FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6370, 298 aa 1>>>pF1KB6370 298 - 298 aa - 298 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9960+/-0.000332; mu= 17.5650+/- 0.021 mean_var=74.5287+/-15.034, 0's: 0 Z-trim(115.7): 148 B-trim: 33 in 1/55 Lambda= 0.148564 statistics sampled from 26226 (26386) to 26226 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.309), width: 16 Scan time: 7.620 The best scores are: opt bits E(85289) NP_001176 (OMIM: 194460) zinc-alpha-2-glycoprotein ( 298) 2062 451.1 1.3e-126 NP_005505 (OMIM: 106300,142830,608579) major histo ( 362) 719 163.3 6.5e-40 XP_011512859 (OMIM: 106300,142830,608579) PREDICTE ( 323) 709 161.1 2.6e-39 NP_001287678 (OMIM: 104300,176100,176200,235200,61 ( 337) 698 158.7 1.4e-38 XP_011512845 (OMIM: 104300,176100,176200,235200,61 ( 348) 698 158.8 1.4e-38 NP_000401 (OMIM: 104300,176100,176200,235200,61263 ( 348) 698 158.8 1.4e-38 NP_001229687 (OMIM: 142800,608579) HLA class I his ( 365) 694 157.9 2.7e-38 NP_002107 (OMIM: 142800,608579) HLA class I histoc ( 365) 679 154.7 2.5e-37 XP_011512866 (OMIM: 143110) PREDICTED: HLA class I ( 343) 663 151.3 2.6e-36 NP_061823 (OMIM: 143110) HLA class I histocompatib ( 346) 663 151.3 2.6e-36 XP_016866302 (OMIM: 143110) PREDICTED: HLA class I ( 388) 663 151.3 2.8e-36 XP_016866301 (OMIM: 143110) PREDICTED: HLA class I ( 420) 663 151.3 3e-36 XP_016866300 (OMIM: 143110) PREDICTED: HLA class I ( 431) 663 151.3 3e-36 XP_016866299 (OMIM: 143110) PREDICTED: HLA class I ( 435) 663 151.3 3.1e-36 NP_001091949 (OMIM: 143110) HLA class I histocompa ( 442) 663 151.3 3.1e-36 XP_016885777 (OMIM: 142800,608579) PREDICTED: HLA ( 362) 661 150.8 3.6e-36 XP_005275388 (OMIM: 142800,608579) PREDICTED: HLA ( 391) 661 150.9 3.8e-36 NP_002118 (OMIM: 142871,600807) HLA class I histoc ( 338) 658 150.2 5.3e-36 XP_016866305 (OMIM: 142871,600807) PREDICTED: HLA ( 343) 658 150.2 5.4e-36 NP_001522 (OMIM: 600764) major histocompatibility ( 341) 649 148.3 2e-35 NP_001229971 (OMIM: 142840,177900,609423) HLA clas ( 366) 641 146.6 7.1e-35 NP_002108 (OMIM: 142840,177900,609423) HLA class I ( 366) 635 145.3 1.7e-34 NP_620578 (OMIM: 104300,176100,176200,235200,61263 ( 325) 627 143.5 5.2e-34 NP_005507 (OMIM: 143010) HLA class I histocompatib ( 358) 618 141.6 2.1e-33 XP_016866298 (OMIM: 143010) PREDICTED: HLA class I ( 359) 618 141.6 2.1e-33 XP_016866296 (OMIM: 143010) PREDICTED: HLA class I ( 399) 606 139.1 1.4e-32 XP_016866297 (OMIM: 143010) PREDICTED: HLA class I ( 399) 606 139.1 1.4e-32 NP_620576 (OMIM: 104300,176100,176200,235200,61263 ( 260) 541 125.0 1.6e-28 XP_011507765 (OMIM: 600764) PREDICTED: major histo ( 254) 503 116.8 4.3e-26 XP_016866304 (OMIM: 143110) PREDICTED: HLA class I ( 228) 488 113.6 3.7e-25 XP_016866303 (OMIM: 143110) PREDICTED: HLA class I ( 324) 488 113.7 4.8e-25 NP_004098 (OMIM: 601437) IgG receptor FcRn large s ( 365) 453 106.3 9.5e-23 NP_001129491 (OMIM: 601437) IgG receptor FcRn larg ( 365) 453 106.3 9.5e-23 NP_620575 (OMIM: 104300,176100,176200,235200,61263 ( 334) 434 102.2 1.5e-21 NP_001181929 (OMIM: 600764) major histocompatibili ( 249) 414 97.8 2.4e-20 NP_001181964 (OMIM: 600764) major histocompatibili ( 214) 409 96.6 4.4e-20 XP_006711349 (OMIM: 600764) PREDICTED: major histo ( 312) 408 96.6 6.8e-20 NP_001091948 (OMIM: 143110) HLA class I histocompa ( 254) 387 92.0 1.3e-18 NP_005922 (OMIM: 602436) MHC class I polypeptide-r ( 383) 387 92.1 1.8e-18 NP_001170990 (OMIM: 600169) MHC class I polypeptid ( 332) 384 91.4 2.5e-18 NP_000238 (OMIM: 600169) MHC class I polypeptide-r ( 383) 374 89.4 1.2e-17 NP_001276089 (OMIM: 602436) MHC class I polypeptid ( 351) 371 88.7 1.8e-17 NP_001181928 (OMIM: 600764) major histocompatibili ( 296) 370 88.4 1.8e-17 NP_001754 (OMIM: 188370) T-cell surface glycoprote ( 327) 343 82.6 1.1e-15 NP_001307581 (OMIM: 188370) T-cell surface glycopr ( 316) 332 80.3 5.5e-15 NP_001297142 (OMIM: 600764) major histocompatibili ( 178) 322 77.9 1.6e-14 NP_001757 (OMIM: 188410) antigen-presenting glycop ( 335) 303 74.1 4.3e-13 XP_011508427 (OMIM: 188410) PREDICTED: antigen-pre ( 335) 303 74.1 4.3e-13 NP_002114 (OMIM: 123400,126200,212750,604305) HLA ( 261) 299 73.1 6.4e-13 NP_001230890 (OMIM: 123400,126200,212750,604305) H ( 269) 299 73.1 