FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6342, 291 aa 1>>>pF1KB6342 291 - 291 aa - 291 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2979+/-0.000762; mu= 6.8180+/- 0.046 mean_var=128.0021+/-24.917, 0's: 0 Z-trim(112.6): 27 B-trim: 0 in 0/54 Lambda= 0.113362 statistics sampled from 13305 (13331) to 13305 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.756), E-opt: 0.2 (0.41), width: 16 Scan time: 2.660 The best scores are: opt bits E(32554) CCDS12072.1 MBD3 gene_id:53615|Hs108|chr19 ( 291) 1956 330.5 8.9e-91 CCDS62481.1 MBD3 gene_id:53615|Hs108|chr19 ( 259) 1685 286.2 1.8e-77 CCDS11953.1 MBD2 gene_id:8932|Hs108|chr18 ( 411) 1329 228.0 8.8e-60 CCDS12209.1 MBD3L1 gene_id:85509|Hs108|chr19 ( 194) 496 91.6 4.8e-19 CCDS45871.1 MBD2 gene_id:8932|Hs108|chr18 ( 302) 440 82.6 4e-16 >>CCDS12072.1 MBD3 gene_id:53615|Hs108|chr19 (291 aa) initn: 1956 init1: 1956 opt: 1956 Z-score: 1743.2 bits: 330.5 E(32554): 8.9e-91 Smith-Waterman score: 1956; 100.0% identity (100.0% similar) in 291 aa overlap (1-291:1-291) 10 20 30 40 50 60 pF1KB6 MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 TFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 NKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 NKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 IASALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 IASALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLE 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 EALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 EALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV 250 260 270 280 290 >>CCDS62481.1 MBD3 gene_id:53615|Hs108|chr19 (259 aa) initn: 1685 init1: 1685 opt: 1685 Z-score: 1504.4 bits: 286.2 E(32554): 1.8e-77 Smith-Waterman score: 1685; 100.0% identity (100.0% similar) in 255 aa overlap (37-291:5-259) 10 20 30 40 50 60 pF1KB6 ECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRT :::::::::::::::::::::::::::::: CCDS62 MERKSPSGKKFRSKPQLARYLGGSMDLSTFDFRT 10 20 30 70 80 90 100 110 120 pF1KB6 GKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 GKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSD 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 PQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIASALH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 PQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIASALH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 TSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 TSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMAD 160 170 180 190 200 210 250 260 270 280 290 pF1KB6 MLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV ::::::::::::::::::::::::::::::::::::::::::::: CCDS62 MLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV 220 230 240 250 >>CCDS11953.1 MBD2 gene_id:8932|Hs108|chr18 (411 aa) initn: 1356 init1: 1328 opt: 1329 Z-score: 1186.8 bits: 228.0 E(32554): 8.8e-60 Smith-Waterman score: 1329; 76.0% identity (92.5% similar) in 254 aa overlap (4-254:148-401) 10 20 30 pF1KB6 MERKRWECPALPQGWEREEVPRRSGLSAGHRDV :: .::::: ::..::: :.::::::. :: CCDS11 GGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDV 120 130 140 150 160 170 40 50 60 70 80 90 pF1KB6 FYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKP .:.::::::::::::::::::...:::.::::::::. ::..:..::.: : :: :::: CCDS11 YYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKP 180 190 200 210 220 230 100 110 120 130 140 150 pF1KB6 DLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAE ::::.::.:::::::::::::.:::::::::::::. .:::::::::.:.::.: :..: CCDS11 DLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTE 240 250 260 270 280 290 160 170 180 190 200 210 pF1KB6 ELVKTMDLPKGLQGVGPGCTDETLLSAIASALHTSTMPITGQLSAAVEKNPGVWLNTTQP ...:::.::::::::::: .:::::::.:::::::. :::::.::::::::.:::::.:: CCDS11 QIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQP 300 310 320 330 340 350 220 230 240 250 260 270 pF1KB6 LCKAFMVTDEDIRKQEELVQQVRKRLEEALMADML---AHVEELARDGEAPLDKACAEDD :::::.::::::::::: ::::::.::::::::.: : .::. CCDS11 LCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA 360 370 380 390 400 410 280 290 pF1KB6 DEEDEEEEEEEPDPDPEMEHV >>CCDS12209.1 MBD3L1 gene_id:85509|Hs108|chr19 (194 aa) initn: 449 init1: 190 opt: 496 Z-score: 455.4 bits: 91.6 E(32554): 4.8e-19 Smith-Waterman score: 496; 44.6% identity (71.5% similar) in 193 aa overlap (74-264:1-193) 50 60 70 80 90 100 pF1KB6 RSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQ : :: :: . : :: :.:: :.:..:.:. CCDS12 MAKSSQRKQRDCVNQCKSKPGLSTSIPLRM 10 20 30 110 120 130 140 150 160 pF1KB6 TASIFKQPVTKITNHPSNKVKSDP-QKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLP .. ::.:::.:: ::.:.:. ......:.:. :...:.::.:.. : :: .:.:: CCDS12 SSYTFKRPVTRITPHPGNEVRYHQWEESLEKPQQVCWQRRLQGLQAYSSAGELSSTLDLA 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB6 KGLQGVGPGCTDETLLSAIASAL-HTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVT . :: . :. : .:: .::.: :. :: . : ::: :. .. .: ::: :.:: CCDS12 NTLQKLVPSYTGGSLLEDLASGLEHSCPMPHLACSSDAVEIIPAEGVGISQLLCKQFLVT 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB6 DEDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEE .::::::: :. ::.:: ::.:: ::. : .:: :. .: CCDS12 EEDIRKQEGKVKTVRERLAIALIADGLANEAEKVRDQEGRPEKR 160 170 180 190 290 pF1KB6 PDPDPEMEHV >>CCDS45871.1 MBD2 gene_id:8932|Hs108|chr18 (302 aa) initn: 440 init1: 440 opt: 440 Z-score: 403.0 bits: 82.6 E(32554): 4e-16 Smith-Waterman score: 440; 63.9% identity (84.5% similar) in 97 aa overlap (4-100:148-244) 10 20 30 pF1KB6 MERKRWECPALPQGWEREEVPRRSGLSAGHRDV :: .::::: ::..::: :.::::::. :: CCDS45 GGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDV 120 130 140 150 160 170 40 50 60 70 80 90 pF1KB6 FYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKP .:.::::::::::::::::::...:::.::::::::. ::..:..::.: : :: : . CCDS45 YYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKLRW 180 190 200 210 220 230 100 110 120 130 140 150 pF1KB6 DLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAE . . : CCDS45 NTHRPAPWHALSRLCLLIRCLLCLECAYPLPLHLVNSYSSKTQLHCLHLWEACPAYSRQN 240 250 260 270 280 290 291 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:55:23 2016 done: Fri Nov 4 18:55:24 2016 Total Scan time: 2.660 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]