Result of FASTA (omim) for
pF1KB6123
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6123, 586 aa
1>>>pF1KB6123 586 - 586 aa - 586 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1481+/-0.000361; mu= 19.8563+/- 0.022
mean_var=68.5185+/-13.655, 0's: 0 Z-trim(113.0): 27 B-trim: 1062 in 1/53
Lambda= 0.154942
statistics sampled from 22143 (22168) to 22143 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.26), width: 16
Scan time: 8.890
The best scores are: opt bits E(85289)
NP_004066 (OMIM: 601933) cryptochrome-1 [Homo sapi ( 586) 4079 921.2 0
XP_016874321 (OMIM: 601933) PREDICTED: cryptochrom ( 558) 3700 836.5 0
NP_066940 (OMIM: 603732) cryptochrome-2 isoform 1 ( 614) 2978 675.1 1.8e-193
NP_001120929 (OMIM: 603732) cryptochrome-2 isoform ( 532) 2690 610.7 3.9e-174
>>NP_004066 (OMIM: 601933) cryptochrome-1 [Homo sapiens] (586 aa)
initn: 4079 init1: 4079 opt: 4079 Z-score: 4924.6 bits: 921.2 E(85289): 0
Smith-Waterman score: 4079; 100.0% identity (100.0% similar) in 586 aa overlap (1-586:1-586)
10 20 30 40 50 60
pF1KB6 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 DLDANLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DLDANLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 GVEVIVRISHTLYDLDKIIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GVEVIVRISHTLYDLDKIIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 PLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 ANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 TNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 VACFLTRGDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VACFLTRGDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 RTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 IERMKQIYQQLSRYRGLGLLASVPSNPNGNGGFMGYSAENIPGCSSSGSCSQGSGILHYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IERMKQIYQQLSRYRGLGLLASVPSNPNGNGGFMGYSAENIPGCSSSGSCSQGSGILHYA
490 500 510 520 530 540
550 560 570 580
pF1KB6 HGDSQQTHLLKQGRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN
::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HGDSQQTHLLKQGRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN
550 560 570 580
>>XP_016874321 (OMIM: 601933) PREDICTED: cryptochrome-1 (558 aa)
initn: 3700 init1: 3700 opt: 3700 Z-score: 4467.1 bits: 836.5 E(85289): 0
Smith-Waterman score: 3700; 99.6% identity (99.6% similar) in 537 aa overlap (50-586:22-558)
20 30 40 50 60 70
pF1KB6 ALKECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQ
: :::::::::::::::::::::::::::
XP_016 MMIIFHKMMASYSNTTYWIISNSVRFLLQCLEDLDANLRKLNSRLFVIRGQ
10 20 30 40 50
80 90 100 110 120 130
pF1KB6 PADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKII
60 70 80 90 100 110
140 150 160 170 180 190
pF1KB6 ELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEELG
120 130 140 150 160 170
200 210 220 230 240 250
pF1KB6 FDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGC
180 190 200 210 220 230
260 270 280 290 300 310
pF1KB6 LSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIP
240 250 260 270 280 290
320 330 340 350 360 370
pF1KB6 WDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK
300 310 320 330 340 350
380 390 400 410 420 430
pF1KB6 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGF
360 370 380 390 400 410
440 450 460 470 480 490
pF1KB6 PAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGL
420 430 440 450 460 470
500 510 520 530 540 550
pF1KB6 LASVPSNPNGNGGFMGYSAENIPGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASVPSNPNGNGGFMGYSAENIPGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGT
480 490 500 510 520 530
560 570 580
pF1KB6 GLSGGKRPSQEEDTQSIGPKVQRQSTN
:::::::::::::::::::::::::::
XP_016 GLSGGKRPSQEEDTQSIGPKVQRQSTN
540 550
>>NP_066940 (OMIM: 603732) cryptochrome-2 isoform 1 [Hom (614 aa)
initn: 2976 init1: 2976 opt: 2978 Z-score: 3594.3 bits: 675.1 E(85289): 1.8e-193
Smith-Waterman score: 2978; 74.8% identity (89.3% similar) in 563 aa overlap (4-566:44-600)
10 20 30
pF1KB6 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRC
..:::::::::::::::: ..:: .::
NP_066 VAGAVWTVMAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPALLAAVRGARCVRC
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 VYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFKEWNI
:::::::::.::.::::::::::: :::::..::::::::::.:::::::::::::::..
