FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6271, 670 aa 1>>>pF1KB6271 670 - 670 aa - 670 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0192+/-0.000358; mu= 12.1613+/- 0.022 mean_var=153.9861+/-30.722, 0's: 0 Z-trim(118.7): 152 B-trim: 386 in 1/54 Lambda= 0.103355 statistics sampled from 31693 (31894) to 31693 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.374), width: 16 Scan time: 13.530 The best scores are: opt bits E(85289) NP_443156 (OMIM: 601031) rhophilin-1 [Homo sapiens ( 670) 4513 685.3 1.9e-196 XP_011515121 (OMIM: 601031) PREDICTED: rhophilin-1 ( 676) 4473 679.4 1.2e-194 XP_005250829 (OMIM: 601031) PREDICTED: rhophilin-1 ( 723) 4393 667.5 4.9e-191 XP_005250830 (OMIM: 601031) PREDICTED: rhophilin-1 ( 722) 4376 664.9 2.8e-190 XP_011515120 (OMIM: 601031) PREDICTED: rhophilin-1 ( 712) 4353 661.5 3e-189 XP_011515119 (OMIM: 601031) PREDICTED: rhophilin-1 ( 729) 4353 661.5 3e-189 XP_011515122 (OMIM: 601031) PREDICTED: rhophilin-1 ( 664) 4343 660.0 8e-189 XP_006716565 (OMIM: 601031) PREDICTED: rhophilin-1 ( 728) 4336 659.0 1.8e-188 XP_016868504 (OMIM: 601031) PREDICTED: rhophilin-1 ( 621) 4179 635.5 1.8e-181 XP_011515123 (OMIM: 601031) PREDICTED: rhophilin-1 ( 627) 4139 629.5 1.1e-179 XP_011515124 (OMIM: 601031) PREDICTED: rhophilin-1 ( 627) 4139 629.5 1.1e-179 XP_016868502 (OMIM: 601031) PREDICTED: rhophilin-1 ( 686) 3815 581.3 4.1e-165 XP_016868505 (OMIM: 601031) PREDICTED: rhophilin-1 ( 621) 2980 456.7 1.2e-127 XP_011515125 (OMIM: 601031) PREDICTED: rhophilin-1 ( 627) 2940 450.8 7.3e-126 XP_016868503 (OMIM: 601031) PREDICTED: rhophilin-1 ( 626) 2923 448.2 4.2e-125 NP_056281 (OMIM: 606584) tyrosine-protein phosphat (1636) 453 80.3 6.3e-14 NP_001243121 (OMIM: 608074) programmed cell death ( 271) 269 52.2 3.1e-06 NP_037506 (OMIM: 608074) programmed cell death 6-i ( 868) 275 53.5 3.9e-06 NP_001155901 (OMIM: 608074) programmed cell death ( 873) 266 52.2 9.8e-06 XP_005265088 (OMIM: 606584) PREDICTED: tyrosine-pr (1626) 266 52.4 1.5e-05 NP_001291411 (OMIM: 606584) tyrosine-protein phosp (1510) 232 47.3 0.00049 >>NP_443156 (OMIM: 601031) rhophilin-1 [Homo sapiens] (670 aa) initn: 4513 init1: 4513 opt: 4513 Z-score: 3647.9 bits: 685.3 E(85289): 1.9e-196 Smith-Waterman score: 4513; 100.0% identity (100.0% similar) in 670 aa overlap (1-670:1-670) 10 20 30 40 50 60 pF1KB6 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 GSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 GSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 DRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 DRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAP 610 620 630 640 650 660 670 pF1KB6 PSSLKHPGWP :::::::::: NP_443 PSSLKHPGWP 670 >>XP_011515121 (OMIM: 601031) PREDICTED: rhophilin-1 iso (676 aa) initn: 4484 init1: 3234 opt: 4473 Z-score: 3615.6 bits: 679.4 E(85289): 1.2e-194 Smith-Waterman score: 4473; 99.0% identity (99.0% similar) in 676 aa overlap (1-670:1-676) 10 20 30 40 50 60 pF1KB6 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 RFLTPARSLGLFFH------WYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRS :::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_011 RFLTPARSLGLFFHCLTQHCRYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 CTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB6 PASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB6 AHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAI 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB6 LGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTH 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB6 QKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB6 IAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSS 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB6 RLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCA 610 620 630 640 650 660 660 670 pF1KB6 PVKPAPPSSLKHPGWP :::::::::::::::: XP_011 PVKPAPPSSLKHPGWP 670 >>XP_005250829 (OMIM: 601031) PREDICTED: rhophilin-1 iso (723 aa) initn: 4499 init1: 4379 opt: 4393 Z-score: 3550.8 bits: 667.5 E(85289): 4.9e-191 Smith-Waterman score: 4393; 98.1% identity (98.8% similar) in 668 aa overlap (5-670:56-723) 10 20 30 pF1KB6 MILEERPDGAGAGEESPRLQ--GCDSLTQIQCGQ : : . .: .:.:. :::::::::::: XP_005 PRKTRVSSLRGRREGLRDVCAWRGCRVHRGEDPVRVHVGPMNPQLHAVGCDSLTQIQCGQ 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB6 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFE 