Result of FASTA (omim) for
pF1KB6249
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6249, 756 aa
1>>>pF1KB6249 756 - 756 aa - 756 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.5724+/-0.000678; mu= -19.6814+/- 0.040
mean_var=900.3757+/-199.349, 0's: 0 Z-trim(115.3): 971 B-trim: 0 in 0/57
Lambda= 0.042743
statistics sampled from 24432 (25667) to 24432 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.301), width: 16
Scan time: 11.980
The best scores are: opt bits E(85289)
NP_001547 (OMIM: 603258,615592) inhibitor of nucle ( 756) 5051 328.8 5e-89
XP_005273547 (OMIM: 603258,615592) PREDICTED: inhi ( 805) 4901 319.6 3.2e-86
XP_011542819 (OMIM: 603258,615592) PREDICTED: inhi ( 805) 4901 319.6 3.2e-86
NP_001177649 (OMIM: 603258,615592) inhibitor of nu ( 754) 4798 313.2 2.5e-84
XP_005273549 (OMIM: 603258,615592) PREDICTED: inhi ( 706) 4707 307.6 1.2e-82
NP_001229707 (OMIM: 603258,615592) inhibitor of nu ( 697) 4574 299.4 3.4e-80
XP_005273551 (OMIM: 603258,615592) PREDICTED: inhi ( 674) 4441 291.1 9.9e-78
XP_011542821 (OMIM: 603258,615592) PREDICTED: inhi ( 746) 4424 290.2 2.2e-77
XP_005273548 (OMIM: 603258,615592) PREDICTED: inhi ( 746) 4424 290.2 2.2e-77
XP_005273550 (OMIM: 603258,615592) PREDICTED: inhi ( 700) 3992 263.5 2.2e-69
XP_011542822 (OMIM: 603258,615592) PREDICTED: inhi ( 720) 3992 263.5 2.2e-69
XP_011542823 (OMIM: 603258,615592) PREDICTED: inhi ( 595) 3316 221.7 7.1e-57
XP_005273553 (OMIM: 603258,615592) PREDICTED: inhi ( 595) 3316 221.7 7.1e-57
XP_005273552 (OMIM: 603258,615592) PREDICTED: inhi ( 595) 3316 221.7 7.1e-57
XP_005273555 (OMIM: 603258,615592) PREDICTED: inhi ( 595) 3316 221.7 7.1e-57
XP_011542820 (OMIM: 603258,615592) PREDICTED: inhi ( 755) 3316 221.8 8.1e-57
XP_011542824 (OMIM: 603258,615592) PREDICTED: inhi ( 526) 2986 201.3 8.8e-51
XP_016868885 (OMIM: 603258,615592) PREDICTED: inhi ( 526) 2986 201.3 8.8e-51
NP_001269 (OMIM: 600664,613630) inhibitor of nucle ( 745) 2488 170.8 1.9e-41
XP_016871100 (OMIM: 600664,613630) PREDICTED: inhi ( 814) 2451 168.5 9.6e-41
NP_001307857 (OMIM: 600664,613630) inhibitor of nu ( 719) 2409 165.9 5.4e-40
XP_016871101 (OMIM: 600664,613630) PREDICTED: inhi ( 598) 2157 150.2 2.3e-35
XP_016871102 (OMIM: 600664,613630) PREDICTED: inhi ( 410) 857 69.8 2.5e-11
NP_001136082 (OMIM: 608650) serine/threonine-prote (1036) 447 45.1 0.0018
NP_055498 (OMIM: 608650) serine/threonine-protein (1036) 447 45.1 0.0018
XP_011537101 (OMIM: 603168) PREDICTED: serine/thre (1044) 430 44.1 0.0037
NP_003556 (OMIM: 603168) serine/threonine-protein (1050) 430 44.1 0.0037
XP_011537100 (OMIM: 603168) PREDICTED: serine/thre (1073) 430 44.1 0.0037
>>NP_001547 (OMIM: 603258,615592) inhibitor of nuclear f (756 aa)
initn: 5051 init1: 5051 opt: 5051 Z-score: 1719.3 bits: 328.8 E(85289): 5e-89
Smith-Waterman score: 5051; 100.0% identity (100.0% similar) in 756 aa overlap (1-756:1-756)
10 20 30 40 50 60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
670 680 690 700 710 720
730 740 750
pF1KB6 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
::::::::::::::::::::::::::::::::::::
NP_001 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
730 740 750
>>XP_005273547 (OMIM: 603258,615592) PREDICTED: inhibito (805 aa)
initn: 4901 init1: 4901 opt: 4901 Z-score: 1669.0 bits: 319.6 E(85289): 3.2e-86
Smith-Waterman score: 4901; 100.0% identity (100.0% similar) in 735 aa overlap (1-735:1-735)
10 20 30 40 50 60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
670 680 690 700 710 720
730 740 750
pF1KB6 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
:::::::::::::::
XP_005 NAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEEKMEMQSGIILNLSVCLFACLFVTG
730 740 750 760 770 780
>>XP_011542819 (OMIM: 603258,615592) PREDICTED: inhibito (805 aa)
initn: 4901 init1: 4901 opt: 4901 Z-score: 1669.0 bits: 319.6 E(85289): 3.2e-86
Smith-Waterman score: 4901; 100.0% identity (100.0% similar) in 735 aa overlap (1-735:1-735)
10 20 30 40 50 60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
670 680 690 700 710 720
730 740 750
pF1KB6 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
:::::::::::::::
XP_011 NAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEEKMEMQSGIILNLSVCLFACLFVTG
