FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6103, 577 aa 1>>>pF1KB6103 577 - 577 aa - 577 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.5882+/-0.000468; mu= 7.4485+/- 0.029 mean_var=118.9622+/-23.815, 0's: 0 Z-trim(111.6): 32 B-trim: 64 in 1/50 Lambda= 0.117590 statistics sampled from 20193 (20214) to 20193 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.237), width: 16 Scan time: 8.440 The best scores are: opt bits E(85289) XP_006712618 (OMIM: 601182) PREDICTED: origin reco ( 577) 3717 642.4 1.2e-183 NP_006181 (OMIM: 601182) origin recognition comple ( 577) 3717 642.4 1.2e-183 XP_011509554 (OMIM: 601182) PREDICTED: origin reco ( 597) 3016 523.5 7.8e-148 XP_011509555 (OMIM: 601182) PREDICTED: origin reco ( 597) 3016 523.5 7.8e-148 >>XP_006712618 (OMIM: 601182) PREDICTED: origin recognit (577 aa) initn: 3717 init1: 3717 opt: 3717 Z-score: 3418.1 bits: 642.4 E(85289): 1.2e-183 Smith-Waterman score: 3717; 100.0% identity (100.0% similar) in 577 aa overlap (1-577:1-577) 10 20 30 40 50 60 pF1KB6 MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 VSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 EEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 WMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 DHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 IASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFR 490 500 510 520 530 540 550 560 570 pF1KB6 DHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA ::::::::::::::::::::::::::::::::::::: XP_006 DHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA 550 560 570 >>NP_006181 (OMIM: 601182) origin recognition complex su (577 aa) initn: 3717 init1: 3717 opt: 3717 Z-score: 3418.1 bits: 642.4 E(85289): 1.2e-183 Smith-Waterman score: 3717; 100.0% identity (100.0% similar) in 577 aa overlap (1-577:1-577) 10 20 30 40 50 60 pF1KB6 MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 VSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 EEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 WMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 DHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 IASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFR 490 500 510 520 530 540 550 560 570 pF1KB6 DHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA ::::::::::::::::::::::::::::::::::::: NP_006 DHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA 550 560 570 >>XP_011509554 (OMIM: 601182) PREDICTED: origin recognit (597 aa) initn: 3703 init1: 3007 opt: 3016 Z-score: 2775.1 bits: 523.5 E(85289): 7.8e-148 Smith-Waterman score: 3667; 96.6% identity (96.6% similar) in 597 aa overlap (1-577:1-597) 10 20 30 40 50 60 pF1KB6 MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED 10 20 30 40 50 60 70 80 90 100 pF1KB6 DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKL----------- ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLDLTFWPFFLTP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 ---------ASELAKTPQKSVSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLS ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQRCASTIYASELAKTPQKSVSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 TAPRSLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAPRSLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSA 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB6 PVGKETPSKRMKRDKTSDLVEEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVGKETPSKRMKRDKTSDLVEEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVS 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB6 PSFSAELKQLNQQYEKLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSFSAELKQLNQQYEKLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVIN 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB6 GFFPGISVKSVLNSITEEVLDHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFFPGISVKSVLNSITEEVLDHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQML 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB6 RGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSY 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB6 ENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQC 490 500 510 520 530 540 530 540 550 560 570 pF1KB6 REAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA 550 560 570 580 590 >>XP_011509555 (OMIM: 601182) PREDICTED: origin recognit (597 aa) initn: 3703 init1: 3007 opt: 3016 Z-score: 2775.1 bits: 523.5 E(85289): 7.8e-148 Smith-Waterman score: 3667; 96.6% identity (96.6% similar) in 597 aa overlap (1-577:1-597) 10 20 30 40 50 60 pF1KB6 MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED 10 20 30 40 50 60 70 80 90 100 pF1KB6 DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKL----------- ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLDLTFWPFFLTP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 ---------ASELAKTPQKSVSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLS ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQRCASTIYASELAKTPQKSVSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 TAPRSLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAPRSLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSA 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB6 PVGKETPSKRMKRDKTSDLVEEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVGKETPSKRMKRDKTSDLVEEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVS 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB6 PSFSAELKQLNQQYEKLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSFSAELKQLNQQYEKLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVIN 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB6 GFFPGISVKSVLNSITEEVLDHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFFPGISVKSVLNSITEEVLDHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQML 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB6 RGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSY 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB6 ENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQC 490 500 510 520 530 540 530 540 550 560 570 pF1KB6 REAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA 550 560 570 580 590 577 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:14:21 2016 done: Sat Nov 5 08:14:22 2016 Total Scan time: 8.440 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]