FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6330, 288 aa 1>>>pF1KB6330 288 - 288 aa - 288 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0100+/-0.000327; mu= 17.9025+/- 0.020 mean_var=74.8785+/-14.814, 0's: 0 Z-trim(116.1): 20 B-trim: 4 in 2/53 Lambda= 0.148216 statistics sampled from 27081 (27101) to 27081 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.318), width: 16 Scan time: 7.560 The best scores are: opt bits E(85289) NP_005524 (OMIM: 600735) interferon-induced 35 kDa ( 288) 1893 413.7 2e-115 NP_001317159 (OMIM: 600735) interferon-induced 35 ( 286) 1867 408.2 9.6e-114 XP_016880073 (OMIM: 600735) PREDICTED: interferon- ( 268) 1769 387.2 1.9e-107 XP_016880074 (OMIM: 600735) PREDICTED: interferon- ( 266) 1743 381.6 8.7e-106 NP_004679 (OMIM: 603525) N-myc-interactor [Homo sa ( 307) 392 92.8 8.9e-19 XP_005246998 (OMIM: 603525) PREDICTED: N-myc-inter ( 307) 392 92.8 8.9e-19 XP_016860736 (OMIM: 603525) PREDICTED: N-myc-inter ( 307) 392 92.8 8.9e-19 >>NP_005524 (OMIM: 600735) interferon-induced 35 kDa pro (288 aa) initn: 1893 init1: 1893 opt: 1893 Z-score: 2193.1 bits: 413.7 E(85289): 2e-115 Smith-Waterman score: 1893; 99.7% identity (100.0% similar) in 288 aa overlap (1-288:1-288) 10 20 30 40 50 60 pF1KB6 MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 VTTIQVMVSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGS :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VTTIQVMMSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 VMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNI 190 200 210 220 230 240 250 260 270 280 pF1KB6 PDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG :::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG 250 260 270 280 >>NP_001317159 (OMIM: 600735) interferon-induced 35 kDa (286 aa) initn: 1069 init1: 1069 opt: 1867 Z-score: 2163.1 bits: 408.2 E(85289): 9.6e-114 Smith-Waterman score: 1867; 99.0% identity (99.3% similar) in 288 aa overlap (1-288:1-286) 10 20 30 40 50 60 pF1KB6 MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 VTTIQVMVSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGS :::::. :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTTIQM--SSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGS 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNI 180 190 200 210 220 230 250 260 270 280 pF1KB6 PDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG 240 250 260 270 280 >>XP_016880073 (OMIM: 600735) PREDICTED: interferon-indu (268 aa) initn: 1769 init1: 1769 opt: 1769 Z-score: 2050.2 bits: 387.2 E(85289): 1.9e-107 Smith-Waterman score: 1769; 99.6% identity (100.0% similar) in 268 aa overlap (21-288:1-268) 10 20 30 40 50 60 pF1KB6 MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP :::::::::::::::::::::::::::::::::::::::: XP_016 MRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP 10 20 30 40 70 80 90 100 110 120 pF1KB6 EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 VTTIQVMVSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGS :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTIQVMMSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 VMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNI 170 180 190 200 210 220 250 260 270 280 pF1KB6 PDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG 230 240 250 260 >>XP_016880074 (OMIM: 600735) PREDICTED: interferon-indu (266 aa) initn: 1069 init1: 1069 opt: 1743 Z-score: 2020.2 bits: 381.6 E(85289): 8.7e-106 Smith-Waterman score: 1743; 98.9% identity (99.3% similar) in 268 aa overlap (21-288:1-266) 10 20 30 40 50 60 pF1KB6 MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP :::::::::::::::::::::::::::::::::::::::: XP_016 MRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDP 10 20 30 40 70 80 90 100 110 120 pF1KB6 EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 VTTIQVMVSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGS :::::. :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTIQM--SSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGS 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 VMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNI 160 170 180 190 200 210 250 260 270 280 pF1KB6 PDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG 220 230 240 250 260 >>NP_004679 (OMIM: 603525) N-myc-interactor [Homo sapien (307 aa) initn: 244 init1: 117 opt: 392 Z-score: 458.1 bits: 92.8 E(85289): 8.9e-19 