FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6317, 260 aa 1>>>pF1KB6317 260 - 260 aa - 260 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8411+/-0.000332; mu= -1.8302+/- 0.021 mean_var=153.4978+/-30.866, 0's: 0 Z-trim(119.5): 15 B-trim: 0 in 0/58 Lambda= 0.103520 statistics sampled from 33513 (33528) to 33513 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.393), width: 16 Scan time: 7.780 The best scores are: opt bits E(85289) NP_060926 (OMIM: 607659) ELL-associated factor 2 i ( 260) 1710 266.5 3.3e-71 XP_016862352 (OMIM: 607659) PREDICTED: ELL-associa ( 263) 1619 253.0 4.2e-67 XP_005247675 (OMIM: 607659) PREDICTED: ELL-associa ( 271) 1469 230.6 2.4e-60 XP_016862351 (OMIM: 607659) PREDICTED: ELL-associa ( 130) 858 139.2 3.6e-33 NP_001306970 (OMIM: 607659) ELL-associated factor ( 130) 858 139.2 3.6e-33 XP_016862350 (OMIM: 607659) PREDICTED: ELL-associa ( 130) 858 139.2 3.6e-33 NP_149074 (OMIM: 608315) ELL-associated factor 1 [ ( 268) 667 110.8 2.7e-24 XP_011532468 (OMIM: 608315) PREDICTED: ELL-associa ( 167) 297 55.5 7.5e-08 XP_005265575 (OMIM: 608315) PREDICTED: ELL-associa ( 167) 297 55.5 7.5e-08 XP_011532467 (OMIM: 608315) PREDICTED: ELL-associa ( 167) 297 55.5 7.5e-08 >>NP_060926 (OMIM: 607659) ELL-associated factor 2 isofo (260 aa) initn: 1710 init1: 1710 opt: 1710 Z-score: 1399.3 bits: 266.5 E(85289): 3.3e-71 Smith-Waterman score: 1710; 100.0% identity (100.0% similar) in 260 aa overlap (1-260:1-260) 10 20 30 40 50 60 pF1KB6 MNSAAGFSHLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSSEGYLEVGEGEQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MNSAAGFSHLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSSEGYLEVGEGEQVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCDSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 QYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCDSSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQYRIPDIDASHNRFRDNSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQYRIPDIDASHNRFRDNSGL 190 200 210 220 230 240 250 260 pF1KB6 LMNTLRNDLQLSESGSDSDD :::::::::::::::::::: NP_060 LMNTLRNDLQLSESGSDSDD 250 260 >>XP_016862352 (OMIM: 607659) PREDICTED: ELL-associated (263 aa) initn: 1893 init1: 1619 opt: 1619 Z-score: 1325.8 bits: 253.0 E(85289): 4.2e-67 Smith-Waterman score: 1619; 99.6% identity (99.6% similar) in 247 aa overlap (1-247:1-247) 10 20 30 40 50 60 pF1KB6 MNSAAGFSHLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSSEGYLEVGEGEQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNSAAGFSHLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSSEGYLEVGEGEQVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCDSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCDSSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQYRIPDIDASHNRFRDNSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQYRIPDIDASHNRFRDNSGL 190 200 210 220 230 240 250 260 pF1KB6 LMNTLRNDLQLSESGSDSDD ::::: : XP_016 LMNTLNNLSSHSFSSLYDPLLSH 250 260 >>XP_005247675 (OMIM: 607659) PREDICTED: ELL-associated (271 aa) initn: 1465 init1: 1465 opt: 1469 Z-score: 1204.5 bits: 230.6 E(85289): 2.4e-60 Smith-Waterman score: 1469; 97.8% identity (98.3% similar) in 230 aa overlap (31-260:42-271) 10 20 30 40 50 60 pF1KB6 MNSAAGFSHLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSSEGYLEVGEGEQVT : . :::::::::::::::::::::::: XP_005 LSSVPFSGSVICVFIWFFHAFFSNSIYSLLFSSFSDDFKPASIDTSSEGYLEVGEGEQVT 20 30 40 50 60 70 70 80 90 100 110 120 pF1KB6 ITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKI 80 90 100 110 120 130 130 