730 740 750 760 770 780
>>NP_001177649 (OMIM: 603258,615592) inhibitor of nuclea (754 aa)
initn: 4798 init1: 4798 opt: 4798 Z-score: 1635.0 bits: 313.2 E(85289): 2.5e-84
Smith-Waterman score: 4798; 100.0% identity (100.0% similar) in 722 aa overlap (35-756:33-754)
10 20 30 40 50 60
pF1KB6 PSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQI
::::::::::::::::::::::::::::::
NP_001 SGGCHSPGFGRPSPAFPAPGSPPPAPRPCRQETGEQIAIKQCRQELSPRNRERWCLEIQI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 MRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 TLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 VSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 DILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 KPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 QLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 FFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 VDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 VRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 VRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQ
670 680 690 700 710 720
730 740 750
pF1KB6 DTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
::::::::::::::::::::::::::::::::
NP_001 DTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
730 740 750
>>XP_005273549 (OMIM: 603258,615592) PREDICTED: inhibito (706 aa)
initn: 4707 init1: 4707 opt: 4707 Z-score: 1604.9 bits: 307.6 E(85289): 1.2e-82
Smith-Waterman score: 4707; 100.0% identity (100.0% similar) in 704 aa overlap (1-704:1-704)
10 20 30 40 50 60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKRP
670 680 690 700
730 740 750
pF1KB6 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
>>NP_001229707 (OMIM: 603258,615592) inhibitor of nuclea (697 aa)
initn: 4574 init1: 4574 opt: 4574 Z-score: 1560.7 bits: 299.4 E(85289): 3.4e-80
Smith-Waterman score: 4574; 100.0% identity (100.0% similar) in 690 aa overlap (67-756:8-697)
40 50 60 70 80 90
pF1KB6 TGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
::::::::::::::::::::::::::::::
NP_001 MSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
10 20 30
100 110 120 130 140 150
pF1KB6 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB6 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB6 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB6 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB6 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB6 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
340 350 360 370 380 390
460 470 480 490 500 510
pF1KB6 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
400 410 420 430 440 450
520 530 540 550 560 570
pF1KB6 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
460 470 480 490 500 510
580 590 600 610 620 630
pF1KB6 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
520 530 540 550 560 570
640 650 660 670 680 690
pF1KB6 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
580 590 600 610 620 630
700 710 720 730 740 750
pF1KB6 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
640 650 660 670 680 690
>>XP_005273551 (OMIM: 603258,615592) PREDICTED: inhibito (674 aa)
initn: 4441 init1: 4441 opt: 4441 Z-score: 1516.5 bits: 291.1 E(85289): 9.9e-78
Smith-Waterman score: 4441; 99.6% identity (99.6% similar) in 667 aa overlap (1-667:1-667)
10 20 30 40 50 60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
:: ::
XP_005 ACPGHRGCKPQEFP
670
>>XP_011542821 (OMIM: 603258,615592) PREDICTED: inhibito (746 aa)
initn: 4424 init1: 4424 opt: 4424 Z-score: 1510.4 bits: 290.2 E(85289): 2.2e-77
Smith-Waterman score: 4424; 100.0% identity (100.0% similar) in 669 aa overlap (67-735:8-676)
40 50 60 70 80 90
pF1KB6 TGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
::::::::::::::::::::::::::::::
XP_011 MSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
10 20 30
100 110 120 130 140 150
pF1KB6 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB6 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB6 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB6 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB6 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB6 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
340 350 360 370 380 390
460 470 480 490 500 510
