FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6118, 546 aa 1>>>pF1KB6118 546 - 546 aa - 546 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5440+/-0.000766; mu= 4.8860+/- 0.046 mean_var=182.5034+/-36.895, 0's: 0 Z-trim(115.4): 16 B-trim: 0 in 0/52 Lambda= 0.094938 statistics sampled from 15945 (15955) to 15945 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.809), E-opt: 0.2 (0.49), width: 16 Scan time: 4.170 The best scores are: opt bits E(32554) CCDS55900.1 FAM124A gene_id:220108|Hs108|chr13 ( 546) 3816 534.7 1.1e-151 CCDS9427.1 FAM124A gene_id:220108|Hs108|chr13 ( 582) 3588 503.5 2.9e-142 CCDS81767.1 FAM124A gene_id:220108|Hs108|chr13 ( 301) 1945 278.2 9.3e-75 CCDS46527.1 FAM124B gene_id:79843|Hs108|chr2 ( 455) 761 116.2 8.6e-26 CCDS2461.1 FAM124B gene_id:79843|Hs108|chr2 ( 272) 753 114.9 1.2e-25 >>CCDS55900.1 FAM124A gene_id:220108|Hs108|chr13 (546 aa) initn: 3816 init1: 3816 opt: 3816 Z-score: 2836.8 bits: 534.7 E(32554): 1.1e-151 Smith-Waterman score: 3816; 100.0% identity (100.0% similar) in 546 aa overlap (1-546:1-546) 10 20 30 40 50 60 pF1KB6 MDPKAGGGGEEDDCVDSGAETGGSDYSHLSSTSSELSVEEAQDPFLVSIHIIADPGESQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MDPKAGGGGEEDDCVDSGAETGGSDYSHLSSTSSELSVEEAQDPFLVSIHIIADPGESQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LQEAIDNVLAWIHPDLPLFRVSERRASRRRRKPPKGAQPALAVVLFLQEEYGEEQILQLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LQEAIDNVLAWIHPDLPLFRVSERRASRRRRKPPKGAQPALAVVLFLQEEYGEEQILQLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RTLQQPPWRHHHTEQVHGRFLPYLPCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RTLQQPPWRHHHTEQVHGRFLPYLPCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DNYADSLRFYQLILRRSPSQKKADFCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 DNYADSLRFYQLILRRSPSQKKADFCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 FRVRDIGELVPLLPNPCSPISEGRWQTEDHDGNKILLQAQRVHKKFPKPGRVHHASEKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 FRVRDIGELVPLLPNPCSPISEGRWQTEDHDGNKILLQAQRVHKKFPKPGRVHHASEKKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 HSTPLPSTAVPSHTPGSSQQSPLNSPHPGPIRTGLPPGHQQEFAGRANSTPNPPWSFQRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 HSTPLPSTAVPSHTPGSSQQSPLNSPHPGPIRTGLPPGHQQEFAGRANSTPNPPWSFQRS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 KSLFCLPTGGPSLASSAEPQWFSNTGAPGHRASEWRHGHLLSIDDLEGAQETDVDTGLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 KSLFCLPTGGPSLASSAEPQWFSNTGAPGHRASEWRHGHLLSIDDLEGAQETDVDTGLRL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 SSSDLSVVSAYSAPSRFCSTVETPLPSERCSSHWAAHKDSREGPLPTVSRVTTEASWASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SSSDLSVVSAYSAPSRFCSTVETPLPSERCSSHWAAHKDSREGPLPTVSRVTTEASWASL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 PFFTKRSSSSSATARAAPPAPSTSTLTDSSPQLPCDTPKVKQTDGDMPPPPGSAGPGDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 PFFTKRSSSSSATARAAPPAPSTSTLTDSSPQLPCDTPKVKQTDGDMPPPPGSAGPGDND 490 500 510 520 530 540 pF1KB6 MEEFYI :::::: CCDS55 MEEFYI >>CCDS9427.1 FAM124A gene_id:220108|Hs108|chr13 (582 aa) initn: 3588 init1: 3588 opt: 3588 Z-score: 2667.6 bits: 503.5 E(32554): 2.9e-142 Smith-Waterman score: 3699; 93.6% identity (93.8% similar) in 578 aa overlap (5-546:5-582) 10 20 30 pF1KB6 MDPKAGGGGEEDDCVDSGAETGGSDYSHLSSTSS-------------------------- :::::::::::::::::::::::::::::. CCDS94 MDPKAGGGGEEDDCVDSGAETGGSDYSHLSSTSNGFSTWRMPCCLFLYCTHGDKEKGRWS 10 20 30 40 50 60 40 50 60 70 80 pF1KB6 ----------ELSVEEAQDPFLVSIHIIADPGESQPLQEAIDNVLAWIHPDLPLFRVSER :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 