Smith-Waterman score: 392; 29.0% identity (64.5% similar) in 290 aa overlap (6-283:23-305) 10 20 30 40 pF1KB6 MSAPLDAALHALQEEQARLKMRLW-DLQQLRKELGDSPKD-KV : ..: .: .. ...: ..:.:. :: .. :. .. NP_004 MEADKDDTQQILKEHSPDEFIKDEQNKGLIDEITKKNIQLKKEIQKLETELQEATKEFQI 10 20 30 40 50 60 50 60 70 80 90 pF1KB6 PFSVPKIPLVFRG-----HTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQ ..:. . : . . .: .. :. . .. . :.:::::. .::..:.. NP_004 KEDIPETKMKFLSVETPENDSQLSNISCSFQVSSKVPYEIQKGQALITFEKEEVAQNVVS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 QKEHTINMEECRLRVQVQPLELPMVTTIQVMVSSQLSGRRVLVTGFPASLRLSEEELLDK ...: ..... :.: ..: .:. . .. .: ..: .. :: .: .:: :... :: NP_004 MSKHHVQIKDVNLEVTAKP--VPLNSGVRFQVYVEVSKMKINVTEIPDTLR--EDQMRDK 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 LEIFFGKTRNGGGDVDVREL--LPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRV- ::. :.:.:::::.:: . ::... :.. :::... . .. :: .:. :: NP_004 LELSFSKSRNGGGEVDRVDYDRQSGSAVITFVEIGVADKILKKKEY--PLYINQTCHRVT 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB6 -SPYVNGEIQKAEIRSQPVPRSVLVLNIPDI-LDGPELHDVLEIHFQKPTRGGGEVEALT :::.. ...: .: : :.::. .. : .: ..:...::::. :::::... NP_004 VSPYTEIHLKKYQIFSGTSKRTVLLTGMEGIQMDEEIVEDLINIHFQRAKNGGGEVDVVK 240 250 260 270 280 290 280 pF1KB6 VVPQGQQGLAVFTSESG :: .: : NP_004 C-SLGQPHIAYFEE 300 >>XP_005246998 (OMIM: 603525) PREDICTED: N-myc-interacto (307 aa) initn: 244 init1: 117 opt: 392 Z-score: 458.1 bits: 92.8 E(85289): 8.9e-19 Smith-Waterman score: 392; 29.0% identity (64.5% similar) in 290 aa overlap (6-283:23-305) 10 20 30 40 pF1KB6 MSAPLDAALHALQEEQARLKMRLW-DLQQLRKELGDSPKD-KV : ..: .: .. ...: ..:.:. :: .. :. .. XP_005 MEADKDDTQQILKEHSPDEFIKDEQNKGLIDEITKKNIQLKKEIQKLETELQEATKEFQI 10 20 30 40 50 60 50 60 70 80 90 pF1KB6 PFSVPKIPLVFRG-----HTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQ ..:. . : . . .: .. :. . .. . :.:::::. .::..:.. XP_005 KEDIPETKMKFLSVETPENDSQLSNISCSFQVSSKVPYEIQKGQALITFEKEEVAQNVVS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 QKEHTINMEECRLRVQVQPLELPMVTTIQVMVSSQLSGRRVLVTGFPASLRLSEEELLDK ...: ..... :.: ..: .:. . .. .: ..: .. :: .: .:: :... :: XP_005 MSKHHVQIKDVNLEVTAKP--VPLNSGVRFQVYVEVSKMKINVTEIPDTLR--EDQMRDK 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 LEIFFGKTRNGGGDVDVREL--LPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRV- ::. :.:.:::::.:: . ::... :.. :::... . .. :: .:. :: XP_005 LELSFSKSRNGGGEVDRVDYDRQSGSAVITFVEIGVADKILKKKEY--PLYINQTCHRVT 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB6 -SPYVNGEIQKAEIRSQPVPRSVLVLNIPDI-LDGPELHDVLEIHFQKPTRGGGEVEALT :::.. ...: .: : :.::. .. : .: ..:...::::. :::::... XP_005 VSPYTEIHLKKYQIFSGTSKRTVLLTGMEGIQMDEEIVEDLINIHFQRAKNGGGEVDVVK 240 250 260 270 280 290 280 pF1KB6 VVPQGQQGLAVFTSESG :: .: : XP_005 C-SLGQPHIAYFEE 300 >>XP_016860736 (OMIM: 603525) PREDICTED: N-myc-interacto (307 aa) initn: 244 init1: 117 opt: 392 Z-score: 458.1 bits: 92.8 E(85289): 8.9e-19 Smith-Waterman score: 392; 29.0% identity (64.5% similar) in 290 aa overlap (6-283:23-305) 10 20 30 40 pF1KB6 MSAPLDAALHALQEEQARLKMRLW-DLQQLRKELGDSPKD-KV : ..: .: .. ...: ..:.:. :: .. :. .. XP_016 MEADKDDTQQILKEHSPDEFIKDEQNKGLIDEITKKNIQLKKEIQKLETELQEATKEFQI 10 20 30 40 50 60 50 60 70 80 90 pF1KB6 PFSVPKIPLVFRG-----HTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQ ..:. . : . . .: .. :. . .. . :.:::::. .::..:.. XP_016 KEDIPETKMKFLSVETPENDSQLSNISCSFQVSSKVPYEIQKGQALITFEKEEVAQNVVS 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 QKEHTINMEECRLRVQVQPLELPMVTTIQVMVSSQLSGRRVLVTGFPASLRLSEEELLDK ...: ..... :.: ..: .:. . .. .: ..: .. :: .: .:: :... :: XP_016 MSKHHVQIKDVNLEVTAKP--VPLNSGVRFQVYVEVSKMKINVTEIPDTLR--EDQMRDK 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 LEIFFGKTRNGGGDVDVREL--LPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRV- ::. :.:.:::::.:: . ::... :.. :::... . .. :: .:. :: XP_016 LELSFSKSRNGGGEVDRVDYDRQSGSAVITFVEIGVADKILKKKEY--PLYINQTCHRVT 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB6 -SPYVNGEIQKAEIRSQPVPRSVLVLNIPDI-LDGPELHDVLEIHFQKPTRGGGEVEALT :::.. ...: .: : :.::. .. : .: ..:...::::. :::::... XP_016 VSPYTEIHLKKYQIFSGTSKRTVLLTGMEGIQMDEEIVEDLINIHFQRAKNGGGEVDVVK 240 250 260 270 280 290 280 pF1KB6 VVPQGQQGLAVFTSESG :: .: : XP_016 C-SLGQPHIAYFEE 300 288 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:31:26 2016 done: Fri Nov 4 20:31:27 2016 Total Scan time: 7.560 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]