FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6194, 706 aa 1>>>pF1KB6194 706 - 706 aa - 706 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.4754+/-0.000619; mu= -22.2240+/- 0.037 mean_var=687.9193+/-151.514, 0's: 0 Z-trim(115.2): 1956 B-trim: 0 in 0/56 Lambda= 0.048900 statistics sampled from 22919 (25479) to 22919 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.299), width: 16 Scan time: 9.660 The best scores are: opt bits E(85289) XP_006717528 (OMIM: 600448) PREDICTED: protein kin ( 706) 4935 365.0 5.7e-100 XP_016871899 (OMIM: 600448) PREDICTED: protein kin ( 706) 4935 365.0 5.7e-100 NP_001310194 (OMIM: 600448) protein kinase C theta ( 706) 4935 365.0 5.7e-100 NP_006248 (OMIM: 600448) protein kinase C theta ty ( 706) 4935 365.0 5.7e-100 XP_005252553 (OMIM: 600448) PREDICTED: protein kin ( 740) 4935 365.0 5.9e-100 NP_001269573 (OMIM: 600448) protein kinase C theta ( 670) 4655 345.2 4.9e-94 XP_005252554 (OMIM: 600448) PREDICTED: protein kin ( 697) 4588 340.5 1.3e-92 NP_001310196 (OMIM: 600448) protein kinase C theta ( 627) 4308 320.7 1.1e-86 NP_001310195 (OMIM: 600448) protein kinase C theta ( 581) 4071 303.9 1.1e-81 NP_001269574 (OMIM: 600448) protein kinase C theta ( 581) 4071 303.9 1.1e-81 XP_016871900 (OMIM: 600448) PREDICTED: protein kin ( 581) 4071 303.9 1.1e-81 NP_001229342 (OMIM: 600448) protein kinase C theta ( 643) 3837 287.5 1.1e-76 XP_016862345 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1718 138.0 1.2e-31 NP_001303256 (OMIM: 176977,615559) protein kinase ( 676) 1718 138.0 1.2e-31 NP_006245 (OMIM: 176977,615559) protein kinase C d ( 676) 1718 138.0 1.2e-31 NP_997704 (OMIM: 176977,615559) protein kinase C d ( 676) 1718 138.0 1.2e-31 XP_016862344 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1718 138.0 1.2e-31 XP_006713322 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1718 138.0 1.2e-31 XP_006713320 (OMIM: 176977,615559) PREDICTED: prot ( 692) 1718 138.0 1.2e-31 XP_011531285 (OMIM: 176975) PREDICTED: protein kin ( 436) 1326 110.1 1.8e-23 XP_006712113 (OMIM: 176975) PREDICTED: protein kin ( 460) 1317 109.5 2.9e-23 XP_011531284 (OMIM: 176975) PREDICTED: protein kin ( 497) 1317 109.6 3.1e-23 XP_016859979 (OMIM: 176975) PREDICTED: protein kin ( 587) 1317 109.7 3.5e-23 XP_011531282 (OMIM: 176975) PREDICTED: protein kin ( 587) 1317 109.7 3.5e-23 XP_016859980 (OMIM: 176975) PREDICTED: protein kin ( 587) 1317 109.7 3.5e-23 XP_016859978 (OMIM: 176975) PREDICTED: protein kin ( 587) 1317 109.7 3.5e-23 XP_011531283 (OMIM: 176975) PREDICTED: protein kin ( 587) 1317 109.7 3.5e-23 XP_016859976 (OMIM: 176975) PREDICTED: protein kin ( 623) 1317 109.7 3.6e-23 XP_016859977 (OMIM: 176975) PREDICTED: protein kin ( 623) 1317 109.7 3.6e-23 XP_011531280 (OMIM: 176975) PREDICTED: protein kin ( 623) 1317 109.7 3.6e-23 NP_997700 (OMIM: 176970) protein kinase C beta typ ( 671) 1318 109.8 3.6e-23 XP_011531273 (OMIM: 176975) PREDICTED: protein kin ( 641) 1317 109.7 3.7e-23 XP_011531277 (OMIM: 176975) PREDICTED: protein kin ( 641) 1317 109.7 3.7e-23 XP_016859975 (OMIM: 176975) PREDICTED: protein kin ( 641) 1317 109.7 3.7e-23 XP_005264485 (OMIM: 176975) PREDICTED: protein kin ( 737) 1317 109.8 4e-23 NP_005391 (OMIM: 176975) protein kinase C epsilon ( 737) 1317 109.8 4e-23 XP_016876947 (OMIM: 601367,605437) PREDICTED: prot ( 522) 1311 109.2 4.3e-23 XP_011535257 (OMIM: 601367,605437) PREDICTED: prot ( 603) 1311 109.2 4.7e-23 XP_011535256 (OMIM: 601367,605437) PREDICTED: prot ( 604) 1311 109.2 4.7e-23 NP_006246 (OMIM: 601367,605437) protein kinase C e ( 683) 1311 109.3 5.1e-23 XP_016880328 (OMIM: 176960) PREDICTED: protein kin ( 586) 1294 108.0 1.1e-22 XP_016880327 (OMIM: 176960) PREDICTED: protein kin ( 586) 1294 108.0 1.1e-22 XP_016880329 (OMIM: 176960) PREDICTED: protein kin ( 586) 1294 108.0 1.1e-22 XP_016880326 (OMIM: 176960) PREDICTED: protein kin ( 621) 1294 108.1 1.1e-22 NP_002728 (OMIM: 176960) protein kinase C alpha ty ( 672) 1295 108.2 1.1e-22 NP_002729 (OMIM: 176970) protein kinase C beta typ ( 673) 1275 106.8 3e-22 NP_002730 (OMIM: 176980,605361) protein kinase C g ( 697) 1226 103.3 3.3e-21 NP_001303258 (OMIM: 176980,605361) protein kinase ( 710) 1226 103.3 3.4e-21 XP_016880325 (OMIM: 176960) PREDICTED: protein kin ( 645) 1203 101.7 9.7e-21 XP_011540074 (OMIM: 602549) PREDICTED: serine/thre ( 658) 1137 97.0 2.5e-19 >>XP_006717528 (OMIM: 600448) PREDICTED: protein kinase (706 aa) initn: 4935 init1: 4935 opt: 4935 Z-score: 1915.8 bits: 365.0 E(85289): 5.7e-100 Smith-Waterman score: 4935; 100.0% identity (100.0% similar) in 706 aa overlap (1-706:1-706) 10 20 30 40 50 60 pF1KB6 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 610 620 630 640 650 660 670 680 690 700 pF1KB6 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS :::::::::::::::::::::::::::::::::::::::::::::: XP_006 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS 670 680 690 700 >>XP_016871899 (OMIM: 600448) PREDICTED: protein kinase (706 aa) initn: 4935 init1: 4935 opt: 4935 Z-score: 1915.8 bits: 365.0 E(85289): 5.7e-100 Smith-Waterman score: 4935; 100.0% identity (100.0% similar) in 706 aa overlap (1-706:1-706) 10 20 30 40 50 60 pF1KB6 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 610 620 630 640 650 660 670 680 690 700 pF1KB6 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS :::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS 670 680 690 700 >>NP_001310194 (OMIM: 600448) protein kinase C theta typ (706 aa) initn: 4935 init1: 4935 opt: 4935 Z-score: 1915.8 bits: 365.0 E(85289): 5.7e-100 Smith-Waterman score: 4935; 100.0% identity (100.0% similar) in 706 aa overlap (1-706:1-706) 10 20 30 40 50 60 pF1KB6 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 610 620 630 640 650 660 670 680 690 700 pF1KB6 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS :::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS 670 680 690 700 >>NP_006248 (OMIM: 600448) protein kinase C theta type i (706 aa) initn: 4935 init1: 4935 opt: 4935 Z-score: 1915.8 bits: 365.0 E(85289): 5.7e-100 Smith-Waterman score: 4935; 100.0% identity (100.0% similar) in 706 aa overlap (1-706:1-706) 10 20 30 40 50 60 pF1KB6 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 610 620 630 640 650 660 670 680 690 700 pF1KB6 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS :::::::::::::::::::::::::::::::::::::::::::::: NP_006 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS 670 680 690 700 >>XP_005252553 (OMIM: 600448) PREDICTED: protein kinase (740 aa) initn: 4935 init1: 4935 opt: 4935 Z-score: 1915.5 bits: 365.0 E(85289): 5.9e-100 Smith-Waterman score: 4935; 100.0% identity (100.0% similar) in 706 aa overlap (1-706:35-740) 10 20 30 pF1KB6 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCA :::::::::::::::::::::::::::::: XP_005 LELLLKSKVECRLPESLSPQQVSVWFWGATMSPFLRIGLSNFDCGSCQSCQGEAVNPYCA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 VLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELY 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 SLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB6 QAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCT 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB6 GSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVH 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB6 HRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARP 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB6 PCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGS 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB6 FGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQT 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB6 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB6 LLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLY 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB6 EMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQ 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB6 HPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNM 670 680 690 700 710 720 700 pF1KB6 FRNFSFMNPGMERLIS :::::::::::::::: XP_005 FRNFSFMNPGMERLIS 730 740 >>NP_001269573 (OMIM: 600448) protein kinase C theta typ (670 aa) initn: 4655 init1: 4655 opt: 4655 Z-score: 1809.3 bits: 345.2 E(85289): 4.9e-94 Smith-Waterman score: 4655; 99.7% identity (100.0% similar) in 668 aa overlap (39-706:3-670) 10 20 30 40 50 60 pF1KB6 LSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGR ..:::::::::::::::::::::::::::: NP_001 MSNQNGQMYIQKKPTMYPPWDSTFDAHINKGR 10 20 30 70 80 90 100 110 120 pF1KB6 VMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDT 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 KDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGY 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 QCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHC 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 GTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTE 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB6 QIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKER 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB6 PSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB6 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB6 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB6 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKD 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB6 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 580 590 600 610 620 630 670 680 690 700 pF1KB6 LNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS :::::::::::::::::::::::::::::::::::::: NP_001 LNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS 640 650 660 670 >>XP_005252554 (OMIM: 600448) PREDICTED: protein kinase (697 aa) initn: 4766 init1: 4588 opt: 4588 Z-score: 1783.5 bits: 340.5 E(85289): 1.3e-92 Smith-Waterman score: 4588; 99.7% identity (100.0% similar) in 657 aa overlap (1-657:35-691) 10 20 30 pF1KB6 MSPFLRIGLSNFDCGSCQSCQGEAVNPYCA :::::::::::::::::::::::::::::: XP_005 LELLLKSKVECRLPESLSPQQVSVWFWGATMSPFLRIGLSNFDCGSCQSCQGEAVNPYCA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 VLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELY 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 SLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIK 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB6 QAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCT 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB6 GSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVH 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB6 HRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARP 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB6 PCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGS 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB6 FGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQT 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB6 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB6 LLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLY 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB6 EMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQ 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB6 HPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNM :::::::::::::::::::::::::.. XP_005 HPLFREINWEELERKEIDPPFRPKVETSGKWEK 670 680 690 >>NP_001310196 (OMIM: 600448) protein kinase C theta typ (627 aa) initn: 4483 init1: 4305 opt: 4308 Z-score: 1677.3 bits: 320.7 E(85289): 1.1e-86 Smith-Waterman score: 4308; 99.4% identity (100.0% similar) in 619 aa overlap (39-657:3-621) 10 20 30 40 50 60 pF1KB6 LSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGR ..:::::::::::::::::::::::::::: NP_001 MSNQNGQMYIQKKPTMYPPWDSTFDAHINKGR 10 20 30 70 80 90 100 110 120 pF1KB6 VMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDT 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 KDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGY 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 QCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHC 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 GTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTE 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB6 QIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKER 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB6 PSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB6 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB6 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB6 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKD 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB6 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF :::::::::::::::::::::::::::::::::::::::::::::::.. NP_001 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVETSGKWEK 580 590 600 610 620 670 680 690 700 pF1KB6 LNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS >>NP_001310195 (OMIM: 600448) protein kinase C theta typ (581 aa) initn: 4071 init1: 4071 opt: 4071 Z-score: 1587.3 bits: 303.9 E(85289): 1.1e-81 Smith-Waterman score: 4071; 100.0% identity (100.0% similar) in 580 aa overlap (127-706:2-581) 100 110 120 130 140 150 pF1KB6 RKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHH :::::::::::::::::::::::::::::: NP_001 MDTKDMNEFETEGFFALHQRRGAIKQAKVHH 10 20 30 160 170 180 190 200 210 pF1KB6 VKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINS 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB6 RETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK 100 110 120 130 140 150 280 290 300 310 320 330 pF1KB6 VANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTP 160 170 180 190 200 210 340 350 360 370 380 390 pF1KB6 GKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFL 220 230 240 250 260 270 400 410 420 430 440 450 pF1KB6 AEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFF 280 290 300 310 320 330 460 470 480 490 500 510 pF1KB6 VMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDG 340 350 360 370 380 390 520 530 540 550 560 570 pF1KB6 HIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQ 400 410 420 430 440 450 580 590 600 610 620 630 pF1KB6 SPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE 460 470 480 490 500 510 640 650 660 670 680 690 pF1KB6 INWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSF 520 530 540 550 560 570 700 pF1KB6 MNPGMERLIS :::::::::: NP_001 MNPGMERLIS 580 >>NP_001269574 (OMIM: 600448) protein kinase C theta typ (581 aa) initn: 4071 init1: 4071 opt: 4071 Z-score: 1587.3 bits: 303.9 E(85289): 1.1e-81 Smith-Waterman score: 4071; 100.0% identity (100.0% similar) in 580 aa overlap (127-706:2-581) 100 110 120 130 140 150 pF1KB6 RKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHH :::::::::::::::::::::::::::::: NP_001 MDTKDMNEFETEGFFALHQRRGAIKQAKVHH 10 20 30 160 170 180 190 200 210 pF1KB6 VKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINS 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB6 RETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK 100 110 120 130 140 150 280 290 300 310 320 330 pF1KB6 VANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTP 160 170 180 190 200 210 340 350 360 370 380 390 pF1KB6 GKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFL 220 230 240 250 260 270 400 410 420 430 440 450 pF1KB6 AEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFF 280 290 300 310 320 330 460 470 480 490 500 510 pF1KB6 VMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDG 340 350 360 370 380 390 520 530 540 550 560 570 pF1KB6 HIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQ 400 410 420 430 440 450 580 590 600 610 620 630 pF1KB6 SPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE 460 470 480 490 500 510 640 650 660 670 680 690 pF1KB6 INWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSF 520 530 540 550 560 570 700 pF1KB6 MNPGMERLIS :::::::::: NP_001 MNPGMERLIS 580 706 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:47:04 2016 done: Sat Nov 5 13:47:05 2016 Total Scan time: 9.660 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]