LQVEHTWPSGELSVEEAQDPFLVSIHIIADPGESQPLQEAIDNVLAWIHPDLPLFRVSER 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB6 RASRRRRKPPKGAQPALAVVLFLQEEYGEEQILQLHRTLQQPPWRHHHTEQVHGRFLPYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 RASRRRRKPPKGAQPALAVVLFLQEEYGEEQILQLHRTLQQPPWRHHHTEQVHGRFLPYL 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB6 PCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRYDNYADSLRFYQLILRRSPSQKKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 PCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRYDNYADSLRFYQLILRRSPSQKKAD 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB6 FCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLEFRVRDIGELVPLLPNPCSPISEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 FCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLEFRVRDIGELVPLLPNPCSPISEGR 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB6 WQTEDHDGNKILLQAQRVHKKFPKPGRVHHASEKKRHSTPLPSTAVPSHTPGSSQQSPLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 WQTEDHDGNKILLQAQRVHKKFPKPGRVHHASEKKRHSTPLPSTAVPSHTPGSSQQSPLN 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB6 SPHPGPIRTGLPPGHQQEFAGRANSTPNPPWSFQRSKSLFCLPTGGPSLASSAEPQWFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 SPHPGPIRTGLPPGHQQEFAGRANSTPNPPWSFQRSKSLFCLPTGGPSLASSAEPQWFSN 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB6 TGAPGHRASEWRHGHLLSIDDLEGAQETDVDTGLRLSSSDLSVVSAYSAPSRFCSTVETP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 TGAPGHRASEWRHGHLLSIDDLEGAQETDVDTGLRLSSSDLSVVSAYSAPSRFCSTVETP 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB6 LPSERCSSHWAAHKDSREGPLPTVSRVTTEASWASLPFFTKRSSSSSATARAAPPAPSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS94 LPSERCSSHWAAHKDSREGPLPTVSRVTTEASWASLPFFTKRSSSSSATARAAPPAPSTS 490 500 510 520 530 540 510 520 530 540 pF1KB6 TLTDSSPQLPCDTPKVKQTDGDMPPPPGSAGPGDNDMEEFYI :::::::::::::::::::::::::::::::::::::::::: CCDS94 TLTDSSPQLPCDTPKVKQTDGDMPPPPGSAGPGDNDMEEFYI 550 560 570 580 >>CCDS81767.1 FAM124A gene_id:220108|Hs108|chr13 (301 aa) initn: 1945 init1: 1945 opt: 1945 Z-score: 1455.6 bits: 278.2 E(32554): 9.3e-75 Smith-Waterman score: 1945; 100.0% identity (100.0% similar) in 278 aa overlap (1-278:1-278) 10 20 30 40 50 60 pF1KB6 MDPKAGGGGEEDDCVDSGAETGGSDYSHLSSTSSELSVEEAQDPFLVSIHIIADPGESQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MDPKAGGGGEEDDCVDSGAETGGSDYSHLSSTSSELSVEEAQDPFLVSIHIIADPGESQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LQEAIDNVLAWIHPDLPLFRVSERRASRRRRKPPKGAQPALAVVLFLQEEYGEEQILQLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LQEAIDNVLAWIHPDLPLFRVSERRASRRRRKPPKGAQPALAVVLFLQEEYGEEQILQLH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RTLQQPPWRHHHTEQVHGRFLPYLPCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 RTLQQPPWRHHHTEQVHGRFLPYLPCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DNYADSLRFYQLILRRSPSQKKADFCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 DNYADSLRFYQLILRRSPSQKKADFCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 FRVRDIGELVPLLPNPCSPISEGRWQTEDHDGNKILLQAQRVHKKFPKPGRVHHASEKKR :::::::::::::::::::::::::::::::::::::: CCDS81 FRVRDIGELVPLLPNPCSPISEGRWQTEDHDGNKILLQVLGGRLSVCLGDLRNQLALPQT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 HSTPLPSTAVPSHTPGSSQQSPLNSPHPGPIRTGLPPGHQQEFAGRANSTPNPPWSFQRS CCDS81 L >>CCDS46527.1 FAM124B gene_id:79843|Hs108|chr2 (455 aa) initn: 822 init1: 652 opt: 761 Z-score: 576.5 bits: 116.2 E(32554): 8.6e-26 Smith-Waterman score: 779; 34.5% identity (64.1% similar) in 443 aa overlap (38-466:1-419) 10 20 30 40 50 60 pF1KB6 