FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6164, 602 aa 1>>>pF1KB6164 602 - 602 aa - 602 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5850+/-0.000358; mu= 5.9626+/- 0.023 mean_var=198.8337+/-40.818, 0's: 0 Z-trim(121.1): 45 B-trim: 1914 in 2/56 Lambda= 0.090956 statistics sampled from 37201 (37246) to 37201 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.746), E-opt: 0.2 (0.437), width: 16 Scan time: 12.580 The best scores are: opt bits E(85289) NP_006236 (OMIM: 601646,616355) serine/threonine-p ( 602) 4007 538.3 2.8e-152 NP_851307 (OMIM: 601646,616355) serine/threonine-p ( 570) 3254 439.5 1.5e-122 NP_851308 (OMIM: 601646,616355) serine/threonine-p ( 496) 3230 436.3 1.2e-121 NP_001257405 (OMIM: 601646,616355) serine/threonin ( 451) 2984 404.0 5.7e-112 XP_005267877 (OMIM: 601645) PREDICTED: serine/thre ( 579) 2888 391.5 4.3e-108 XP_005267876 (OMIM: 601645) PREDICTED: serine/thre ( 584) 2888 391.5 4.3e-108 XP_005267879 (OMIM: 601645) PREDICTED: serine/thre ( 556) 2745 372.7 1.9e-102 NP_002710 (OMIM: 601645) serine/threonine-protein ( 524) 2737 371.6 3.7e-102 XP_011535220 (OMIM: 601645) PREDICTED: serine/thre ( 508) 2736 371.5 3.9e-102 XP_011535221 (OMIM: 601645) PREDICTED: serine/thre ( 508) 2736 371.5 3.9e-102 XP_011535216 (OMIM: 601645) PREDICTED: serine/thre ( 542) 2735 371.4 4.5e-102 NP_001155197 (OMIM: 601645) serine/threonine-prote ( 555) 2735 371.4 4.6e-102 XP_005267883 (OMIM: 601645) PREDICTED: serine/thre ( 500) 2733 371.1 5.1e-102 XP_011535218 (OMIM: 601645) PREDICTED: serine/thre ( 515) 2732 370.9 5.7e-102 XP_011535217 (OMIM: 601645) PREDICTED: serine/thre ( 515) 2732 370.9 5.7e-102 XP_011535223 (OMIM: 601645) PREDICTED: serine/thre ( 518) 2726 370.2 9.9e-102 NP_001155198 (OMIM: 601645) serine/threonine-prote ( 540) 2660 361.5 4.1e-99 XP_005267880 (OMIM: 601645) PREDICTED: serine/thre ( 545) 2660 361.5 4.2e-99 XP_005267881 (OMIM: 601645) PREDICTED: serine/thre ( 539) 2560 348.4 3.7e-95 NP_848701 (OMIM: 601645) serine/threonine-protein ( 485) 2509 341.7 3.5e-93 NP_848702 (OMIM: 601645) serine/threonine-protein ( 449) 2500 340.5 7.5e-93 XP_011535222 (OMIM: 601645) PREDICTED: serine/thre ( 449) 2493 339.5 1.4e-92 XP_005267884 (OMIM: 601645) PREDICTED: serine/thre ( 449) 2493 339.5 1.4e-92 XP_016876912 (OMIM: 601645) PREDICTED: serine/thre ( 479) 2409 328.5 3.1e-89 XP_016876911 (OMIM: 601645) PREDICTED: serine/thre ( 497) 2407 328.3 3.8e-89 XP_016876913 (OMIM: 601645) PREDICTED: serine/thre ( 410) 2265 309.6 1.3e-83 NP_006237 (OMIM: 601647) serine/threonine-protein ( 467) 2083 285.8 2.3e-76 NP_001269108 (OMIM: 601647) serine/threonine-prote ( 467) 2083 285.8 2.3e-76 NP_006234 (OMIM: 601643) serine/threonine-protein ( 486) 2063 283.1 1.5e-75 NP_001269109 (OMIM: 601647) serine/threonine-prote ( 462) 2053 281.8 3.5e-75 NP_006235 (OMIM: 601644) serine/threonine-protein ( 497) 2044 280.7 8.3e-75 XP_011543434 (OMIM: 601644) PREDICTED: serine/thre ( 468) 2019 277.4 7.7e-74 NP_001186685 (OMIM: 601643) serine/threonine-prote ( 429) 1997 274.4 5.3e-73 NP_001269110 (OMIM: 601647) serine/threonine-prote ( 391) 1901 261.8 3.1e-69 NP_001269111 (OMIM: 601647) serine/threonine-prote ( 391) 1901 261.8 3.1e-69 XP_011543436 (OMIM: 601644) PREDICTED: serine/thre ( 411) 1899 261.6 3.8e-69 XP_011543435 (OMIM: 601644) PREDICTED: serine/thre ( 411) 1899 261.6 3.8e-69 >>NP_006236 (OMIM: 601646,616355) serine/threonine-prote (602 aa) initn: 4007 init1: 4007 opt: 4007 Z-score: 2854.9 bits: 538.3 E(85289): 2.8e-152 Smith-Waterman score: 4007; 100.0% identity (100.0% similar) in 602 aa overlap (1-602:1-602) 10 20 30 40 50 60 pF1KB6 MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 LALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 LEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 VIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 RALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 FDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 AEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQE 550 560 570 580 590 600 pF1KB6 AL :: NP_006 AL >>NP_851307 (OMIM: 601646,616355) serine/threonine-prote (570 aa) initn: 3233 init1: 3233 opt: 3254 Z-score: 2321.3 bits: 439.5 E(85289): 1.5e-122 Smith-Waterman score: 3730; 94.7% identity (94.7% similar) in 602 aa overlap (1-602:1-570) 10 20 30 40 50 60 pF1KB6 MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQ :::::::::::::::::::::::: :::: NP_851 NSTPPPTQLSKIKYSGGPQIVKKE--------------------------------LFIQ 70 80 130 140 150 160 170 180 pF1KB6 KLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 KLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLF 