FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6351, 266 aa
  1>>>pF1KB6351 266 - 266 aa - 266 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.4685+/-0.000311; mu= 10.8633+/- 0.019
 mean_var=116.4268+/-23.976, 0's: 0 Z-trim(120.0): 13  B-trim: 544 in 1/55
 Lambda= 0.118863
 statistics sampled from 34611 (34624) to 34611 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.406), width:  16
 Scan time:  7.360

The best scores are:                                      opt bits E(85289)
NP_036374 (OMIM: 605189) dickkopf-related protein  ( 266) 1896 335.3 6.9e-92
NP_055236 (OMIM: 605415) dickkopf-related protein  ( 259)  728 135.0 1.3e-31
XP_011542790 (OMIM: 605417) PREDICTED: dickkopf-re ( 224)  531 101.2 1.8e-21
NP_055235 (OMIM: 605417) dickkopf-related protein  ( 224)  531 101.2 1.8e-21
XP_016868805 (OMIM: 605417) PREDICTED: dickkopf-re ( 224)  531 101.2 1.8e-21


>>NP_036374 (OMIM: 605189) dickkopf-related protein 1 pr  (266 aa)
 initn: 1896 init1: 1896 opt: 1896  Z-score: 1770.7  bits: 335.3 E(85289): 6.9e-92
Smith-Waterman score: 1896; 100.0% identity (100.0% similar) in 266 aa overlap (1-266:1-266)

               10        20        30        40        50        60
pF1KB6 MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 SAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 SAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 CMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 CMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYH
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 TKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCG
              190       200       210       220       230       240

              250       260      
pF1KB6 EGLSCRIQKDHHQASNSSRLHTCQRH
       ::::::::::::::::::::::::::
NP_036 EGLSCRIQKDHHQASNSSRLHTCQRH
              250       260      

>>NP_055236 (OMIM: 605415) dickkopf-related protein 2 pr  (259 aa)
 initn: 595 init1: 436 opt: 728  Z-score: 688.3  bits: 135.0 E(85289): 1.3e-31
Smith-Waterman score: 728; 42.5% identity (68.1% similar) in 273 aa overlap (1-265:1-258)

               10        20        30        40        50        60
pF1KB6 MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAV
       : ::  .  .   . ..::.:    ..  :   .:  . :.::.    ::: .  ::.:.
NP_055 MAALMRSKDSSCCLLLLAAVL----MVESSQIGSSRAKLNSIKS---SLGGET--PGQAA
               10        20            30        40             50 

               70           80        90       100       110       
pF1KB6 SAAPGILYPG---GNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKR
       . . : .: :   :.. .  .  : :::. :.:: . .:: :: .:..:    :..::..
NP_055 NRSAG-MYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSA----CMVCRRK
               60        70        80        90           100      

       120       130       140       150          160         170  
pF1KB6 RKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEI---EETITESFGNDH-STLD-GYSRRT
       .::: : .::::.. :.::::.   .. .  .:   . :  .. .. : :. : :..   
NP_055 KKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLG
        110       120       130       140       150       160      

            180       190       200       210       220       230  
pF1KB6 TLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLE
          .:: : ::.::. :::::::  :.:::::::.:::::::..:.::::.:.:::::::
NP_055 RPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLE
        170       180       190       200       210       220      

            240       250       260      
pF1KB6 IFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
       ::::: :..::::.. ::   .:.. :::.::. 
NP_055 IFQRCDCAKGLSCKVWKDATYSSKA-RLHVCQKI
        230       240       250          

>>XP_011542790 (OMIM: 605417) PREDICTED: dickkopf-relate  (224 aa)
 initn: 500 init1: 257 opt: 531  Z-score: 506.6  bits: 101.2 E(85289): 1.8e-21
Smith-Waterman score: 531; 42.5% identity (64.5% similar) in 186 aa overlap (85-265:41-220)

