Result of FASTA (omim) for
pF1KB6227
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6227, 672 aa
1>>>pF1KB6227 672 - 672 aa - 672 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.0433+/-0.000716; mu= -24.0538+/- 0.042
mean_var=884.6909+/-195.796, 0's: 0 Z-trim(116.0): 1599 B-trim: 0 in 0/55
Lambda= 0.043120
statistics sampled from 24705 (26765) to 24705 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.65), E-opt: 0.2 (0.314), width: 16
Scan time: 10.530
The best scores are: opt bits E(85289)
NP_002728 (OMIM: 176960) protein kinase C alpha ty ( 672) 4689 308.8 4.3e-83
XP_016880325 (OMIM: 176960) PREDICTED: protein kin ( 645) 4316 285.6 4e-76
XP_016880326 (OMIM: 176960) PREDICTED: protein kin ( 621) 4198 278.2 6.4e-74
XP_016880327 (OMIM: 176960) PREDICTED: protein kin ( 586) 3988 265.1 5.3e-70
XP_016880328 (OMIM: 176960) PREDICTED: protein kin ( 586) 3988 265.1 5.3e-70
XP_016880329 (OMIM: 176960) PREDICTED: protein kin ( 586) 3988 265.1 5.3e-70
NP_002729 (OMIM: 176970) protein kinase C beta typ ( 673) 3850 256.6 2.2e-67
NP_997700 (OMIM: 176970) protein kinase C beta typ ( 671) 3753 250.6 1.4e-65
XP_016880330 (OMIM: 176960) PREDICTED: protein kin ( 324) 2185 152.6 2.1e-36
NP_002730 (OMIM: 176980,605361) protein kinase C g ( 697) 1866 133.2 3.2e-30
NP_001303258 (OMIM: 176980,605361) protein kinase ( 710) 1866 133.2 3.2e-30
XP_011531282 (OMIM: 176975) PREDICTED: protein kin ( 587) 1536 112.6 4.4e-24
XP_016859980 (OMIM: 176975) PREDICTED: protein kin ( 587) 1536 112.6 4.4e-24
XP_016859979 (OMIM: 176975) PREDICTED: protein kin ( 587) 1536 112.6 4.4e-24
XP_011531283 (OMIM: 176975) PREDICTED: protein kin ( 587) 1536 112.6 4.4e-24
XP_016859978 (OMIM: 176975) PREDICTED: protein kin ( 587) 1536 112.6 4.4e-24
XP_016859977 (OMIM: 176975) PREDICTED: protein kin ( 623) 1536 112.6 4.5e-24
XP_016859976 (OMIM: 176975) PREDICTED: protein kin ( 623) 1536 112.6 4.5e-24
XP_011531280 (OMIM: 176975) PREDICTED: protein kin ( 623) 1536 112.6 4.5e-24
XP_011531277 (OMIM: 176975) PREDICTED: protein kin ( 641) 1536 112.6 4.6e-24
XP_016859975 (OMIM: 176975) PREDICTED: protein kin ( 641) 1536 112.6 4.6e-24
XP_011531273 (OMIM: 176975) PREDICTED: protein kin ( 641) 1536 112.6 4.6e-24
NP_005391 (OMIM: 176975) protein kinase C epsilon ( 737) 1536 112.7 5e-24
XP_005264485 (OMIM: 176975) PREDICTED: protein kin ( 737) 1536 112.7 5e-24
XP_011531285 (OMIM: 176975) PREDICTED: protein kin ( 436) 1487 109.4 3e-23
XP_006712113 (OMIM: 176975) PREDICTED: protein kin ( 460) 1487 109.4 3.1e-23
XP_011531284 (OMIM: 176975) PREDICTED: protein kin ( 497) 1487 109.4 3.3e-23
XP_016876947 (OMIM: 601367,605437) PREDICTED: prot ( 522) 1355 101.2 9.9e-21
XP_011535257 (OMIM: 601367,605437) PREDICTED: prot ( 603) 1355 101.3 1.1e-20
XP_011535256 (OMIM: 601367,605437) PREDICTED: prot ( 604) 1355 101.3 1.1e-20
NP_006246 (OMIM: 601367,605437) protein kinase C e ( 683) 1355 101.4 1.2e-20
NP_001269574 (OMIM: 600448) protein kinase C theta ( 581) 1295 97.6 1.4e-19
XP_016871900 (OMIM: 600448) PREDICTED: protein kin ( 581) 1295 97.6 1.4e-19
NP_001310195 (OMIM: 600448) protein kinase C theta ( 581) 1295 97.6 1.4e-19
NP_001269573 (OMIM: 600448) protein kinase C theta ( 670) 1295 97.7 1.5e-19
NP_006248 (OMIM: 600448) protein kinase C theta ty ( 706) 1295 97.7 1.6e-19
NP_001310194 (OMIM: 600448) protein kinase C theta ( 706) 1295 97.7 1.6e-19
XP_006717528 (OMIM: 600448) PREDICTED: protein kin ( 706) 1295 97.7 1.6e-19
XP_016871899 (OMIM: 600448) PREDICTED: protein kin ( 706) 1295 97.7 1.6e-19
XP_005252553 (OMIM: 600448) PREDICTED: protein kin ( 740) 1295 97.7 1.6e-19
NP_001303256 (OMIM: 176977,615559) protein kinase ( 676) 1272 96.2 4.2e-19
XP_016862344 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1272 96.2 4.2e-19
NP_006245 (OMIM: 176977,615559) protein kinase C d ( 676) 1272 96.2 4.2e-19