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB6 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB6 LALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 LALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAEL 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB6 LEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 LEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEP 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB6 VIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 VIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAE 330 340 350 360 370 380 430 440 450 460 470 480 pF1KB6 RALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 RALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKL 390 400 410 420 430 440 490 500 510 520 530 540 pF1KB6 FDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 FDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPT 450 460 470 480 490 500 550 560 570 580 590 600 pF1KB6 AEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 AEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQE 510 520 530 540 550 560 pF1KB6 AL :: NP_851 AL 570 >>NP_851308 (OMIM: 601646,616355) serine/threonine-prote (496 aa) initn: 3230 init1: 3230 opt: 3230 Z-score: 2305.1 bits: 436.3 E(85289): 1.2e-121 Smith-Waterman score: 3230; 99.2% identity (100.0% similar) in 491 aa overlap (112-602:6-496) 90 100 110 120 130 140 pF1KB6 KKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKF ....:::::::::::::::::::::::::: NP_851 MPYKLKKEKELFIQKLRQCCVLFDFVSDPLSDLKF 10 20 30 150 160 170 180 190 200 pF1KB6 KEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 KEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEP 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB6 TLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 TLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTI 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB6 LHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 LHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKM 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB6 FLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 FLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFL 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB6 NELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 NELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAR 280 290 300 310 320 330 450 460 470 480 490 500 pF1KB6 VLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 VLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKE 340 350 360 370 380 390 510 520 530 540 550 560 pF1KB6 REEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 REEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKD 400 410 420 430 440 450 570 580 590 600 pF1KB6 IKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL ::::::::::::::::::::::::::::::::::::::::: NP_851 IKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL 460 470 480 490 >>NP_001257405 (OMIM: 601646,616355) serine/threonine-pr (451 aa) initn: 2984 init1: 2984 opt: 2984 Z-score: 2131.2 bits: 404.0 E(85289): 5.7e-112 Smith-Waterman score: 2984; 100.0% identity (100.0% similar) in 451 aa overlap (152-602:1-451) 130 140 150 160 170 180 pF1KB6 LRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFR :::::::::::::::::::::::::::::: NP_001 MVEYITHSRDVVTEAIYPEAVTMFSVNLFR 10 20 30 190 200 210 220 230 240 pF1KB6 TLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVL 40 50 60 70 80 90 250 260 270 280 290 300 pF1KB6 ALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELL 100 110 120 130 140 150 310 320 330 340 350 360 pF1KB6 EILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPV 160 170 180 190 200 210 370 380 390 400 410 420 pF1KB6 IVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAER 220 230 240 250 260 270 430 440 450 460 470 480 pF1KB6 ALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLF 280 290 300 310 320 330 490 500 510 520 530 540 pF1KB6 DDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTA 340 350 360 370 380 390 550 560 570 580 590 600 pF1KB6 EDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEA 400 410 420 430 440 450 pF1KB6 L : NP_001 L >>XP_005267877 (OMIM: 601645) PREDICTED: serine/threonin (579 aa) initn: 2926 init1: 2872 opt: 2888 Z-score: 2061.6 bits: 391.5 E(85289): 4.3e-108 Smith-Waterman score: 2921; 74.8% identity (86.5% similar) in 600 aa overlap (1-600:1-577) 10 20 30 40 50 60 pF1KB6 MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPS :: : ::::: ::..: ..: :. :.: ..: : : .. : XP_005 MPNKNKKEKESPKAGK-SGKSSKEGQD----TVESEQI----------------SVRKNS 10 20 30 70 80 90 100 