           60        70        80        90       100       110    
pF1KB6 HPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLAC
                                     :  : .:.: ..: .:    :    .: .:
XP_011 WLCSPLGALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPR---DEK-PFCATC
               20        30        40        50           60       

          120       130       140          150       160        170
pF1KB6 RKRRKRCMRHAMCCPGNYCKNGICVSSDQNH---FRGEIEETITESFGND-HSTLDGYSR
       :  :.::.: ::::::. : : .:.. ..      :   :.  :.. :.  : . ..  .
XP_011 RGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPK
         70        80        90       100       110       120      

              180       190       200       210       220          
pF1KB6 RTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGS-H
       :    .:    :::::  :::. ::. :::::::::.::::::: :::::... .: . .
XP_011 RKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQ
        130       140       150       160       170       180      

     230       240       250       260         
pF1KB6 GLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH   
       . :::::: :: :: :: :   ..  . .::..::.    
XP_011 APEIFQRCDCGPGLLCRSQLTSNR--QHARLRVCQKIEKL
        190       200       210         220    

>>NP_055235 (OMIM: 605417) dickkopf-related protein 4 pr  (224 aa)
 initn: 500 init1: 257 opt: 531  Z-score: 506.6  bits: 101.2 E(85289): 1.8e-21
Smith-Waterman score: 531; 42.5% identity (64.5% similar) in 186 aa overlap (85-265:41-220)

           60        70        80        90       100       110    
pF1KB6 HPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLAC
                                     :  : .:.: ..: .:    :    .: .:
NP_055 WLCSPLGALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPR---DEK-PFCATC
               20        30        40        50           60       

          120       130       140          150       160        170
pF1KB6 RKRRKRCMRHAMCCPGNYCKNGICVSSDQNH---FRGEIEETITESFGND-HSTLDGYSR
       :  :.::.: ::::::. : : .:.. ..      :   :.  :.. :.  : . ..  .
NP_055 RGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPK
         70        80        90       100       110       120      

              180       190       200       210       220          
pF1KB6 RTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGS-H
       :    .:    :::::  :::. ::. :::::::::.::::::: :::::... .: . .
NP_055 RKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQ
        130       140       150       160       170       180      

     230       240       250       260         
pF1KB6 GLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH   
       . :::::: :: :: :: :   ..  . .::..::.    
NP_055 APEIFQRCDCGPGLLCRSQLTSNR--QHARLRVCQKIEKL
        190       200       210         220    

>>XP_016868805 (OMIM: 605417) PREDICTED: dickkopf-relate  (224 aa)
 initn: 500 init1: 257 opt: 531  Z-score: 506.6  bits: 101.2 E(85289): 1.8e-21
Smith-Waterman score: 531; 42.5% identity (64.5% similar) in 186 aa overlap (85-265:41-220)

           60        70        80        90       100       110    
pF1KB6 HPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLAC
                                     :  : .:.: ..: .:    :    .: .:
XP_016 WLCSPLGALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPR---DEK-PFCATC
               20        30        40        50           60       

          120       130       140          150       160        170
pF1KB6 RKRRKRCMRHAMCCPGNYCKNGICVSSDQNH---FRGEIEETITESFGND-HSTLDGYSR
       :  :.::.: ::::::. : : .:.. ..      :   :.  :.. :.  : . ..  .
XP_016 RGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPK
         70        80        90       100       110       120      

              180       190       200       210       220          
pF1KB6 RTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGS-H
       :    .:    :::::  :::. ::. :::::::::.::::::: :::::... .: . .
XP_016 RKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQ
        130       140       150       160       170       180      

     230       240       250       260         
pF1KB6 GLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH   
       . :::::: :: :: :: :   ..  . .::..::.    
XP_016 APEIFQRCDCGPGLLCRSQLTSNR--QHARLRVCQKIEKL
        190       200       210         220    




266 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 18:37:27 2016 done: Fri Nov  4 18:37:28 2016
 Total Scan time:  7.360 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]