Result of FASTA (omim) for
pF1KB6013
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6013, 576 aa
1>>>pF1KB6013 576 - 576 aa - 576 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.2170+/-0.000392; mu= -1.4333+/- 0.024
mean_var=224.5347+/-46.112, 0's: 0 Z-trim(119.2): 115 B-trim: 400 in 1/60
Lambda= 0.085592
statistics sampled from 32839 (33020) to 32839 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.387), width: 16
Scan time: 9.630
The best scores are: opt bits E(85289)
NP_783165 (OMIM: 610895) WAP, Kazal, immunoglobuli ( 576) 4123 522.6 1.4e-147
NP_001317270 (OMIM: 610895) WAP, Kazal, immunoglob ( 483) 3427 436.6 8.8e-122
NP_444514 (OMIM: 608021) WAP, Kazal, immunoglobuli ( 548) 1582 208.8 3.7e-53
NP_001624 (OMIM: 176870) protein AMBP preproprotei ( 352) 345 55.9 2.5e-07
NP_006643 (OMIM: 613941) kunitz-type protease inhi ( 89) 238 42.3 0.0008
NP_065131 (OMIM: 609031) eppin isoform 1 precursor ( 133) 224 40.7 0.0037
NP_001159575 (OMIM: 270420,605124) kunitz-type pro ( 195) 221 40.4 0.0064
NP_066925 (OMIM: 270420,605124) kunitz-type protea ( 252) 221 40.5 0.0078
>>NP_783165 (OMIM: 610895) WAP, Kazal, immunoglobulin, K (576 aa)
initn: 4123 init1: 4123 opt: 4123 Z-score: 2770.8 bits: 522.6 E(85289): 1.4e-147
Smith-Waterman score: 4123; 100.0% identity (100.0% similar) in 576 aa overlap (1-576:1-576)
10 20 30 40 50 60
pF1KB6 MWAPRCRRFWSRWEQVAALLLLLLLLGVPPRSLALPPIRYSHAGICPNDMNPNLWVDAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 MWAPRCRRFWSRWEQVAALLLLLLLLGVPPRSLALPPIRYSHAGICPNDMNPNLWVDAQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 TCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 TCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 SECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 WPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 WPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 ITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 ITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 PLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 CHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 CHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 GNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 GNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 ALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_783 ALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAML
490 500 510 520 530 540
550 560 570
pF1KB6 RPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH
::::::::::::::::::::::::::::::::::::
NP_783 RPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH
550 560 570
>>NP_001317270 (OMIM: 610895) WAP, Kazal, immunoglobulin (483 aa)
initn: 3427 init1: 3427 opt: 3427 Z-score: 2307.4 bits: 436.6 E(85289): 8.8e-122
Smith-Waterman score: 3427; 100.0% identity (100.0% similar) in 483 aa overlap (94-576:1-483)
70 80 90 100 110 120
pF1KB6 RECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQGSEC
::::::::::::::::::::::::::::::
NP_001 MDVKGKKGPVGMPKEATCDHFMCLQQGSEC
10 20 30
130 140 150 160 170 180
pF1KB6 DIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWPN
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB6 TSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPEITW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPEITW
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB6 EKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLS
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB6 VVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHR
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB6 NLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNG
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB6 NNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGRALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGRALV
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB6 TVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAMLRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAMLRPD
400 410 420 430 440 450
550 560 570
pF1KB6 SFVGASSARRVRKLREVMHKKTCDVLKEFLGLH
:::::::::::::::::::::::::::::::::
NP_001 SFVGASSARRVRKLREVMHKKTCDVLKEFLGLH
460 470 480
>>NP_444514 (OMIM: 608021) WAP, Kazal, immunoglobulin, K (548 aa)
initn: 1756 init1: 535 opt: 1582 Z-score: 1075.3 bits: 208.8 E(85289): 3.7e-53
Smith-Waterman score: 2193; 56.1% identity (77.0% similar) in 560 aa overlap (19-572:7-546)
10 20 30 40 50 60
pF1KB6 MWAPRCRRFWSRWEQVAALLLLLLLLGVPPRSLALPPIRYSHAGICPNDMNPNLWVDAQS
:: ::::: . . :: . :: :.:::...:::::::::
NP_444 MPALRPLLPLLLLLRLTSGAGLLPGLG-SHPGVCPNQLSPNLWVDAQS
10 20 30 40
70 80 90 100 110 120
pF1KB6 TCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQG
::.::: ::.: . :::: :::: .::::::. : .:.. :.:. :.: :::
NP_444 TCERECSRDQDCAAAEKCCINVCGLHSCVAARF---PG--SPAAPTTAASCEGFVCPQQG
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB6 SECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFT
:.::::::::::.:.::::::::::::::::::::::::::::: .:. : .: :.. ..
