FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6349, 266 aa 1>>>pF1KB6349 266 - 266 aa - 266 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2005+/-0.000358; mu= 15.7823+/- 0.022 mean_var=85.6952+/-18.307, 0's: 0 Z-trim(113.9): 117 B-trim: 0 in 0/55 Lambda= 0.138547 statistics sampled from 23328 (23452) to 23328 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.275), width: 16 Scan time: 6.070 The best scores are: opt bits E(85289) NP_002115 (OMIM: 126200,142857,180300,181000) majo ( 266) 1810 371.6 8.1e-103 NP_001230894 (OMIM: 126200,142857,180300,181000) m ( 266) 1664 342.4 4.9e-94 XP_011546040 (OMIM: 126200,142857,180300,181000) P ( 266) 1637 337.1 2.1e-92 NP_002116 (OMIM: 604776) major histocompatibility ( 266) 1599 329.5 4e-90 NP_072049 (OMIM: 612735) major histocompatibility ( 266) 1596 328.9 6.1e-90 XP_011512864 (OMIM: 604776) PREDICTED: major histo ( 276) 1584 326.5 3.3e-89 NP_001230890 (OMIM: 123400,126200,212750,604305) H ( 269) 1127 235.1 1e-61 NP_001230891 (OMIM: 123400,126200,212750,604305) H ( 261) 1124 234.5 1.5e-61 NP_001287719 (OMIM: 615161) HLA class II histocomp ( 264) 1106 230.9 1.8e-60 XP_005249108 (OMIM: 615161) PREDICTED: HLA class I ( 275) 1103 230.3 2.9e-60 NP_002114 (OMIM: 123400,126200,212750,604305) HLA ( 261) 1102 230.1 3.2e-60 NP_002112 (OMIM: 142858) HLA class II histocompati ( 258) 1085 226.7 3.3e-59 XP_011512862 (OMIM: 615161) PREDICTED: HLA class I ( 256) 1082 226.1 5e-59 NP_002111 (OMIM: 600629) HLA class II histocompati ( 273) 988 207.3 2.4e-53 NP_001185787 (OMIM: 615161) HLA class II histocomp ( 227) 902 190.1 3.1e-48 XP_011512863 (OMIM: 615161) PREDICTED: HLA class I ( 219) 896 188.9 7e-48 NP_620576 (OMIM: 104300,176100,176200,235200,61263 ( 260) 276 65.0 1.6e-10 NP_002109 (OMIM: 142856) HLA class II histocompati ( 263) 275 64.8 1.8e-10 NP_620578 (OMIM: 104300,176100,176200,235200,61263 ( 325) 276 65.1 1.9e-10 XP_011512845 (OMIM: 104300,176100,176200,235200,61 ( 348) 276 65.1 2e-10 NP_000401 (OMIM: 104300,176100,176200,235200,61263 ( 348) 276 65.1 2e-10 NP_001287678 (OMIM: 104300,176100,176200,235200,61 ( 337) 274 64.7 2.5e-10 XP_011507765 (OMIM: 600764) PREDICTED: major histo ( 254) 256 61.0 2.5e-09 NP_001176 (OMIM: 194460) zinc-alpha-2-glycoprotein ( 298) 252 60.3 4.9e-09 NP_001522 (OMIM: 600764) major histocompatibility ( 341) 250 59.9 7.1e-09 NP_291032 (OMIM: 142880) HLA class II histocompati ( 260) 240 57.8 2.3e-08 NP_001229454 (OMIM: 142880) HLA class II histocomp ( 260) 240 57.8 2.3e-08 NP_001229453 (OMIM: 142880) HLA class II histocomp ( 260) 240 57.8 2.3e-08 NP_002110 (OMIM: 142930) HLA class II histocompati ( 250) 233 56.4 6e-08 NP_620577 (OMIM: 104300,176100,176200,235200,61263 ( 246) 230 55.8 9e-08 NP_620573 (OMIM: 104300,176100,176200,235200,61263 ( 256) 230 55.8 9.2e-08 NP_620572 (OMIM: 104300,176100,176200,235200,61263 ( 242) 229 55.6 1e-07 NP_620579 (OMIM: 104300,176100,176200,235200,61263 ( 168) 227 55.0 1e-07 NP_620575 (OMIM: 104300,176100,176200,235200,61263 ( 334) 230 55.9 1.1e-07 NP_002113 (OMIM: 146880,212750) HLA class II histo ( 255) 227 55.2 1.4e-07 XP_016866307 (OMIM: 142871,600807) PREDICTED: HLA ( 246) 226 55.0 1.6e-07 XP_016866306 (OMIM: 142871,600807) PREDICTED: HLA ( 246) 226 55.0 1.6e-07 NP_005505 (OMIM: 106300,142830,608579) major histo ( 362) 223 54.5 3.1e-07 NP_002107 (OMIM: 142800,608579) HLA class I histoc ( 365) 223 54.5 3.1e-07 NP_001181928 (OMIM: 600764) major histocompatibili ( 296) 221 54.1 3.6e-07 NP_064440 (OMIM: 613503) HLA class II histocompati ( 255) 216 53.0 6.4e-07 XP_006715142 (OMIM: 146880,212750) PREDICTED: HLA ( 206) 214 52.5 7.2e-07 NP_061984 (OMIM: 142860) HLA class II histocompati ( 254) 209 51.6 1.7e-06 XP_016866304 (OMIM: 143110) PREDICTED: HLA class I ( 228) 208 51.4 1.8e-06 XP_011512866 (OMIM: 143110) PREDICTED: HLA class I ( 343) 209 51.7 2.1e-06 XP_016866303 (OMIM: 143110) PREDICTED: HLA class I ( 324) 208 51.5 2.3e-06 NP_061823 (OMIM: 143110) HLA class I histocompatib ( 346) 208 51.5 2.4e-06 XP_016866302 (OMIM: 143110) PREDICTED: HLA class I ( 388) 208 51.6 2.6e-06 XP_016866301 (OMIM: 143110) PREDICTED: HLA class I ( 420) 208 51.6 2.8e-06 XP_016866300 (OMIM: 143110) PREDICTED: HLA class I ( 431) 208 51.6 2.8e-06 >>NP_002115 (OMIM: 126200,142857,180300,181000) major hi (266 aa) initn: 1810 init1: 1810 opt: 1810 Z-score: 1966.9 bits: 371.6 E(85289): 8.1e-103 Smith-Waterman score: 1810; 100.0% identity (100.0% similar) in 266 aa overlap (1-266:1-266) 10 20 30 40 50 60 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 250 260 pF1KB6 FLGAGLFIYFRNQKGHSGLQPTGFLS :::::::::::::::::::::::::: NP_002 FLGAGLFIYFRNQKGHSGLQPTGFLS 250 260 >>NP_001230894 (OMIM: 126200,142857,180300,181000) major (266 aa) initn: 1664 init1: 1664 opt: 1664 Z-score: 1809.2 bits: 342.4 E(85289): 4.9e-94 Smith-Waterman score: 1664; 91.4% identity (96.6% similar) in 266 aa overlap (1-266:1-266) 10 20 30 40 50 60 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF ::::.:::::::..::::::::::::::.:::::::: ::::::::::::.::::: NP_001 MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYSTSECHFFNGTERVRYLDRYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV .::::.:::::::::::::::::::::::::::::.::: :. ::.:::::::::::::: NP_001 HNQEENVRFDSDVGEFRAVTELGRPDAEYWNSQKDLLEQKRGRVDNYCRHNYGVVESFTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG ::::.:::::::::::::::::::::::::::::::::::: ::::::.:.::::::.:: NP_001 QRRVHPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKTGVVSTGLIHNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 250 260 pF1KB6 FLGAGLFIYFRNQKGHSGLQPTGFLS ::::::::::::::::::::: :::: NP_001 FLGAGLFIYFRNQKGHSGLQPRGFLS 250 260 >>XP_011546040 (OMIM: 126200,142857,180300,181000) PREDI (266 aa) initn: 1637 init1: 1637 opt: 1637 Z-score: 1780.0 bits: 337.1 E(85289): 2.1e-92 Smith-Waterman score: 1637; 90.6% identity (95.5% similar) in 266 aa overlap (1-266:1-266) 10 20 30 40 50 60 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF ::::::::::::.:::::::::::::::.:::.:::::: : .::::::::::.::.: : XP_011 MVCLKLPGGSCMAALTVTLMVLSSPLALAGDTQPRFLWQGKYKCHFFNGTERVQFLERLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV ::::: :::::::::.::::::::: :: :::::::::. :. ::: ::::::: ::::: XP_011 YNQEEFVRFDSDVGEYRAVTELGRPVAESWNSQKDILEDRRGQVDTVCRHNYGVGESFTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG ::::.:.:::::.:::::::::::::::::::::::::::: ::::::::.::::::::: XP_011 QRRVHPEVTVYPAKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_011 DWTFQTLVMLETVPRSGEVYTCQVEHPSVMSPLTVEWRARSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 250 260 pF1KB6 FLGAGLFIYFRNQKGHSGLQPTGFLS :::::::::::::::::::::::::: XP_011 FLGAGLFIYFRNQKGHSGLQPTGFLS 250 260 >>NP_002116 (OMIM: 604776) major histocompatibility comp (266 aa) initn: 1619 init1: 1599 opt: 1599 Z-score: 1739.0 bits: 329.5 E(85289): 4e-90 Smith-Waterman score: 1599; 88.7% identity (95.9% similar) in 266 aa overlap (1-266:1-266) 10 20 30 40 50 60 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF :::::::::: :. ::::::::::::::.:::::::: : : :::::::::::::: : . NP_002 MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV :::::..::::::::.:::::::::::::::::::.::. :::::::::::::: ::::: NP_002 YNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG ::::.:::::::..:: :::::::::::.:::::::::::: :.::::::.::::::::: NP_002 QRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: NP_002 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 250 260 pF1KB6 FLGAGLFIYFRNQKGHSGLQPTGFLS ::::::::::.::::::::.:::..: NP_002 FLGAGLFIYFKNQKGHSGLHPTGLVS 250 260 >>NP_072049 (OMIM: 612735) major histocompatibility comp (266 aa) initn: 1596 init1: 1596 opt: 1596 Z-score: 1735.7 bits: 328.9 E(85289): 6.1e-90 Smith-Waterman score: 1596; 89.1% identity (94.7% similar) in 266 aa overlap (1-266:1-266) 10 20 30 40 50 60 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF :::::::::: ..::::::::::: ::..:::::::: : ::::::::::::.::::: NP_072 MVCLKLPGGSSLAALTVTLMVLSSRLAFAGDTRPRFLELRKSECHFFNGTERVRYLDRYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV .:::: .::::::::.::::::::: :: ::::::.::: :. ::.:::::::: ::::: NP_072 HNQEEFLRFDSDVGEYRAVTELGRPVAESWNSQKDLLEQKRGRVDNYCRHNYGVGESFTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG ::::.:.:::::.:::::::::::::::::::::::::::: ::::::::.::::::::: NP_072 QRRVHPQVTVYPAKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_072 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSALTVEWRARSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 250 260 pF1KB6 FLGAGLFIYFRNQKGHSGLQPTGFLS :::::::::::::::::::::::::: NP_072 FLGAGLFIYFRNQKGHSGLQPTGFLS 250 260 >>XP_011512864 (OMIM: 604776) PREDICTED: major histocomp (276 aa) initn: 1584 init1: 1584 opt: 1584 Z-score: 1722.6 bits: 326.5 E(85289): 3.3e-89 Smith-Waterman score: 1584; 89.3% identity (95.8% similar) in 262 aa overlap (1-262:1-262) 10 20 30 40 50 60 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF :::::::::: :. ::::::::::::::.:::::::: : : :::::::::::::: : . XP_011 MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV :::::..::::::::.:::::::::::::::::::.::. :::::::::::::: ::::: XP_011 YNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG ::::.:::::::..:: :::::::::::.:::::::::::: :.::::::.::::::::: XP_011 QRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: XP_011 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLL 190 200 210 220 230 240 250 260 pF1KB6 FLGAGLFIYFRNQKGHSGLQPTGFLS ::::::::::.::::::::.:: XP_011 FLGAGLFIYFKNQKGHSGLHPTVLSSESLKERKRSC 250 260 270 >>NP_001230890 (OMIM: 123400,126200,212750,604305) HLA c (269 aa) initn: 1125 init1: 1098 opt: 1127 Z-score: 1229.0 bits: 235.1 E(85289): 1e-61 Smith-Waterman score: 1127; 64.1% identity (82.4% similar) in 262 aa overlap (4-265:7-268) 10 20 30 40 50 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLD :..:: ....:. : .::: :: . :. :..: : :.: :::::::.. NP_001 MSWKKALRIPGDLRVATVTLMLAMLSSLLAEGRDSPEDFVFQFKGMCYFTNGTERVRLVT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 RYFYNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVES ::.::.:: .::::::: .:::: ::::::::::::..:: .:: .:: ::::: :. NP_001 RYIYNREEYARFDSDVGVYRAVTPQGRPDAEYWNSQKEVLEGTRAELDTVCRHNYEVAFR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 FTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLI .::::.: ::. ::.:. :.:::::::::. ::::.:.:::: : ::: ::.::: :: NP_001 GILQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPGQIKVRWFRNDQEETAGVVSTPLI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 QNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVL .::::::: ::::: .:. :.::::.:::::. ::.::::::.::::::::::::::::: NP_001 RNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSKMLSGVGGFVL 190 200 210 220 230 240 240 250 260 pF1KB6 GLLFLGAGLFIYFRNQKGHSGLQPTGFLS ::.::: ::.: :.::: .: :.:.: NP_001 GLIFLGLGLIIRQRSQKGPQGPPPAGLLH 250 260 >>NP_001230891 (OMIM: 123400,126200,212750,604305) HLA c (261 aa) initn: 1121 init1: 1121 opt: 1124 Z-score: 1226.0 