NP_997704 (OMIM: 176977,615559) protein kinase C d ( 676) 1272 96.2 4.2e-19
XP_006713322 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1272 96.2 4.2e-19
XP_016862345 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1272 96.2 4.2e-19
XP_006713320 (OMIM: 176977,615559) PREDICTED: prot ( 692) 1272 96.2 4.2e-19
NP_001310196 (OMIM: 600448) protein kinase C theta ( 627) 1207 92.1 6.6e-18
XP_005252554 (OMIM: 600448) PREDICTED: protein kin ( 697) 1207 92.2 7e-18
XP_011540074 (OMIM: 602549) PREDICTED: serine/thre ( 658) 1127 87.2 2.1e-16
>>NP_002728 (OMIM: 176960) protein kinase C alpha type [ (672 aa)
initn: 4689 init1: 4689 opt: 4689 Z-score: 1612.9 bits: 308.8 E(85289): 4.3e-83
Smith-Waterman score: 4689; 100.0% identity (100.0% similar) in 672 aa overlap (1-672:1-672)
10 20 30 40 50 60
pF1KB6 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
610 620 630 640 650 660
670
pF1KB6 PQFVHPILQSAV
::::::::::::
NP_002 PQFVHPILQSAV
670
>>XP_016880325 (OMIM: 176960) PREDICTED: protein kinase (645 aa)
initn: 4313 init1: 4313 opt: 4316 Z-score: 1487.6 bits: 285.6 E(85289): 4e-76
Smith-Waterman score: 4316; 99.4% identity (99.5% similar) in 623 aa overlap (1-621:1-623)
10 20 30 40 50 60
pF1KB6 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
XP_016 EDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
550 560 570 580 590 600
610 620 630 640 650
pF1KB6 DWEKLENREIQPPFKPKV--CGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSY
:::::::::::::::::: : :
XP_016 DWEKLENREIQPPFKPKVTLCTKMHWLQWASRSSVSTFPEPWVTK
610 620 630 640
>>XP_016880326 (OMIM: 176960) PREDICTED: protein kinase (621 aa)
initn: 4198 init1: 4198 opt: 4198 Z-score: 1448.1 bits: 278.2 E(85289): 6.4e-74
Smith-Waterman score: 4198; 99.7% identity (100.0% similar) in 605 aa overlap (68-672:17-621)
40 50 60 70 80 90
pF1KB6 KFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDD
.:::::::::::::::::::::::::::::
XP_016 MQPASANLQAPLSCSPHVCCFVVHKRCHEFVTFSCPGADKGPDTDD
10 20 30 40
100 110 120 130 140 150
pF1KB6 PRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTE
50 60 70 80 90 100
160 170 180 190 200 210
pF1KB6 KRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRS
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB6 TLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKL
170 180 190 200 210 220
280 290 300 310 320 330
pF1KB6 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT
230 240 250 260 270 280
340 350 360 370 380 390
pF1KB6 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP
290 300 310 320 330 340
400 410 420 430 440 450
pF1KB6 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR
350 360 370 380 390 400
460 470 480 490 500 510
pF1KB6 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK
410 420 430 440 450 460
520 530 540 550 560 570
pF1KB6 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP
::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::
XP_016 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHP
470 480 490 500 510 520
580 590 600 610 620 630
pF1KB6 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVL
530 540 550 560 570 580
640 650 660 670
pF1KB6 TPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
:::::::::::::::::::::::::::::::::::
XP_016 TPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
590 600 610 620
>>XP_016880327 (OMIM: 176960) PREDICTED: protein kinase (586 aa)
initn: 3988 init1: 3988 opt: 3988 Z-score: 1377.8 bits: 265.1 E(85289): 5.3e-70
Smith-Waterman score: 3988; 99.5% identity (100.0% similar) in 579 aa overlap (94-672:8-586)
70 80 90 100 110 120
pF1KB6 GFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLY
:..:::::::::::::::::::::::::::
XP_016 MLSVSSWDSNDPRSKHKFKIHTYGSPTFCDHCGSLLY
10 20 30
130 140 150 160 170 180
pF1KB6 GLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNL
