FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6236, 676 aa 1>>>pF1KB6236 676 - 676 aa - 676 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.3793+/-0.000775; mu= -21.2133+/- 0.046 mean_var=867.7871+/-192.365, 0's: 0 Z-trim(112.4): 1750 B-trim: 0 in 0/53 Lambda= 0.043538 statistics sampled from 18968 (21250) to 18968 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.585), E-opt: 0.2 (0.249), width: 16 Scan time: 8.290 The best scores are: opt bits E(85289) NP_001303256 (OMIM: 176977,615559) protein kinase ( 676) 4626 308.1 7.2e-83 XP_016862345 (OMIM: 176977,615559) PREDICTED: prot ( 676) 4626 308.1 7.2e-83 XP_006713322 (OMIM: 176977,615559) PREDICTED: prot ( 676) 4626 308.1 7.2e-83 NP_006245 (OMIM: 176977,615559) protein kinase C d ( 676) 4626 308.1 7.2e-83 XP_016862344 (OMIM: 176977,615559) PREDICTED: prot ( 676) 4626 308.1 7.2e-83 NP_997704 (OMIM: 176977,615559) protein kinase C d ( 676) 4626 308.1 7.2e-83 XP_006713320 (OMIM: 176977,615559) PREDICTED: prot ( 692) 4626 308.1 7.2e-83 NP_001269574 (OMIM: 600448) protein kinase C theta ( 581) 1718 125.3 6.3e-28 XP_016871900 (OMIM: 600448) PREDICTED: protein kin ( 581) 1718 125.3 6.3e-28 NP_001310195 (OMIM: 600448) protein kinase C theta ( 581) 1718 125.3 6.3e-28 NP_001269573 (OMIM: 600448) protein kinase C theta ( 670) 1718 125.4 6.9e-28 XP_016871899 (OMIM: 600448) PREDICTED: protein kin ( 706) 1718 125.4 7.1e-28 NP_006248 (OMIM: 600448) protein kinase C theta ty ( 706) 1718 125.4 7.1e-28 NP_001310194 (OMIM: 600448) protein kinase C theta ( 706) 1718 125.4 7.1e-28 XP_006717528 (OMIM: 600448) PREDICTED: protein kin ( 706) 1718 125.4 7.1e-28 XP_005252553 (OMIM: 600448) PREDICTED: protein kin ( 740) 1718 125.5 7.3e-28 NP_001310196 (OMIM: 600448) protein kinase C theta ( 627) 1504 111.9 7.4e-24 NP_006246 (OMIM: 601367,605437) protein kinase C e ( 683) 1505 112.0 7.4e-24 XP_005252554 (OMIM: 600448) PREDICTED: protein kin ( 697) 1504 112.0 7.8e-24 XP_011535257 (OMIM: 601367,605437) PREDICTED: prot ( 603) 1499 111.6 8.9e-24 XP_011535256 (OMIM: 601367,605437) PREDICTED: prot ( 604) 1499 111.6 9e-24 XP_016876947 (OMIM: 601367,605437) PREDICTED: prot ( 522) 1491 111.0 1.2e-23 NP_001229342 (OMIM: 600448) protein kinase C theta ( 643) 1397 105.2 7.9e-22 XP_011531285 (OMIM: 176975) PREDICTED: protein kin ( 436) 1351 102.1 4.7e-21 XP_006712113 (OMIM: 176975) PREDICTED: protein kin ( 460) 1351 102.1 4.8e-21 XP_011531284 (OMIM: 176975) PREDICTED: protein kin ( 497) 1351 102.2 5e-21 XP_016859978 (OMIM: 176975) PREDICTED: protein kin ( 587) 1351 102.3 5.5e-21 XP_011531283 (OMIM: 176975) PREDICTED: protein kin ( 587) 1351 102.3 5.5e-21 XP_016859979 (OMIM: 176975) PREDICTED: protein kin ( 587) 1351 102.3 5.5e-21 XP_016859980 (OMIM: 176975) PREDICTED: protein kin ( 587) 1351 102.3 5.5e-21 XP_011531282 (OMIM: 176975) PREDICTED: protein kin ( 587) 1351 102.3 5.5e-21 XP_016859977 (OMIM: 176975) PREDICTED: protein kin ( 623) 1351 102.3 5.7e-21 XP_011531280 (OMIM: 176975) PREDICTED: protein kin ( 623) 1351 102.3 5.7e-21 XP_016859976 (OMIM: 176975) PREDICTED: protein kin ( 623) 1351 102.3 5.7e-21 XP_011531273 (OMIM: 176975) PREDICTED: protein kin ( 641) 1351 102.3 5.8e-21 XP_011531277 (OMIM: 176975) PREDICTED: protein kin ( 641) 1351 102.3 5.8e-21 XP_016859975 (OMIM: 176975) PREDICTED: protein kin ( 641) 1351 102.3 5.8e-21 NP_005391 (OMIM: 176975) protein kinase C epsilon ( 737) 1351 102.4 6.3e-21 XP_005264485 (OMIM: 176975) PREDICTED: protein kin ( 737) 1351 102.4 6.3e-21 NP_997700 (OMIM: 176970) protein kinase C beta typ ( 671) 1316 100.2 2.7e-20 XP_016880329 (OMIM: 176960) PREDICTED: protein kin ( 586) 1271 97.2 1.8e-19 XP_016880328 (OMIM: 176960) PREDICTED: protein kin ( 586) 1271 97.2 1.8e-19 XP_016880327 (OMIM: 176960) PREDICTED: protein kin ( 586) 1271 97.2 1.8e-19 XP_016880326 (OMIM: 176960) PREDICTED: protein kin ( 621) 1271 97.3 1.9e-19 NP_002728 (OMIM: 176960) protein kinase C alpha ty ( 672) 1272 97.4 1.9e-19 NP_002729 (OMIM: 176970) protein kinase C beta typ ( 673) 1265 97.0 2.5e-19 NP_002730 (OMIM: 176980,605361) protein kinase C g ( 697) 