FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6116, 582 aa 1>>>pF1KB6116 582 - 582 aa - 582 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6287+/-0.000374; mu= 17.1688+/- 0.023 mean_var=74.5428+/-15.218, 0's: 0 Z-trim(114.4): 88 B-trim: 975 in 2/52 Lambda= 0.148550 statistics sampled from 24126 (24219) to 24126 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.652), E-opt: 0.2 (0.284), width: 16 Scan time: 8.950 The best scores are: opt bits E(85289) NP_068758 (OMIM: 259450,607063,610968) peptidyl-pr ( 582) 3999 866.7 0 XP_011523401 (OMIM: 259450,607063,610968) PREDICTE ( 601) 2892 629.5 9.8e-180 NP_009201 (OMIM: 616257) peptidyl-prolyl cis-trans ( 570) 2331 509.2 1.5e-143 NP_001271270 (OMIM: 616257) peptidyl-prolyl cis-tr ( 623) 2119 463.8 7.4e-130 XP_011523402 (OMIM: 259450,607063,610968) PREDICTE ( 510) 2006 439.5 1.2e-122 XP_011513417 (OMIM: 616257) PREDICTED: peptidyl-pr ( 359) 1537 338.9 1.7e-92 NP_001271272 (OMIM: 616257) peptidyl-prolyl cis-tr ( 338) 1357 300.4 6.5e-81 NP_476433 (OMIM: 186946) peptidyl-prolyl cis-trans ( 142) 335 81.1 2.7e-15 NP_004461 (OMIM: 186946) peptidyl-prolyl cis-trans ( 142) 335 81.1 2.7e-15 NP_001128680 (OMIM: 186946) peptidyl-prolyl cis-tr ( 142) 335 81.1 2.7e-15 XP_005273905 (OMIM: 186946) PREDICTED: peptidyl-pr ( 142) 335 81.1 2.7e-15 NP_001128684 (OMIM: 607062) peptidyl-prolyl cis-tr ( 221) 320 78.0 3.6e-14 NP_057678 (OMIM: 610571) peptidyl-prolyl cis-trans ( 201) 312 76.3 1.1e-13 NP_851939 (OMIM: 607062) peptidyl-prolyl cis-trans ( 222) 312 76.3 1.2e-13 NP_060416 (OMIM: 614505,614557) peptidyl-prolyl ci ( 211) 308 75.4 2.1e-13 NP_001137254 (OMIM: 610571) peptidyl-prolyl cis-tr ( 146) 297 73.0 7.8e-13 NP_001139247 (OMIM: 602623,608516) peptidyl-prolyl ( 457) 297 73.3 2e-12 NP_001139248 (OMIM: 602623,608516) peptidyl-prolyl ( 457) 297 73.3 2e-12 NP_004108 (OMIM: 602623,608516) peptidyl-prolyl ci ( 457) 297 73.3 2e-12 NP_463460 (OMIM: 186945) peptidyl-prolyl cis-trans ( 108) 260 65.0 1.5e-10 NP_000792 (OMIM: 186945) peptidyl-prolyl cis-trans ( 108) 260 65.0 1.5e-10 NP_002005 (OMIM: 600611) peptidyl-prolyl cis-trans ( 459) 268 67.0 1.5e-10 XP_005246695 (OMIM: 607062) PREDICTED: peptidyl-pr ( 181) 261 65.3 2e-10 XP_011519231 (OMIM: 600611) PREDICTED: peptidyl-pr ( 414) 263 65.9 2.9e-10 NP_004107 (OMIM: 600620) peptidyl-prolyl cis-trans ( 108) 246 62.0 1.2e-09 NP_001139249 (OMIM: 602623,608516) peptidyl-prolyl ( 268) 241 61.1 5.3e-09 XP_016859085 (OMIM: 600620) PREDICTED: peptidyl-pr ( 79) 217 55.7 6.7e-08 XP_016859082 (OMIM: 600620) PREDICTED: peptidyl-pr ( 79) 217 55.7 6.7e-08 XP_016859083 (OMIM: 600620) PREDICTED: peptidyl-pr ( 79) 217 55.7 6.7e-08 NP_001309893 (OMIM: 600620) peptidyl-prolyl cis-tr ( 79) 217 55.7 6.7e-08 XP_016859084 (OMIM: 600620) PREDICTED: peptidyl-pr ( 79) 217 55.7 6.7e-08 NP_001309892 (OMIM: 600620) peptidyl-prolyl cis-tr ( 79) 217 55.7 6.7e-08 XP_011534867 (OMIM: 186947) PREDICTED: peptidyl-pr ( 191) 215 55.5 1.9e-07 NP_002004 (OMIM: 186947) peptidyl-prolyl cis-trans ( 224) 215 55.5 2.2e-07 XP_016876582 (OMIM: 186947) PREDICTED: peptidyl-pr ( 196) 176 47.1 6.4e-05 XP_016876581 (OMIM: 186947) PREDICTED: peptidyl-pr ( 229) 176 47.2 7.2e-05 XP_016868231 (OMIM: 604839) PREDICTED: inactive pe ( 266) 175 47.0 9.5e-05 XP_006716216 (OMIM: 604839) PREDICTED: inactive pe ( 282) 175 47.0 0.0001 XP_016868230 (OMIM: 604839) PREDICTED: inactive pe ( 317) 175 47.0 0.00011 NP_001128683 (OMIM: 604839) inactive peptidyl-prol ( 322) 175 47.0 0.00011 NP_003593 (OMIM: 604839) inactive peptidyl-prolyl ( 327) 175 47.0 0.00011 NP_001137253 (OMIM: 610571) peptidyl-prolyl cis-tr ( 99) 141 39.5 0.0065 >>NP_068758 (OMIM: 259450,607063,610968) peptidyl-prolyl (582 aa) initn: 3999 init1: 3999 opt: 3999 Z-score: 4630.2 bits: 866.7 E(85289): 0 Smith-Waterman score: 3999; 100.0% identity (100.0% similar) in 582 aa overlap (1-582:1-582) 10 20 30 40 50 60 pF1KB6 MFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 MGDFVRYHYNGTFEDGKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MGDFVRYHYNGTFEDGKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 PHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 YNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 YNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 GYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 GYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 TLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 TLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 SAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFTSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 SAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFTSH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 DYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 ELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 ELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPG 490 500 510 520 530 540 550 560 570 580 pF1KB6 QDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEEL :::::::::::::::::::::::::::::::::::::::::: NP_068 QDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEEL 550 560 570 580 >>XP_011523401 (OMIM: 259450,607063,610968) PREDICTED: p (601 aa) initn: 4883 init1: 2892 opt: 2892 Z-score: 3347.8 bits: 629.5 E(85289): 9.8e-180 Smith-Waterman score: 3951; 96.8% identity (96.8% similar) in 601 aa overlap (1-582:1-601) 10 20 30 40 50 60 pF1KB6 MFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 MGDFVRYHYNGTFEDGKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDFVRYHYNGTFEDGKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 YNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 GYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 TLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPG 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 SAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFTS- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFTSG 370 380 390 400 410 420 420 430 440 450 460 pF1KB6 ------------------HDYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLA :::::::::::::::::::::::::::::::::::::::::: XP_011 ETDAGSHEPSRPHFRGQRHDYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB6 HGESGARGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGESGARGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEE 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB6 FSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEE 550 560 570 580 590 600 pF1KB6 L : XP_011 L >>NP_009201 (OMIM: 616257) peptidyl-prolyl cis-trans iso (570 aa) initn: 2390 init1: 1502 opt: 2331 Z-score: 2698.4 bits: 509.2 E(85289): 1.5e-143 Smith-Waterman score: 2331; 58.0% identity (80.0% similar) in 571 aa overlap (15-582:12-570) 10 20 30 40 50 pF1KB6 MFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLED--VVIERYHIPRACPRE ::: ::: :. :.:.:..: : . ::: .: ::: NP_009 MAFRGWRPPPPPLLLLLLWVT-------GQAAPVAGLGSDAELQIERRFVPDECPRT 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 VQMGDFVRYHYNGTFEDGKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLI :. :::::::: ::: ::.::::::::.. . :: :.::::::..:.:::::::: . NP_009 VRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 VPPHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVR .::.:.::. :..:.:::...:.:::.:.:.::.:: ::. : ..:: ::: .: .:::: NP_009 IPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 YHYNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYG ::::::.:::: ::.:... ::::::: :::: :::.:::::: ::.: : :::::::: NP_009 YHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 EKGYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLM : : : :: :::::: : :.:.:::::....:. .: .: : . .:::.::::::.:. NP_009 EDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 DGTLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKI ::::::::::::.:..:::::::.:::::.:: :.:.::.:::..::::.:::.: :. : NP_009 DGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGN-I 300 310 320 330 340 360 370 380 390 400 410 pF1KB6 PGSAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFT ::::::.:..::::::::.: . : . .: . :. .: ::...:::: :::::: : . NP_009 PGSAVLVFDIHVIDFHNPSDSISITSHYKPPD-CSVLSKKGDYLKYHYNASLLDGTLLDS 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB6 SHDYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARG-VPGSAVLL . . : . .::...:. :.: ::. :::::.: .:.::::..::.:. : :::::::. NP_009 TWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLV 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB6 FEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRL :..::. ::: ::.:.:. . ::::..: . .::: :::: .:.:::. :::.: NP_009 FDIELLELVAGLPEGYMFIWNGEVSPNLFEEIDKDGNGEVLLEEFSEYIHAQVASGKGKL 470 480 490 500 510 520 540 550 560 570 580 pF1KB6 MPGQDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEEL :: : : . .:: ::::: :::.:..:.::: :.: :.:: NP_009 APGFDAELIVKNMFTNQDRNGDGKVTAEEFKLK---DQEAKHDEL 530 540 550 560 570 >>NP_001271270 (OMIM: 616257) peptidyl-prolyl cis-trans (623 aa) initn: 2206 init1: 1318 opt: 2119 Z-score: 2452.3 bits: 463.8 E(85289): 7.4e-130 Smith-Waterman score: 2203; 53.4% identity (74.0% similar) in 607 aa overlap (32-582:22-623) 10 20 30 40 50 pF1KB6 FPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLED--VVIERYHIPRACPREV :.:.:..: : . ::: .: ::: : NP_001 MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTV 10 20 30 40 50 60 70 80 pF1KB6 QMGDFVRYHYNGTFEDGKKFDS-------------------------------------- . :::::::: ::: ::.:::: NP_001 RSGDFVRYHYVGTFPDGQKFDSRYWDTAEDKADKSPCPQVRVGVNTSPSCRLKQKGVGIY 60 70 80 90 100 110 90 100 110 120 pF1KB6 ---------------SYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYG ::::.. . :: :.::::::..:.:::::::: . .::.:.:: NP_001 WKDLQFLVRVQNHGLSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYG 120 130 140 150 160 170 130 140 150 160 170 180 pF1KB6 SIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYHYNGTLL . :..:.:::...:.:::.:.:.::.:: ::. : ..:: ::: .: .::::::::::.: NP_001 NEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFL 180 190 200 210 220 230 190 200 210 220 230 240 pF1KB6 DGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEKGYGTVI ::: ::.:... ::::::: :::: :::.:::::: ::.: : ::::::::: : : : NP_001 DGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDI 240 250 260 270 280 290 250 260 270 280 290 300 pF1KB6 PPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDSS : :::::: : :.:.:::::....:. .: .: : . .:::.::::::.:.:::::::: NP_001 PGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSS 300 310 320 330 340 350 310 320 330 340 350 360 pF1KB6 YSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPGSAVLIF ::::.:..:::::::.:::::.:: :.:.::.:::..::::.:::.: :. :::::::.: NP_001 YSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGN-IPGSAVLVF 360 370 380 390 400 410 370 380 390 400 410 420 pF1KB6 NVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFTSHDYGAPQ ..::::::::.: . : . .: . :. .: ::...:::: :::::: : .. . : NP_001 DIHVIDFHNPSDSISITSHYKPPD-CSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTY 420 430 440 450 460 430 440 450 460 470 480 pF1KB6 EATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARG-VPGSAVLLFEVELVSR . .::...:. :.: ::. :::::.: .:.::::..::.:. : :::::::.:..::. NP_001 NIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLEL 470 480 490 500 510 520 490 500 510 520 530 540 pF1KB6 EDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEK ::: ::.:.:. . ::::..: . .::: :::: .:.:::. :::.: :: : : NP_001 VAGLPEGYMFIWNGEVSPNLFEEIDKDGNGEVLLEEFSEYIHAQVASGKGKLAPGFDAEL 530 540 550 560 570 580 550 560 570 580 pF1KB6 TIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEEL . .:: ::::: :::.:..:.::: :.: :.:: NP_001 IVKNMFTNQDRNGDGKVTAEEFKLK---DQEAKHDEL 590 600 610 620 >>XP_011523402 (OMIM: 259450,607063,610968) PREDICTED: p (510 