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB6 IPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVE
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB6 IWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQ
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB6 KFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEE
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB6 LYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGG
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB6 DLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFG
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB6 MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE
400 410 420 430 440 450
550 560 570 580 590 600
pF1KB6 DELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_016 DELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE
460 470 480 490 500 510
610 620 630 640 650 660
pF1KB6 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQF
520 530 540 550 560 570
670
pF1KB6 VHPILQSAV
:::::::::
XP_016 VHPILQSAV
580
>>XP_016880328 (OMIM: 176960) PREDICTED: protein kinase (586 aa)
initn: 3988 init1: 3988 opt: 3988 Z-score: 1377.8 bits: 265.1 E(85289): 5.3e-70
Smith-Waterman score: 3988; 99.5% identity (100.0% similar) in 579 aa overlap (94-672:8-586)
70 80 90 100 110 120
pF1KB6 GFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLY
:..:::::::::::::::::::::::::::
XP_016 MLSVSSWDSNDPRSKHKFKIHTYGSPTFCDHCGSLLY
10 20 30
130 140 150 160 170 180
pF1KB6 GLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNL
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB6 IPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVE
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB6 IWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQ
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB6 KFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEE
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB6 LYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGG
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB6 DLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFG
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB6 MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE
400 410 420 430 440 450
550 560 570 580 590 600
pF1KB6 DELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_016 DELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE
460 470 480 490 500 510
610 620 630 640 650 660
pF1KB6 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQF
520 530 540 550 560 570
670
pF1KB6 VHPILQSAV
:::::::::
XP_016 VHPILQSAV
580
>>XP_016880329 (OMIM: 176960) PREDICTED: protein kinase (586 aa)
initn: 3988 init1: 3988 opt: 3988 Z-score: 1377.8 bits: 265.1 E(85289): 5.3e-70
Smith-Waterman score: 3988; 99.5% identity (100.0% similar) in 579 aa overlap (94-672:8-586)
70 80 90 100 110 120
pF1KB6 GFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLY
:..:::::::::::::::::::::::::::
XP_016 MLSVSSWDSNDPRSKHKFKIHTYGSPTFCDHCGSLLY
10 20 30
130 140 150 160 170 180
pF1KB6 GLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNL
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB6 IPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVE
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB6 IWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQ
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB6 KFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEE
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB6 LYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGG
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB6 DLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFG
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB6 MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE
400 410 420 430 440 450
550 560 570 580 590 600