110 120 pF1KB6 NSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQ . : : .::: . ::::..::.::::. :.::::::::.::: : ..:.:::: XP_005 LVAVPSTVSAKIKVPVSQPIVKKDKRQNSSRFSASNNRELQKLPSLKDVPPADQEKLFIQ 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 KLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLF ::::::::::::::::::::.::::::.:.::::::::.:.:.:: ::::.: ::.::.: XP_005 KLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 LALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAEL : ::.::::::::::::::: ::::::::::::::::.:::.:::::::::::::::::: XP_005 LQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAEL 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB6 LEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEP ::::::::::::::::::::.::..::::::::::::::::::::::::::::.:.:::: XP_005 LEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEP 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB6 VIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAE :...:::.:::::::::::::::::::::::::::: :.::::::::::::::::::::: XP_005 VVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB6 RALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKL ::::::::::::::::::::..::::::.::::::.:::::::::::::::::::::::: XP_005 RALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB6 FDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPT :::::::.:::: : ...:::::: : :::.::. :::: .. . .:::. : XP_005 FDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB6 AEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQE ::.:.:..::. :: : :: ::.. : ::::::::: .: :::::: ::.:. :::. XP_005 FEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADEL--ASQD 520 530 540 550 560 570 pF1KB6 AL XP_005 GR >>XP_005267876 (OMIM: 601645) PREDICTED: serine/threonin (584 aa) initn: 2872 init1: 2872 opt: 2888 Z-score: 2061.6 bits: 391.5 E(85289): 4.3e-108 Smith-Waterman score: 2888; 79.1% identity (90.5% similar) in 546 aa overlap (55-600:39-582) 30 40 50 60 70 80 pF1KB6 GKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKE : .. : . : : .::: . ::::. XP_005 LRKAELESPKAGKSGKSSKEGQDTVESEQISVRKNSLVAVPSTVSAKIKVPVSQPIVKKD 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB6 RRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEV .::.::::. :.::::::::.::: : ..:.::::::::::::::::::::::::.::: XP_005 KRQNSSRFSASNNRELQKLPSLKDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEV 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB6 KRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLE :::.:.::::::::.:.:.:: ::::.: ::.::.::::::::::::::::::::::::: XP_005 KRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLE 130 140 150 160 170 180 210 220 230 240 250 260 pF1KB6 AAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHR ::::::::::::::::::::::::::::::::::::: ::.::::::::::::::: ::: XP_005 AAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHR 190 200 210 220 230 240 270 280 290 300 310 320 pF1KB6 IYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLI :::::::::::::.:::.::::::::::::::::::::::::::::::::::::::.::. XP_005 IYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLL 250 260 270 280 290 300 330 340 350 360 370 380 pF1KB6 RVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNEL .::::::::::::::::::::::::::::.:.:::::...:::.:::::::::::::::: XP_005 KVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNEL 310 320 330 340 350 360 390 400 410 420 430 440 pF1KB6 EEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLP :::::::::::: :.:::::::::::::::::::::::::::::::::::::::::..:: XP_005 EEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILP 370 380 390 400 410 420 450 460 470 480 490 500 pF1KB6 IMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREE ::::.::::::.:::::::::::::::::::::::::::::::.:::: : ...:::::: XP_005 IMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREE 430 440 450 460 470 480 510 520 530 540 550 560 pF1KB6 MWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKK : :::.::. :::: .. . .:::. : ::.:.:..::. :: : :: :: XP_005 AWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKK 490 500 510 520 530 540 570 580 590 600 pF1KB6 EKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL .. : ::::::::: .: :::::: ::.:. :::. XP_005 DRPLARRKSELPQDPHTKKALEAHCRADEL--ASQDGR 550 560 570 580 >>XP_005267879 (OMIM: 601645) PREDICTED: serine/threonin (556 aa) initn: 2734 init1: 2734 opt: 2745 Z-score: 1960.4 bits: 372.7 E(85289): 1.9e-102 Smith-Waterman score: 2745; 80.2% identity (91.7% similar) in 505 aa overlap (55-559:39-543) 30 40 50 60 70 80 pF1KB6 GKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKE : .. : . : : .::: . ::::. XP_005 