FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6173, 653 aa 1>>>pF1KB6173 653 - 653 aa - 653 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2405+/-0.000508; mu= 11.7808+/- 0.031 mean_var=248.4760+/-48.746, 0's: 0 Z-trim(116.9): 2090 B-trim: 156 in 1/55 Lambda= 0.081364 statistics sampled from 26022 (28381) to 26022 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.333), width: 16 Scan time: 10.380 The best scores are: opt bits E(85289) NP_598009 (OMIM: 605467) neurotrophin receptor-int ( 653) 4451 536.7 9.9e-152 NP_001265663 (OMIM: 605467) neurotrophin receptor- ( 611) 4162 502.7 1.6e-141 NP_057409 (OMIM: 605467) neurotrophin receptor-int ( 621) 3871 468.6 3e-131 XP_011524629 (OMIM: 605467) PREDICTED: neurotrophi ( 548) 3731 452.1 2.5e-126 XP_016881663 (OMIM: 605467) PREDICTED: neurotrophi ( 548) 3731 452.1 2.5e-126 NP_057408 (OMIM: 605467) neurotrophin receptor-int ( 548) 3731 452.1 2.5e-126 XP_011524630 (OMIM: 605467) PREDICTED: neurotrophi ( 338) 2316 285.7 1.9e-76 XP_016881664 (OMIM: 605467) PREDICTED: neurotrophi ( 296) 1666 209.3 1.6e-53 XP_011524531 (OMIM: 609601) PREDICTED: zinc finger ( 553) 1039 136.1 3.3e-31 XP_011524532 (OMIM: 609601) PREDICTED: zinc finger ( 553) 1039 136.1 3.3e-31 XP_006722621 (OMIM: 609601) PREDICTED: zinc finger ( 553) 1039 136.1 3.3e-31 XP_006720894 (OMIM: 604191) PREDICTED: zinc finger ( 670) 913 121.4 1.1e-26 NP_001158002 (OMIM: 604077) zinc finger protein 13 ( 390) 891 118.5 4.6e-26 XP_011524765 (OMIM: 616798) PREDICTED: zinc finger ( 859) 851 114.3 1.9e-24 NP_065879 (OMIM: 616798) zinc finger protein 28 ho ( 868) 851 114.3 1.9e-24 XP_011524764 (OMIM: 616798) PREDICTED: zinc finger ( 771) 843 113.3 3.4e-24 NP_001289038 (OMIM: 601473) zinc finger protein 75 ( 537) 838 112.5 4.1e-24 NP_001310970 (OMIM: 601473) zinc finger protein 75 ( 537) 838 112.5 4.1e-24 XP_011513176 (OMIM: 602240) PREDICTED: zinc finger ( 391) 814 109.5 2.4e-23 NP_001265051 (OMIM: 602240) zinc finger protein wi ( 391) 814 109.5 2.4e-23 NP_001265050 (OMIM: 602240) zinc finger protein wi ( 391) 814 109.5 2.4e-23 XP_011513175 (OMIM: 602240) PREDICTED: zinc finger ( 391) 814 109.5 2.4e-23 XP_016882708 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882711 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882707 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882716 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882713 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_011525569 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_011525575 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882714 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_011525571 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882710 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882706 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882715 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 NP_003416 (OMIM: 194554) zinc finger protein 45 [H ( 682) 818 110.3 2.4e-23 XP_016882712 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016882709 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_011525573 (OMIM: 194554) PREDICTED: zinc finger ( 682) 818 110.3 2.4e-23 XP_016866755 (OMIM: 602240) PREDICTED: zinc finger ( 578) 814 109.7 3e-23 NP_006289 (OMIM: 602240) zinc finger protein with ( 578) 814 109.7 3e-23 NP_001265048 (OMIM: 602240) zinc finger protein wi ( 578) 814 109.7 3e-23 XP_011513172 (OMIM: 602240) PREDICTED: zinc finger ( 578) 814 109.7 3e-23 NP_003437 (OMIM: 300024) zinc finger protein 157 [ ( 506) 810 109.2 3.9e-23 XP_016881639 (OMIM: 604750) PREDICTED: zinc finger ( 688) 799 108.1 1.1e-22 XP_006723037 (OMIM: 604750) PREDICTED: zinc finger ( 700) 797 107.8 1.4e-22 XP_016881638 (OMIM: 604750) PREDICTED: zinc finger ( 700) 797 107.8 1.4e-22 NP_001138296 (OMIM: 604750) zinc finger protein 23 ( 700) 797 107.8 1.4e-22 NP_006621 (OMIM: 604750) zinc finger protein 234 [ ( 700) 797 107.8 1.4e-22 XP_011525581 (OMIM: 604086) PREDICTED: zinc finger ( 549) 790 106.9 2.1e-22 XP_011525580 (OMIM: 604086) PREDICTED: zinc finger ( 549) 790 106.9 2.1e-22 >>NP_598009 (OMIM: 605467) neurotrophin receptor-interac (653 aa) initn: 4451 init1: 4451 opt: 4451 Z-score: 2845.0 bits: 536.7 E(85289): 9.9e-152 Smith-Waterman score: 4451; 100.0% identity (100.0% similar) in 653 aa overlap (1-653:1-653) 10 20 30 40 50 60 pF1KB6 MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 DVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 AGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 AGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 QLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 QLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 WMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 WMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 WGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 WGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 CALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 CALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 KIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 KIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 GNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 GNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 GKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 GKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAF 550 560 570 580 590 600 610 620 630 640 650 pF1KB6 RQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_598 RQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS 610 620 630 640 650 >>NP_001265663 (OMIM: 605467) neurotrophin receptor-inte (611 aa) initn: 4162 init1: 4162 opt: 4162 Z-score: 2662.0 bits: 502.7 E(85289): 1.6e-141 Smith-Waterman score: 4162; 100.0% identity (100.0% similar) in 611 aa overlap (43-653:1-611) 20 30 40 50 60 70 pF1KB6 PVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKPDVVSQLEEAEDF :::::::::::::::::::::::::::::: NP_001 MLENYRNLVSVEHQLSKPDVVSQLEEAEDF 10 20 30 80 90 100 110 120 130 pF1KB6 WPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALY 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB6 AEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQP 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB6 KARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQ 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB6 PAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEY 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB6 RDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQ 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB6 GGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSG 340 350 360 370 380 390 440 450 460 470 480 490 pF1KB6 ALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRST 400 410 420 430 440 450 500 510 520 530 540 550 pF1KB6 KQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQ 460 470 480 490 500 510 560 570 580 590 600 610 pF1KB6 HQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRT 520 530 540 550 560 570 620 630 640 650 pF1KB6 HTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS ::::::::::::::::::::::::::::::::::::::::: NP_001 HTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS 580 590 600 610 >>NP_057409 (OMIM: 605467) neurotrophin receptor-interac (621 aa) initn: 3871 init1: 3871 opt: 3871 Z-score: 2477.3 bits: 468.6 E(85289): 3e-131 Smith-Waterman score: 4153; 95.1% identity (95.1% similar) in 653 aa overlap (1-653:1-621) 10 20 30 40 50 60 pF1KB6 MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVE------ 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 DVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEV :::::::::::::::::::::::::::::::::: NP_057 --------------------------YPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEV 60 70 80 130 140 150 160 170 180 pF1KB6 AGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 AGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALD 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB6 QLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVT 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB6 WMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 WMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREE 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB6 WGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 WGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRD 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB6 CALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQ 330 340 350 360 370 380 430 440 450 460 470 480 pF1KB6 KIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKE 390 400 410 420 430 440 490 500 510 520 530 540 pF1KB6 GNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDC 450 460 470 480 490 500 550 560 570 580 590 600 pF1KB6 GKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAF 510 520 530 540 550 560 610 620 630 640 650 pF1KB6 RQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS 570 580 590 600 610 620 >>XP_011524629 (OMIM: 605467) PREDICTED: neurotrophin re (548 aa) initn: 3731 init1: 3731 opt: 3731 Z-score: 2389.1 bits: 452.1 E(85289): 2.5e-126 Smith-Waterman score: 3731; 100.0% identity (100.0% similar) in 548 aa overlap (106-653:1-548) 80 90 100 110 120 130 pF1KB6 ERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAED :::::::::::::::::::::::::::::: XP_011 MNIEVVEVLTLNQEVAGPRNAQIQALYAED 10 20 30 140 150 160 170 180 190 pF1KB6 GSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB6 GTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDV 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB6 MLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGV 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB6 QEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALD 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB6 TNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQI 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB6 TFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQR 400 410 420 430 440 450 560 570 580 590 600 610 pF1KB6 VHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTG 460 470 480 490 500 510 620 630 640 650 pF1KB6 ERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS :::::::::::::::::::::::::::::::::::::: XP_011 ERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS 520 530 540 >>XP_016881663 (OMIM: 605467) PREDICTED: neurotrophin re (548 aa) initn: 3731 init1: 3731 opt: 3731 Z-score: 2389.1 bits: 452.1 E(85289): 2.5e-126 Smith-Waterman score: 3731; 100.0% identity (100.0% similar) in 548 aa overlap (106-653:1-548) 80 90 100 110 120 130 pF1KB6 ERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAED :::::::::::::::::::::::::::::: XP_016 MNIEVVEVLTLNQEVAGPRNAQIQALYAED 10 20 30 140 150 160 170 180 190 pF1KB6 GSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB6 GTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDV 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB6 MLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGV 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB6 QEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALD 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB6 TNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQI 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB6 TFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQR 400 410 420 430 440 450 560 570 580 590 600 610 pF1KB6 VHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTG 460 470 480 490 500 510 620 630 640 650 pF1KB6 ERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS :::::::::::::::::::::::::::::::::::::: XP_016 ERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS 520 530 540 >>NP_057408 (OMIM: 605467) neurotrophin receptor-interac (548 aa) initn: 3731 init1: 3731 opt: 3731 Z-score: 2389.1 bits: 452.1 E(85289): 2.5e-126 Smith-Waterman score: 3731; 100.0% identity (100.0% similar) in 548 aa overlap (106-653:1-548) 80 90 100 110 120 130 pF1KB6 ERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAED :::::::::::::::::::::::::::::: NP_057 MNIEVVEVLTLNQEVAGPRNAQIQALYAED 10 20 30 140 150 160 170 180 190 pF1KB6 GSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB6 GTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDV 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB6 MLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGV 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB6 QEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALD 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB6 TNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQI 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB6 TFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQR 400 410 420 430 440 450 560 570 580 590 600 610 pF1KB6 VHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 VHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTG 460 470 480 490 500 510 620 630 640 650 pF1KB6 ERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS :::::::::::::::::::::::::::::::::::::: NP_057 ERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS 520 530 540 >>XP_011524630 (OMIM: 605467) PREDICTED: neurotrophin re (338 aa) initn: 2316 init1: 2316 opt: 2316 Z-score: 1493.6 bits: 285.7 E(85289): 1.9e-76 Smith-Waterman score: 2316; 100.0% identity (100.0% similar) in 338 aa overlap (316-653:1-338) 290 300 310 320 330 340 pF1KB6 PVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPE :::::::::::::::::::::::::::::: XP_011 MLETFGHLVSVGWETTLENKELAPNSDIPE 10 20 30 350 360 370 380 390 400 pF1KB6 EEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRES 40 50 60 70 80 90 410 420 430 440 450 460 pF1KB6 QANSGALDTNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QANSGALDTNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSR 100 110 120 130 140 150 470 480 490 500 510 520 pF1KB6 VKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVH 160 170 180 190 200 210 530 540 550 560 570 580 pF1KB6 KKIHTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKIHTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTH 220 230 240 250 260 270 590 600 610 620 630 640 pF1KB6 TGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTK 280 290 300 310 320 330 650 pF1KB6 RKKKQPTS :::::::: XP_011 RKKKQPTS >>XP_016881664 (OMIM: 605467) PREDICTED: neurotrophin re (296 aa) initn: 1664 init1: 1664 opt: 1666 Z-score: 1081.9 bits: 209.3 E(85289): 1.6e-53 Smith-Waterman score: 1666; 95.0% identity (96.6% similar) in 262 aa overlap (1-262:1-259) 10 20 30 40 50 60 pF1KB6 MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 AGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 QLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 WMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREE :::::: ... : : :. XP_016 WMSEEE---GASDLPGCGCGLQPGGVGAAGPDTEDRVPRCDAGDLWAPGLCGVGDYTGK 250 260 270 280 290 >>XP_011524531 (OMIM: 609601) PREDICTED: zinc finger pro (553 aa) initn: 4455 init1: 735 opt: 1039 Z-score: 681.2 bits: 136.1 E(85289): 3.3e-31 Smith-Waterman