GGEEDDCVDSGAETGGSDYSHLSSTSSELSVEEAQDPFLVSIHIIADPGESQPLQEAIDN ..:.: :. ...:..:. :... ::...:. CCDS46 MDETQGPLAMTVHLLANSGHGSLLQRTLDQ 10 20 30 70 80 90 100 110 120 pF1KB6 VLAWIHPDLPLFRVSERRASRR---RRKPPKGAQPALAVVLFLQEEYGEEQILQLHRTLQ .: : :.. ::.:::: . . . . .. :...:.:::.: ::...... .:: CCDS46 LLDCICPEVRLFQVSERASPVKYCEKSHSKRSRFPGMSVLLFLHESPGEDRLFRVLDSLQ 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 QPPWRHHHTEQVHGRFLPYLPCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRYDNYA . ::. . :....::. ::. .:.:..: :.:..: :: :.::.: :.:: .::: CCDS46 HSPWQCYPTQDTRGRLCPYFFANQEFYSLDSQLPIWGVRQVHCGSEILRVTLYCSFDNYE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 DSLRFYQLILRRSPSQKKADFCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLEFRVR :..:.:..::.: . .:..::.: .... . .:.:::.:: . : .::::.:.:. CCDS46 DAIRLYEMILQREATLQKSNFCFFVLYASKSFALQLSLKQLPPGMSVDPKESSVLQFKVQ 160 170 180 190 200 210 250 260 270 280 290 pF1KB6 DIGELVPLLPNPCSPISEGRWQTEDHDGNKILLQAQR-----VHKKFPKPGRVHHASEKK .::.::::::::: ::: ::::.:.::::::::.: :.. . : . .:. CCDS46 EIGQLVPLLPNPCMPISSTRWQTQDYDGNKILLQVQLNPELGVKNGILGAGMLPLGSRLT 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB6 RHSTPLPSTAVPSHTPGS-SQQSPLNSPHPGPIRTGLPPGHQQEFAGRANSTPNPPWSFQ :. : ... :. :: :. :.: .: : . .. :: .: .: ::: CCDS46 SVSAKRTSEPRSQRNQGKRSQGHSLELPEP----SGSPTS--DRCAG--TSWKSPGRSFQ 280 290 300 310 320 360 370 380 390 400 410 pF1KB6 RSKSLFCLPTGGPSLASSAEPQWFSNTGAPGHRASEWRHGHLLSIDDLEGAQETDVDTGL :. :. : : : :. : : . . . :.. ::. ::.::::: CCDS46 VSS-----PAMGAHLHLS------SHHLESGARMKVLNREN--SFQKLEA--ETNVDTGL 330 340 350 360 420 430 440 450 460 470 pF1KB6 RLSSSDLSVVSAYSAPSRFCSTVETPLPSERCSSHWAAHKDS-----REGPLPTVSRVTT . .:. . ... : .: . :. : :. :.. : .::: CCDS46 TIINSE-PRQTYFGGFPRDLQTSQPPFCLPASSLGVATSKNNSVLKERVSPLPLAGQRDL 370 380 390 400 410 420 480 490 500 510 520 530 pF1KB6 EASWASLPFFTKRSSSSSATARAAPPAPSTSTLTDSSPQLPCDTPKVKQTDGDMPPPPGS CCDS46 GTRKTISECLLHLQVQGEEKEEDEEEFFI 430 440 450 >>CCDS2461.1 FAM124B gene_id:79843|Hs108|chr2 (272 aa) initn: 756 init1: 645 opt: 753 Z-score: 573.9 bits: 114.9 E(32554): 1.2e-25 Smith-Waterman score: 753; 40.6% identity (74.9% similar) in 271 aa overlap (38-302:1-269) 10 20 30 40 50 60 pF1KB6 GGEEDDCVDSGAETGGSDYSHLSSTSSELSVEEAQDPFLVSIHIIADPGESQPLQEAIDN ..:.: :. ...:..:. :... ::...:. CCDS24 MDETQGPLAMTVHLLANSGHGSLLQRTLDQ 10 20 30 70 80 90 100 110 120 pF1KB6 VLAWIHPDLPLFRVSERRASRR---RRKPPKGAQPALAVVLFLQEEYGEEQILQLHRTLQ .: : :.. ::.:::: . . . . .. :...:.:::.: ::...... .:: CCDS24 LLDCICPEVRLFQVSERASPVKYCEKSHSKRSRFPGMSVLLFLHESPGEDRLFRVLDSLQ 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 QPPWRHHHTEQVHGRFLPYLPCSQDFFTLAPGTPLWAIRPVHYGKEIVRFTVYCRYDNYA . ::. . :....::. ::. .:.:..: :.:..: :: :.::.: :.:: .::: CCDS24 HSPWQCYPTQDTRGRLCPYFFANQEFYSLDSQLPIWGVRQVHCGSEILRVTLYCSFDNYE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 DSLRFYQLILRRSPSQKKADFCIFPIFSNLDVDIQFSLKRLPCDQCPVPTDSSVLEFRVR :..:.:..::.: . .:..::.: .... . .:.:::.:: . : .::::.:.:. CCDS24 DAIRLYEMILQREATLQKSNFCFFVLYASKSFALQLSLKQLPPGMSVDPKESSVLQFKVQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 DIGELVPLLPNPCSPISEGRWQTEDHDGNKILLQAQRVHKKFPKPGRV---HHASEKKRH .::.::::::::: ::: ::::.:.:::::::: : ... :: ::.: .. CCDS24 EIGQLVPLLPNPCMPISSTRWQTQDYDGNKILLQ--RWESSSVAQTRVRWCHHSSLRSSP 220 230 240 250 260 310 320 330 340 350 360 pF1KB6 STPLPSTAVPSHTPGSSQQSPLNSPHPGPIRTGLPPGHQQEFAGRANSTPNPPWSFQRSK : CCDS24 SGFK 270 546 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:56:03 2016 done: Sat Nov 5 10:56:04 2016 Total Scan time: 4.170 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]