FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6174, 630 aa 1>>>pF1KB6174 630 - 630 aa - 630 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.1246+/-0.000314; mu= 4.7398+/- 0.020 mean_var=247.7124+/-49.434, 0's: 0 Z-trim(124.7): 103 B-trim: 0 in 0/60 Lambda= 0.081489 statistics sampled from 46649 (46760) to 46649 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.821), E-opt: 0.2 (0.548), width: 16 Scan time: 13.920 The best scores are: opt bits E(85289) NP_001191066 (OMIM: 156535) methyl-CpG-binding dom ( 630) 4561 549.0 1.8e-155 XP_011524295 (OMIM: 156535) PREDICTED: methyl-CpG- ( 630) 4561 549.0 1.8e-155 XP_011524296 (OMIM: 156535) PREDICTED: methyl-CpG- ( 630) 4561 549.0 1.8e-155 NP_001191067 (OMIM: 156535) methyl-CpG-binding dom ( 629) 4543 546.9 7.8e-155 XP_006722519 (OMIM: 156535) PREDICTED: methyl-CpG- ( 662) 4483 539.9 1.1e-152 NP_001310871 (OMIM: 156535) methyl-CpG-binding dom ( 680) 4475 539.0 2.1e-152 XP_016881240 (OMIM: 156535) PREDICTED: methyl-CpG- ( 647) 3748 453.5 1.1e-126 XP_016881247 (OMIM: 156535) PREDICTED: methyl-CpG- ( 615) 3746 453.2 1.2e-126 XP_016881246 (OMIM: 156535) PREDICTED: methyl-CpG- ( 615) 3746 453.2 1.2e-126 XP_016881248 (OMIM: 156535) PREDICTED: methyl-CpG- ( 615) 3746 453.2 1.2e-126 XP_016881243 (OMIM: 156535) PREDICTED: methyl-CpG- ( 627) 3746 453.2 1.2e-126 NP_001310876 (OMIM: 156535) methyl-CpG-binding dom ( 665) 3746 453.2 1.3e-126 XP_011524305 (OMIM: 156535) PREDICTED: methyl-CpG- ( 584) 3744 453.0 1.4e-126 XP_011524304 (OMIM: 156535) PREDICTED: methyl-CpG- ( 584) 3744 453.0 1.4e-126 XP_016881253 (OMIM: 156535) PREDICTED: methyl-CpG- ( 584) 3744 453.0 1.4e-126 XP_016881250 (OMIM: 156535) PREDICTED: methyl-CpG- ( 596) 3744 453.0 1.4e-126 XP_016881245 (OMIM: 156535) PREDICTED: methyl-CpG- ( 616) 3744 453.0 1.4e-126 XP_011524293 (OMIM: 156535) PREDICTED: methyl-CpG- ( 634) 3744 453.0 1.5e-126 NP_001310878 (OMIM: 156535) methyl-CpG-binding dom ( 461) 3364 408.2 3.3e-113 XP_016881255 (OMIM: 156535) PREDICTED: methyl-CpG- ( 574) 2592 317.5 8.1e-86 XP_016881256 (OMIM: 156535) PREDICTED: methyl-CpG- ( 574) 2592 317.5 8.1e-86 NP_001191069 (OMIM: 156535) methyl-CpG-binding dom ( 574) 2592 317.5 8.1e-86 NP_056723 (OMIM: 156535) methyl-CpG-binding domain ( 556) 2459 301.9 4e-81 NP_056671 (OMIM: 156535) methyl-CpG-binding domain ( 605) 2452 301.1 7.6e-81 XP_016881249 (OMIM: 156535) PREDICTED: methyl-CpG- ( 605) 2452 301.1 7.6e-81 NP_001191068 (OMIM: 156535) methyl-CpG-binding dom ( 605) 2452 301.1 7.6e-81 XP_005258328 (OMIM: 156535) PREDICTED: methyl-CpG- ( 605) 2452 301.1 7.6e-81 XP_016881242 (OMIM: 156535) PREDICTED: methyl-CpG- ( 637) 2374 291.9 4.5e-78 XP_016881244 (OMIM: 156535) PREDICTED: methyl-CpG- ( 617) 2373 291.8 4.8e-78 NP_001191065 (OMIM: 156535) methyl-CpG-binding dom ( 655) 2366 291.0 8.9e-78 NP_001191070 (OMIM: 156535) methyl-CpG-binding dom ( 567) 2361 290.4 1.2e-77 XP_016881262 (OMIM: 156535) PREDICTED: methyl-CpG- ( 526) 1974 244.8 5.6e-64 XP_016881263 (OMIM: 156535) PREDICTED: methyl-CpG- ( 526) 1974 244.8 5.6e-64 NP_001310883 (OMIM: 156535) methyl-CpG-binding dom ( 576) 1974 244.9 6e-64 NP_002375 (OMIM: 156535) methyl-CpG-binding domain ( 503) 1969 244.2 8.2e-64 XP_016881265 (OMIM: 156535) PREDICTED: methyl-CpG- ( 503) 1969 244.2 8.2e-64 XP_016881264 (OMIM: 156535) PREDICTED: methyl-CpG- ( 515) 1969 244.2 8.3e-64 XP_011524308 (OMIM: 156535) PREDICTED: methyl-CpG- ( 535) 1969 244.2 8.6e-64 NP_001191072 (OMIM: 156535) methyl-CpG-binding