NP_444 SDCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB6 WPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPE
:: .:: ::::: .:: .. .: ::: ..: :.: .: :.:. ::: ::: :
NP_444 WPPSSPGPPETTARPTPGAAPVP------PALYSSPSPQAVQVGGTASLHCDVSGRPPPA
170 180 190 200 210
250 260 270 280 290 300
pF1KB6 ITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADF
.::::: ..:::..:::... ::::::.:.:::.:::. .:::.:::::::.::.:::::
NP_444 VTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADF
220 230 240 250 260 270
310 320 330 340 350
pF1KB6 PLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDC-GEEQTR---WHFDAQANNCLTF
:::::. . : .. : : :: ::: :: . : : . . ::.: : ..:.::
NP_444 PLSVVQREPARDAAPSIPA----PA-ECL--PDVQACTGPTSPHLVLWHYDPQRGGCMTF
280 290 300 310 320
360 370 380 390 400 410
pF1KB6 TFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVY
: :::::::. :: :: :: :::.::::... :::::. ::. :::
NP_444 PARGCDGAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVY
330 340 350 360 370 380
420 430 440 450 460 470
pF1KB6 GGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEP
::::::::::.:::.::..:: :: . ::::. :.::. :.:::::.:.::..:. :::
NP_444 GGCEGNGNNFHSRESCEDACPVPR-TPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEP
390 400 410 420 430 440
480 490 500 510 520 530
pF1KB6 DS--GRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVD
.. : : :....::::.:::::::: . ::::: .::::::::.:... ::.:::::
NP_444 EAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGEVR
450 460 470 480 490 500
540 550 560 570
pF1KB6 GGMAMLRPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH
:.:.: :.: :.: .::.:. :...:..:..:..:
NP_444 DGVAVLDAGSYVRAASEKRVKKILELLEKQACELLNRFQD
510 520 530 540
>>NP_001624 (OMIM: 176870) protein AMBP preproprotein [H (352 aa)
initn: 426 init1: 241 opt: 345 Z-score: 252.5 bits: 55.9 E(85289): 2.5e-07
Smith-Waterman score: 345; 31.5% identity (59.6% similar) in 178 aa overlap (271-439:166-340)
250 260 270 280 290
pF1KB6 ITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARN--VAGVLRA
..: .. . . .:.: . :. : : .
NP_001 KKFSRHHGPTITAKLYGRAPQLRETLLQDFRVVAQGVGIPEDSIFTMADRGECVPGEQEP
140 150 160 170 180 190
300 310 320 330 340 350
pF1KB6 DFPLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSED-------CGEEQTRWHFDAQAN
. :. . : ..:. .: .: . ..: : :: . : .:. ... .
NP_001 E-PILIPRVRRAVLPQEEEGSGGGQLVTEVTKKEDSCQLGYSAGPCMGMTSRYFYNGTSM
200 210 220 230 240 250
360 370 380 390 400 410
pF1KB6 NCLTFTFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQC
: :: .: : : :.: : . :. .: . .:::.:: ..:::.:. ::... :.:
NP_001 ACETFQYGGCMGNGNNFVTEKECLQTCRT--VAACNLPIVRGPCRAFIQLWAFDAVKGKC
260 270 280 290 300 310
420 430 440 450 460 470
pF1KB6 QSFVYGGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSE
: ::::.::::.: :.. :.: : :
NP_001 VLFPYGGCQGNGNKFYSEKECREYCGVPGDGDEELLRFSN
320 330 340 350
>>NP_006643 (OMIM: 613941) kunitz-type protease inhibito (89 aa)
initn: 312 init1: 215 opt: 238 Z-score: 189.6 bits: 42.3 E(85289): 0.0008
Smith-Waterman score: 238; 50.9% identity (75.5% similar) in 53 aa overlap (386-438:36-88)
360 370 380 390 400 410
pF1KB6 FTFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFV
:..: .:::..: :: .: .::.:. :.