LRKAELESPKAGKSGKSSKEGQDTVESEQISVRKNSLVAVPSTVSAKIKVPVSQPIVKKD 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB6 RRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEV .::.::::. :.::::::::.::: : ..:.::::::::::::::::::::::::.::: XP_005 KRQNSSRFSASNNRELQKLPSLKDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEV 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB6 KRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLE :::.:.::::::::.:.:.:: ::::.: ::.::.::::::::::::::::::::::::: XP_005 KRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLE 130 140 150 160 170 180 210 220 230 240 250 260 pF1KB6 AAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHR ::::::::::::::::::::::::::::::::::::: ::.::::::::::::::: ::: XP_005 AAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHR 190 200 210 220 230 240 270 280 290 300 310 320 pF1KB6 IYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLI :::::::::::::.:::.::::::::::::::::::::::::::::::::::::::.::. XP_005 IYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLL 250 260 270 280 290 300 330 340 350 360 370 380 pF1KB6 RVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNEL .::::::::::::::::::::::::::::.:.:::::...:::.:::::::::::::::: XP_005 KVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNEL 310 320 330 340 350 360 390 400 410 420 430 440 pF1KB6 EEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLP :::::::::::: :.:::::::::::::::::::::::::::::::::::::::::..:: XP_005 EEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILP 370 380 390 400 410 420 450 460 470 480 490 500 pF1KB6 IMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREE ::::.::::::.:::::::::::::::::::::::::::::::.:::: : ...:::::: XP_005 IMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREE 430 440 450 460 470 480 510 520 530 540 550 560 pF1KB6 MWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKK : :::.::. :::: .. . .:::. : ::.:.:..::. :: :.. XP_005 AWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQLVGRKAV 490 500 510 520 530 540 570 580 590 600 pF1KB6 EKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL XP_005 STTQVRKV 550 >>NP_002710 (OMIM: 601645) serine/threonine-protein phos (524 aa) initn: 2703 init1: 2703 opt: 2737 Z-score: 1955.1 bits: 371.6 E(85289): 3.7e-102 Smith-Waterman score: 2737; 81.6% identity (92.3% similar) in 495 aa overlap (106-600:30-522) 80 90 100 110 120 130 pF1KB6 GGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDP ..: : ..:.::::::::::::::::::: NP_002 MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDP 10 20 30 40 50 140 150 160 170 180 190 pF1KB6 LSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFD :::::.::::::.:.::::::::.:.:.:: ::::.: ::.::.:::::::::::::::: NP_002 LSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFD 60 70 80 90 100 110 200 210 220 230 240 250 pF1KB6 PEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRER :::::::::::::::::::::::::::::::::::::::::::::: ::.:::::::::: NP_002 PEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRER 120 130 140 150 160 170 260 270 280 290 300 310 pF1KB6 DFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPL ::::: ::::::::::::::::.:::.::::::::::::::::::::::::::::::::: NP_002 DFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPL 180 190 200 210 220 230 320 330 340 350 360 370 pF1KB6 KEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSP :::::.::..::::::::::::::::::::::::::::.:.:::::...:::.::::::: NP_002 KEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSP 240 250 260 270 280 290 380 390 400 410 420 430 pF1KB6 KEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLI ::::::::::::::::::::: :.:::::::::::::::::::::::::::::::::::: NP_002 KEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLI 300 310 320 330 340 350 440 450 460 470 480 490 pF1KB6 SDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKG :::::..::::::.::::::.:::::::::::::::::::::::::::::::.:::: : NP_002 SDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKE 360 370 380 390 400 410 500 510 520 530 540 550 pF1KB6 RFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEA ...:::::: : :::.::. :::: .. . .:::. : ::.:.:..::. :: NP_002 KLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEA 420 430 440 450 460 470 560 570 580 590 600 pF1KB6 VQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL : :: ::.. : ::::::::: .: :::::: ::.:. :::. NP_002 HQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADEL--ASQDGR 480 490 500 510 520 >>XP_011535220 (OMIM: 601645) PREDICTED: serine/threonin (508 aa) initn: 2727 init1: 2703 opt: 2736 Z-score: 1954.6 bits: 371.5 E(85289): 3.9e-102 Smith-Waterman score: 2736; 