140 150 160 170 180 pF1KB6 QYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCDSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCDSSS 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB6 DSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQYRIPDIDASHNRFRDNSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQYRIPDIDASHNRFRDNSGL 200 210 220 230 240 250 250 260 pF1KB6 LMNTLRNDLQLSESGSDSDD :::::::::::::::::::: XP_005 LMNTLRNDLQLSESGSDSDD 260 270 >>XP_016862351 (OMIM: 607659) PREDICTED: ELL-associated (130 aa) initn: 858 init1: 858 opt: 858 Z-score: 716.5 bits: 139.2 E(85289): 3.6e-33 Smith-Waterman score: 858; 100.0% identity (100.0% similar) in 130 aa overlap (131-260:1-130) 110 120 130 140 150 160 pF1KB6 EKLSSNITVKKTRVEGSSKIQYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIE :::::::::::::::::::::::::::::: XP_016 MWNSARTPNLVKHSPSEDKMSPASPIDDIE 10 20 30 170 180 190 200 210 220 pF1KB6 RELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMT 40 50 60 70 80 90 230 240 250 260 pF1KB6 QYRIPDIDASHNRFRDNSGLLMNTLRNDLQLSESGSDSDD :::::::::::::::::::::::::::::::::::::::: XP_016 QYRIPDIDASHNRFRDNSGLLMNTLRNDLQLSESGSDSDD 100 110 120 130 >>NP_001306970 (OMIM: 607659) ELL-associated factor 2 is (130 aa) initn: 858 init1: 858 opt: 858 Z-score: 716.5 bits: 139.2 E(85289): 3.6e-33 Smith-Waterman score: 858; 100.0% identity (100.0% similar) in 130 aa overlap (131-260:1-130) 110 120 130 140 150 160 pF1KB6 EKLSSNITVKKTRVEGSSKIQYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIE :::::::::::::::::::::::::::::: NP_001 MWNSARTPNLVKHSPSEDKMSPASPIDDIE 10 20 30 170 180 190 200 210 220 pF1KB6 RELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMT 40 50 60 70 80 90 230 240 250 260 pF1KB6 QYRIPDIDASHNRFRDNSGLLMNTLRNDLQLSESGSDSDD :::::::::::::::::::::::::::::::::::::::: NP_001 QYRIPDIDASHNRFRDNSGLLMNTLRNDLQLSESGSDSDD 100 110 120 130 >>XP_016862350 (OMIM: 607659) PREDICTED: ELL-associated (130 aa) initn: 858 init1: 858 opt: 858 Z-score: 716.5 bits: 139.2 E(85289): 3.6e-33 Smith-Waterman score: 858; 100.0% identity (100.0% similar) in 130 aa overlap (131-260:1-130) 110 120 130 140 150 160 pF1KB6 EKLSSNITVKKTRVEGSSKIQYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIE :::::::::::::::::::::::::::::: XP_016 MWNSARTPNLVKHSPSEDKMSPASPIDDIE 10 20 30 170 180 190 200 210 220 pF1KB6 RELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMT 40 50 60 70 80 90 230 240 250 260 pF1KB6 QYRIPDIDASHNRFRDNSGLLMNTLRNDLQLSESGSDSDD :::::::::::::::::::::::::::::::::::::::: XP_016 QYRIPDIDASHNRFRDNSGLLMNTLRNDLQLSESGSDSDD 100 110 120 130 >>NP_149074 (OMIM: 608315) ELL-associated factor 1 [Homo (268 aa) initn: 865 init1: 597 opt: 667 Z-score: 557.2 bits: 110.8 E(85289): 2.7e-24 Smith-Waterman score: 847; 54.7% identity (73.2% similar) in 276 aa overlap (1-260:1-268) 10 20 30 40 50 60 pF1KB6 MNSAAGFSHLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSSEGYLEVGEGEQVT ::..:. :::.:. :.:::::::.:: .:::.:::::::::::: :: :.::.:..:: NP_149 MNGTAN-PLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 ITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKI ::::.: :::::.:::::.:.:: :.:.::::::::: ::::::.: :::::.:::::: NP_149 ITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKI 60 70 80 90 100 110 130 140 150 160 pF1KB6 QYRKEQQQQQMWNSA---------------RTPNLVKHSPSEDKMSPASPIDDIERELKA : : ::: . ... . : : :: .:. :: .:::.:::.: NP_149 QARMEQQPTRPPQTSQPPPPPPPMPFRAPTKPPVGPKTSPLKDNPSPEPQLDDIKRELRA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB6 EASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQ-YRI :.....:::: ..::.: : :::.:.:.::.: :: .: .:. : : NP_149 EVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGED-------NGPASPPQPSHQQPYNS 180 190 200 210 220 230 230 240 250 260 pF1KB6 PDIDASHNRFRDNSGLLMNTLRNDLQLSESGSDSDD :. . ..:. :::::::::::::::::::: NP_149 RPAVANGTSRPQGSNQLMNTLRNDLQLSESGSDSDD 240 250 260 >>XP_011532468 (OMIM: 608315) PREDICTED: ELL-associated (167 aa) initn: 338 init1: 192 opt: 297 Z-score: 262.0 bits: 55.5 E(85289): 7.5e-08 Smith-Waterman score: 320; 40.8% identity (62.1% similar) in 174 aa overlap (103-260:1-167) 80 90 100 110 120 130 pF1KB6 VTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKIQYRKEQQQQQMW ..:.. . . .::::::: : ::: . XP_011 MKSQLHCHISLAEGSSKIQARMEQQPTRPP 10 20 30 140 150 160 170 pF1KB6 NSA---------------RTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCD ... . : : :: .:. :: .:::.:::.::.....:::: . XP_011 QTSQPPPPPPPMPFRAPTKPPVGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSS 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB6 SSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQ-YRIPDIDASHNRFRD .::.: : :::.:.:.::.: :: .: .:. : : :. . . XP_011 GSSSSDSESSSGSDDDSSSSGGED-------NGPASPPQPSHQQPYNSRPAVANGTSRPQ 100 110 120 130 140 240 250 260 pF1KB6 NSGLLMNTLRNDLQLSESGSDSDD .:. :::::::::::::::::::: XP_011 GSNQLMNTLRNDLQLSESGSDSDD 150 160 >>XP_005265575 (OMIM: 608315) PREDICTED: ELL-associated (167 aa) initn: 338 init1: 192 opt: 297 Z-score: 262.0 bits: 55.5 E(85289): 7.5e-08 Smith-Waterman score: 320; 40.8% identity (62.1% similar) in 174 aa overlap (103-260:1-167) 80 90 100 110 120 130 pF1KB6 VTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKIQYRKEQQQQQMW ..:.. . . .::::::: : ::: . XP_005 MKSQLHCHISLAEGSSKIQARMEQQPTRPP 10 20 30 140 150 160 170 pF1KB6 NSA---------------RTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCD ... . : : :: .:. :: .:::.:::.::.....:::: . XP_005 QTSQPPPPPPPMPFRAPTKPPVGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSS 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB6 SSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQ-YRIPDIDASHNRFRD .::.: : :::.:.:.::.: :: .: .:. : : :. . . XP_005 GSSSSDSESSSGSDDDSSSSGGED-------NGPASPPQPSHQQPYNSRPAVANGTSRPQ 100 110 120 130 140 240 250 260 pF1KB6 NSGLLMNTLRNDLQLSESGSDSDD .:. :::::::::::::::::::: XP_005 GSNQLMNTLRNDLQLSESGSDSDD 150 160 >>XP_011532467 (OMIM: 608315) PREDICTED: ELL-associated (167 aa) initn: 338 init1: 192 opt: 297 Z-score: 262.0 bits: 55.5 E(85289): 7.5e-08 Smith-Waterman score: 320; 40.8% identity (62.1% similar) in 174 aa overlap (103-260:1-167) 80 90 100 110 120 130 pF1KB6 VTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKIQYRKEQQQQQMW ..:.. . . .::::::: : ::: . XP_011 MKSQLHCHISLAEGSSKIQARMEQQPTRPP 10 20 30 140 150 160 170 pF1KB6 NSA---------------RTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCD ... . : : :: .:. :: .:::.:::.::.....:::: . XP_011 QTSQPPPPPPPMPFRAPTKPPVGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSS 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB6 SSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQ-YRIPDIDASHNRFRD .::.: : :::.:.:.::.: :: .: .:. : : :. . . XP_011 GSSSSDSESSSGSDDDSSSSGGED-------NGPASPPQPSHQQPYNSRPAVANGTSRPQ 100 110 120 130 140 240 250 260 pF1KB6 NSGLLMNTLRNDLQLSESGSDSDD .:. :::::::::::::::::::: XP_011 GSNQLMNTLRNDLQLSESGSDSDD 150 160 260 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:25:23 2016 done: Fri Nov 4 19:25:24 2016 Total Scan time: 7.780 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]