1219 94.1 1.9e-18 NP_001303258 (OMIM: 176980,605361) protein kinase ( 710) 1219 94.1 1.9e-18 XP_016880325 (OMIM: 176960) PREDICTED: protein kin ( 645) 1159 90.3 2.5e-17 NP_002732 (OMIM: 601032) serine/threonine-protein ( 942) 1092 86.3 5.8e-16 >>NP_001303256 (OMIM: 176977,615559) protein kinase C de (676 aa) initn: 4626 init1: 4626 opt: 4626 Z-score: 1608.8 bits: 308.1 E(85289): 7.2e-83 Smith-Waterman score: 4626; 100.0% identity (100.0% similar) in 676 aa overlap (1-676:1-676) 10 20 30 40 50 60 pF1KB6 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 610 620 630 640 650 660 670 pF1KB6 AGFSFVNPKFEHLLED :::::::::::::::: NP_001 AGFSFVNPKFEHLLED 670 >>XP_016862345 (OMIM: 176977,615559) PREDICTED: protein (676 aa) initn: 4626 init1: 4626 opt: 4626 Z-score: 1608.8 bits: 308.1 E(85289): 7.2e-83 Smith-Waterman score: 4626; 100.0% identity (100.0% similar) in 676 aa overlap (1-676:1-676) 10 20 30 40 50 60 pF1KB6 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 610 620 630 640 650 660 670 pF1KB6 AGFSFVNPKFEHLLED :::::::::::::::: XP_016 AGFSFVNPKFEHLLED 670 >>XP_006713322 (OMIM: 176977,615559) PREDICTED: protein (676 aa) initn: 4626 init1: 4626 opt: 4626 Z-score: 1608.8 bits: 308.1 E(85289): 7.2e-83 Smith-Waterman score: 4626; 100.0% identity (100.0% similar) in 676 aa overlap (1-676:1-676) 10 20 30 40 50 60 pF1KB6 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 610 620 630 640 650 660 670 pF1KB6 AGFSFVNPKFEHLLED :::::::::::::::: XP_006 AGFSFVNPKFEHLLED 670 >>NP_006245 (OMIM: 176977,615559) protein kinase C delta (676 aa) initn: 4626 init1: 4626 opt: 4626 Z-score: 1608.8 bits: 308.1 E(85289): 7.2e-83 Smith-Waterman score: 4626; 100.0% identity (100.0% similar) in 676 aa overlap (1-676:1-676) 10 20 30 40 50 60 pF1KB6 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 610 620 630 640 650 660 670 pF1KB6 AGFSFVNPKFEHLLED :::::::::::::::: NP_006 AGFSFVNPKFEHLLED 670 >>XP_016862344 (OMIM: 176977,615559) PREDICTED: protein (676 aa) initn: 4626 init1: 4626 opt: 4626 Z-score: 1608.8 bits: 308.1 E(85289): 7.2e-83 Smith-Waterman score: 4626; 100.0% identity (100.0% similar) in 676 aa overlap (1-676:1-676) 10 20 30 40 50 60 pF1KB6 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 610 620 630 640 650 660 670 pF1KB6 AGFSFVNPKFEHLLED :::::::::::::::: XP_016 AGFSFVNPKFEHLLED 670 >>NP_997704 (OMIM: 176977,615559) protein kinase C delta (676 aa) initn: 4626 init1: 4626 opt: 4626 Z-score: 1608.8 bits: 308.1 E(85289): 7.2e-83 Smith-Waterman score: 4626; 100.0% identity (100.0% similar) in 676 aa overlap (1-676:1-676) 10 20 30 40 50 60 pF1KB6 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_997 PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF 610 620 630 640 650 660 670 pF1KB6 AGFSFVNPKFEHLLED :::::::::::::::: NP_997 AGFSFVNPKFEHLLED 670 >>XP_006713320 (OMIM: 176977,615559) PREDICTED: protein (692 aa) initn: 4626 init1: 4626 opt: 4626 Z-score: 1608.7 bits: 308.1 E(85289): 7.2e-83 Smith-Waterman score: 4626; 100.0% identity (100.0% similar) in 676 aa overlap (1-676:17-692) 10 20 30 40 pF1KB6 MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTL :::::::::::::::::::::::::::::::::::::::::::: XP_006 MRERQRLPESPTAGPTMAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 VQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEF 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 WLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIAT 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 FFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKER 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB6 FNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQ 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB6 KLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKC 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB6 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB6 AENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB6 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB6 YTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB6 REPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 