FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6271, 670 aa 1>>>pF1KB6271 670 - 670 aa - 670 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4763+/-0.00082; mu= 15.4116+/- 0.050 mean_var=129.2660+/-24.653, 0's: 0 Z-trim(111.2): 76 B-trim: 0 in 0/51 Lambda= 0.112806 statistics sampled from 12135 (12210) to 12135 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.375), width: 16 Scan time: 4.390 The best scores are: opt bits E(32554) CCDS47927.1 RHPN1 gene_id:114822|Hs108|chr8 ( 670) 4513 746.1 3.6e-215 CCDS12427.1 RHPN2 gene_id:85415|Hs108|chr19 ( 686) 1649 280.0 7.5e-75 CCDS2754.1 PTPN23 gene_id:25930|Hs108|chr3 (1636) 453 85.7 5.6e-16 >>CCDS47927.1 RHPN1 gene_id:114822|Hs108|chr8 (670 aa) initn: 4513 init1: 4513 opt: 4513 Z-score: 3976.4 bits: 746.1 E(32554): 3.6e-215 Smith-Waterman score: 4513; 100.0% identity (100.0% similar) in 670 aa overlap (1-670:1-670) 10 20 30 40 50 60 pF1KB6 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 GSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 DRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 DRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAP 610 620 630 640 650 660 670 pF1KB6 PSSLKHPGWP :::::::::: CCDS47 PSSLKHPGWP 670 >>CCDS12427.1 RHPN2 gene_id:85415|Hs108|chr19 (686 aa) initn: 1600 init1: 1405 opt: 1649 Z-score: 1457.3 bits: 280.0 E(32554): 7.5e-75 Smith-Waterman score: 1649; 42.2% identity (71.3% similar) in 658 aa overlap (20-667:23-675) 10 20 30 40 50 pF1KB6 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENL .::. :.: ..::..:: ..::: : ..:::::::: CCDS12 MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 YRATSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKET ....:..::: : ::::.:::.::.:::::: :. .: .. :: :.:.:::::::: CCDS12 LKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKET 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 KELDWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCF :..:... ::..: :..::: :: :: .: :::: :::::.:.:.::: .:. :: : CCDS12 KDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 LDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTE ...::. :.:..::.: :::::::::..:. : .::.::::: :::.::::.: ::. CCDS12 VESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 GARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPAS : . :..:::::::... :...:.:.:: ::: : : .: ..:.::::: ::: .: :. CCDS12 GLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPG- 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 MAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHY .. . ...:::::.:. :. .: .:.: ::.. .: ::..:. :::... .:::: CCDS12 -IRNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHY 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 HVAMALCDGS--PATEGELPTHEQVFLQPPTSSKPRG--PVLP-QELEERRQLGKAHLKR .:. : : . :.:. . :.. :. . :.: :. .. ..::::::.::.: CCDS12 FTAILLIDHQVKPGTDLD---HQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRR 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB6 AILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPK :. .::..: .::. :: ...:. :. . .:: ::. ..:::. . .::.. : CCDS12 AMAHHEESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAK 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB6 THQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSP :.:. . .:..:. :.:..:::::::::..:: ...: :: .:.::::..: CCDS12 TEQEVDIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB6 VLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLP : . . : .:..:: .:::::::.. :.: .::. ::. :: ..::::: CCDS12 VQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLD 540 550 560 570 580 590 600 610 620 630 640 pF1KB6 S-SRLPSLGDRRPV-LLGPRGLLRSQREHGCKTPASTWASPR-PLLNW--SRKAQQGKTG : : . . . : . ... . :: . : . .:.: ... :.. . CCDS12 STSSMHNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSAST 600 610 620 630 640 650 650 660 670 pF1KB6 GCPQPCAPVKPAPPSSLKHPGWP : . ..: ..: : CCDS12 LCLPSVGAARPQVKKKLPSPFSLLNSDSSWY 660 670 680 >>CCDS2754.1 PTPN23 gene_id:25930|Hs108|chr3 (1636 aa) initn: 448 init1: 231 opt: 453 Z-score: 400.4 bits: 85.7 E(32554): 5.6e-16 Smith-Waterman score: 474; 29.6% identity (55.3% similar) in 416 aa overlap (103-506:2-370) 80 90 100 110 120 130 pF1KB6 ELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVT-VPMIPLGLKETKELDWSTPLKELIS ::: .::: : :::. .. .. .:... CCDS27 MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVL 10 20 30 140 150 160 170 180 pF1KB6 VHFGEDGASYEAEIRELEALRQ-AMRTPSRNESGLELLTAYYNQLCFLDARF-LTPARSL ..::. .:. :...:: ::: :.:.: :. : .: : .:: .:..: . .. CCDS27 KNYGENPEAYNEELKKLELLRQNAVRVP-RDFEGCSVLRKYLGQLHYLQSRVPMGSGQEA 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB6 GLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRA .. : . ..: . .. . .:.. .:.:.::::...:: . : :: . . :: : CCDS27 AVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCA 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB6 AGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRL ::::. :::.: .: : ::: : .::..:::::..: :: : .. . CCDS27 AGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLE-----KSML--DNRKSFLV 160 170 180 190 200 310 320 330 340 350 360 pF1KB6 AQEAAQVAAEYRLVHRTMAQPPVHDY---VPVSWTALVHVKAEYFRSLAHYHVAMALCDG :. .:::. :. . :.. .: . . . .: ::..: :: ..:: :. : CCDS27 ARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHM------G 210 220 230 240 250 370 380 390 400 410 420 pF1KB6 SPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHAL . : : :.. :: :... :. .::..: CCDS27 KQAEE------------------------QQKFGERV----AYFQSALDKLNEAIKLAK- 260 270 280 430 440 450 460 470 480 pF1KB6 CRVLREVDLLRAVISQTLQRSLAKYAELDREDDFC--EAAEAPD-IQPKTHQ---KPEAR . : .. .. :.. .:: ...:: ::. : : .:: :: CCDS27 ----GQPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPV 290 300 310 320 330 340 490 500 510 520 530 540 pF1KB6 MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP : ::::: .: :... :.. CCDS27 NPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLD 350 360 370 380 390 400 670 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:01:11 2016 done: Sat Nov 5 19:01:12 2016 Total Scan time: 4.390 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]