FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6135, 592 aa 1>>>pF1KB6135 592 - 592 aa - 592 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.4918+/-0.000635; mu= -12.1072+/- 0.038 mean_var=639.5516+/-140.378, 0's: 0 Z-trim(116.5): 1570 B-trim: 36 in 1/56 Lambda= 0.050715 statistics sampled from 25592 (27735) to 25592 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.68), E-opt: 0.2 (0.325), width: 16 Scan time: 9.490 The best scores are: opt bits E(85289) NP_002735 (OMIM: 176982) protein kinase C zeta typ ( 592) 4089 315.6 3e-85 XP_016857279 (OMIM: 176982) PREDICTED: protein kin ( 600) 4063 313.7 1.1e-84 XP_011540075 (OMIM: 176982) PREDICTED: protein kin ( 595) 3652 283.6 1.3e-75 XP_016857278 (OMIM: 176982) PREDICTED: protein kin ( 603) 3626 281.7 4.8e-75 NP_001229803 (OMIM: 176982) protein kinase C zeta ( 488) 3313 258.7 3.3e-68 XP_016857280 (OMIM: 176982) PREDICTED: protein kin ( 510) 3299 257.7 7e-68 NP_002731 (OMIM: 600539) protein kinase C iota typ ( 596) 2960 233.0 2.2e-60 XP_011540076 (OMIM: 176982) PREDICTED: protein kin ( 491) 2876 226.7 1.4e-58 XP_016857288 (OMIM: 176982) PREDICTED: protein kin ( 409) 2768 218.7 3e-56 NP_001028754 (OMIM: 176982) protein kinase C zeta ( 409) 2768 218.7 3e-56 NP_001028753 (OMIM: 176982) protein kinase C zeta ( 409) 2768 218.7 3e-56 XP_016857290 (OMIM: 176982) PREDICTED: protein kin ( 405) 2743 216.9 1.1e-55 XP_016857287 (OMIM: 176982) PREDICTED: protein kin ( 417) 2742 216.8 1.1e-55 XP_016857285 (OMIM: 176982) PREDICTED: protein kin ( 417) 2742 216.8 1.1e-55 XP_016857294 (OMIM: 176982) PREDICTED: protein kin ( 355) 2407 192.2 2.5e-48 XP_016857293 (OMIM: 176982) PREDICTED: protein kin ( 355) 2407 192.2 2.5e-48 XP_011540078 (OMIM: 176982) PREDICTED: protein kin ( 412) 2331 186.7 1.3e-46 XP_011540080 (OMIM: 176982) PREDICTED: protein kin ( 412) 2331 186.7 1.3e-46 XP_016862349 (OMIM: 600539) PREDICTED: protein kin ( 464) 2331 186.8 1.4e-46 XP_016857289 (OMIM: 176982) PREDICTED: protein kin ( 408) 2306 184.9 4.5e-46 XP_016857284 (OMIM: 176982) PREDICTED: protein kin ( 420) 2305 184.8 4.9e-46 XP_016857283 (OMIM: 176982) PREDICTED: protein kin ( 420) 2305 184.8 4.9e-46 XP_016857282 (OMIM: 176982) PREDICTED: protein kin ( 420) 2305 184.8 4.9e-46 XP_016857281 (OMIM: 176982) PREDICTED: protein kin ( 420) 2305 184.8 4.9e-46 XP_016857286 (OMIM: 176982) PREDICTED: protein kin ( 416) 2280 183.0 1.7e-45 XP_016857292 (OMIM: 176982) PREDICTED: protein kin ( 358) 2266 181.9 3.2e-45 XP_011540077 (OMIM: 176982) PREDICTED: protein kin ( 416) 2260 181.5 4.7e-45 XP_016857291 (OMIM: 176982) PREDICTED: protein kin ( 358) 1970 160.2 1.1e-38 XP_011531285 (OMIM: 176975) PREDICTED: protein kin ( 436) 1271 109.2 3e-23 XP_006712113 (OMIM: 176975) PREDICTED: protein kin ( 460) 1271 109.2 3e-23 XP_011531284 (OMIM: 176975) PREDICTED: protein kin ( 497) 1271 109.3 3.2e-23 XP_016859979 (OMIM: 176975) PREDICTED: protein kin ( 587) 1271 109.4 3.5e-23 XP_016859980 (OMIM: 176975) PREDICTED: protein kin ( 587) 1271 109.4 3.5e-23 XP_011531282 (OMIM: 176975) PREDICTED: protein kin ( 587) 1271 109.4 3.5e-23 XP_011531283 (OMIM: 176975) PREDICTED: protein kin ( 587) 1271 109.4 3.5e-23 XP_016859978 (OMIM: 176975) PREDICTED: protein kin ( 587) 1271 109.4 3.5e-23 XP_016859977 (OMIM: 176975) PREDICTED: protein kin ( 623) 1271 109.4 3.6e-23 XP_011531280 (OMIM: 176975) PREDICTED: protein kin ( 623) 1271 109.4 3.6e-23 XP_016859976 (OMIM: 176975) PREDICTED: protein kin ( 623) 1271 109.4 3.6e-23 XP_011531277 (OMIM: 176975) PREDICTED: protein kin ( 641) 1271 109.4 3.7e-23 XP_016859975 (OMIM: 176975) PREDICTED: protein kin ( 641) 1271 109.4 3.7e-23 XP_011531273 (OMIM: 176975) PREDICTED: protein kin ( 641) 1271 109.4 3.7e-23 XP_005264485 (OMIM: 176975) PREDICTED: protein kin ( 737) 1271 109.5 4e-23 NP_005391 (OMIM: 176975) protein kinase C epsilon ( 737) 1271 109.5 4e-23 NP_997700 (OMIM: 176970) protein kinase C beta typ ( 671) 1226 106.2 3.7e-22 XP_016876947 (OMIM: 601367,605437) PREDICTED: prot ( 522) 1193 103.6 1.7e-21 XP_011535257 (OMIM: 601367,605437) PREDICTED: prot ( 603) 1193 103.7 1.9e-21 XP_011535256 (OMIM: 601367,605437) PREDICTED: prot ( 604) 1193 103.7 1.9e-21 NP_006246 (OMIM: 601367,605437) protein kinase C e ( 683) 1193 103.8 2e-21 XP_016880329 (OMIM: 176960) PREDICTED: protein kin ( 586) 1120 98.3 7.4e-20 >>NP_002735 (OMIM: 176982) protein kinase C zeta type is (592 aa) initn: 4089 init1: 4089 opt: 4089 Z-score: 1651.4 bits: 315.6 E(85289): 3e-85 Smith-Waterman score: 4089; 100.0% identity (100.0% similar) in 592 aa overlap (1-592:1-592) 10 20 30 40 50 60 pF1KB6 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT 490 500 510 520 530 540 550 560 570 580 590 pF1KB6 DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 550 560 570 580 590 >>XP_016857279 (OMIM: 176982) PREDICTED: protein kinase (600 aa) initn: 2265 init1: 2265 opt: 4063 Z-score: 1641.1 bits: 313.7 E(85289): 1.1e-84 Smith-Waterman score: 4063; 98.7% identity (98.7% similar) in 600 aa overlap (1-592:1-600) 10 20 30 40 50 60 pF1KB6 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 KHVFEQASSNPFLVGLHSCFQTTSRL--------FLVIEYVNGGDLMFHMQRQRKLPEEH :::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_016 KHVFEQASSNPFLVGLHSCFQTTSRLRRLSPCRLFLVIEYVNGGDLMFHMQRQRKLPEEH 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB6 ARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB6 GTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILE 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB6 KPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQAL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB6 PPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 550 560 570 580 590 600 >>XP_011540075 (OMIM: 176982) PREDICTED: protein kinase (595 aa) initn: 3652 init1: 3652 opt: 3652 Z-score: 1478.6 bits: 283.6 E(85289): 1.3e-75 Smith-Waterman score: 3652; 99.2% identity (100.0% similar) in 529 aa overlap (1-529:1-529) 10 20 30 40 50 60 pF1KB6 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT :::::::::::::::::::::::::::::::::::::::::::::.... XP_011 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLMHRQLRCTDARTTWT 490 500 510 520 530 540 550 560 570 580 590 pF1KB6 DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV XP_011 PRRCGRTDDMDAQTMWMHGRRRHTDDSSTDDSDARTPRRRGRTDDADAQMTWTHR 550 560 570 580 590 >>XP_016857278 (OMIM: 176982) PREDICTED: protein kinase (603 aa) initn: 3650 init1: 2265 opt: 3626 Z-score: 1468.3 bits: 281.7 E(85289): 4.8e-75 Smith-Waterman score: 3626; 97.8% identity (98.5% similar) in 537 aa overlap (1-529:1-537) 10 20 30 40 50 60 pF1KB6 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 KHVFEQASSNPFLVGLHSCFQTTSRL--------FLVIEYVNGGDLMFHMQRQRKLPEEH :::::::::::::::::::::::::: :::::::::::::::::::::::::: XP_016 KHVFEQASSNPFLVGLHSCFQTTSRLRRLSPCRLFLVIEYVNGGDLMFHMQRQRKLPEEH 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB6 ARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB6 GTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILE 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB6 KPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::.... XP_016 KPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLMHRQLRC 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB6 PPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV XP_016 TDARTTWTPRRCGRTDDMDAQTMWMHGRRRHTDDSSTDDSDARTPRRRGRTDDADAQMTW 550 560 570 580 590 600 >>NP_001229803 (OMIM: 176982) protein kinase C zeta type (488 aa) initn: 3313 init1: 3313 opt: 3313 Z-score: 1345.5 bits: 258.7 E(85289): 3.3e-68 Smith-Waterman score: 3313; 99.4% identity (99.6% similar) in 485 aa overlap (108-592:4-488) 80 90 100 110 120 130 pF1KB6 EAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKR : :.::::::::::::::::::::::::: NP_001 MLTPRTDESIYRRGARRWRKLYRANGHLFQAKR 10 20 30 140 150 160 170 180 190 pF1KB6 FNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDD 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 KNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRV 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB6 IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLH 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB6 SCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDL 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB6 KLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWAL 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB6 GVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDP 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB6 KERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPV 400 410 420 430 440 450 560 570 580 590 pF1KB6 QLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV ::::::::::::::::::::::::::::::::::: NP_001 QLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 460 470 480 >>XP_016857280 (OMIM: 176982) PREDICTED: protein kinase (510 aa) initn: 3299 init1: 3299 opt: 3299 Z-score: 1339.7 bits: 257.7 E(85289): 7e-68 Smith-Waterman score: 3299; 99.8% identity (100.0% similar) in 481 aa overlap (112-592:30-510) 90 100 110 120 130 140 pF1KB6 LARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRR .::::::::::::::::::::::::::::: XP_016 MCTAHSIGVLGWWRGAGLRRPVFYSEMVGESIYRRGARRWRKLYRANGHLFQAKRFNRR 10 20 30 40 50 150 160 170 180 190 200 pF1KB6 AYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNED 60 70 80 90 100 110 210 220 230 240 250 260 pF1KB6 ADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRG 120 130 140 150 160 170 270 280 290 300 310 320 pF1KB6 SYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQ 180 190 200 210 220 230 330 340 350 360 370 380 pF1KB6 TTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDN 240 250 260 270 280 290 390 400 410 420 430 440 pF1KB6 VLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLM 300 310 320 330 340 350 450 460 470 480 490 500 pF1KB6 FEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERL 360 370 380 390 400 410 510 520 530 540 550 560 pF1KB6 GCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTP 420 430 440 450 460 470 570 580 590 pF1KB6 DDEDAIKRIDQSEFEGFEYINPLLLSTEESV ::::::::::::::::::::::::::::::: XP_016 DDEDAIKRIDQSEFEGFEYINPLLLSTEESV 480 490 500 510 >>NP_002731 (OMIM: 600539) protein kinase C iota type [H (596 aa) initn: 2917 init1: 1317 opt: 2960 Z-score: 1205.0 bits: 233.0 E(85289): 2.2e-60 Smith-Waterman score: 2960; 72.8% identity (88.5% similar) in 589 aa overlap (11-592:18-596) 10 20 30 40 50 pF1KB6 MPSRTGPKMEGSGG---RVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRL ::: .::.::.: :::.:: . . .:: ::.:::::: . NP_002 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 HQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGE ... .:.::.: ::::::::::.:::::::: . .: :.::::: .::.::.::::: NP_002 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 DKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHK :::::::::::::::: :::: ::::::::::.:. :..:::::.::::.:::::::::: NP_002 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK 130 140 150 160 170 180 180 190 200 210 220 pF1KB6 RCHGLVPLTCRKHMDSVMPSQEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDS .:: :: . : .: .: ::: :.:... .: . : : :: :.:. . . NP_002 KCHKLVTIECGRH---SLP-QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVG 190 200 210 220 230 230 240 250 260 270 280 pF1KB6 EDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELV :. : ... .. : :..::::::::.::::::::::::::::::.:.:::::::::::: NP_002 EE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELV 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 HDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKL .:::::::::::::::::::..:::::::::::: ::::.:::::::::::::::::::: NP_002 NDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB6 PEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT ::::::::.::: .:::.:::::::::::::::::::..::::::::::::::: ::::: NP_002 PEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB6 STFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYL ::::::::::::::::::.::::::::::::::::::::::::::. .::::.:::::: NP_002 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYL 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB6 FQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLL ::::::: ::::: :::::. :::.::::::::::::.:::::.::..: :::..:::.. NP_002 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMM 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB6 EKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL :.::..:::.:.:. ..::::::.:::.:::::::::.: ...::::::::::::::::. NP_002 EQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLM 540 550 560 570 580 590 590 pF1KB6 STEESV :.:: : NP_002 SAEECV >>XP_011540076 (OMIM: 176982) PREDICTED: protein kinase (491 aa) initn: 2861 init1: 2861 opt: 2876 Z-score: 1172.6 bits: 226.7 E(85289): 1.4e-58 Smith-Waterman score: 2876; 98.3% identity (99.5% similar) in 422 aa overlap (108-529:4-425) 80 90 100 110 120 130 pF1KB6 EAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKR : :.::::::::::::::::::::::::: XP_011 MLTPRTDESIYRRGARRWRKLYRANGHLFQAKR 10 20 30 140 150 160 170 180 190 pF1KB6 FNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDD 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 KNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRV 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB6 IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLH 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB6 SCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDL 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB6 KLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWAL 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB6 GVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDP 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB6 KERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPV ::::::::::::::::::::::::::::.... XP_011 KERLGCRPQTGFSDIKSHAFFRSIDWDLMHRQLRCTDARTTWTPRRCGRTDDMDAQTMWM 400 410 420 430 440 450 560 570 580 590 pF1KB6 QLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV XP_011 HGRRRHTDDSSTDDSDARTPRRRGRTDDADAQMTWTHR 460 470 480 490 >>XP_016857288 (OMIM: 176982) PREDICTED: protein kinase (409 aa) initn: 2768 init1: 2768 opt: 2768 Z-score: 1130.8 bits: 218.7 E(85289): 3e-56 Smith-Waterman score: 2768; 100.0% identity (100.0% similar) in 409 aa overlap (184-592:1-409) 160 170 180 190 200 210 pF1KB6 LARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIA :::::::::::::::::::::::::::::: XP_016 MDSVMPSQEPPVDDKNEDADLPSEETDGIA 10 20 30 220 230 240 250 260 270 pF1KB6 YISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKK 40 50 60 70 80 90 280 290 300 310 320 330 pF1KB6 NDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYV 100 110 120 130 140 150 340 350 360 370 380 390 pF1KB6 NGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLT 160 170 180 190 200 210 400 410 420 430 440 450 pF1KB6 DYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDI 220 230 240 250 260 270 460 470 480 490 500 510 pF1KB6 ITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK 280 290 300 310 320 330 520 530 540 550 560 570 pF1KB6 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS 340 350 360 370 380 390 580 590 pF1KB6 EFEGFEYINPLLLSTEESV ::::::::::::::::::: XP_016 EFEGFEYINPLLLSTEESV 400 >>NP_001028754 (OMIM: 176982) protein kinase C zeta type (409 aa) initn: 2768 init1: 2768 opt: 2768 Z-score: 1130.8 bits: 218.7 E(85289): 3e-56 Smith-Waterman score: 2768; 100.0% identity (100.0% similar) in 409 aa overlap (184-592:1-409) 160 170 180 190 200 210 pF1KB6 LARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIA :::::::::::::::::::::::::::::: NP_001 MDSVMPSQEPPVDDKNEDADLPSEETDGIA 10 20 30 220 230 240 250 260 270 pF1KB6 YISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKK 40 50 60 70 80 90 280 290 300 310 320 330 pF1KB6 NDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYV 100 110 120 130 140 150 340 350 360 370 380 390 pF1KB6 NGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLT 160 170 180 190 200 210 400 410 420 430 440 450 pF1KB6 DYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDI 220 230 240 250 260 270 460 470 480 490 500 510 pF1KB6 ITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK 280 290 300 310 320 330 520 530 540 550 560 570 pF1KB6 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS 340 350 360 370 380 390 580 590 pF1KB6 EFEGFEYINPLLLSTEESV ::::::::::::::::::: NP_001 EFEGFEYINPLLLSTEESV 400 592 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:56:14 2016 done: Fri Nov 4 21:56:15 2016 Total Scan time: 9.490 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]