aa) initn: 3996 init1: 2005 opt: 2006 Z-score: 2322.7 bits: 439.5 E(85289): 1.2e-122 Smith-Waterman score: 3065; 95.4% identity (95.6% similar) in 475 aa overlap (127-582:36-510) 100 110 120 130 140 150 pF1KB6 RLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTV :. :::::::::::::::::::::::::: XP_011 GTTSPGPVPGKCRWGILCATTTTALLKMARSLIQAGLIPPDATLYFDVVLLDVWNKEDTV 10 20 30 40 50 60 160 170 180 190 200 210 pF1KB6 QVSTLLRPPHCPRMVQDGDFVRYHYNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVSTLLRPPHCPRMVQDGDFVRYHYNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQ 70 80 90 100 110 120 220 230 240 250 260 270 pF1KB6 GLLGMCPGERRKIIIPPFLAYGEKGYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLLGMCPGERRKIIIPPFLAYGEKGYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELP 130 140 150 160 170 180 280 290 300 310 320 330 pF1KB6 PGCVRRAGAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGCVRRAGAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMG 190 200 210 220 230 240 340 350 360 370 380 390 pF1KB6 ERRRITIPPHLAYGENGTGDKIPGSAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERRRITIPPHLAYGENGTGDKIPGSAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETT 250 260 270 280 290 300 400 410 420 430 pF1KB6 KLGDFVRYHYNCSLLDGTQLFTS-------------------HDYGAPQEATLGANKVIE ::::::::::::::::::::::: :::::::::::::::::: XP_011 KLGDFVRYHYNCSLLDGTQLFTSGETDAGSHEPSRPHFRGQRHDYGAPQEATLGANKVIE 310 320 330 340 350 360 440 450 460 470 480 490 pF1KB6 GLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEVELVSREDGLPTGYLFVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEVELVSREDGLPTGYLFVW 370 380 390 400 410 420 500 510 520 530 540 550 pF1KB6 HKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRN 430 440 450 460 470 480 560 570 580 pF1KB6 QDGKITVDELKLKSDEDEERVHEEL ::::::::::::::::::::::::: XP_011 QDGKITVDELKLKSDEDEERVHEEL 490 500 510 >>XP_011513417 (OMIM: 616257) PREDICTED: peptidyl-prolyl (359 aa) initn: 2290 init1: 1509 opt: 1537 Z-score: 1781.8 bits: 338.9 E(85289): 1.7e-92 Smith-Waterman score: 1537; 61.7% identity (82.1% similar) in 347 aa overlap (15-359:12-351) 10 20 30 40 50 pF1KB6 MFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLED--VVIERYHIPRACPRE ::: ::: :. :.:.:..: : . ::: .: ::: XP_011 MAFRGWRPPPPPLLLLLLWVT-------GQAAPVAGLGSDAELQIERRFVPDECPRT 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 VQMGDFVRYHYNGTFEDGKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLI :. :::::::: ::: ::.::::::::.. . :: :.::::::..:.:::::::: . XP_011 VRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 VPPHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVR .::.:.::. :..:.:::...:.:::.:.:.::.:: ::. : ..:: ::: .: .:::: XP_011 IPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 YHYNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYG ::::::.:::: ::.:... ::::::: :::: :::.:::::: ::.: : :::::::: XP_011 YHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 EKGYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLM : : : :: :::::: : :.:.:::::....:. .: .: : . .:::.::::::.:. XP_011 EDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 DGTLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKI ::::::::::::.:..:::::::.:::::.:: :.:.::.:::..::::.:::.: : . XP_011 DGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGGET 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 PGSAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFT : XP_011 PSIHPSKIY >>NP_001271272 (OMIM: 616257) peptidyl-prolyl cis-trans (338 aa) initn: 2120 init1: 553 opt: 1357 Z-score: 1573.7 bits: 300.4 E(85289): 6.5e-81 Smith-Waterman score: 1357; 56.3% identity (80.4% similar) in 341 aa overlap (243-582:3-338) 220 230 240 250 260 270 pF1KB6 GMDQGLLGMCPGERRKIIIPPFLAYGEKGYGTVIPPQASLVFHVLLIDVHNPKDAVQLET : :: :::::: : :.:.:::::....:. NP_001 MAGKDIPGQASLVFDVALLDLHNPKDSISIEN 10 20 30 280 290 300 310 320 330 pF1KB6 LELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQG .: .: : . .:::.::::::.:.::::::::::::.:..:::::::.:::::.:: : NP_001 KVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLG 40 50 60 70 80 90 340 350 360 370 380 390 pF1KB6 ACMGERRRITIPPHLAYGENGTGDKIPGSAVLIFNVHVIDFHNPADVVEIRTLSRPSETC .:.::.:::..::::.:::.: :. :::::::.:..::::::::.: . : . .: . : NP_001 VCIGEKRRIVVPPHLGYGEEGRGN-IPGSAVLVFDIHVIDFHNPSDSISITSHYKPPD-C 100 110 120 130 140 150 400 410 420 430 440 450 pF1KB6 NETTKLGDFVRYHYNCSLLDGTQLFTSHDYGAPQEATLGANKVIEGLDTGLQGMCVGERR . .: ::...:::: :::::: : .. . : . .::...:. :.: ::. :::::.: NP_001 SVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKR 160 170 180 190 200 210 460 470 480 490 500 510 pF1KB6 QLIVPPHLAHGESGARG-VPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDL .:.::::..::.:. : :::::::.:..::. ::: ::.:.:. . ::::..: NP_001 TVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFIWNGEVSPNLFEEIDK 220 230 240 250 260 270 520 530 540 550 560 570 pF1KB6 NKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRNQDGKITVDELKLKS . .::: :::: .:.:::. :::.: :: : : . .:: ::::: :::.:..:.::: NP_001 DGNGEVLLEEFSEYIHAQVASGKGKLAPGFDAELIVKNMFTNQDRNGDGKVTAEEFKLK- 280 290 300 310 320 580 pF1KB6 DEDEERVHEEL :.: :.:: NP_001 --DQEAKHDEL 330 >>NP_476433 (OMIM: 186946) peptidyl-prolyl cis-trans iso (142 aa) initn: 661 init1: 326 opt: 335 Z-score: 395.6 bits: 81.1 E(85289): 2.7e-15 Smith-Waterman score: 335; 46.2% identity (69.8% similar) in 106 aa overlap (156-261:31-136) 130 140 150 160 170 180 pF1KB6 GSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYHYNGTL .:... : ::: . :: ...::.: : NP_476 MRLSWFRVLTVLSICLSAVATATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL 10 20 30 40 50 60 190 200 210 220 230 240 pF1KB6 LDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEKGYGTV ::: ::.: .. . .:.: .::: :::::::: ::.::..:: :.:::.: NP_476 EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPK 70 80 90 100 110 120 250 260 270 280 290 300 pF1KB6 IPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDS :: :.:::.: :. . NP_476 IPGGATLVFEVELLKIERRTEL 130 140 >>NP_004461 (OMIM: 186946) peptidyl-prolyl cis-trans iso (142 aa) initn: 661 init1: 326 opt: 335 Z-score: 395.6 bits: 81.1 E(85289): 2.7e-15 Smith-Waterman score: 335; 46.2% identity (69.8% similar) in 106 aa overlap (156-261:31-136) 130 140 150 160 170 180 pF1KB6 GSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYHYNGTL .:... : ::: . :: ...::.: : NP_004 MRLSWFRVLTVLSICLSAVATATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL 10 20 30 40 50 60 190 200 210 220 230 240 pF1KB6 LDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEKGYGTV ::: ::.: .. . .:.: .::: :::::::: ::.::..:: :.:::.: NP_004 EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPK 70 80 90 100 110 120 250 260 270 280 290 300 pF1KB6 IPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDS :: :.:::.: :. . NP_004 IPGGATLVFEVELLKIERRTEL 130 140 >>NP_001128680 (OMIM: 186946) peptidyl-prolyl cis-trans (142 aa) initn: 661 init1: 326 opt: 335 Z-score: 395.6 bits: 81.1 E(85289): 2.7e-15 Smith-Waterman score: 335; 46.2% identity (69.8% similar) in 106 aa overlap (156-261:31-136) 130 140 150 160 170 180 pF1KB6 GSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYHYNGTL .:... : ::: . :: ...::.: : NP_001 MRLSWFRVLTVLSICLSAVATATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL 10 20 30 40 50 60 190 200 210 220 230 240 pF1KB6 LDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEKGYGTV ::: ::.: .. . .:.: .::: :::::::: ::.::..:: :.:::.: NP_001 EDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPK 70 80 90 100 110 120 250 260 270 280 290 300 pF1KB6 IPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDS :: :.:::.: :. . NP_001 IPGGATLVFEVELLKIERRTEL 130 140 582 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:47:02 2016 done: Fri Nov 4 21:47:03 2016 Total Scan time: 8.950 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]