pF1KB6 DELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_016 DELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE
460 470 480 490 500 510
610 620 630 640 650 660
pF1KB6 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQF
520 530 540 550 560 570
670
pF1KB6 VHPILQSAV
:::::::::
XP_016 VHPILQSAV
580
>>NP_002729 (OMIM: 176970) protein kinase C beta type is (673 aa)
initn: 4039 init1: 2056 opt: 3850 Z-score: 1330.8 bits: 256.6 E(85289): 2.2e-67
Smith-Waterman score: 3850; 80.3% identity (92.1% similar) in 674 aa overlap (1-670:1-673)
10 20 30 40 50 60
pF1KB6 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
::: : . ... . :::::::::::::::::.::: ::::::::::::::::::::
NP_002 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
::::::::::::::::::::::::::::::::: .::::::::::::::.::::::::::
NP_002 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
::::::::::::::: :::::.::.::::::: ::::.:::::..:.. . : : ::::
NP_002 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
:::.:::::::::::::::::::::.:::::::::. .:::.:::.: :.:: :::::::
NP_002 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
:::::::: :.:::::::::::.:::.: ..::.:::.::::::.:::.: :.: :
NP_002 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
250 260 270 280 290 300
310 320 330 340 350
pF1KB6 LRQKFEKAKLGPAGNKV----ISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLA
::::::.::.. :.:: . . .. . ..: ::.:::::::::::::::::::::.
NP_002 LRQKFERAKISQ-GTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLS
310 320 330 340 350
360 370 380 390 400 410
pF1KB6 DRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFV
.::::.::::.:::::::::::::::::::::::::: ::::::::::::::.::::::
NP_002 ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFV
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB6 MEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGH
:::::::::::::::::.::::.::::::::.::::::...:::::::::::::::::::
NP_002 MEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB6 IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQP
:::::::::::.. :::::.:::::::::::::::::::::::::::.:::::::::::
NP_002 IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQA
480 490 500 510 520 530
540 550 560 570 580 590
pF1KB6 PFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAF
::.::::::::::::::::.::::.:::::.::::::::::.::::::::::::..::::
NP_002 PFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF
540 550 560 570 580 590
600 610 620 630 640 650
pF1KB6 FRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGF
:: ::::::: .:::::.:::.::..:::::.:::: :::::::: :: :::::.::::
NP_002 FRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGF
600 610 620 630 640 650
660 670
pF1KB6 SYVNPQFVHPILQSAV
:.:: .:..: ..:
NP_002 SFVNSEFLKPEVKS
660 670
>>NP_997700 (OMIM: 176970) protein kinase C beta type is (671 aa)
initn: 3785 init1: 1806 opt: 3753 Z-score: 1298.2 bits: 250.6 E(85289): 1.4e-65
Smith-Waterman score: 3753; 79.7% identity (91.2% similar) in 670 aa overlap (1-664:1-668)
10 20 30 40 50 60
pF1KB6 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
::: : . ... . :::::::::::::::::.::: ::::::::::::::::::::
NP_997 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
::::::::::::::::::::::::::::::::: .::::::::::::::.::::::::::
NP_997 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
::::::::::::::: :::::.::.::::::: ::::.:::::..:.. . : : ::::
NP_997 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
:::.:::::::::::::::::::::.:::::::::. .:::.:::.: :.:: :::::::
NP_997 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
:::::::: :.:::::::::::.:::.: ..::.:::.::::::.:::.: :.: :
NP_997 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
250 260 270 280 290 300
310 320 330 340 350
pF1KB6 LRQKFEKAKLGPAGNKV----ISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLA
::::::.::.. :.:: . . .. . ..: ::.:::::::::::::::::::::.
