FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6342, 291 aa 1>>>pF1KB6342 291 - 291 aa - 291 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4170+/-0.000311; mu= 6.2321+/- 0.020 mean_var=135.0989+/-26.830, 0's: 0 Z-trim(120.0): 75 B-trim: 344 in 1/56 Lambda= 0.110344 statistics sampled from 34631 (34707) to 34631 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.407), width: 16 Scan time: 6.590 The best scores are: opt bits E(85289) NP_001268382 (OMIM: 603573) methyl-CpG-binding dom ( 291) 1956 322.2 7.4e-88 NP_001268383 (OMIM: 603573) methyl-CpG-binding dom ( 259) 1685 279.0 6.5e-75 NP_003918 (OMIM: 603547) methyl-CpG-binding domain ( 411) 1329 222.5 1.1e-57 NP_660209 (OMIM: 607963) methyl-CpG-binding domain ( 194) 496 89.7 4.9e-18 NP_056647 (OMIM: 603547) methyl-CpG-binding domain ( 302) 440 80.9 3.4e-15 NP_653215 (OMIM: 607964) methyl-CpG-binding domain ( 208) 286 56.2 6e-08 NP_002375 (OMIM: 156535) methyl-CpG-binding domain ( 503) 243 49.6 1.4e-05 XP_016881265 (OMIM: 156535) PREDICTED: methyl-CpG- ( 503) 243 49.6 1.4e-05 XP_016881264 (OMIM: 156535) PREDICTED: methyl-CpG- ( 515) 243 49.6 1.5e-05 NP_001310881 (OMIM: 156535) methyl-CpG-binding dom ( 524) 243 49.6 1.5e-05 XP_016881263 (OMIM: 156535) PREDICTED: methyl-CpG- ( 526) 243 49.6 1.5e-05 XP_016881262 (OMIM: 156535) PREDICTED: methyl-CpG- ( 526) 243 49.6 1.5e-05 NP_001191072 (OMIM: 156535) methyl-CpG-binding dom ( 535) 243 49.7 1.5e-05 XP_011524308 (OMIM: 156535) PREDICTED: methyl-CpG- ( 535) 243 49.7 1.5e-05 NP_001191080 (OMIM: 156535) methyl-CpG-binding dom ( 536) 243 49.7 1.5e-05 XP_016881261 (OMIM: 156535) PREDICTED: methyl-CpG- ( 546) 243 49.7 1.5e-05 XP_016881259 (OMIM: 156535) PREDICTED: methyl-CpG- ( 549) 243 49.7 1.5e-05 NP_056669 (OMIM: 156535) methyl-CpG-binding domain ( 549) 243 49.7 1.5e-05 XP_016881260 (OMIM: 156535) PREDICTED: methyl-CpG- ( 549) 243 49.7 1.5e-05 NP_001191071 (OMIM: 156535) methyl-CpG-binding dom ( 550) 243 49.7 1.5e-05 NP_056723 (OMIM: 156535) methyl-CpG-binding domain ( 556) 243 49.7 1.5e-05 XP_011524309 (OMIM: 156535) PREDICTED: methyl-CpG- ( 559) 243 49.7 1.6e-05 XP_016881258 (OMIM: 156535) PREDICTED: methyl-CpG- ( 559) 243 49.7 1.6e-05 XP_016881257 (OMIM: 156535) PREDICTED: methyl-CpG- ( 561) 243 49.7 1.6e-05 NP_001191070 (OMIM: 156535) methyl-CpG-binding dom ( 567) 243 49.7 1.6e-05 XP_016881266 (OMIM: 156535) PREDICTED: methyl-CpG- ( 571) 243 49.7 1.6e-05 XP_016881255 (OMIM: 156535) PREDICTED: methyl-CpG- ( 574) 243 49.7 1.6e-05 XP_016881256 (OMIM: 156535) PREDICTED: methyl-CpG- ( 574) 243 49.7 1.6e-05 NP_001191069 (OMIM: 156535) methyl-CpG-binding dom ( 574) 243 49.7 1.6e-05 NP_001310883 (OMIM: 156535) methyl-CpG-binding dom ( 576) 243 49.7 1.6e-05 XP_016881254 (OMIM: 156535) PREDICTED: methyl-CpG- ( 581) 243 49.7 1.6e-05 XP_011524304 (OMIM: 156535) PREDICTED: methyl-CpG- ( 584) 243 49.7 1.6e-05 XP_016881253 (OMIM: 156535) PREDICTED: methyl-CpG- ( 584) 243 49.7 1.6e-05 XP_011524305 (OMIM: 156535) PREDICTED: methyl-CpG- ( 584) 243 49.7 1.6e-05 NP_056670 (OMIM: 156535) methyl-CpG-binding domain ( 586) 243 49.7 1.6e-05 NP_001310879 (OMIM: 156535) methyl-CpG-binding dom ( 589) 243 49.7 1.6e-05 XP_016881252 (OMIM: 156535) PREDICTED: methyl-CpG- ( 589) 243 49.7 1.6e-05 XP_016881251 (OMIM: 156535) PREDICTED: methyl-CpG- ( 590) 243 49.7 1.6e-05 XP_016881250 (OMIM: 156535) PREDICTED: methyl-CpG- ( 596) 243 49.7 1.6e-05 XP_011524303 (OMIM: 156535) PREDICTED: methyl-CpG- ( 599) 243 49.7 1.6e-05 NP_001310880 (OMIM: 156535) methyl-CpG-binding dom ( 602) 243 49.7 1.7e-05 NP_001191068 (OMIM: 156535) methyl-CpG-binding dom ( 605) 243 49.7 1.7e-05 XP_016881249 (OMIM: 156535) PREDICTED: methyl-CpG- ( 605) 243 49.7 1.7e-05 XP_005258328 (OMIM: 156535) PREDICTED: methyl-CpG- ( 605) 243 49.7 1.7e-05 NP_056671 (OMIM: 156535) methyl-CpG-binding domain ( 605) 243 49.7 1.7e-05 XP_011524301 (OMIM: 156535) PREDICTED: methyl-CpG- ( 609) 243 49.7 1.7e-05 XP_016881248 (OMIM: 156535) PREDICTED: methyl-CpG- ( 615) 243 49.7 1.7e-05 XP_016881247 (OMIM: 156535) PREDICTED: methyl-CpG- ( 615) 243 49.7 1.7e-05 XP_016881246 (OMIM: 156535) PREDICTED: methyl-CpG- ( 615) 243 49.7 1.7e-05 XP_016881245 (OMIM: 156535) PREDICTED: methyl-CpG- ( 616) 243 49.7 1.7e-05 >>NP_001268382 (OMIM: 603573) methyl-CpG-binding domain (291 aa) initn: 1956 init1: 1956 opt: 1956 Z-score: 1698.3 bits: 322.2 E(85289): 7.4e-88 Smith-Waterman score: 1956; 100.0% identity (100.0% similar) in 291 aa overlap (1-291:1-291) 10 20 30 40 50 60 pF1KB6 MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 NKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 IASALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IASALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLE 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 EALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV 250 260 270 280 290 >>NP_001268383 (OMIM: 603573) methyl-CpG-binding domain (259 aa) initn: 1685 init1: 1685 opt: 1685 Z-score: 1465.9 bits: 279.0 E(85289): 6.5e-75 Smith-Waterman score: 1685; 100.0% identity (100.0% similar) in 255 aa overlap (37-291:5-259) 10 20 30 40 50 60 pF1KB6 ECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRT :::::::::::::::::::::::::::::: NP_001 MERKSPSGKKFRSKPQLARYLGGSMDLSTFDFRT 10 20 30 70 80 90 100 110 120 pF1KB6 GKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSD 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 PQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIASALH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIASALH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 TSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMAD 160 170 180 190 200 210 250 260 270 280 290 pF1KB6 MLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV ::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV 220 230 240 250 >>NP_003918 (OMIM: 603547) methyl-CpG-binding domain pro (411 aa) initn: 1356 init1: 1328 opt: 1329 Z-score: 1156.6 bits: 222.5 E(85289): 1.1e-57 Smith-Waterman score: 1329; 76.0% identity (92.5% similar) in 254 aa overlap (4-254:148-401) 10 20 30 pF1KB6 MERKRWECPALPQGWEREEVPRRSGLSAGHRDV :: .::::: ::..::: :.::::::. :: NP_003 GGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDV 120 130 140 150 160 170 40 50 60 70 80 90 pF1KB6 FYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKP .:.::::::::::::::::::...:::.::::::::. ::..:..::.: : :: :::: NP_003 YYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKP 180 190 200 210 220 230 100 110 120 130 140 150 pF1KB6 DLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAE ::::.::.:::::::::::::.:::::::::::::. .:::::::::.:.::.: :..: NP_003 DLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTE 240 250 260 270 280 290 160 170 180 190 200 210 pF1KB6 ELVKTMDLPKGLQGVGPGCTDETLLSAIASALHTSTMPITGQLSAAVEKNPGVWLNTTQP ...:::.::::::::::: .:::::::.:::::::. :::::.::::::::.:::::.:: NP_003 QIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQP 300 310 320 330 340 350 220 230 240 250 260 270 pF1KB6 LCKAFMVTDEDIRKQEELVQQVRKRLEEALMADML---AHVEELARDGEAPLDKACAEDD :::::.::::::::::: ::::::.::::::::.: : .::. NP_003 LCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA 360 370 380 390 400 410 280 290 pF1KB6 DEEDEEEEEEEPDPDPEMEHV >>NP_660209 (OMIM: 607963) methyl-CpG-binding domain pro (194 aa) initn: 449 init1: 190 opt: 496 Z-score: 444.8 bits: 89.7 E(85289): 4.9e-18 Smith-Waterman score: 496; 44.6% identity (71.5% similar) in 193 aa overlap (74-264:1-193) 50 60 70 80 90 100 pF1KB6 RSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQ : :: :: . : :: :.:: :.:..:.:. NP_660 MAKSSQRKQRDCVNQCKSKPGLSTSIPLRM 10 20 30 110 120 130 140 150 160 pF1KB6 TASIFKQPVTKITNHPSNKVKSDP-QKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLP .. ::.:::.:: ::.:.:. ......:.:. :...:.::.:.. : :: .:.:: NP_660 SSYTFKRPVTRITPHPGNEVRYHQWEESLEKPQQVCWQRRLQGLQAYSSAGELSSTLDLA 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB6 KGLQGVGPGCTDETLLSAIASAL-HTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVT . :: . :. : .:: .::.: :. :: . : ::: :. .. .: ::: :.:: NP_660 NTLQKLVPSYTGGSLLEDLASGLEHSCPMPHLACSSDAVEIIPAEGVGISQLLCKQFLVT 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB6 DEDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEE .::::::: :. ::.:: ::.:: ::. : .:: :. .: NP_660 EEDIRKQEGKVKTVRERLAIALIADGLANEAEKVRDQEGRPEKR 160 170 180 190 290 pF1KB6 PDPDPEMEHV >>NP_056647 (OMIM: 603547) methyl-CpG-binding domain pro (302 aa) initn: 440 init1: 440 opt: 440 Z-score: 393.8 bits: 80.9 E(85289): 3.4e-15 Smith-Waterman score: 440; 63.9% identity (84.5% similar) in 97 aa overlap (4-100:148-244) 10 20 30 pF1KB6 MERKRWECPALPQGWEREEVPRRSGLSAGHRDV :: .::::: ::..::: :.::::::. :: NP_056 GGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDV 120 130 140 150 160 170 40 50 60 70 80 90 pF1KB6 FYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKP .:.::::::::::::::::::...:::.::::::::. ::..:..::.: : :: : . NP_056 YYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKLRW 180 190 200 210 220 230 100 110 120 130 140 150 pF1KB6 DLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAE . . : NP_056 NTHRPAPWHALSRLCLLIRCLLCLECAYPLPLHLVNSYSSKTQLHCLHLWEACPAYSRQN 240 250 260 270 280 290 >>NP_653215 (OMIM: 607964) methyl-CpG-binding domain pro (208 aa) initn: 224 init1: 115 opt: 286 Z-score: 263.6 bits: 56.2 E(85289): 6e-08 Smith-Waterman score: 286; 30.9% identity (61.3% similar) in 194 aa overlap (67-258:16-208) 40 50 60 70 80 90 pF1KB6 SPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLN ::. . : . :. : ... . NP_653 MGEPAFTSFPSLPVLGKLKRNMMPWALQKKREIHMAKAHRRRAAR 10 20 30 40 100 110 120 130 140 150 pF1KB6 