dom ( 535) 1969 244.2 8.6e-64 XP_016881261 (OMIM: 156535) PREDICTED: methyl-CpG- ( 546) 1969 244.3 8.7e-64 NP_056669 (OMIM: 156535) methyl-CpG-binding domain ( 549) 1969 244.3 8.7e-64 XP_016881260 (OMIM: 156535) PREDICTED: methyl-CpG- ( 549) 1969 244.3 8.7e-64 XP_016881259 (OMIM: 156535) PREDICTED: methyl-CpG- ( 549) 1969 244.3 8.7e-64 NP_001191071 (OMIM: 156535) methyl-CpG-binding dom ( 550) 1969 244.3 8.7e-64 XP_011524309 (OMIM: 156535) PREDICTED: methyl-CpG- ( 559) 1969 244.3 8.8e-64 XP_016881258 (OMIM: 156535) PREDICTED: methyl-CpG- ( 559) 1969 244.3 8.8e-64 XP_016881257 (OMIM: 156535) PREDICTED: methyl-CpG- ( 561) 1969 244.3 8.9e-64 XP_016881266 (OMIM: 156535) PREDICTED: methyl-CpG- ( 571) 1969 244.3 9e-64 XP_016881254 (OMIM: 156535) PREDICTED: methyl-CpG- ( 581) 1969 244.3 9.1e-64 XP_016881252 (OMIM: 156535) PREDICTED: methyl-CpG- ( 589) 1969 244.3 9.2e-64 >>NP_001191066 (OMIM: 156535) methyl-CpG-binding domain (630 aa) initn: 4561 init1: 4561 opt: 4561 Z-score: 2912.2 bits: 549.0 E(85289): 1.8e-155 Smith-Waterman score: 4561; 100.0% identity (100.0% similar) in 630 aa overlap (1-630:1-630) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 550 560 570 580 590 600 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ :::::::::::::::::::::::::::::: NP_001 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ 610 620 630 >>XP_011524295 (OMIM: 156535) PREDICTED: methyl-CpG-bind (630 aa) initn: 4561 init1: 4561 opt: 4561 Z-score: 2912.2 bits: 549.0 E(85289): 1.8e-155 Smith-Waterman score: 4561; 100.0% identity (100.0% similar) in 630 aa overlap (1-630:1-630) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 550 560 570 580 590 600 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ :::::::::::::::::::::::::::::: XP_011 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ 610 620 630 >>XP_011524296 (OMIM: 156535) PREDICTED: methyl-CpG-bind (630 aa) initn: 4561 init1: 4561 opt: 4561 Z-score: 2912.2 bits: 549.0 E(85289): 1.8e-155 Smith-Waterman score: 4561; 100.0% identity (100.0% similar) in 630 aa overlap (1-630:1-630) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 550 560 570 580 590 600 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ :::::::::::::::::::::::::::::: XP_011 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ 610 620 630 >>NP_001191067 (OMIM: 156535) methyl-CpG-binding domain (629 aa) initn: 3081 init1: 3081 opt: 4543 Z-score: 2900.8 bits: 546.9 E(85289): 7.8e-155 Smith-Waterman score: 4543; 99.8% identity (99.8% similar) in 630 aa overlap (1-630:1-629) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: NP_001 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAM-RLLPSVWSESED 370 380 390 400 410 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 540 550 560 570 580 590 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ :::::::::::::::::::::::::::::: NP_001 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ 600 610 620 >>XP_006722519 (OMIM: 156535) PREDICTED: methyl-CpG-bind (662 aa) initn: 4690 init1: 4483 opt: 4483 Z-score: 2862.4 bits: 539.9 E(85289): 1.1e-152 Smith-Waterman score: 4483; 99.8% identity (100.0% similar) in 619 aa overlap (1-619:1-619) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 550 560 570 580 590 600 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ ::::::::::::::::::. XP_006 IFSLGGTRFRDTAVWLPRAGTREGKMDVKCGRPRTQWSPRARAGTHEDGLEPMSVSHHLQ 610 620 630 640 650 660 >>NP_001310871 (OMIM: 