FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6350, 293 aa 1>>>pF1KB6350 293 - 293 aa - 293 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1156+/-0.000397; mu= 16.3095+/- 0.024 mean_var=67.2792+/-13.504, 0's: 0 Z-trim(111.4): 78 B-trim: 0 in 0/50 Lambda= 0.156363 statistics sampled from 19946 (19966) to 19946 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.234), width: 16 Scan time: 7.030 The best scores are: opt bits E(85289) NP_055100 (OMIM: 602238) exosome complex component ( 293) 1898 437.2 1.7e-122 XP_016870047 (OMIM: 602238) PREDICTED: exosome com ( 181) 1186 276.5 2.7e-74 XP_005272233 (OMIM: 602238) PREDICTED: exosome com ( 181) 1186 276.5 2.7e-74 NP_001269638 (OMIM: 602238) exosome complex compon ( 263) 1130 264.0 2.3e-70 XP_006717086 (OMIM: 602238) PREDICTED: exosome com ( 163) 1069 250.1 2.2e-66 NP_001269637 (OMIM: 602238) exosome complex compon ( 267) 912 214.8 1.5e-55 >>NP_055100 (OMIM: 602238) exosome complex component RRP (293 aa) initn: 1898 init1: 1898 opt: 1898 Z-score: 2320.0 bits: 437.2 E(85289): 1.7e-122 Smith-Waterman score: 1898; 100.0% identity (100.0% similar) in 293 aa overlap (1-293:1-293) 10 20 30 40 50 60 pF1KB6 MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNC 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 IISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG 250 260 270 280 290 >>XP_016870047 (OMIM: 602238) PREDICTED: exosome complex (181 aa) initn: 1186 init1: 1186 opt: 1186 Z-score: 1454.9 bits: 276.5 E(85289): 2.7e-74 Smith-Waterman score: 1186; 100.0% identity (100.0% similar) in 181 aa overlap (113-293:1-181) 90 100 110 120 130 140 pF1KB6 IVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLIS :::::::::::::::::::::::::::::: XP_016 MNLPGGELRRRSAEDELAMRGFLQEGDLIS 10 20 30 150 160 170 180 190 200 pF1KB6 AEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGF 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB6 IWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEA 100 110 120 130 140 150 270 280 290 pF1KB6 SLPHQIKDILKPEIMEEIVMETRQRLLEQEG ::::::::::::::::::::::::::::::: XP_016 SLPHQIKDILKPEIMEEIVMETRQRLLEQEG 160 170 180 >>XP_005272233 (OMIM: 602238) PREDICTED: exosome complex (181 aa) initn: 1186 init1: 1186 opt: 1186 Z-score: 1454.9 bits: 276.5 E(85289): 2.7e-74 Smith-Waterman score: 1186; 100.0% identity (100.0% similar) in 181 aa overlap (113-293:1-181) 90 100 110 120 130 140 pF1KB6 IVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLIS :::::::::::::::::::::::::::::: XP_005 MNLPGGELRRRSAEDELAMRGFLQEGDLIS 10 20 30 150 160 170 180 190 200 pF1KB6 AEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGF 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB6 IWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEA 100 110 120 130 140 150 270 280 290 pF1KB6 SLPHQIKDILKPEIMEEIVMETRQRLLEQEG ::::::::::::::::::::::::::::::: XP_005 SLPHQIKDILKPEIMEEIVMETRQRLLEQEG 160 170 180 >>NP_001269638 (OMIM: 602238) exosome complex component (263 aa) initn: 1692 init1: 1130 opt: 1130 Z-score: 1384.3 bits: 264.0 E(85289): 2.3e-70 Smith-Waterman score: 1636; 89.8% identity (89.8% similar) in 293 aa overlap (1-293:1-263) 10 20 30 40 50 60 pF1KB6 MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGEL :::::::::::::::::::::::::::::: NP_001 ERVNKLICVKALKTRYIGEVGDIVVGRITE------------------------------ 70 80 90 130 140 150 160 170 180 pF1KB6 RRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVK 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 RQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNC 160 170 180 190 200 210 250 260 270 280 290 pF1KB6 IISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG 220 230 240 250 260 >>XP_006717086 (OMIM: 602238) PREDICTED: exosome complex (163 aa) initn: 1069 init1: 1069 opt: 1069 Z-score: 1312.9 bits: 250.1 E(85289): 2.2e-66 Smith-Waterman score: 1069; 100.0% identity (100.0% similar) in 163 aa overlap (131-293:1-163) 110 120 130 140 150 160 pF1KB6 NSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRS :::::::::::::::::::::::::::::: XP_006 MRGFLQEGDLISAEVQAVFSDGAVSLHTRS 10 20 30 170 180 190 200 210 220 pF1KB6 LKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFI 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB6 ANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEI 100 110 120 130 140 150 290 pF1KB6 VMETRQRLLEQEG ::::::::::::: XP_006 VMETRQRLLEQEG 160 >>NP_001269637 (OMIM: 602238) exosome complex component (267 aa) initn: 908 init1: 908 opt: 912 Z-score: 1118.5 bits: 214.8 E(85289): 1.5e-55 Smith-Waterman score: 1674; 91.1% identity (91.1% similar) in 293 aa overlap (1-293:1-267) 10 20 30 40 50 60 pF1KB6 MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVK :::::::::::::::::::::: :::::::::::: NP_001 RRRSAEDELAMRGFLQEGDLIS--------------------------GVLVQVSPSLVK 130 140 150 190 200 210 220 230 240 pF1KB6 RQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNC 160 170 180 190 200 210 250 260 270 280 290 pF1KB6 IISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG 220 230 240 250 260 293 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:34:07 2016 done: Fri Nov 4 20:34:08 2016 Total Scan time: 7.030 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]