bits: 234.5 E(85289): 1.5e-61 Smith-Waterman score: 1124; 66.9% identity (83.5% similar) in 254 aa overlap (4-255:7-258) 10 20 30 40 50 pF1KB6 MVCLKLPGGSCMTALTVTLMV--LSSPLALSGDTRPRFLWQPKRECHFFNGTERVRF :..::: . : :::::. ::.:.: . :. :..: : :.: :::::::. NP_001 MSWKKALRIPGG--LRAATVTLMLSMLSTPVAEGRDSPEDFVYQFKGMCYFTNGTERVRL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 LDRYFYNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVV ..: .::.:: :::::::::::::: :: : ::::::::::::. ::::: ::::: . NP_001 VSRSIYNREEIVRFDSDVGEFRAVTLLGLPAAEYWNSQKDILERKRAAVDRVCRHNYQLE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 ESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTG :.::::.: ::. ::.:. :.:::::::::. :::..:.:::: : ::: ::.::: NP_001 LRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 LIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGF ::.::::::: ::::: .:. :.::::.:::::. ::.::::::.:::::::::::.::: NP_001 LIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSKMLSGIGGF 180 190 200 210 220 230 240 250 260 pF1KB6 VLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS ::::.::: ::.:. :.::: NP_001 VLGLIFLGLGLIIHHRSQKGLLH 240 250 260 >>NP_001287719 (OMIM: 615161) HLA class II histocompatib (264 aa) initn: 1083 init1: 809 opt: 1106 Z-score: 1206.4 bits: 230.9 E(85289): 1.8e-60 Smith-Waterman score: 1106; 64.1% identity (81.3% similar) in 262 aa overlap (4-265:3-263) 10 20 30 40 50 60 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF :..::: .:.:: :..::.:.: . : :: : : :.: ::::::: . ::. NP_001 MALQIPGGFWAAAVTVMLVMLSTPVAEARDFPKDFLVQFKGMCYFTNGTERVRGVARYI 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV ::.:: :::::::::.::::::: . : ::. ::.::: ::::: ::::: . :. NP_001 YNREEYGRFDSDVGEFQAVTELGR-SIEDWNNYKDFLEQERAAVDKVCRHNYEAELRTTL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG ::.:.: ::. ::.:. :.:::::::::. :::..:.:::: : ::: ::.:::.::.:: NP_001 QRQVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTSLIRNG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL ::::: ::::: .:. :..:::::::::. ::.::::::.:::::::::::.:::::::. NP_001 DWTFQILVMLEITPQRGDIYTCQVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVLGLI 180 190 200 210 220 230 250 260 pF1KB6 FLGAGLFIYFRNQKGHSGLQPTGFLS ::: ::.: :.::: : :.:.: NP_001 FLGLGLIIRHRGQKGPRGPPPAGLLH 240 250 260 >>XP_005249108 (OMIM: 615161) PREDICTED: HLA class II hi (275 aa) initn: 1083 init1: 809 opt: 1103 Z-score: 1203.0 bits: 230.3 E(85289): 2.9e-60 Smith-Waterman score: 1103; 63.9% identity (81.0% similar) in 263 aa overlap (4-266:3-264) 10 20 30 40 50 60 pF1KB6 MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF :..::: .:.:: :..::.:.: . : :: : : :.: ::::::: . ::. XP_005 MALQIPGGFWAAAVTVMLVMLSTPVAEARDFPKDFLVQFKGMCYFTNGTERVRGVARYI 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV ::.:: :::::::::.::::::: . : ::. ::.::: ::::: ::::: . :. XP_005 YNREEYGRFDSDVGEFQAVTELGR-SIEDWNNYKDFLEQERAAVDKVCRHNYEAELRTTL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG ::.:.: ::. ::.:. :.:::::::::. :::..:.:::: : ::: ::.:::.::.:: XP_005 QRQVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTSLIRNG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL ::::: ::::: .:. :..:::::::::. ::.::::::.:::::::::::.:::::::. XP_005 DWTFQILVMLEITPQRGDIYTCQVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVLGLI 180 190 200 210 220 230 250 260 pF1KB6 FLGAGLFIYFRNQKGHSGLQPTGFLS ::: ::.: :.::: : :.: .: XP_005 FLGLGLIIRHRGQKGPRGPPPAGNISAMIQSGERAQA 240 250 260 270 266 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:47:20 2016 done: Fri Nov 4 18:47:21 2016 Total Scan time: 6.070 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]