FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6242, 687 aa 1>>>pF1KB6242 687 - 687 aa - 687 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5742+/-0.000427; mu= 14.5503+/- 0.027 mean_var=117.3397+/-23.486, 0's: 0 Z-trim(115.0): 210 B-trim: 914 in 1/53 Lambda= 0.118400 statistics sampled from 24973 (25190) to 24973 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.295), width: 16 Scan time: 11.340 The best scores are: opt bits E(85289) NP_001184148 (OMIM: 600129,606799,614613) cAMP-spe ( 687) 4507 781.5 0 NP_001184149 (OMIM: 600129,606799,614613) cAMP-spe ( 679) 4337 752.4 1.2e-216 NP_001098101 (OMIM: 600129,606799,614613) cAMP-spe ( 809) 4315 748.7 1.9e-215 NP_001184147 (OMIM: 600129,606799,614613) cAMP-spe ( 745) 4313 748.4 2.3e-215 XP_011541779 (OMIM: 600129,606799,614613) PREDICTE ( 662) 4309 747.7 3.3e-215 XP_016865057 (OMIM: 600129,606799,614613) PREDICTE ( 738) 4309 747.7 3.6e-215 XP_016865056 (OMIM: 600129,606799,614613) PREDICTE ( 743) 4309 747.7 3.7e-215 XP_011541773 (OMIM: 600129,606799,614613) PREDICTE ( 748) 4309 747.7 3.7e-215 XP_016865055 (OMIM: 600129,606799,614613) PREDICTE ( 748) 4309 747.7 3.7e-215 NP_001159371 (OMIM: 600129,606799,614613) cAMP-spe ( 748) 4309 747.7 3.7e-215 XP_011541775 (OMIM: 600129,606799,614613) PREDICTE ( 748) 4309 747.7 3.7e-215 XP_011541771 (OMIM: 600129,606799,614613) PREDICTE ( 797) 4309 747.7 3.9e-215 XP_016865054 (OMIM: 600129,606799,614613) PREDICTE ( 797) 4309 747.7 3.9e-215 XP_011541772 (OMIM: 600129,606799,614613) PREDICTE ( 797) 4309 747.7 3.9e-215 XP_005248595 (OMIM: 600129,606799,614613) PREDICTE ( 673) 4304 746.8 6.1e-215 NP_006194 (OMIM: 600129,606799,614613) cAMP-specif ( 673) 4304 746.8 6.1e-215 XP_016865058 (OMIM: 600129,606799,614613) PREDICTE ( 699) 4304 746.8 6.3e-215 XP_005248594 (OMIM: 600129,606799,614613) PREDICTE ( 699) 4304 746.8 6.3e-215 XP_016865060 (OMIM: 600129,606799,614613) PREDICTE ( 553) 3628 631.3 3e-180 XP_016865059 (OMIM: 600129,606799,614613) PREDICTE ( 553) 3628 631.3 3e-180 NP_001184151 (OMIM: 600129,606799,614613) cAMP-spe ( 585) 3541 616.4 9.4e-176 NP_001184150 (OMIM: 600129,606799,614613) cAMP-spe ( 507) 3328 580.0 7.5e-165 NP_001184152 (OMIM: 600129,606799,614613) cAMP-spe ( 518) 3304 575.9 1.3e-163 NP_001032417 (OMIM: 600127) cAMP-specific 3',5'-cy ( 721) 3239 564.9 3.7e-160 NP_001284370 (OMIM: 600127) cAMP-specific 3',5'-cy ( 661) 3226 562.7 1.6e-159 NP_001284369 (OMIM: 600127) cAMP-specific 3',5'-cy ( 644) 3225 562.5 1.8e-159 NP_002591 (OMIM: 600127) cAMP-specific 3',5'-cycli ( 736) 3225 562.5 2e-159 NP_001032418 (OMIM: 600127) cAMP-specific 3',5'-cy ( 736) 3225 562.5 2e-159 NP_000914 (OMIM: 600128) cAMP-specific 3',5'-cycli ( 712) 3052 533.0 1.5e-150 NP_001317101 (OMIM: 600128) cAMP-specific 3',5'-cy ( 712) 3052 533.0 1.5e-150 NP_001092288 (OMIM: 600128) cAMP-specific 3',5'-cy ( 680) 3045 531.7 3.4e-150 NP_001092289 (OMIM: 600128) cAMP-specific 3',5'-cy ( 606) 2926 511.4 4.1e-144 XP_011526358 (OMIM: 600128) PREDICTED: cAMP-specif ( 606) 2926 511.4 4.1e-144 XP_016856934 (OMIM: 600127) PREDICTED: cAMP-specif ( 597) 2922 510.7 6.4e-144 NP_001032416 (OMIM: 600127) cAMP-specific 3',5'-cy ( 564) 2720 476.2 1.5e-133 XP_006710743 (OMIM: 600127) PREDICTED: cAMP-specif ( 531) 2714 475.1 2.9e-133 XP_016856935 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 2713 475.0 3.3e-133 XP_011539868 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 2713 475.0 3.3e-133 XP_005270982 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 2669 467.4 5.9e-131 XP_005270981 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 2669 467.4 5.9e-131 NP_001284371 (OMIM: 600127) cAMP-specific 3',5'-cy ( 503) 2506 439.6 1.4e-122 XP_011526360 (OMIM: 600128) PREDICTED: cAMP-specif ( 481) 2374 417.0 8.2e-116 NP_006193 (OMIM: 600126) cAMP-specific 3',5'-cycli ( 647) 2207 388.6 4e-107 XP_005259990 (OMIM: 600126) PREDICTED: cAMP-specif ( 582) 2201 387.5 7.5e-107 NP_001104779 (OMIM: 600126) cAMP-specific 3',5'-cy ( 825) 2203 388.0 7.8e-107 NP_001104778 (OMIM: 600126) cAMP-specific 3',5'-cy ( 860) 2203 388.0 8e-107 XP_011526356 (OMIM: 600126) PREDICTED: cAMP-specif ( 864) 2203 388.0 8e-107 NP_001230050 (OMIM: 600126) cAMP-specific 3',5'-cy ( 864) 2203 388.0 8e-107 XP_016882354 (OMIM: 600126) PREDICTED: cAMP-specif ( 885) 2203 388.0 8.2e-107 NP_001104777 (OMIM: 600126) cAMP-specific 3',5'-cy ( 886) 2203 388.0 8.2e-107 >>NP_001184148 (OMIM: 600129,606799,614613) cAMP-specifi (687 aa) initn: 4507 init1: 4507 opt: 4507 Z-score: 4167.1 bits: 781.5 E(85289): 0 Smith-Waterman score: 4507; 100.0% identity (100.0% similar) in 687 aa overlap (1-687:1-687) 10 20 30 40 50 60 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 LTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 QISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 IMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 DNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 HNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 PEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE 610 620 630 640 650 660 670 680 pF1KB6 QVEEEAVGEEEESQPEACVIDDRSPDT ::::::::::::::::::::::::::: NP_001 QVEEEAVGEEEESQPEACVIDDRSPDT 670 680 >>NP_001184149 (OMIM: 600129,606799,614613) cAMP-specifi (679 aa) initn: 4337 init1: 4337 opt: 4337 Z-score: 4010.3 bits: 752.4 E(85289): 1.2e-216 Smith-Waterman score: 4337; 98.4% identity (99.1% similar) in 673 aa overlap (15-687:7-679) 10 20 30 40 50 60 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANF : .:. : :: ... :::::::::::::::::::::::::::::: NP_001 MSIIMKPRSRSTSSLRTAEAVCFDVDNGTSAGRSPLDPMTSPGSGLILQANF 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 VHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 LTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSE 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 QISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTV 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB6 IMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB6 LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB6 LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLL 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB6 DNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB6 HNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDD 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB6 PEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE 600 610 620 630 640 650 670 680 pF1KB6 QVEEEAVGEEEESQPEACVIDDRSPDT ::::::::::::::::::::::::::: NP_001 QVEEEAVGEEEESQPEACVIDDRSPDT 660 670 >>NP_001098101 (OMIM: 600129,606799,614613) cAMP-specifi (809 aa) initn: 4304 init1: 4304 opt: 4315 Z-score: 3988.9 bits: 748.7 E(85289): 1.9e-215 Smith-Waterman score: 4315; 98.4% identity (99.1% similar) in 672 aa overlap (20-687:138-809) 10 20 30 40 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYS----FDVDNGTSAGRSPLD :::. . .:.. ::::::::::::::: NP_001 GYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLD 110 120 130 140 150 160 50 60 70 80 90 100 pF1KB6 PMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFA 170 180 190 200 210 220 110 120 130 140 150 160 pF1KB6 QVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWC 230 240 250 260 270 280 170 180 190 200 210 220 pF1KB6 LDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIP 290 300 310 320 330 340 230 240 250 260 270 280 pF1KB6 SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLH 350 360 370 380 390 400 290 300 310 320 330 340 pF1KB6 VFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHA 410 420 430 440 450 460 350 360 370 380 390 400 pF1KB6 ADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYND 470 480 490 500 510 520 410 420 430 440 450 460 pF1KB6 SSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKT 530 540 550 560 570 580 470 480 490 500 510 520 pF1KB6 MVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGD 590 600 610 620 630 640 530 540 550 560 570 580 pF1KB6 RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREW 650 660 670 680 690 700 590 600 610 620 630 640 pF1KB6 YQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKT 710 720 730 740 750 760 650 660 670 680 pF1KB6 LCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT :::::::::::::::::::::::::::::::::::::::::: NP_001 LCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 770 780 790 800 >>NP_001184147 (OMIM: 600129,606799,614613) cAMP-specifi (745 aa) initn: 4304 init1: 4304 opt: 4313 Z-score: 3987.5 bits: 748.4 E(85289): 2.3e-215 Smith-Waterman score: 4313; 98.1% identity (99.1% similar) in 673 aa overlap (16-687:73-745) 10 20 30 40 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYS-FDVDNGTSAGRSPL :. .. ::. ... :::::::::::::: NP_001 SKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFDVDNGTSAGRSPL 50 60 70 80 90 100 50 60 70 80 90 100 pF1KB6 DPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPF 110 120 130 140 150 160 110 120 130 140 150 160 pF1KB6 AQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDW 170 180 190 200 210 220 170 180 190 200 210 220 pF1KB6 CLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEI 230 240 250 260 270 280 230 240 250 260 270 280 pF1KB6 PSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGL 290 300 310 320 330 340 290 300 310 320 330 340 pF1KB6 HVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIH 350 360 370 380 390 400 350 360 370 380 390 400 pF1KB6 AADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYN 410 420 430 440 450 460 410 420 430 440 450 460 pF1KB6 DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLK 470 480 490 500 510 520 470 480 490 500 510 520 pF1KB6 TMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQG 530 540 550 560 570 580 530 540 550 560 570 580 pF1KB6 DRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRE 590 600 610 620 630 640 590 600 610 620 630 640 pF1KB6 WYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSK 650 660 670 680 690 700 650 660 670 680 pF1KB6 TLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT ::::::::::::::::::::::::::::::::::::::::::: NP_001 TLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 710 720 730 740 >>XP_011541779 (OMIM: 600129,606799,614613) PREDICTED: c (662 aa) initn: 4309 init1: 4309 opt: 4309 Z-score: 3984.6 bits: 747.7 E(85289): 3.3e-215 Smith-Waterman score: 4309; 100.0% identity (100.0% similar) in 658 aa overlap (30-687:5-662) 10 20 30 40 50 60 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANF ::::::::::::::::::::::::::::::: XP_011 MQRLSFDVDNGTSAGRSPLDPMTSPGSGLILQANF 10 20 30 70 80 90 100 110 120 pF1KB6 VHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 LTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 QISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB6 IMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB6 LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB6 LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB6 DNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDK 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB6 HNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDD 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB6 PEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDE 580 590 600 610 620 630 670 680 pF1KB6 QVEEEAVGEEEESQPEACVIDDRSPDT ::::::::::::::::::::::::::: XP_011 QVEEEAVGEEEESQPEACVIDDRSPDT 640 650 660 >>XP_016865057 (OMIM: 600129,606799,614613) PREDICTED: c (738 aa) initn: 4309 init1: 4309 opt: 4309 Z-score: 3983.9 bits: 747.7 E(85289): 3.6e-215 Smith-Waterman score: 4309; 99.4% identity (99.8% similar) in 662 aa overlap (26-687:77-738) 10 20 30 40 50 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLI ..: .::::::::::::::::::::::::: XP_016 EQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGRSPLDPMTSPGSGLI 50 60 70 80 90 100 60 70 80 90 100 110 pF1KB6 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 110 120 130 140 150 160 120 130 140 150 160 170 pF1KB6 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 170 180 190 200 210 220 180 190 200 210 220 230 pF1KB6 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 230 240 250 260 270 280 240 250 260 270 280 290 pF1KB6 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 290 300 310 320 330 340 300 310 320 330 340 350 pF1KB6 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 350 360 370 380 390 400 360 370 380 390 400 410 pF1KB6 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 410 420 430 440 450 460 420 430 440 450 460 470 pF1KB6 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 470 480 490 500 510 520 480 490 500 510 520 530 pF1KB6 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 530 540 550 560 570 580 540 550 560 570 580 590 pF1KB6 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 590 600 610 620 630 640 600 610 620 630 640 650 pF1KB6 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 650 660 670 680 690 700 660 670 680 pF1KB6 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT :::::::::::::::::::::::::::::::: XP_016 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 710 720 730 >>XP_016865056 (OMIM: 600129,606799,614613) PREDICTED: c (743 aa) initn: 4309 init1: 4309 opt: 4309 Z-score: 3983.9 bits: 747.7 E(85289): 3.7e-215 Smith-Waterman score: 4309; 99.4% identity (99.8% similar) in 662 aa overlap (26-687:82-743) 10 20 30 40 50 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLI ..: .::::::::::::::::::::::::: XP_016 EQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGRSPLDPMTSPGSGLI 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB6 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB6 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB6 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB6 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB6 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 360 370 380 390 400 410 360 370 380 390 400 410 pF1KB6 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 420 430 440 450 460 470 420 430 440 450 460 470 pF1KB6 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 480 490 500 510 520 530 480 490 500 510 520 530 pF1KB6 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 540 550 560 570 580 590 540 550 560 570 580 590 pF1KB6 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 600 610 620 630 640 650 600 610 620 630 640 650 pF1KB6 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 660 670 680 690 700 710 660 670 680 pF1KB6 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT :::::::::::::::::::::::::::::::: XP_016 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 720 730 740 >>XP_011541773 (OMIM: 600129,606799,614613) PREDICTED: c (748 aa) initn: 4309 init1: 4309 opt: 4309 Z-score: 3983.8 bits: 747.7 E(85289): 3.7e-215 Smith-Waterman score: 4309; 99.4% identity (99.8% similar) in 662 aa overlap (26-687:87-748) 10 20 30 40 50 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLI ..: .::::::::::::::::::::::::: XP_011 EQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGRSPLDPMTSPGSGLI 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB6 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB6 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB6 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB6 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB6 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 360 370 380 390 400 410 360 370 380 390 400 410 pF1KB6 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 420 430 440 450 460 470 420 430 440 450 460 470 pF1KB6 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 480 490 500 510 520 530 480 490 500 510 520 530 pF1KB6 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 540 550 560 570 580 590 540 550 560 570 580 590 pF1KB6 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 600 610 620 630 640 650 600 610 620 630 640 650 pF1KB6 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 660 670 680 690 700 710 660 670 680 pF1KB6 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT :::::::::::::::::::::::::::::::: XP_011 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 720 730 740 >>XP_016865055 (OMIM: 600129,606799,614613) PREDICTED: c (748 aa) initn: 4309 init1: 4309 opt: 4309 Z-score: 3983.8 bits: 747.7 E(85289): 3.7e-215 Smith-Waterman score: 4309; 99.4% identity (99.8% similar) in 662 aa overlap (26-687:87-748) 10 20 30 40 50 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLI ..: .::::::::::::::::::::::::: XP_016 EQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGRSPLDPMTSPGSGLI 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB6 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB6 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB6 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB6 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB6 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 360 370 380 390 400 410 360 370 380 390 400 410 pF1KB6 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 420 430 440 450 460 470 420 430 440 450 460 470 pF1KB6 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 480 490 500 510 520 530 480 490 500 510 520 530 pF1KB6 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 540 550 560 570 580 590 540 550 560 570 580 590 pF1KB6 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 600 610 620 630 640 650 600 610 620 630 640 650 pF1KB6 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 660 670 680 690 700 710 660 670 680 pF1KB6 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT :::::::::::::::::::::::::::::::: XP_016 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 720 730 740 >>NP_001159371 (OMIM: 600129,606799,614613) cAMP-specifi (748 aa) initn: 4309 init1: 4309 opt: 4309 Z-score: 3983.8 bits: 747.7 E(85289): 3.7e-215 Smith-Waterman score: 4309; 99.4% identity (99.8% similar) in 662 aa overlap (26-687:87-748) 10 20 30 40 50 pF1KB6 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLI ..: .::::::::::::::::::::::::: NP_001 EQADLKSESENIQRPTSLPLKILPLIAITSAESSGFDVDNGTSAGRSPLDPMTSPGSGLI 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB6 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB6 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB6 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB6 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB6 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 360 370 380 390 400 410 360 370 380 390 400 410 pF1KB6 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 420 430 440 450 460 470 420 430 440 450 460 470 pF1KB6 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 480 490 500 510 520 530 480 490 500 510 520 530 pF1KB6 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 540 550 560 570 580 590 540 550 560 570 580 590 pF1KB6 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 600 610 620 630 640 650 600 610 620 630 640 650 pF1KB6 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 660 670 680 690 700 710 660 670 680 pF1KB6 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT :::::::::::::::::::::::::::::::: NP_001 IPLDEQVEEEAVGEEEESQPEACVIDDRSPDT 720 730 740 687 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:42:44 2016 done: Sat Nov 5 18:42:46 2016 Total Scan time: 11.340 Total Display time: 0.210 Function used was FASTA [36.3.4 Apr, 2011]