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB6 KGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAAS 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB6 LCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPV 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB6 HDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRG 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB6 PVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYA 450 460 470 480 490 500 460 470 480 490 500 510 pF1KB6 ELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVG 510 520 530 540 550 560 520 530 540 550 560 570 pF1KB6 PVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVV 570 580 590 600 610 620 580 590 600 610 620 630 pF1KB6 TELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPR 630 640 650 660 670 680 640 650 660 670 pF1KB6 PLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP :::::::::::::::::::::::::::::::::::::: XP_005 PLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP 690 700 710 720 >>XP_005250830 (OMIM: 601031) PREDICTED: rhophilin-1 iso (722 aa) initn: 4480 init1: 2301 opt: 4376 Z-score: 3537.1 bits: 664.9 E(85289): 2.8e-190 Smith-Waterman score: 4376; 97.9% identity (98.7% similar) in 668 aa overlap (5-670:56-722) 10 20 30 pF1KB6 MILEERPDGAGAGEESPRLQ--GCDSLTQIQCGQ : : . .: .:.:. :::::::::::: XP_005 PRKTRVSSLRGRREGLRDVCAWRGCRVHRGEDPVRVHVGPMNPQLHAVGCDSLTQIQCGQ 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB6 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFE 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB6 KGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAAS 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB6 LCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPV 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB6 HDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRG :::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::: XP_005 HDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSP-TEGELPTHEQVFLQPPTSSKPRG 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB6 PVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYA 450 460 470 480 490 500 460 470 480 490 500 510 pF1KB6 ELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVG 510 520 530 540 550 560 520 530 540 550 560 570 pF1KB6 PVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVV 570 580 590 600 610 620 580 590 600 610 620 630 pF1KB6 TELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPR 630 640 650 660 670 680 640 650 660 670 pF1KB6 PLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP :::::::::::::::::::::::::::::::::::::: XP_005 PLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP 690 700 710 720 >>XP_011515120 (OMIM: 601031) PREDICTED: rhophilin-1 iso (712 aa) initn: 4350 init1: 3234 opt: 4353 Z-score: 3518.6 bits: 661.5 E(85289): 3e-189 Smith-Waterman score: 4353; 97.0% identity (97.8% similar) in 674 aa overlap (5-670:39-712) 10 20 30 pF1KB6 MILEERPDGAGAGEESPRLQ--GCDSLTQIQCGQ : : . .: .:.:. :::::::::::: XP_011 PRKTRVSSLRGRREGLRDVCAWRGCRVHRGEDPVRVHVGPMNPQLHAVGCDSLTQIQCGQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR 130 140 150 160 170 180 160 170 180 190 200 pF1KB6 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFH------WYDSLTGVPAQQ :::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHCLTQHCRYDSLTGVPAQQ 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB6 RALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSP 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB6 DMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRT 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB6 MAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPT 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB6 SSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQR 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB6 SLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKN 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB6 RWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWW 550 560 570 580 590 600 570 580 590 600 610 620 pF1KB6 RHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPAS 610 620 630 640 650 660 630 640 650 660 670 pF1KB6 TWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP :::::::::::::::::::::::::::::::::::::::::::: XP_011 TWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP 670 680 690 700 710 >>XP_011515119 (OMIM: 601031) PREDICTED: