Result of FASTA (omim) for
pF1KB6359
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6359, 254 aa
1>>>pF1KB6359 254 - 254 aa - 254 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2615+/-0.000411; mu= 15.4650+/- 0.026
mean_var=67.1866+/-13.305, 0's: 0 Z-trim(110.9): 37 B-trim: 0 in 0/52
Lambda= 0.156471
statistics sampled from 19324 (19345) to 19324 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.227), width: 16
Scan time: 6.700
The best scores are: opt bits E(85289)
NP_005780 (OMIM: 605129) proteasome activator comp ( 254) 1620 374.6 9.6e-104
NP_001253974 (OMIM: 605129) proteasome activator c ( 265) 1545 357.7 1.2e-98
NP_001317158 (OMIM: 605129) proteasome activator c ( 193) 1239 288.5 5.9e-78
NP_789839 (OMIM: 605129) proteasome activator comp ( 267) 879 207.3 2.3e-53
NP_006254 (OMIM: 600654) proteasome activator comp ( 249) 679 162.2 8.3e-40
NP_001268457 (OMIM: 600654) proteasome activator c ( 233) 600 144.3 1.8e-34
NP_788955 (OMIM: 600654) proteasome activator comp ( 250) 600 144.3 1.9e-34
NP_002809 (OMIM: 602161) proteasome activator comp ( 239) 426 105.0 1.2e-22
XP_006720276 (OMIM: 602161) PREDICTED: proteasome ( 162) 386 95.9 4.7e-20
NP_001268458 (OMIM: 600654) proteasome activator c ( 236) 265 68.7 1.1e-11
>>NP_005780 (OMIM: 605129) proteasome activator complex (254 aa)
initn: 1620 init1: 1620 opt: 1620 Z-score: 1983.6 bits: 374.6 E(85289): 9.6e-104
Smith-Waterman score: 1620; 100.0% identity (100.0% similar) in 254 aa overlap (1-254:1-254)
10 20 30 40 50 60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
190 200 210 220 230 240
250
pF1KB6 KIKRPRSSNAETLY
::::::::::::::
NP_005 KIKRPRSSNAETLY
250
>>NP_001253974 (OMIM: 605129) proteasome activator compl (265 aa)
initn: 1545 init1: 1545 opt: 1545 Z-score: 1891.8 bits: 357.7 E(85289): 1.2e-98
Smith-Waterman score: 1545; 100.0% identity (100.0% similar) in 241 aa overlap (14-254:25-265)
10 20 30 40
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPI
::::::::::::::::::::::::::::::::::::
NP_001 MEKWILKKIKYLQSGGLSASYYSYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 LNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGML
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB6 KSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB6 SEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYV
190 200 210 220 230 240
230 240 250
pF1KB6 TLHDMILKNIEKIKRPRSSNAETLY
:::::::::::::::::::::::::
NP_001 TLHDMILKNIEKIKRPRSSNAETLY
250 260
>>NP_001317158 (OMIM: 605129) proteasome activator compl (193 aa)
initn: 1239 init1: 1239 opt: 1239 Z-score: 1520.5 bits: 288.5 E(85289): 5.9e-78
Smith-Waterman score: 1239; 100.0% identity (100.0% similar) in 193 aa overlap (62-254:1-193)
40 50 60 70 80 90
pF1KB6 NFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDE
::::::::::::::::::::::::::::::
NP_001 MNLPVPDPILLTNSHDGLDGPTYKKRRLDE
10 20 30
100 110 120 130 140 150
pF1KB6 CEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGN
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB6 NFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDE
100 110 120 130 140 150
220 230 240 250
pF1KB6 KEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
:::::::::::::::::::::::::::::::::::::::::::
NP_001 KEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
160 170 180 190
>>NP_789839 (OMIM: 605129) proteasome activator complex (267 aa)
initn: 1606 init1: 879 opt: 879 Z-score: 1079.2 bits: 207.3 E(85289): 2.3e-53
Smith-Waterman score: 1584; 95.1% identity (95.1% similar) in 267 aa overlap (1-254:1-267)
10 20 30 40 50 60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
70 80 90 100 110 120
130 140 150 160
pF1KB6 KVKPEIRLLIEKCNT-------------VKMWVQLLIPRIEDGNNFGVSIQEETVAELRT
::::::::::::::: ::::::::::::::::::::::::::::::::
NP_789 KVKPEIRLLIEKCNTPSGKGPHICFDLQVKMWVQLLIPRIEDGNNFGVSIQEETVAELRT
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB6 VESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 VESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQ
190 200 210 220 230 240
230 240 250
pF1KB6 YVTLHDMILKNIEKIKRPRSSNAETLY
:::::::::::::::::::::::::::
NP_789 YVTLHDMILKNIEKIKRPRSSNAETLY
250 260
>>NP_006254 (OMIM: 600654) proteasome activator complex (249 aa)
initn: 672 init1: 473 opt: 679 Z-score: 835.7 bits: 162.2 E(85289): 8.3e-40
Smith-Waterman score: 679; 40.9% identity (74.2% similar) in 252 aa overlap (3-254:2-249)
10 20 30 40 50 60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: :: .:.....
NP_006 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
...:::::. .... .:. :: ... . : : : .. :...: ...