TALPVRQTASIFKQPVTKITNHPSNKVKSDP-QKAVDQPRQLFWEKKLSGLNAFDIAEEL .:::.: :. ::..:::.: .::.:.:. .. ...:.:: ..:..:. . : NP_653 SALPMRLTSCIFRRPVTRIRSHPDNQVRRRKGDEHLEKPQQLCAYRRLQALQPCSSQGEG 50 60 70 80 90 100 160 170 180 190 200 210 pF1KB6 VKTMDLPKGLQGVGPGCTDETLLSAIASALHTSTMPITGQLSA-AVEKNPGVWLNTTQPL . . : . :. ..:: . :.: : : ... : :.. : : .::. . :: NP_653 SSPLHLESVLSILAPGTAGESLDRAGAERVRSPLEPTPGRFPAVAGGPTPGMGCQLPPPL 110 120 130 140 150 160 220 230 240 250 260 270 pF1KB6 CKAFMVTDEDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEDDDEED .. .:: :::.: . :...:.:: .::.:: ::. :. : NP_653 -SGQLVTPADIRRQARRVKKARERLAKALQADRLARRAEMLTGG 170 180 190 200 280 290 pF1KB6 EEEEEEEPDPDPEMEHV >>NP_002375 (OMIM: 156535) methyl-CpG-binding domain pro (503 aa) initn: 262 init1: 238 opt: 243 Z-score: 221.0 bits: 49.6 E(85289): 1.4e-05 Smith-Waterman score: 243; 52.4% identity (77.8% similar) in 63 aa overlap (6-67:5-67) 10 20 30 40 50 pF1KB6 MERKRW-ECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDL : .:::: ::.:.:: :.:: . :. :..: ::.: ..::: .:.:::: . :: NP_002 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 STFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHP . :::. : NP_002 TLFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKAD 60 70 80 90 100 110 >>XP_016881265 (OMIM: 156535) PREDICTED: methyl-CpG-bind (503 aa) initn: 262 init1: 238 opt: 243 Z-score: 221.0 bits: 49.6 E(85289): 1.4e-05 Smith-Waterman score: 243; 52.4% identity (77.8% similar) in 63 aa overlap (6-67:5-67) 10 20 30 40 50 pF1KB6 MERKRW-ECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDL : .:::: ::.:.:: :.:: . :. :..: ::.: ..::: .:.:::: . :: XP_016 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 STFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHP . :::. : XP_016 TLFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKAD 60 70 80 90 100 110 >>XP_016881264 (OMIM: 156535) PREDICTED: methyl-CpG-bind (515 aa) initn: 262 init1: 238 opt: 243 Z-score: 220.9 bits: 49.6 E(85289): 1.5e-05 Smith-Waterman score: 243; 52.4% identity (77.8% similar) in 63 aa overlap (6-67:5-67) 10 20 30 40 50 pF1KB6 MERKRW-ECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDL : .:::: ::.:.:: :.:: . :. :..: ::.: ..::: .:.:::: . :: XP_016 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 STFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHP . :::. : XP_016 TLFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKAD 60 70 80 90 100 110 >>NP_001310881 (OMIM: 156535) methyl-CpG-binding domain (524 aa) initn: 264 init1: 240 opt: 243 Z-score: 220.8 bits: 49.6 E(85289): 1.5e-05 Smith-Waterman score: 243; 52.4% identity (77.8% similar) in 63 aa overlap (6-67:5-67) 10 20 30 40 50 pF1KB6 MERKRW-ECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDL : .:::: ::.:.:: :.:: . :. :..: ::.: ..::: .:.:::: . :: NP_001 MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 STFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHP . :::. : NP_001 TLFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKAD 60 70 80 90 100 110 291 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:55:24 2016 done: Fri Nov 4 18:55:25 2016 Total Scan time: 6.590 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]