156535) methyl-CpG-binding domain (680 aa) initn: 4475 init1: 4475 opt: 4475 Z-score: 2857.1 bits: 539.0 E(85289): 2.1e-152 Smith-Waterman score: 4475; 100.0% identity (100.0% similar) in 617 aa overlap (1-617:1-617) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 550 560 570 580 590 600 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ ::::::::::::::::: NP_001 IFSLGGTRFRDTAVWLPSLQGRHSGREDGCKVWETEDTVEPTSTSWNPRGWPGTHVSLSP 610 620 630 640 650 660 >>XP_016881240 (OMIM: 156535) PREDICTED: methyl-CpG-bind (647 aa) initn: 4379 init1: 3725 opt: 3748 Z-score: 2395.5 bits: 453.5 E(85289): 1.1e-126 Smith-Waterman score: 4337; 97.4% identity (97.6% similar) in 619 aa overlap (1-619:1-604) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV :::::::::::::::::::::::::: ::::::::::::::::::: XP_016 LVFLREGASSPVQVPGPVAASTEALL---------------QVKQEKADTQDEWTPGTAV 490 500 510 520 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 530 540 550 560 570 580 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ ::::::::::::::::::. XP_016 IFSLGGTRFRDTAVWLPRAGTREGKMDVKCGRPRTQWSPRARAGTHEDGLEPMSVSHHLQ 590 600 610 620 630 640 >>XP_016881247 (OMIM: 156535) PREDICTED: methyl-CpG-bind (615 aa) initn: 3725 init1: 3725 opt: 3746 Z-score: 2394.5 bits: 453.2 E(85289): 1.2e-126 Smith-Waterman score: 4415; 97.6% identity (97.6% similar) in 630 aa overlap (1-630:1-615) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV ::::::::::::::::::::::::::: :::::::::::::::::: XP_016 LVFLREGASSPVQVPGPVAASTEALLQ---------------VKQEKADTQDEWTPGTAV 490 500 510 520 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 530 540 550 560 570 580 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ :::::::::::::::::::::::::::::: XP_016 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ 590 600 610 >>XP_016881246 (OMIM: 156535) PREDICTED: methyl-CpG-bind (615 aa) initn: 3725 init1: 3725 opt: 3746 Z-score: 2394.5 bits: 453.2 E(85289): 1.2e-126 Smith-Waterman score: 4415; 97.6% identity (97.6% similar) in 630 aa overlap (1-630:1-615) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV ::::::::::::::::::::::::::: :::::::::::::::::: XP_016 LVFLREGASSPVQVPGPVAASTEALLQ---------------VKQEKADTQDEWTPGTAV 490 500 510 520 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 530 540 550 560 570 580 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ :::::::::::::::::::::::::::::: XP_016 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ 590 600 610 >>XP_016881248 (OMIM: 156535) PREDICTED: methyl-CpG-bind (615 aa) initn: 3725 init1: 3725 opt: 3746 Z-score: 2394.5 bits: 453.2 E(85289): 1.2e-126 Smith-Waterman score: 4415; 97.6% identity (97.6% similar) in 630 aa overlap (1-630:1-615) 10 20 30 40 50 60 pF1KB6 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PICLRPPRPGLRRQWKCVQRRCLRHLAHRLRRRHQRCQRRTPLAVAPPTGKHARRKGGCD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAV ::::::::::::::::::::::::::: :::::::::::::::::: XP_016 LVFLREGASSPVQVPGPVAASTEALLQ---------------VKQEKADTQDEWTPGTAV 490 500 510 520 550 560 570 580 590 600 pF1KB6 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITE 530 540 550 560 570 580 610 620 630 pF1KB6 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ :::::::::::::::::::::::::::::: XP_016 IFSLGGTRFRDTAVWLPRSKDLKKPGARKQ 590 600 610 630 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:41:39 2016 done: Sat Nov 5 13:41:41 2016 Total Scan time: 13.920 Total Display time: 0.170 Function used was FASTA [36.3.4 Apr, 2011]