FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6155, 597 aa 1>>>pF1KB6155 597 - 597 aa - 597 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0364+/-0.000326; mu= 11.9350+/- 0.020 mean_var=125.8406+/-25.680, 0's: 0 Z-trim(119.4): 34 B-trim: 557 in 2/55 Lambda= 0.114331 statistics sampled from 33285 (33319) to 33285 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.391), width: 16 Scan time: 10.910 The best scores are: opt bits E(85289) NP_055249 (OMIM: 606073) NADPH-dependent diflavin ( 597) 4103 688.0 2.3e-197 NP_001137500 (OMIM: 606073) NADPH-dependent diflav ( 590) 4030 676.0 9.8e-194 XP_016870116 (OMIM: 606073) PREDICTED: NADPH-depen ( 555) 3739 628.0 2.6e-179 XP_016870115 (OMIM: 606073) PREDICTED: NADPH-depen ( 564) 3584 602.4 1.3e-171 NP_001137498 (OMIM: 606073) NADPH-dependent diflav ( 606) 3581 601.9 2e-171 XP_011516849 (OMIM: 606073) PREDICTED: NADPH-depen ( 537) 3116 525.2 2.2e-148 NP_001137499 (OMIM: 606073) NADPH-dependent diflav ( 521) 2543 430.7 6.1e-120 XP_011516847 (OMIM: 606073) PREDICTED: NADPH-depen ( 572) 2385 404.6 4.6e-112 XP_011516850 (OMIM: 606073) PREDICTED: NADPH-depen ( 332) 1695 290.7 5.4e-78 NP_000932 (OMIM: 124015,201750,207410,613571) NADP ( 680) 946 167.3 1.5e-40 XP_011523164 (OMIM: 145500,163730,611162) PREDICTE ( 931) 676 122.9 4.9e-27 XP_011523162 (OMIM: 145500,163730,611162) PREDICTE (1152) 676 122.9 5.8e-27 XP_011523161 (OMIM: 145500,163730,611162) PREDICTE (1153) 676 122.9 5.8e-27 NP_000616 (OMIM: 145500,163730,611162) nitric oxid (1153) 676 122.9 5.8e-27 XP_016867722 (OMIM: 104300,145500,163729,189800,60 ( 997) 609 111.8 1.1e-23 NP_000594 (OMIM: 104300,145500,163729,189800,60136 (1203) 609 111.9 1.3e-23 XP_016867721 (OMIM: 104300,145500,163729,189800,60 (1203) 609 111.9 1.3e-23 NP_001191143 (OMIM: 163731) nitric oxide synthase, (1098) 599 110.2 3.7e-23 NP_001191142 (OMIM: 163731) nitric oxide synthase, (1098) 599 110.2 3.7e-23 XP_016874836 (OMIM: 163731) PREDICTED: nitric oxid (1434) 599 110.3 4.6e-23 NP_000611 (OMIM: 163731) nitric oxide synthase, br (1434) 599 110.3 4.6e-23 XP_016874834 (OMIM: 163731) PREDICTED: nitric oxid (1468) 599 110.3 4.7e-23 XP_011536700 (OMIM: 163731) PREDICTED: nitric oxid (1468) 599 110.3 4.7e-23 XP_016874835 (OMIM: 163731) PREDICTED: nitric oxid (1468) 599 110.3 4.7e-23 NP_001191147 (OMIM: 163731) nitric oxide synthase, (1468) 599 110.3 4.7e-23 XP_011523163 (OMIM: 145500,163730,611162) PREDICTE (1129) 513 96.0 7.1e-19 NP_002445 (OMIM: 236270,601634,602568) methionine ( 698) 271 56.0 5e-07 NP_076915 (OMIM: 236270,601634,602568) methionine ( 725) 271 56.0 5.1e-07 NP_001153582 (OMIM: 104300,145500,163729,189800,60 ( 614) 189 42.4 0.0053 XP_006716065 (OMIM: 104300,145500,163729,189800,60 ( 705) 185 41.8 0.0093 XP_016867723 (OMIM: 104300,145500,163729,189800,60 ( 751) 185 41.8 0.0098 >>NP_055249 (OMIM: 606073) NADPH-dependent diflavin oxid (597 aa) initn: 4103 init1: 4103 opt: 4103 Z-score: 3664.2 bits: 688.0 E(85289): 2.3e-197 Smith-Waterman score: 4103; 100.0% identity (100.0% similar) in 597 aa overlap (1-597:1-597) 10 20 30 40 50 60 pF1KB6 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD 490 500 510 520 530 540 550 560 570 580 590 pF1KB6 RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 550 560 570 580 590 >>NP_001137500 (OMIM: 606073) NADPH-dependent diflavin o (590 aa) initn: 2675 init1: 2675 opt: 4030 Z-score: 3599.2 bits: 676.0 E(85289): 9.8e-194 Smith-Waterman score: 4030; 98.8% identity (98.8% similar) in 597 aa overlap (1-597:1-590) 10 20 30 40 50 60 pF1KB6 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS ::::::::::::::::::::::::::::::: :::::::::::::::::::::: NP_001 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLL-------ILVAVVQFQTRLKEPRRGLCSS 370 380 390 400 410 430 440 450 460 470 480 pF1KB6 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB6 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD 480 490 500 510 520 530 550 560 570 580 590 pF1KB6 RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 540 550 560 570 580 590 >>XP_016870116 (OMIM: 606073) PREDICTED: NADPH-dependent (555 aa) initn: 3739 init1: 3739 opt: 3739 Z-score: 3340.1 bits: 628.0 E(85289): 2.6e-179 Smith-Waterman score: 3739; 100.0% identity (100.0% similar) in 542 aa overlap (1-542:1-542) 10 20 30 40 50 60 pF1KB6 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD 490 500 510 520 530 540 550 560 570 580 590 pF1KB6 RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA :: XP_016 RQATPSPCQRTSRKP 550 >>XP_016870115 (OMIM: 606073) PREDICTED: NADPH-dependent (564 aa) initn: 3581 init1: 3581 opt: 3584 Z-score: 3201.9 bits: 602.4 