NP_997 LRQKFERAKISQ-GTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLS
310 320 330 340 350
360 370 380 390 400 410
pF1KB6 DRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFV
.::::.::::.:::::::::::::::::::::::::: ::::::::::::::.::::::
NP_997 ERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFV
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB6 MEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGH
:::::::::::::::::.::::.::::::::.::::::...:::::::::::::::::::
NP_997 MEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB6 IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQP
:::::::::::.. :::::.:::::::::::::::::::::::::::.:::::::::::
NP_997 IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQA
480 490 500 510 520 530
540 550 560 570 580 590
pF1KB6 PFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAF
::.::::::::::::::::.::::.:::::.::::::::::.::::::::::::..::::
NP_997 PFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAF
540 550 560 570 580 590
600 610 620 630 640 650
pF1KB6 FRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPV-LTPPDQLVIANIDQSDFE
:: ::::::: .:::::.:::. : . :::: ::: ::: ::: :.: : :.::..:
NP_997 FRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTR-QPVELTPTDKLFIMNLDQNEFA
600 610 620 630 640 650
660 670
pF1KB6 GFSYVNPQFVHPILQSAV
::::.::.::
NP_997 GFSYTNPEFVINV
660 670
>>XP_016880330 (OMIM: 176960) PREDICTED: protein kinase (324 aa)
initn: 2185 init1: 2185 opt: 2185 Z-score: 774.4 bits: 152.6 E(85289): 2.1e-36
Smith-Waterman score: 2185; 100.0% identity (100.0% similar) in 306 aa overlap (1-306:1-306)
10 20 30 40 50 60
pF1KB6 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
::::::
XP_016 LRQKFELRMQTWGTGQDHLLEPHP
310 320
>>NP_002730 (OMIM: 176980,605361) protein kinase C gamma (697 aa)
initn: 3193 init1: 1554 opt: 1866 Z-score: 663.6 bits: 133.2 E(85289): 3.2e-30
Smith-Waterman score: 3499; 71.4% identity (88.5% similar) in 689 aa overlap (1-666:1-683)
10 20 30 40 50
pF1KB6 MADVFPG-NDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWG
:: . :: .:: .. : :::::::: :::::.::: :::::::::::::::::::
NP_002 MAGLGPGVGDSEGGPRPL--FCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWG
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 FGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCG
.::::.::::: ::::.:::::::: :::: :::.:::::.::::..:.:.:::::::::
NP_002 IGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 SLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYL--KAEVADEKLHVTV
::::::.::::::. :.::::..:: .::::::.::::.:::. : .: .::: .::::
NP_002 SLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADE-IHVTV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 RDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKD
.:.:::::::::::::::::::::::.: .::::.:...:::: :::.:.:.:::.: .
NP_002 GEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB6 RRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEG
::::::.::::::.::::::..:::::::.: :..:::::::::::::::::. ..:
NP_002 RRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADAD---
240 250 260 270 280 290
300 310 320 330 340
pF1KB6 NMELRQKFE----------KAKLGPAGNKVISPSEDRKQPSNNL-----DRVKLTDFNFL
: : :::: ....::... . ::: . .:. . :....::.::
NP_002 NCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFL
300 310 320 330 340 350
350 360 370 380 390
pF1KB6 MVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP----
::::::::::::::.:.:..::::::::::::..:::::.::.:::::::: . :
NP_002 MVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRP
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB6 -FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR
::::::: ::: ::::::::::.::::::::::.::::::.:.::::::.:::::::..
NP_002 HFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQ
420 430 440 450 460 470
460 470 480 490 500 510
pF1KB6 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK
:::::::::::::::.::::::.:::::::... :.::::::::::::::::::::::::
NP_002 GIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGK
480 490 500 510 520 530
520 530 540 550 560 570
pF1KB6 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP
:::::..:::::::::::::::::::.::::.:::..:.::::::.:::.::::..::::
NP_002 SVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHP
540 550 560 570 580 590
580 590 600 610 620 630
pF1KB6 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVL
.:::: ::.:: .: :.::: ::::.:: :: :::.:. ::...:::::::::. :.:
NP_002 GKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPAL
600 610 620 630 640 650
640 650 660 670
pF1KB6 TPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
::::.::.:.:::.::.::.::::.::::
NP_002 TPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
660 670 680 690
672 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 13:53:36 2016 done: Sat Nov 5 13:53:38 2016
Total Scan time: 10.530 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]