NP_006 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDK--GPPCGPVNCNEKIVVLLQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
..::::. .::. : : :.:: ::::::::::::..::.. . ..... .. :::
NP_006 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQIS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: :..:.:.::::.:
NP_006 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFE
180 190 200 210 220 230
250
pF1KB6 KIKRPRSSNAETLY
:.:.::. . .:
NP_006 KLKKPRGETKGMIY
240
>>NP_001268457 (OMIM: 600654) proteasome activator compl (233 aa)
initn: 597 init1: 398 opt: 600 Z-score: 739.7 bits: 144.3 E(85289): 1.8e-34
Smith-Waterman score: 600; 40.5% identity (73.1% similar) in 227 aa overlap (3-229:2-224)
10 20 30 40 50 60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: :: .:.....
NP_001 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
...:::::. .... .:. :: ... . : : : .. :...: ...
NP_001 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPVNCNEKIVVLLQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
..::::. .::. : : :.:: ::::::::::::..::.. . ..... .. :::
NP_001 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQIS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: ::
NP_001 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRLCYMTSS
180 190 200 210 220 230
250
pF1KB6 KIKRPRSSNAETLY
>>NP_788955 (OMIM: 600654) proteasome activator complex (250 aa)
initn: 597 init1: 398 opt: 600 Z-score: 739.3 bits: 144.3 E(85289): 1.9e-34
Smith-Waterman score: 600; 40.5% identity (73.1% similar) in 227 aa overlap (3-229:2-224)
10 20 30 40 50 60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: :: .:.....
NP_788 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
...:::::. .... .:. :: ... . : : : .. :...: ...
NP_788 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDKG--PPCGPVNCNEKIVVLLQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
..::::. .::. : : :.:: ::::::::::::..::.. . ..... .. :::
NP_788 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQIS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: ::
NP_788 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRQGQGRGGQR
180 190 200 210 220 230
250
pF1KB6 KIKRPRSSNAETLY
NP_788 QLSQATHSLTLQARG
240 250
>>NP_002809 (OMIM: 602161) proteasome activator complex (239 aa)
initn: 582 init1: 399 opt: 426 Z-score: 527.3 bits: 105.0 E(85289): 1.2e-22
Smith-Waterman score: 535; 33.6% identity (66.8% similar) in 250 aa overlap (5-254:7-239)
10 20 30 40 50
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQI
.... :.. .:. ::. . .:::... :.:.:.. :...:.: ::. :::..
NP_002 MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 HSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDI
.. ...:.::: . : .. .:... .: :.: .:......
NP_002 RAPLDIPIPDP---PPKDDEMETDKQEKKEVHKC--------------GFLPGNEKVLSL
70 80 90 100
120 130 140 150 160 170
pF1KB6 IEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQ
. ::::. : ::: : :.: :::.:::::.:::.:::... .. .:.... ..
NP_002 LALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTT
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 ISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKN
::.:. :. :.: .: :: ::: : : :: : :: .. .:: :. :. .: .:
NP_002 ISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSN
170 180 190 200 210 220
240 250
pF1KB6 IEKIKRPRSSNAETLY
.::: :.. . ..:
NP_002 LEKIVNPKGEEKPSMY
230
>>XP_006720276 (OMIM: 602161) PREDICTED: proteasome acti (162 aa)
initn: 384 init1: 360 opt: 386 Z-score: 481.0 bits: 95.9 E(85289): 4.7e-20
Smith-Waterman score: 386; 39.5% identity (68.4% similar) in 152 aa overlap (103-254:11-162)
80 90 100 110 120 130
pF1KB6 TNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEK
: :.: .:....... ::::. : ::
XP_006 METDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEK
10 20 30 40
140 150 160 170 180 190
pF1KB6 CNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSK
: : :.: :::.:::::.:::.:::... .. .:.... .. ::.:. :. :.:
XP_006 CILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAK
50 60 70 80 90 100
200 210 220 230 240 250
pF1KB6 IAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAET
.: :: ::: : : :: : :: .. .:: :. :. .: .:.::: :.. . .
XP_006 ASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPS
110 120 130 140 150 160
pF1KB6 LY
.:
XP_006 MY
>>NP_001268458 (OMIM: 600654) proteasome activator compl (236 aa)
initn: 460 init1: 261 opt: 265 Z-score: 330.9 bits: 68.7 E(85289): 1.1e-11
Smith-Waterman score: 639; 40.9% identity (71.0% similar) in 252 aa overlap (3-254:2-236)
10 20 30 40 50 60
pF1KB6 MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
..:.:. :.. ::: ::: . ...:.:....::::. :::.::::: :: .:.....
NP_001 MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKA
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
...:::::. .... .:. :: ... . : : : .. :...: ...
NP_001 PLDIPVPDPVKEKEKEE--RKKQQEKEDKDEKKKGEDEDK--GPPCGPVNCNEKIVVLLQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
..::::. .::. : : :.:: ::::::::::::..: : .. :::
NP_001 RLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQLE-------------GFHTQIS
120 130 140 150 160
190 200 210 220 230 240
pF1KB6 RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
.:. :. :.: :: ::: :::. : :.:: :: ..::.. :.:: :..:.:.::::.:
NP_001 KYFSERGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFE
170 180 190 200 210 220
250
pF1KB6 KIKRPRSSNAETLY
:.:.::. . .:
NP_001 KLKKPRGETKGMIY
230
254 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 18:35:08 2016 done: Fri Nov 4 18:35:09 2016
Total Scan time: 6.700 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]