NP_066 VYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGV
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB6 TKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIIELNGGQPPLTYKRF
:.:..::::::::::::::: :.: ::::::... ::::::::.:::::: .::::::::
NP_066 TRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKRF
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB6 QTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGG
:..::.:: . :: .::. .:.: . ....::: ::::::::::: :.::. ::: ::
NP_066 QAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQGG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB6 ETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLY
:::::.::..::::::::::.::::::::::::::::::::::::::::::::..: :::
NP_066 ETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLY
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB6 KKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEG
::::.::.:::::.::::::::::::::::::::.:::::::.:::::.:::::::::::
NP_066 KKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEG
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB6 RTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSIN
.:::::::::::::::::::::::::::::::::::::.::: :..::.:::::::.:.:
NP_066 KTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVFDELLLDADFSVN
380 390 400 410 420 430
400 410 420 430 440 450
pF1KB6 AGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEG
::::::::::.::::::::::::::::::::.::::::::: :..::..:::.::::::.
NP_066 AGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPSRYIYEPWNAPES
440 450 460 470 480 490
460 470 480 490 500 510
pF1KB6 IQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLASVPSNPNGNGGF
:::.:::.:::.::.:.:::::.::::::::::::::::::::: ::::::: . .
NP_066 IQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVED---L
500 510 520 530 540 550
520 530 540 550 560 570
pF1KB6 MGYSAENIPGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGTGLSGGKRPSQEEDT
:: :. :..:: :. .: : .. . :. .. : :: :
NP_066 SHPVAE--PSSSQAGSMSS-AGPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTP
560 570 580 590 600
580
pF1KB6 QSIGPKVQRQSTN
NP_066 ELPSKDA
610
>>NP_001120929 (OMIM: 603732) cryptochrome-2 isoform 2 [ (532 aa)
initn: 2685 init1: 2685 opt: 2690 Z-score: 3247.2 bits: 610.7 E(85289): 3.9e-174
Smith-Waterman score: 2690; 74.2% identity (89.5% similar) in 515 aa overlap (52-566:11-518)
30 40 50 60 70 80
pF1KB6 KECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPA
: :::: :::::..::::::::::.:::::
NP_001 MPAPPGRTHTW-FLLQSLEDLDTSLRKLNSRLFVVRGQPA
10 20 30
90 100 110 120 130 140
pF1KB6 DVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIIEL
::::::::::..:.:..::::::::::::::: :.: ::::::... ::::::::.::::
NP_001 DVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIEL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 NGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEELGFD
:: .:::::::::..::.:: . :: .::. .:.: . ....::: :::::::::::
NP_001 NGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFP
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB6 TDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLS
:.::. ::: :::::::.::..::::::::::.:::::::::::::::::::::::::::
NP_001 TEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLS
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB6 CRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWD
:::::..: :::::::.::.:::::.::::::::::::::::::::.:::::::.:::::
NP_001 CRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWD
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB6 KNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVF
.:::::::::::.:::::::::::::::::::::::::::::::::::::.::: :..::
NP_001 RNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVF
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB6 EELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPA
.:::::::.:.:::::::::::.::::::::::::::::::::.::::::::: :..::.
NP_001 DELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPS
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB6 KYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLA
.:::.::::::.:::.:::.:::.::.:.:::::.::::::::::::::::::::: :::
NP_001 RYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLA
400 410 420 430 440 450
510 520 530 540 550 560
pF1KB6 SVPSNPNGNGGFMGYSAENIPGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGTGL
:::: . ... . . :. :..:: :. .: : .. . :. .. : :
NP_001 SVPSCVED----LSHPVAE-PSSSQAGSMSS-AGPRPLPSGPASPKRKLEAAEEPPGEEL
460 470 480 490 500 510
570 580
pF1KB6 SGGKRPSQEEDTQSIGPKVQRQSTN
: :
NP_001 SKRARVAELPTPELPSKDA
520 530
586 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:58:05 2016 done: Sat Nov 5 10:58:06 2016
Total Scan time: 8.890 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]