rhophilin-1 iso (729 aa) initn: 4470 init1: 3234 opt: 4353 Z-score: 3518.5 bits: 661.5 E(85289): 3e-189 Smith-Waterman score: 4353; 97.0% identity (97.8% similar) in 674 aa overlap (5-670:56-729) 10 20 30 pF1KB6 MILEERPDGAGAGEESPRLQ--GCDSLTQIQCGQ : : . .: .:.:. :::::::::::: XP_011 PRKTRVSSLRGRREGLRDVCAWRGCRVHRGEDPVRVHVGPMNPQLHAVGCDSLTQIQCGQ 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR 150 160 170 180 190 200 160 170 180 190 200 pF1KB6 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFH------WYDSLTGVPAQQ :::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHCLTQHCRYDSLTGVPAQQ 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB6 RALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSP 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB6 DMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRT 330 340 350 360 370 380 330 340 350 360 370 380 pF1KB6 MAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPT 390 400 410 420 430 440 390 400 410 420 430 440 pF1KB6 SSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQR 450 460 470 480 490 500 450 460 470 480 490 500 pF1KB6 SLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKN 510 520 530 540 550 560 510 520 530 540 550 560 pF1KB6 RWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWW 570 580 590 600 610 620 570 580 590 600 610 620 pF1KB6 RHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPAS 630 640 650 660 670 680 630 640 650 660 670 pF1KB6 TWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP :::::::::::::::::::::::::::::::::::::::::::: XP_011 TWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP 690 700 710 720 >>XP_011515122 (OMIM: 601031) PREDICTED: rhophilin-1 iso (664 aa) initn: 4350 init1: 3234 opt: 4343 Z-score: 3511.0 bits: 660.0 E(85289): 8e-189 Smith-Waterman score: 4343; 98.2% identity (98.6% similar) in 663 aa overlap (16-670:2-664) 10 20 30 40 50 pF1KB6 MILEERPDGAGAGEESPRLQ--GCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLY .:.:. :::::::::::::::::::::::::::::::::::::: XP_011 MNPQLHAVGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLY 10 20 30 40 60 70 80 90 100 110 pF1KB6 RATSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RATSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 ELDWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELDWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB6 DARFLTPARSLGLFFH------WYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQD :::::::::::::::: ::::::::::::::::::::::::::::::::::::: XP_011 DARFLTPARSLGLFFHCLTQHCRYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQD 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB6 RSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB6 SPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFR 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB6 SLAHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLAHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKR 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB6 AILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPK 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB6 THQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 THQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSP 470 480 490 500 510 520 540 550 560 570 580 590 pF1KB6 VLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLP 530 540 550 560 570 580 600 610 620 630 640 650 pF1KB6 SSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQP 590 600 610 620 630 640 660 670 pF1KB6 CAPVKPAPPSSLKHPGWP :::::::::::::::::: XP_011 CAPVKPAPPSSLKHPGWP 650 660 >>XP_006716565 (OMIM: 601031) PREDICTED: rhophilin-1 iso (728 aa) initn: 4451 init1: 2073 opt: 4336 Z-score: 3504.8 bits: 659.0 E(85289): 1.8e-188 Smith-Waterman score: 4336; 96.9% identity (97.6% similar) in 674 aa overlap (5-670:56-728) 10 20 30 pF1KB6 MILEERPDGAGAGEESPRLQ--GCDSLTQIQCGQ : : . .: .:.:. :::::::::::: XP_006 PRKTRVSSLRGRREGLRDVCAWRGCRVHRGEDPVRVHVGPMNPQLHAVGCDSLTQIQCGQ 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELS 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALR 150 160 170 180 190 200 160 170 180 190 200 pF1KB6 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFH------WYDSLTGVPAQQ :::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_006 QAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHCLTQHCRYDSLTGVPAQQ 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB6 RALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSP 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB6 DMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRT 330 340 350 360 370 380 330 340 350 360 370 380 pF1KB6 MAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPT :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: XP_006 MAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSP-TEGELPTHEQVFLQPPT 390 400 410 420 430 440 390 400 410 420 430 440 pF1KB6 SSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQR 450 460 470 480 490 500 450 460 470 480 490 500 pF1KB6 SLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKN 510 520 530 540 550 560 510 520 530 540 550 560 pF1KB6 RWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWW 570 580 590 600 610 620 570 580 590 600 610 620 pF1KB6 RHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTPAS 630 640 650 660 670 680 630 640 650 660 670 pF1KB6 TWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP :::::::::::::::::::::::::::::::::::::::::::: XP_006 TWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP 690 700 710 720 >>XP_016868504 (OMIM: 601031) PREDICTED: rhophilin-1 iso (621 aa) initn: 4179 init1: 4179 opt: 4179 Z-score: 3379.2 bits: 635.5 E(85289): 1.8e-181 Smith-Waterman score: 4179; 100.0% identity (100.0% similar) in 621 aa overlap (50-670:1-621) 20 30 40 50 60 70 pF1KB6 QGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNS :::::::::::::::::::::::::::::: XP_016 MRTGAENLYRATSNNRVRETVALELSYVNS 10 20 30 80 90 100 110 120 130 pF1KB6 NLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGA 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB6 SYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSL 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB6 TGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLREN 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB6 FSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAE 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB6 YRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQ 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB6 VFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAV 340 350 360 370 380 390 440 450 460 470 480 490 pF1KB6 ISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPL 400 410 420 430 440 450 500 510 520 530 540 550 pF1KB6 SVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVN 460 470 480 490 500 510 560 570 580 590 600 610 pF1KB6 GQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREH 520 530 540 550 560 570 620 630 640 650 660 670 pF1KB6 GCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP 580 590 600 610 620 >>XP_011515123 (OMIM: 601031) PREDICTED: rhophilin-1 iso (627 aa) initn: 4150 init1: 3234 opt: 4139 Z-score: 3346.9 bits: 629.5 E(85289): 1.1e-179 Smith-Waterman score: 4139; 98.9% identity (98.9% similar) in 627 aa overlap (50-670:1-627) 20 30 40 50 60 70 pF1KB6 QGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRATSNNRVRETVALELSYVNS :::::::::::::::::::::::::::::: XP_011 MRTGAENLYRATSNNRVRETVALELSYVNS 10 20 30 80 90 100 110 120 130 pF1KB6 NLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGA 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB6 SYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFH----- ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHCLTQH 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB6 -WYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAF 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB6 SLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEA 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB6 AQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGE 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB6 LPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREV 340 350 360 370 380 390 440 450 460 470 480 490 pF1KB6 DLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIF 400 410 420 430 440 450 500 510 520 530 540 550 pF1KB6 HRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGD 460 470 480 490 500 510 560 570 580 590 600 610 pF1KB6 YIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLL 520 530 540 550 560 570 620 630 640 650 660 670 pF1KB6 RSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP 580 590 600 610 620 670 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:01:12 2016 done: Sat Nov 5 19:01:14 2016 Total Scan time: 13.530 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]