FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6343, 264 aa 1>>>pF1KB6343 264 - 264 aa - 264 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2972+/-0.000339; mu= 3.3792+/- 0.021 mean_var=181.8356+/-36.582, 0's: 0 Z-trim(121.5): 5 B-trim: 410 in 1/59 Lambda= 0.095112 statistics sampled from 38314 (38319) to 38314 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.775), E-opt: 0.2 (0.449), width: 16 Scan time: 7.860 The best scores are: opt bits E(85289) NP_057683 (OMIM: 605602,613838) myozenin-2 [Homo s ( 264) 1789 256.7 3.1e-68 XP_006714297 (OMIM: 605602,613838) PREDICTED: myoz ( 195) 1276 186.3 3.7e-47 NP_067068 (OMIM: 605603) myozenin-1 [Homo sapiens] ( 299) 305 53.2 6.7e-07 NP_001116325 (OMIM: 610735) myozenin-3 [Homo sapie ( 251) 265 47.6 2.6e-05 NP_588612 (OMIM: 610735) myozenin-3 [Homo sapiens] ( 251) 265 47.6 2.6e-05 >>NP_057683 (OMIM: 605602,613838) myozenin-2 [Homo sapie (264 aa) initn: 1789 init1: 1789 opt: 1789 Z-score: 1346.1 bits: 256.7 E(85289): 3.1e-68 Smith-Waterman score: 1789; 100.0% identity (100.0% similar) in 264 aa overlap (1-264:1-264) 10 20 30 40 50 60 pF1KB6 MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWI 190 200 210 220 230 240 250 260 pF1KB6 SENIPIVITTEPTDDTTVPESEDL :::::::::::::::::::::::: NP_057 SENIPIVITTEPTDDTTVPESEDL 250 260 >>XP_006714297 (OMIM: 605602,613838) PREDICTED: myozenin (195 aa) initn: 1276 init1: 1276 opt: 1276 Z-score: 967.5 bits: 186.3 E(85289): 3.7e-47 Smith-Waterman score: 1276; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KB6 MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWI ::::::: XP_006 DYRSFNRGSRLHWRK 190 >>NP_067068 (OMIM: 605603) myozenin-1 [Homo sapiens] (299 aa) initn: 524 init1: 271 opt: 305 Z-score: 244.8 bits: 53.2 E(85289): 6.7e-07 Smith-Waterman score: 470; 35.2% identity (58.2% similar) in 287 aa overlap (9-257:11-296) 10 20 30 40 50 pF1KB6 MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLF :.::.. . :.. .:..::::.:.:::.:::::: :.:::...: NP_067 MPLSGTPAPNKKRKSSKLIMELTGGGQESSGLNLGKKISVPRDVMLEELSLLTNRGSKMF 10 20 30 40 50 60 60 70 80 90 100 pF1KB6 KMRQRRSDKYTFENF-QYQSRAQINH------SIAMQNGKV-DG-----SNLEGGSQQAP :.:: : .:. .:: . : ....: ... : : . .: :: .:::: . NP_067 KLRQMRVEKFIYENHPDVFSDSSMDHFQKFLPTVGGQLGTAGQGFSYSKSNGRGGSQAGG 70 80 90 100 110 120 110 120 130 140 pF1KB6 LTPPNT--PDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTA-------------------V . : . . . : : .:: . :: : NP_067 SGSAGQYGSDQQHHLGSGSGAGGTGGPAGQAGRGGAAGTAGVGETGSGDQAGGEGKHITV 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB6 PKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKF : : ::::.:.. ::. : :. .::::: :.::::.: :.::.::::. . : NP_067 FKTYISPWERAMGVDPQQKMELGIDLLAYGAKAELPKYKSFNRTAMPYGGYEKASKRMTF 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB6 KVPDFELL-LLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTE---PTDDTTVPE ..: :.: ::..: .. . . ::.: :::::: :.: . :. ... : : : NP_067 QMPKFDLGPLLSEP-LVLYNQNLSNRPSFNRTPIPWLSSGEPVDYNVDIGIPLDGETEEL 250 260 270 280 290 pF1KB6 SEDL >>NP_001116325 (OMIM: 610735) myozenin-3 [Homo sapiens] (251 aa) initn: 449 init1: 184 opt: 265 Z-score: 216.3 bits: 47.6 E(85289): 2.6e-05 Smith-Waterman score: 436; 34.1% identity (58.3% similar) in 264 aa overlap (9-245:4-246) 10 20 30 40 50 60 pF1KB6 MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKM :..: . : : .. . : .:::::.:.:.:.:.:::: .:::. ::. NP_001 MIPKEQKGPVMAAMGDLT-EPVPTLDLGKKLSVPQDLMMEELSLRNNRGSLLFQK 10 20 30 40 50 70 80 90 100 pF1KB6 RQRRSDKYTFENFQYQSRAQINHS-------------IAMQNGKVDGSNLEGGSQQAPLT :::: .:.::: . ..::.. : .: :: .: : .. . : . NP_001 RQRRVQKFTFE-LAASQRAMLAGSARRKVTGTAESGTVANANGP-EGPNYRSELHIFPAS 60 70 80 90 100 110 110 120 130 140 150 pF1KB6 PPNT---PDPRSP--------PNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAI : . :. : :.:. .::::. ::: .:::::: ::. : :. ::.. . NP_001 PGASLGGPEGAHPAAAPAGCVPSPSALAPGYAEPLKGVPPEKFNHTAISKGYRCPWQEFV 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 SNDPELLEALYPKLFKPEGKAELP---DYRSFNRVATPFGGFEKASRMVKFKVPDFELLL : . .. .:... : :::.::.. .:::: .. : : .. NP_001 SY----------RDYQSDGRSHTPSPNDYRNFNKTPVPFGGPLVGG---TFPRPGTPFI- 180 190 200 210 220 230 240 250 260 pF1KB6 LTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL :. .: .. : : ::::. .::. .:.: NP_001 ---PEPLSGLELLRLRPSFNRVAQGWV-RNLPESEEL 220 230 240 250 >>NP_588612 (OMIM: 610735) myozenin-3 [Homo sapiens] (251 aa) initn: 449 init1: 184 opt: 265 Z-score: 216.3 bits: 47.6 E(85289): 2.6e-05 Smith-Waterman score: 436; 34.1% identity (58.3% similar) in 264 aa overlap (9-245:4-246) 10 20 30 40 50 60 pF1KB6 MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKM :..: . : : .. . : .:::::.:.:.:.:.:::: .:::. ::. NP_588 MIPKEQKGPVMAAMGDLT-EPVPTLDLGKKLSVPQDLMMEELSLRNNRGSLLFQK 10 20 30 40 50 70 80 90 100 pF1KB6 RQRRSDKYTFENFQYQSRAQINHS-------------IAMQNGKVDGSNLEGGSQQAPLT :::: .:.::: . ..::.. : .: :: .: : .. . : . NP_588 RQRRVQKFTFE-LAASQRAMLAGSARRKVTGTAESGTVANANGP-EGPNYRSELHIFPAS 60 70 80 90 100 110 110 120 130 140 150 pF1KB6 PPNT---PDPRSP--------PNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAI : . :. : :.:. .::::. ::: .:::::: ::. : :. ::.. . NP_588 PGASLGGPEGAHPAAAPAGCVPSPSALAPGYAEPLKGVPPEKFNHTAISKGYRCPWQEFV 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 SNDPELLEALYPKLFKPEGKAELP---DYRSFNRVATPFGGFEKASRMVKFKVPDFELLL : . .. .:... : :::.::.. .:::: .. : : .. NP_588 SY----------RDYQSDGRSHTPSPNDYRNFNKTPVPFGGPLVGG---TFPRPGTPFI- 180 190 200 210 220 230 240 250 260 pF1KB6 LTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL :. .: .. : : ::::. .::. .:.: NP_588 ---PEPLSGLELLRLRPSFNRVAQGWV-RNLPESEEL 220 230 240 250 264 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:00:31 2016 done: Sat Nov 5 04:00:32 2016 Total Scan time: 7.860 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]