NP_006 SLSFLLILTLCLELRSELARDTIKDLLPNVCAFPMEKGPCQTYMTRWFFNFETGECELFA
10 20 30 40 50 60
420 430 440 450 460 470
pF1KB6 YGGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEE
:::: ::.::: .: ::. : :
NP_006 YGGCGGNSNNFLRKEKCEKFCKFT
70 80
>>NP_065131 (OMIM: 609031) eppin isoform 1 precursor [Ho (133 aa)
initn: 248 init1: 189 opt: 224 Z-score: 177.8 bits: 40.7 E(85289): 0.0037
Smith-Waterman score: 224; 39.7% identity (64.7% similar) in 68 aa overlap (373-440:64-131)
350 360 370 380 390 400
pF1KB6 RWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRW
.: :.. .: .: ::: :: .:
NP_065 PKIREECEFQERDVCTKDRQCQDNKKCCVFSCGKKCLDLKQDVCEMPKETGPCLAYFLHW
40 50 60 70 80 90
410 420 430 440 450 460
pF1KB6 AYNSQTGQCQSFVYGGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSD
:... . :. ::::::.::.:::.:. : ..: :
NP_065 WYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCKNKRFP
100 110 120 130
470 480 490 500 510 520
pF1KB6 FVILGRVSELTEEPDSGRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTV
>>NP_001159575 (OMIM: 270420,605124) kunitz-type proteas (195 aa)
initn: 209 init1: 209 opt: 221 Z-score: 173.4 bits: 40.4 E(85289): 0.0064
Smith-Waterman score: 221; 34.6% identity (60.7% similar) in 107 aa overlap (386-485:76-178)
360 370 380 390 400 410
pF1KB6 FTFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFV
:. :. :::.: ::: .. . ..:..:.
NP_001 RNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFI
50 60 70 80 90 100
420 430 440 450 460
pF1KB6 YGGCEGNGNNFESREACEESC-------PFPRGNQRCRACKPRQKLVTSFCRSDFVILGR
::::.:: :...:.::: : :.: :.. .. : ...: : :
NP_001 YGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIR
110 120 130 140 150 160
470 480 490 500 510 520
pF1KB6 VSELTEEPDSGRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLI
:.. ..: ::: ::
NP_001 VARRNQE----RALRTVWSSGDDKEQLVKNTYVL
170 180 190
>>NP_066925 (OMIM: 270420,605124) kunitz-type protease i (252 aa)
initn: 209 init1: 209 opt: 221 Z-score: 171.8 bits: 40.5 E(85289): 0.0078
Smith-Waterman score: 260; 27.2% identity (47.5% similar) in 202 aa overlap (328-485:38-235)
300 310 320 330 340 350
pF1KB6 ADFPLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDCGEEQTRWHFDAQANNCLTFT
:: : . :: ... ..: :.
NP_066 RRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFV
10 20 30 40 50 60
360 370 380
pF1KB6 FGHCHRNLNHFETYEACMLACMS------GPLAA--------------------------
.: : : :.. : : :. : . : ::.
NP_066 YGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMF
70 80 90 100 110 120
390 400 410 420 430
pF1KB6 -----CSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESC----
:. :. :::.: ::: .. . ..:..:.::::.:: :...:.::: :
NP_066 NYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQ
130 140 150 160 170 180
440 450 460 470 480 490
pF1KB6 ---PFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDSGRALVTVDEVLKDEK
:.: :.. .. : ...: : ::.. ..: ::: ::
NP_066 ENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQE----RALRTVWSSGDDKE
190 200 210 220 230 240
500 510 520 530 540 550
pF1KB6 MGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAMLRPDSFVGASSARR
NP_066 QLVKNTYVL
250
576 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 00:03:28 2016 done: Sat Nov 5 00:03:29 2016
Total Scan time: 9.630 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]