E(85289): 1.3e-171 Smith-Waterman score: 3711; 98.4% identity (98.4% similar) in 551 aa overlap (1-542:1-551) 10 20 30 40 50 60 pF1KB6 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 430 440 450 460 470 480 490 500 510 520 530 pF1KB6 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQ---------EQKVYVQHRLREL :::::::::::::::::::::::::::::::::::::: ::::::::::::: XP_016 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB6 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF ::::::::::: XP_016 GSLVWELLDRQATPSPCQRTSRKP 550 560 >>NP_001137498 (OMIM: 606073) NADPH-dependent diflavin o (606 aa) initn: 3581 init1: 3581 opt: 3581 Z-score: 3198.7 bits: 601.9 E(85289): 2e-171 Smith-Waterman score: 4075; 98.5% identity (98.5% similar) in 606 aa overlap (1-597:1-606) 10 20 30 40 50 60 pF1KB6 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 430 440 450 460 470 480 490 500 510 520 530 pF1KB6 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQ---------EQKVYVQHRLREL :::::::::::::::::::::::::::::::::::::: ::::::::::::: NP_001 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB6 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 550 560 570 580 590 600 pF1KB6 QTETWA :::::: NP_001 QTETWA >>XP_011516849 (OMIM: 606073) PREDICTED: NADPH-dependent (537 aa) initn: 3116 init1: 3116 opt: 3116 Z-score: 2785.0 bits: 525.2 E(85289): 2.2e-148 Smith-Waterman score: 3610; 98.3% identity (98.3% similar) in 537 aa overlap (70-597:1-537) 40 50 60 70 80 90 pF1KB6 LDSYPVVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGD :::::::::::::::::::::::::::::: XP_011 MKNFWRFIFRKNLPSTALCQMDFAVLGLGD 10 20 30 100 110 120 130 140 150 pF1KB6 SSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPP 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB6 PPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB6 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB6 EPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQ 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB6 EELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQI 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB6 LVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPG 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB6 TGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQ- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB6 --------EQKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEE :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PALFSALQEQKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEE 460 470 480 490 500 510 580 590 pF1KB6 GGLCSPDAAAYLARLQQTRRFQTETWA ::::::::::::::::::::::::::: XP_011 GGLCSPDAAAYLARLQQTRRFQTETWA 520 530 >>NP_001137499 (OMIM: 606073) NADPH-dependent diflavin o (521 aa) initn: 3461 init1: 2543 opt: 2543 Z-score: 2274.4 bits: 430.7 E(85289): 6.1e-120 Smith-Waterman score: 3397; 93.7% identity (93.7% similar) in 542 aa overlap (1-542:1-508) 10 20 30 40 50 60 pF1KB6 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF ::::::::::::::::: ::::::::: NP_001 GSALLPVCLGDDQHELG----------------------------------LPSKFTLLF 130 140 190 200 210 220 230 240 pF1KB6 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB6 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB6 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB6 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 330 340 350 360 370 380 430 440 450 460 470 480 pF1KB6 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 390 400 410 420 430 440 490 500 510 520 530 540 pF1KB6 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD 450 460 470 480 490 500 550 560 570 580 590 pF1KB6 RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA :: NP_001 RQATPSPCQRTSRKP 510 520 >>XP_011516847 (OMIM: 606073) PREDICTED: NADPH-dependent (572 aa) initn: 3303 init1: 2385 opt: 2385 Z-score: 2132.9 bits: 404.6 E(85289): 4.6e-112 Smith-Waterman score: 3733; 92.9% identity (92.9% similar) in 606 aa overlap (1-597:1-572) 10 20 30 40 50 60 pF1KB6 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF ::::::::::::::::: ::::::::: XP_011 GSALLPVCLGDDQHELG----------------------------------LPSKFTLLF 130 140 190 200 210 220 230 240 pF1KB6 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB6 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB6 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB6 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS 330 340 350 360 370 380 430 440 450 460 470 480 pF1KB6 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN 390 400 410 420 430 440 490 500 510 520 530 pF1KB6 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQ---------EQKVYVQHRLREL :::::::::::::::::::::::::::::::::::::: ::::::::::::: XP_011 FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLREL 450 460 470 480 490 500 540 550 560 570 580 590 pF1KB6 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRF 510 520 530 540 550 560 pF1KB6 QTETWA :::::: XP_011 QTETWA 570 >>XP_011516850 (OMIM: 606073) PREDICTED: NADPH-dependent (332 aa) initn: 1721 init1: 1695 opt: 1695 Z-score: 1521.3 bits: 290.7 E(85289): 5.4e-78 Smith-Waterman score: 2189; 97.3% identity (97.3% similar) in 332 aa overlap (275-597:1-332) 250 260 270 280 290 300 pF1KB6 GDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSHYLD :::::::::::::::::::::::::::::: XP_011 MLQPREPDVSSPTRLPQPCSMRHLVSHYLD 10 20 30 310 320 330 340 350 360 pF1KB6 IASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTA 40 50 60 70 80 90 370 380 390 400 410 420 pF1KB6 AAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSSWLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSSWLAS 100 110 120 130 140 150 430 440 450 460 470 480 pF1KB6 LDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNFLFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNFLFF 160 170 180 190 200 210 490 500 510 520 530 pF1KB6 GCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQ---------EQKVYVQHRLRELGSLV :::::::::::::::::::::::::::::::::: ::::::::::::::::: XP_011 GCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLRELGSLV 220 230 240 250 260 270 540 550 560 570 580 590 pF1KB6 WELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTET 280 290 300 310 320 330 pF1KB6 WA :: XP_011 WA >>NP_000932 (OMIM: 124015,201750,207410,613571) NADPH--c (680 aa) initn: 784 init1: 311 opt: 946 Z-score: 849.1 bits: 167.3 E(85289): 1.5e-40 Smith-Waterman score: 1049; 33.1% identity (64.0% similar) in 614 aa overlap (6-597:83-680) 10 20 30 pF1KB6 MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGC ..:..:::::::.. ..::...:.: : NP_000 EVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR--YGM 60 70 80 90 100 110 40 50 60 70 80 pF1KB6 RVQALDS--YPVVNL-----INEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLPSTALC : .. : : ...: :.. ::.: :: :.::: :: ..:. .. . .. : NP_000 RGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LS 120 130 140 150 160 90 100 110 120 130 140 pF1KB6 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD . :::.:::...: .:: ..: . .:: :::.. .. . ::::. .: : . : .. NP_000 GVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFIT--WREQ 170 180 190 200 210 220 150 160 170 180 190 200 pF1KB6 LWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF---LQEAPSTGSEGQRVAHPGSQEPPSE .: : . :. . .. :. .. : .: :. .:.:: . NP_000 FWPAVCEHF----GVEATGEESSI-RQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFD 230 240 250 260 270 280 210 220 230 240 250 260 pF1KB6 SK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQ .: :::: . .:.... .. . ..: :.:: : : . .:: : . :.:..: :... . NP_000 AKNPFLAAVTTNRKLNQGTERHLMHL-ELDISDSKIRYESGDHVAVYPANDSALVNQLGK 290 300 310 320 330 270 280 290 300 310 320 pF1KB6 VLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHE .:: : : .. :. . . .. .: : :.: ...::::.. :: . . :: . . NP_000 ILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEP 340 350 360 370 380 390 330 340 350 360 370 380 pF1KB6 LEREKL--LEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPR :.: : . ::..:.: . . . :: :: .: : : : :.: .:.: .. : NP_000 SEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRP--PIDHLCELLPRLQAR 400 410 420 430 440 450 390 400 410 420 430 pF1KB6 AFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSSWLASLDP-GQ--GPVRVPLWVR .::::: .::. ..: ..::...:. . .:. ..:: . .: :. : . ::..:: NP_000 YYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVR 460 470 480 490 500 510 440 450 460 470 480 490 pF1KB6 PGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN-----FLFFGCRWRDQDFY ... .: ::::::::::::::: . ::::. : :. .:..::: :.:. NP_000 KSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYL 520 530 540 550 560 570 500 510 520 530 540 550 pF1KB6 WEAEWQELEKRDCLT-LIPAFSREQEQKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAK .. : .... :: : :::::: .:::::: :.. .:.:.. ::..:. :.:. NP_000 YREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIE-GGAHIYVCGDAR 580 590 600 610 620 630 560 570 580 590 pF1KB6 SMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA .: ::......: : :.. .:. :. .:. :.. ..:. NP_000 NMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS 640 650 660 670 680 597 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:58:04 2016 done: Fri Nov 4 21:58:06 2016 Total Scan time: 10.910 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]