto (560 aa) initn: 2292 init1: 2292 opt: 2313 Z-score: 992.5 bits: 193.5 E(85289): 1.5e-48 Smith-Waterman score: 3770; 97.1% identity (97.1% similar) in 577 aa overlap (1-577:1-560) 10 20 30 40 50 60 pF1KB5 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLG----- 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQ :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ------------GVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQ 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 DPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 GHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAM 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 EARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPS 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB5 GMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAAL 470 480 490 500 510 520 550 560 570 pF1KB5 IMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP ::::::::::::::::::::::::::::::::::::: NP_001 IMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP 530 540 550 560 >>NP_001293135 (OMIM: 300907) cleavage stimulation facto (597 aa) initn: 2043 init1: 2043 opt: 2299 Z-score: 986.3 bits: 192.5 E(85289): 3.4e-48 Smith-Waterman score: 3885; 96.6% identity (96.6% similar) in 597 aa overlap (1-577:1-597) 10 20 30 40 50 60 pF1KB5 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQ---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQGTLQ 250 260 270 280 290 300 300 310 320 330 340 pF1KB5 ----------------VPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGE :::::::::::::::::::::::::::::::::::::::::::: NP_001 HSPVGPAGPASIERVQVPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB5 VEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLD 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB5 GRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGM 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB5 EARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQP 490 500 510 520 530 540 530 540 550 560 570 pF1KB5 GGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP 550 560 570 580 590 >>NP_005841 (OMIM: 154400,605593) splicing factor 3B sub (424 aa) initn: 284 init1: 182 opt: 360 Z-score: 179.2 bits: 42.6 E(85289): 0.003 Smith-Waterman score: 402; 27.4% identity (48.3% similar) in 435 aa overlap (9-397:5-421) 10 20 30 40 50 pF1KB5 MAGLTVRDPAVDRSLR-SVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGY : .:. .:.::.. ...: : ..: ..::::. .. :: ::. .:: NP_005 MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGY 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 GFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKS---LGTGAPVIE---- :: :. ..: : :.. .: .. :. .::..:...... .. . .:. : :. NP_005 GFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLL 60 70 80 90 100 110 120 130 140 150 pF1KB5 ----SPYGETI-SPE---DAPESISKAVASL------PPEQMFELMKQMKLCVQNSPQEA : .: . .:. : . ::. : . . .: :. . :: : : . NP_005 YDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLC--NRPITV 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 RNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQPV---HGAG-PG . .. . :. .. .: :. . :.:: :.: : NP_005 SYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPP 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB5 SGSNVSMNQQNPQAPQAQSLGGMHVNGAPPLMQASMQG-GVPAPGQMPAAVTGPG---PG : . : : . :. :: : . : : :. : :. : : : NP_005 PGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPH 240 250 260 270 280 290 280 290 300 310 pF1KB5 SLAPGG----GM-QAQV--------GMPGSGPVSMERGQVPMQDPRAAMQRGSLPANVPT . ::: :: : :. : : .:: . :: : . : . . : : ..: NP_005 PFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPG-SGGQPPPRPPPGMPHPGPPPMGMP- 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB5 PRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPL ::: : :. .. : . :.:. ::: :: : : :::. . ::: NP_005 PRG--------PPFGSPMGHPGPMPPHGMRGPPPLMPP-HGYTGPPR--PPPYGYQRGPL 360 370 380 390 400 380 390 400 410 420 430 pF1KB5 PEPRPLM---AEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARA : ::: . ::::. ::: NP_005 PPPRPTPRPPVPPRGPL---RGPLPQ 410 420 577 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:52:53 2016 done: Sat Nov 5 10:52:54 2016 Total Scan time: 12.940 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]