610 620 630 640 650 660 650 660 670 pF1KB6 SYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED :::::::::::::::::::::::::::::::: XP_006 SYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED 670 680 690 >>NP_001269574 (OMIM: 600448) protein kinase C theta typ (581 aa) initn: 2757 init1: 1707 opt: 1718 Z-score: 622.3 bits: 125.3 E(85289): 6.3e-28 Smith-Waterman score: 2599; 65.2% identity (83.4% similar) in 580 aa overlap (125-674:1-580) 100 110 120 130 140 150 pF1KB6 CKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIH .: :. . : :. : .:::::::::.: NP_001 MDTKDMNEFETEGFFALHQRRGAIKQAKVH 10 20 30 160 170 180 190 200 210 pF1KB6 YIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAAN ..: ::: :::: ::::::::..::::::::::.:::::::::::::::.:..:::.: : NP_001 HVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAIN 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB6 SRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCRE ::.:.:.::::.:::::::::.:: :::::.:::.:::::..:::::. :::::::.:. NP_001 SRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQT 100 110 120 130 140 150 280 290 300 310 pF1KB6 KVANLCGINQKLLAEALNQV--TQRAS--RRSDSASSE-PVGI----------------Y ::::::::::::.:::: .. ::.: : ... : :: : NP_001 KVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPT 160 170 180 190 200 210 320 330 340 350 360 pF1KB6 QGFEKKTGVAGEDMQDNSGTYGKIWEG---------SSKCNINNFIFHKVLGKGSFGKVL : .. :.. :. :. . .. : . : .:..::.::.:::::::::. NP_001 PGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVF 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB6 LGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLF :.:.: ...::::::::::::.::::::::::::::.:: :.:::::..::::::..:: NP_001 LAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLF 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB6 FVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRD ::::.:::::::::::. .:.: :::::::::. ::::::::::.::::::::.:::.: NP_001 FVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKD 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB6 GHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIG ::::::::::::::..:.....:::::::::::::: : ::. ::::::::::::::::: NP_001 GHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIG 400 410 420 430 440 450 550 560 570 580 590 600 pF1KB6 QSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFK ::::::.::.:::.:::.:.: ::::. ::.::.: ::: ::: ::::: :.:. ::.:. NP_001 QSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFR 460 470 480 490 500 510 610 620 630 640 650 660 pF1KB6 TINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFS ::: ::.....:::::::::: : ::::.:::::: :::..:. ::.::::. : .:: NP_001 EINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFS 520 530 540 550 560 570 670 pF1KB6 FVNPKFEHLLED :.:: .:.:. NP_001 FMNPGMERLIS 580 >>XP_016871900 (OMIM: 600448) PREDICTED: protein kinase (581 aa) initn: 2757 init1: 1707 opt: 1718 Z-score: 622.3 bits: 125.3 E(85289): 6.3e-28 Smith-Waterman score: 2599; 65.2% identity (83.4% similar) in 580 aa overlap (125-674:1-580) 100 110 120 130 140 150 pF1KB6 CKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIH .: :. . : :. : .:::::::::.: XP_016 MDTKDMNEFETEGFFALHQRRGAIKQAKVH 10 20 30 160 170 180 190 200 210 pF1KB6 YIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAAN ..: ::: :::: ::::::::..::::::::::.:::::::::::::::.:..:::.: : XP_016 HVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAIN 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB6 SRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCRE ::.:.:.::::.:::::::::.:: :::::.:::.:::::..:::::. :::::::.:. XP_016 SRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQT 100 110 120 130 140 150 280 290 300 310 pF1KB6 KVANLCGINQKLLAEALNQV--TQRAS--RRSDSASSE-PVGI----------------Y ::::::::::::.:::: .. ::.: : ... : :: : XP_016 KVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPT 160 170 180 190 200 210 320 330 340 350 360 pF1KB6 QGFEKKTGVAGEDMQDNSGTYGKIWEG---------SSKCNINNFIFHKVLGKGSFGKVL : .. :.. :. :. . .. : . : .:..::.::.:::::::::. XP_016 PGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVF 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB6 LGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLF :.:.: ...::::::::::::.::::::::::::::.:: :.:::::..::::::..:: XP_016 LAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLF 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB6 FVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRD ::::.:::::::::::. .:.: :::::::::. ::::::::::.::::::::.:::.: XP_016 FVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKD 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB6 GHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIG ::::::::::::::..:.....:::::::::::::: : ::. ::::::::::::::::: XP_016 GHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIG 400 410 420 430 440 450 550 560 570 580 590 600 pF1KB6 QSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFK ::::::.::.:::.:::.:.: ::::. ::.::.: ::: ::: ::::: :.:. ::.:. XP_016 QSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFR 460 470 480 490 500 510 610 620 630 640 650 660 pF1KB6 TINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFS ::: ::.....:::::::::: : ::::.:::::: :::..:. ::.::::. : .:: XP_016 EINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFS 520 530 540 550 560 570 670 pF1KB6 FVNPKFEHLLED :.:: .:.:. XP_016 FMNPGMERLIS 580 >>NP_001310195 (OMIM: 600448) protein kinase C theta typ (581 aa) initn: 2757 init1: 1707 opt: 1718 Z-score: 622.3 bits: 125.3 E(85289): 6.3e-28 Smith-Waterman score: 2599; 65.2% identity (83.4% similar) in 580 aa overlap (125-674:1-580) 100 110 120 130 140 150 pF1KB6 CKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIH .: :. . : :. : .:::::::::.: NP_001 MDTKDMNEFETEGFFALHQRRGAIKQAKVH 10 20 30 160 170 180 190 200 210 pF1KB6 YIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAAN ..: ::: :::: ::::::::..::::::::::.:::::::::::::::.:..:::.: : NP_001 HVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAIN 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB6 SRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCRE ::.:.:.::::.:::::::::.:: :::::.:::.:::::..:::::. :::::::.:. NP_001 SRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQT 100 110 120 130 140 150 280 290 300 310 pF1KB6 KVANLCGINQKLLAEALNQV--TQRAS--RRSDSASSE-PVGI----------------Y ::::::::::::.:::: .. ::.: : ... : :: : NP_001 KVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPT 160 170 180 190 200 210 320 330 340 350 360 pF1KB6 QGFEKKTGVAGEDMQDNSGTYGKIWEG---------SSKCNINNFIFHKVLGKGSFGKVL : .. :.. :. :. . .. : . : .:..::.::.:::::::::. NP_001 PGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVF 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB6 LGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLF :.:.: ...::::::::::::.::::::::::::::.:: :.:::::..::::::..:: NP_001 LAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLF 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB6 FVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRD ::::.:::::::::::. .:.: :::::::::. ::::::::::.::::::::.:::.: NP_001 FVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKD 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB6 GHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIG ::::::::::::::..:.....:::::::::::::: : ::. ::::::::::::::::: NP_001 GHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIG 400 410 420 430 440 450 550 560 570 580 590 600 pF1KB6 QSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFK ::::::.::.:::.:::.:.: ::::. ::.::.: ::: ::: ::::: :.:. ::.:. NP_001 QSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFR 460 470 480 490 500 510 610 620 630 640 650 660 pF1KB6 TINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFS ::: ::.....:::::::::: : ::::.:::::: :::..:. ::.::::. : .:: NP_001 EINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFS 520 530 540 550 560 570 670 pF1KB6 FVNPKFEHLLED :.:: .:.:. NP_001 FMNPGMERLIS 580 676 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:21:49 2016 done: Sat Nov 5 14:21:51 2016 Total Scan time: 8.290 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]