pF1KB6 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
400 410 420 430 440 450
520 530 540 550 560 570
pF1KB6 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
460 470 480 490 500 510
580 590 600 610 620 630
pF1KB6 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
520 530 540 550 560 570
640 650 660 670 680 690
pF1KB6 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
580 590 600 610 620 630
700 710 720 730 740 750
pF1KB6 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
:::::::::::::::::::::::::::::::::::::::
XP_011 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEE
640 650 660 670 680 690
XP_011 KMEMQSGIILNLSVCLFACLFVTGSLSLTQAGVQWHDLGSLQPPLPGFK
700 710 720 730 740
>>XP_005273548 (OMIM: 603258,615592) PREDICTED: inhibito (746 aa)
initn: 4424 init1: 4424 opt: 4424 Z-score: 1510.4 bits: 290.2 E(85289): 2.2e-77
Smith-Waterman score: 4424; 100.0% identity (100.0% similar) in 669 aa overlap (67-735:8-676)
40 50 60 70 80 90
pF1KB6 TGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
::::::::::::::::::::::::::::::
XP_005 MSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
10 20 30
100 110 120 130 140 150
pF1KB6 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB6 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB6 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB6 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB6 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB6 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
340 350 360 370 380 390
460 470 480 490 500 510
pF1KB6 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
400 410 420 430 440 450
520 530 540 550 560 570
pF1KB6 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
460 470 480 490 500 510
580 590 600 610 620 630
pF1KB6 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
520 530 540 550 560 570
640 650 660 670 680 690
pF1KB6 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
580 590 600 610 620 630
700 710 720 730 740 750
pF1KB6 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
:::::::::::::::::::::::::::::::::::::::
XP_005 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEE
640 650 660 670 680 690
XP_005 KMEMQSGIILNLSVCLFACLFVTGSLSLTQAGVQWHDLGSLQPPLPGFK
700 710 720 730 740
>>XP_005273550 (OMIM: 603258,615592) PREDICTED: inhibito (700 aa)
initn: 3992 init1: 3992 opt: 3992 Z-score: 1366.7 bits: 263.5 E(85289): 2.2e-69
Smith-Waterman score: 3992; 99.3% identity (99.8% similar) in 610 aa overlap (126-735:21-630)
100 110 120 130 140 150
pF1KB6 MEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQ
... ::::::::::::::::::::::::::
XP_005 MWGLGNERAPWDRGIWKCHPMAQSASALRYLHENRIIHRDLKPENIVLQQ
10 20 30 40 50
160 170 180 190 200 210
pF1KB6 GEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFEC
60 70 80 90 100 110
220 230 240 250 260 270
pF1KB6 ITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEK
120 130 140 150 160 170
280 290 300 310 320 330
pF1KB6 WLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQS
180 190 200 210 220 230
340 350 360 370 380 390
pF1KB6 LKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKI
240 250 260 270 280 290
400 410 420 430 440 450
pF1KB6 TYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAM
300 310 320 330 340 350
460 470 480 490 500 510
pF1KB6 MNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWR
360 370 380 390 400 410
520 530 540 550 560 570
pF1KB6 EMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLR
420 430 440 450 460 470
580 590 600 610 620 630
pF1KB6 EKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSL
480 490 500 510 520 530
640 650 660 670 680 690
pF1KB6 MNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTAS
540 550 560 570 580 590
700 710 720 730 740 750
pF1KB6 NSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQA
::::::::::::::::::::::::::::::::::::::::
XP_005 NSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIE
600 610 620 630 640 650
pF1KB6 S
XP_005 EKMEMQSGIILNLSVCLFACLFVTGSLSLTQAGVQWHDLGSLQPPLPGFK
660 670 680 690 700
756 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 14:28:13 2016 done: Sat Nov 5 14:28:15 2016
Total Scan time: 11.980 Total Display time: 0.200
Function used was FASTA [36.3.4 Apr, 2011]