81.6% identity (92.3% similar) in 495 aa overlap (106-600:14-506) 80 90 100 110 120 130 pF1KB6 GGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDP ..: : ..:.::::::::::::::::::: XP_011 MFKLHFRHSWQEYFRDVPPADQEKLFIQKLRQCCVLFDFVSDP 10 20 30 40 140 150 160 170 180 190 pF1KB6 LSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFD :::::.::::::.:.::::::::.:.:.:: ::::.: ::.::.:::::::::::::::: XP_011 LSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFD 50 60 70 80 90 100 200 210 220 230 240 250 pF1KB6 PEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRER :::::::::::::::::::::::::::::::::::::::::::::: ::.:::::::::: XP_011 PEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRER 110 120 130 140 150 160 260 270 280 290 300 310 pF1KB6 DFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPL ::::: ::::::::::::::::.:::.::::::::::::::::::::::::::::::::: XP_011 DFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPL 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB6 KEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSP :::::.::..::::::::::::::::::::::::::::.:.:::::...:::.::::::: XP_011 KEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSP 230 240 250 260 270 280 380 390 400 410 420 430 pF1KB6 KEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLI ::::::::::::::::::::: :.:::::::::::::::::::::::::::::::::::: XP_011 KEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLI 290 300 310 320 330 340 440 450 460 470 480 490 pF1KB6 SDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKG :::::..::::::.::::::.:::::::::::::::::::::::::::::::.:::: : XP_011 SDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKE 350 360 370 380 390 400 500 510 520 530 540 550 pF1KB6 RFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEA ...:::::: : :::.::. :::: .. . .:::. : ::.:.:..::. :: XP_011 KLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEA 410 420 430 440 450 460 560 570 580 590 600 pF1KB6 VQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL : :: ::.. : ::::::::: .: :::::: ::.:. :::. XP_011 HQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADEL--ASQDGR 470 480 490 500 >>XP_011535221 (OMIM: 601645) PREDICTED: serine/threonin (508 aa) initn: 2727 init1: 2703 opt: 2736 Z-score: 1954.6 bits: 371.5 E(85289): 3.9e-102 Smith-Waterman score: 2736; 81.6% identity (92.3% similar) in 495 aa overlap (106-600:14-506) 80 90 100 110 120 130 pF1KB6 GGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDP ..: : ..:.::::::::::::::::::: XP_011 MFKLHFRHSWQEYFRDVPPADQEKLFIQKLRQCCVLFDFVSDP 10 20 30 40 140 150 160 170 180 190 pF1KB6 LSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFD :::::.::::::.:.::::::::.:.:.:: ::::.: ::.::.:::::::::::::::: XP_011 LSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFD 50 60 70 80 90 100 200 210 220 230 240 250 pF1KB6 PEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRER :::::::::::::::::::::::::::::::::::::::::::::: ::.:::::::::: XP_011 PEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRER 110 120 130 140 150 160 260 270 280 290 300 310 pF1KB6 DFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPL ::::: ::::::::::::::::.:::.::::::::::::::::::::::::::::::::: XP_011 DFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPL 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB6 KEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSP :::::.::..::::::::::::::::::::::::::::.:.:::::...:::.::::::: XP_011 KEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSP 230 240 250 260 270 280 380 390 400 410 420 430 pF1KB6 KEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLI ::::::::::::::::::::: :.:::::::::::::::::::::::::::::::::::: XP_011 KEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLI 290 300 310 320 330 340 440 450 460 470 480 490 pF1KB6 SDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKG :::::..::::::.::::::.:::::::::::::::::::::::::::::::.:::: : XP_011 SDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKE 350 360 370 380 390 400 500 510 520 530 540 550 pF1KB6 RFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEA ...:::::: : :::.::. :::: .. . .:::. : ::.:.:..::. :: XP_011 KLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEA 410 420 430 440 450 460 560 570 580 590 600 pF1KB6 VQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL : :: ::.. : ::::::::: .: :::::: ::.:. :::. XP_011 HQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADEL--ASQDGR 470 480 490 500 602 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:05:29 2016 done: Sat Nov 5 14:05:30 2016 Total Scan time: 12.580 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]