score: 1071; 37.0% identity (63.0% similar) in 538 aa overlap (106-642:1-495) 80 90 100 110 120 130 pF1KB6 ERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAED : .: . :: . : . .. . .:: XP_011 MAVESGVISTLIPQ--DPPEQELILVKVED 10 20 140 150 160 170 180 190 pF1KB6 GSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR ..: : :. .:.:. . : ::.::.: :.. ::::::..:.:::.:::.:. . XP_011 -NFSWD---EKFKQNGSTQSCQELFRQQFRKFCYQETPGPREALSRLQELCYQWLMPELH 30 40 50 60 70 80 200 210 220 230 240 250 pF1KB6 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE .::::::::::::::. :: .:. ::....::. .:.:.:.: . :.: :: XP_011 TKEQILELLVLEQFLSILPEELQIWVQQHNPESGEEAVTLLEDL----EREFDDPGQ--- 90 100 110 120 130 260 270 280 290 300 310 pF1KB6 GTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDV .: ... . . ...: : : :: . .. : .: : :. XP_011 ------QVGTEKSDVGKGIYSLEHVMVPASP---QGPAVPW--KDLTCLRASQ--ESTDI 140 150 160 170 180 320 330 340 350 360 370 pF1KB6 MLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGV :. . .. .:. : .:.:: . : : . ..: .. .: . : ...: XP_011 HLQPLKTQLK-SWKPCL-----SPKSDCENSETATKEGISEE-KSQGLPQ--EPSFRGIS 190 200 210 220 230 380 390 400 410 420 430 pF1KB6 QEVQDTVLKQMESAQEK-DLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGAL .. .. : :: .. :: :.. . . : .. ::. :: : : . : XP_011 EHESNLVWKQGSATGEKLRSPSQ-------GGSFSQVIFTNK-SLGKRDLYDEAERCLIL 240 250 260 270 280 440 450 460 470 480 490 pF1KB6 DTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQ :.... .:.::..: . : .:.:..: . ::. .: . : : :.:: . XP_011 TTDSIMCQKVPPEERPYRCDVCGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYL 290 300 310 320 330 340 500 510 520 530 540 550 pF1KB6 ITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQ : :::.: .. .:::::: : . . :.::::::. :..:::.: ::: : :: XP_011 IIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQ 350 360 370 380 390 400 560 570 580 590 600 610 pF1KB6 RVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHT :.:.::.:.::.:::.::.. : . .: : ::: .::.:..:::::::::.:: ::: :. XP_011 RIHTGEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHS 410 420 430 440 450 460 620 630 640 650 pF1KB6 GERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS ::.:: :..:::::. ::.:: ::: :. XP_011 GEKPYECSECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTFKRSSALVQHQRIHSGDEA 470 480 490 500 510 520 >>XP_011524532 (OMIM: 609601) PREDICTED: zinc finger pro (553 aa) initn: 4455 init1: 735 opt: 1039 Z-score: 681.2 bits: 136.1 E(85289): 3.3e-31 Smith-Waterman score: 1071; 37.0% identity (63.0% similar) in 538 aa overlap (106-642:1-495) 80 90 100 110 120 130 pF1KB6 ERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAED : .: . :: . : . .. . .:: XP_011 MAVESGVISTLIPQ--DPPEQELILVKVED 10 20 140 150 160 170 180 190 pF1KB6 GSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR ..: : :. .:.:. . : ::.::.: :.. ::::::..:.:::.:::.:. . XP_011 -NFSWD---EKFKQNGSTQSCQELFRQQFRKFCYQETPGPREALSRLQELCYQWLMPELH 30 40 50 60 70 80 200 210 220 230 240 250 pF1KB6 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE .::::::::::::::. :: .:. ::....::. .:.:.:.: . :.: :: XP_011 TKEQILELLVLEQFLSILPEELQIWVQQHNPESGEEAVTLLEDL----EREFDDPGQ--- 90 100 110 120 130 260 270 280 290 300 310 pF1KB6 GTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDV .: ... . . ...: : : :: . .. : .: : :. XP_011 ------QVGTEKSDVGKGIYSLEHVMVPASP---QGPAVPW--KDLTCLRASQ--ESTDI 140 150 160 170 180 320 330 340 350 360 370 pF1KB6 MLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGV :. . .. .:. : .:.:: . : : . ..: .. .: . : ...: XP_011 HLQPLKTQLK-SWKPCL-----SPKSDCENSETATKEGISEE-KSQGLPQ--EPSFRGIS 190 200 210 220 230 380 390 400 410 420 430 pF1KB6 QEVQDTVLKQMESAQEK-DLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGAL .. .. : :: .. :: :.. . . : .. ::. :: : : . : XP_011 EHESNLVWKQGSATGEKLRSPSQ-------GGSFSQVIFTNK-SLGKRDLYDEAERCLIL 240 250 260 270 280 440 450 460 470 480 490 pF1KB6 DTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQ :.... .:.::..: . : .:.:..: . ::. .: . : : :.:: . XP_011 TTDSIMCQKVPPEERPYRCDVCGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYL 290 300 310 320 330 340 500 510 520 530 540 550 pF1KB6 ITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQ : :::.: .. .:::::: : . . :.::::::. :..:::.: ::: : :: XP_011 IIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQ 350 360 370 380 390 400 560 570 580 590 600 610 pF1KB6 RVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHT :.:.::.:.::.:::.::.. : . .: : ::: .::.:..:::::::::.:: ::: :. XP_011 RIHTGEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHS 410 420 430 440 450 460 620 630 640 650 pF1KB6 GERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS ::.:: :..:::::. ::.:: ::: :. XP_011 GEKPYECSECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTFKRSSALVQHQRIHSGDEA 470 480 490 500 510 520 653 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:07:14 2016 done: Sat Nov 5 14:07:15 2016 Total Scan time: 10.380 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]