FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6318, 281 aa 1>>>pF1KB6318 281 - 281 aa - 281 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4909+/-0.000327; mu= 15.2085+/- 0.020 mean_var=79.2712+/-16.419, 0's: 0 Z-trim(115.8): 39 B-trim: 1289 in 1/55 Lambda= 0.144051 statistics sampled from 26457 (26495) to 26457 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.311), width: 16 Scan time: 7.040 The best scores are: opt bits E(85289) NP_056286 (OMIM: 609174) kinetochore-associated pr ( 281) 1878 399.5 3.7e-111 XP_016856457 (OMIM: 609174) PREDICTED: kinetochore ( 178) 1190 256.4 2.9e-68 XP_016856458 (OMIM: 609174) PREDICTED: kinetochore ( 178) 1190 256.4 2.9e-68 NP_001284666 (OMIM: 609174) kinetochore-associated ( 172) 1109 239.5 3.3e-63 NP_001284668 (OMIM: 609174) kinetochore-associated ( 178) 1109 239.5 3.3e-63 NP_001036014 (OMIM: 609174) kinetochore-associated ( 213) 1109 239.6 3.9e-63 NP_001284665 (OMIM: 609174) kinetochore-associated ( 240) 970 210.7 2.1e-54 >>NP_056286 (OMIM: 609174) kinetochore-associated protei (281 aa) initn: 1878 init1: 1878 opt: 1878 Z-score: 2116.6 bits: 399.5 E(85289): 3.7e-111 Smith-Waterman score: 1878; 99.3% identity (99.6% similar) in 281 aa overlap (1-281:1-281) 10 20 30 40 50 60 pF1KB6 MAGFPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MAGSPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 AKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 AKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE 190 200 210 220 230 240 250 260 270 280 pF1KB6 TTPTETASRKTSDVVLKRKQTKDCPQRKWYPLRPKKINLDT :::::::::::::.::::::::::::::::::::::::::: NP_056 TTPTETASRKTSDMVLKRKQTKDCPQRKWYPLRPKKINLDT 250 260 270 280 >>XP_016856457 (OMIM: 609174) PREDICTED: kinetochore-ass (178 aa) initn: 1190 init1: 1190 opt: 1190 Z-score: 1346.6 bits: 256.4 E(85289): 2.9e-68 Smith-Waterman score: 1190; 99.4% identity (100.0% similar) in 178 aa overlap (104-281:1-178) 80 90 100 110 120 130 pF1KB6 RDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIVDIATKRKQYPRKI :::::::::::::::::::::::::::::: XP_016 MDSDIKVLEDQFDEIIVDIATKRKQYPRKI 10 20 30 140 150 160 170 180 190 pF1KB6 LECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETVAKEISEAMKSLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETVAKEISEAMKSLPA 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 LIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIETTPTETASRKTSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIETTPTETASRKTSD 100 110 120 130 140 150 260 270 280 pF1KB6 VVLKRKQTKDCPQRKWYPLRPKKINLDT .::::::::::::::::::::::::::: XP_016 MVLKRKQTKDCPQRKWYPLRPKKINLDT 160 170 >>XP_016856458 (OMIM: 609174) PREDICTED: kinetochore-ass (178 aa) initn: 1190 init1: 1190 opt: 1190 Z-score: 1346.6 bits: 256.4 E(85289): 2.9e-68 Smith-Waterman score: 1190; 99.4% identity (100.0% similar) in 178 aa overlap (104-281:1-178) 80 90 100 110 120 130 pF1KB6 RDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIVDIATKRKQYPRKI :::::::::::::::::::::::::::::: XP_016 MDSDIKVLEDQFDEIIVDIATKRKQYPRKI 10 20 30 140 150 160 170 180 190 pF1KB6 LECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETVAKEISEAMKSLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETVAKEISEAMKSLPA 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 LIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIETTPTETASRKTSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIETTPTETASRKTSD 100 110 120 130 140 150 260 270 280 pF1KB6 VVLKRKQTKDCPQRKWYPLRPKKINLDT .::::::::::::::::::::::::::: XP_016 MVLKRKQTKDCPQRKWYPLRPKKINLDT 160 170 >>NP_001284666 (OMIM: 609174) kinetochore-associated pro (172 aa) initn: 1109 init1: 1109 opt: 1109 Z-score: 1255.9 bits: 239.5 E(85289): 3.3e-63 Smith-Waterman score: 1109; 99.4% identity (99.4% similar) in 166 aa overlap (1-166:1-166) 10 20 30 40 50 60 pF1KB6 MAGFPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGSPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETV :::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPVLACIN 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 AKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE >>NP_001284668 (OMIM: 609174) kinetochore-associated pro (178 aa) initn: 1109 init1: 1109 opt: 1109 Z-score: 1255.7 bits: 239.5 E(85289): 3.3e-63 Smith-Waterman score: 1109; 99.4% identity (99.4% similar) in 166 aa overlap (1-166:1-166) 10 20 30 40 50 60 pF1KB6 MAGFPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGSPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETV :::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPGAKPGGLALGAV 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 AKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE >>NP_001036014 (OMIM: 609174) kinetochore-associated pro (213 aa) initn: 1109 init1: 1109 opt: 1109 Z-score: 1254.6 bits: 239.6 E(85289): 3.9e-63 Smith-Waterman score: 1109; 99.4% identity (99.4% similar) in 166 aa overlap (1-166:1-166) 10 20 30 40 50 60 pF1KB6 MAGFPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGSPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETV :::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPVLNGNAFNFSPFNM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 AKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE NP_001 MLAVDLSYMVFITSSPSYGKFEMQRGNSSKGDQ 190 200 210 >>NP_001284665 (OMIM: 609174) kinetochore-associated pro (240 aa) initn: 1574 init1: 970 opt: 970 Z-score: 1097.7 bits: 210.7 E(85289): 2.1e-54 Smith-Waterman score: 1496; 84.7% identity (85.1% similar) in 281 aa overlap (1-281:1-240) 10 20 30 40 50 60 pF1KB6 MAGFPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGSPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETV :::::::::::::::::::::::::::: NP_001 DIATKRKQYPRKILECVIKTIKAKQEIL-------------------------------- 130 140 190 200 210 220 230 240 pF1KB6 AKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---------SLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIE 150 160 170 180 190 250 260 270 280 pF1KB6 TTPTETASRKTSDVVLKRKQTKDCPQRKWYPLRPKKINLDT :::::::::::::.::::::::::::::::::::::::::: NP_001 TTPTETASRKTSDMVLKRKQTKDCPQRKWYPLRPKKINLDT 200 210 220 230 240 281 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:33:52 2016 done: Sat Nov 5 07:33:53 2016 Total Scan time: 7.040 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]