6.5e-13 >>NP_001176 (OMIM: 194460) zinc-alpha-2-glycoprotein pre (298 aa) initn: 2062 init1: 2062 opt: 2062 Z-score: 2394.3 bits: 451.1 E(85289): 1.3e-126 Smith-Waterman score: 2062; 100.0% identity (100.0% similar) in 298 aa overlap (1-298:1-298) 10 20 30 40 50 60 pF1KB6 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 YLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWT 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 RAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS 250 260 270 280 290 >>NP_005505 (OMIM: 106300,142830,608579) major histocomp (362 aa) initn: 572 init1: 209 opt: 719 Z-score: 837.6 bits: 163.3 E(85289): 6.5e-40 Smith-Waterman score: 719; 39.3% identity (66.9% similar) in 305 aa overlap (1-298:1-301) 10 20 30 40 50 pF1KB6 MVRMVPVLLSLLLLLGPAVP-QENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFF :. :.: ..::::. :. :. : .:. :.::..:. . : : ..: ..: :: NP_005 MLVMAPR--TVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFV 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 RYNSK--DRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSN-GSHV :..: . . .: . : . :: : : ...:. ::. . :.:... :::.:. :::. NP_005 RFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 LQGRFGCEI-ENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYV ::. .::.. ..: . .: ::::::: .:... .:. : :::::..:::: NP_005 LQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 QRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKI :: .:::: :: ::.::. .:. :.: :::.. :: : .. :.: : :::..: NP_005 QR-RAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 DVHWTRAGE--VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVV . : : :: .:. :: .. :. :.:.:..:.:: . :.::::: .: .::.. NP_005 TLTWQRDGEDQTQDTELV-ETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTL 240 250 260 270 280 290 pF1KB6 PWEAS :: : NP_005 RWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGS 300 310 320 330 340 350 >>XP_011512859 (OMIM: 106300,142830,608579) PREDICTED: m (323 aa) initn: 562 init1: 208 opt: 709 Z-score: 826.6 bits: 161.1 E(85289): 2.6e-39 Smith-Waterman score: 709; 39.1% identity (66.9% similar) in 302 aa overlap (1-295:1-298) 10 20 30 40 50 pF1KB6 MVRMVPVLLSLLLLLGPAVP-QENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFF :. :.: ..::::. :. :. : .:. :.::..:. . : : ..: ..: :: XP_011 MLVMAPR--TVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFV 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 RYNSK--DRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSN-GSHV :..: . . .: . : . :: : : ...:. ::. . :.:... :::.:. :::. XP_011 RFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 LQGRFGCEI-ENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYV ::. .::.. ..: . .: ::::::: .:... .:. : :::::..:::: XP_011 LQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 QRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKI :: .:::: :: ::.::. .:. :.: :::.. :: : .. :.: : :::..: XP_011 QR-RAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 DVHWTRAGE--VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVV . : : :: .:. :: .. :. :.:.:..:.:: . :.::::: .: .::.. XP_011 TLTWQRDGEDQTQDTELV-ETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTL 240 250 260 270 280 290 pF1KB6 PWEAS : XP_011 RWGGKGGSYSQAACSDSAQGSDVSLTA 300 310 320 >>NP_001287678 (OMIM: 104300,176100,176200,235200,612635 (337 aa) initn: 617 init1: 311 opt: 698 Z-score: 813.6 bits: 158.7 E(85289): 1.4e-38 Smith-Waterman score: 698; 37.7% identity (65.3% similar) in 300 aa overlap (3-298:4-300) 10 20 30 40 50 pF1KB6 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFF : :.:: ::.:: :: : .:: :.. : :.. . :.::: ..: : NP_001 MGPRARPALL-LLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFV 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 RYNSKDRKSQPMGLWRQVE-GMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQ :. ..:. .: : . . . . : : :: :. . .: . :.: .: :. ::.:: NP_001 FYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 GRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRA .:::.... :. ..::: :::.:..:: . : .: : :: .:: . . ... NP_001 VILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQN 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 KAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVH .::::..::: :.. :. ....::.: :: : :: :.. . :.: : ..:: .: .. NP_001 RAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVT-HHVTSSVTTLRCRALNYYPQNITMK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 WTRAGE---VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPW : . . ..: : . ::: ::.::::.:...:::: . :.:.:.: .: :::.: : NP_001 WLKDKQPMDAKEFEPK-DVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIW 240 250 260 270 280 290 pF1KB6 EAS : : NP_001 EPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSSF 300 310 320 330 >>XP_011512845 (OMIM: 104300,176100,176200,235200,612635 (348 aa) initn: 617 init1: 311 opt: 698 Z-score: 813.5 bits: 158.8 E(85289): 1.4e-38 Smith-Waterman score: 698; 37.7% identity (65.3% similar) in 300 aa overlap (3-298:4-300) 10 20 30 40 50 pF1KB6 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFF : :.:: ::.:: :: : .:: :.. : :.. . :.::: ..: : XP_011 MGPRARPALL-LLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFV 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 RYNSKDRKSQPMGLWRQVE-GMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQ :. ..:. .: : . . . . : : :: :. . .: . :.: .: :. ::.:: XP_011 FYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 GRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRA .:::.... :. ..::: :::.:..:: . : .: : :: .:: . . ... XP_011 VILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQN 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 KAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVH .::::..::: :.. :. ....::.: :: : :: :.. . :.: : ..:: .: .. XP_011 RAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVT-HHVTSSVTTLRCRALNYYPQNITMK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 WTRAGE---VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPW : . . ..: : . ::: ::.::::.:...:::: . :.:.:.: .: :::.: : XP_011 WLKDKQPMDAKEFEPK-DVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIW 240 250 260 270 280 290 pF1KB6 EAS : : XP_011 EPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERF 300 310 320 330 340 >>NP_000401 (OMIM: 104300,176100,176200,235200,612635,61 (348 aa) initn: 617 init1: 311 opt: 698 Z-score: 813.5 bits: 158.8 E(85289): 1.4e-38 Smith-Waterman score: 698; 37.7% identity (65.3% similar) in 300 aa overlap (3-298:4-300) 10 20 30 40 50 pF1KB6 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFF : :.:: ::.:: :: : .:: :.. : :.. . :.::: ..: : NP_000 MGPRARPALL-LLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFV 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 RYNSKDRKSQPMGLWRQVE-GMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQ :. ..:. .: : . . . . : : :: :. . .: . :.: .: :. ::.:: NP_000 FYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 GRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRA .:::.... :. ..::: :::.:..:: . : .: : :: .:: . . ... NP_000 VILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQN 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 KAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVH .::::..::: :.. :. ....::.: :: : :: :.. . :.: : ..:: .: .. NP_000 RAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVT-HHVTSSVTTLRCRALNYYPQNITMK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 WTRAGE---VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPW : . . ..: : . ::: ::.::::.:...:::: . :.:.:.: .: :::.: : NP_000 WLKDKQPMDAKEFEPK-DVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIW 240 250 260 270 280 290 pF1KB6 EAS : : NP_000 EPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE 300 310 320 330 340 >>NP_001229687 (OMIM: 142800,608579) HLA class I histoco (365 aa) initn: 444 init1: 218 opt: 694 Z-score: 808.5 bits: 157.9 E(85289): 2.7e-38 Smith-Waterman score: 694; 38.5% identity (66.1% similar) in 304 aa overlap (1-298:1-301) 10 20 30 40 50 60 pF1KB6 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFR :. :.: : :::: : . .. : .:. :..:..:. . : : :.: ..: :: : NP_001 MAVMAPRTL-LLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVR 10 20 30 40 50 70 80 90 100 110 pF1KB6 YNSK--DRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDS-NGSHVL ..: ..: .: . : . :: : : :... .::. . .: . :::.: .:::.. NP_001 FDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 QGRFGCEI-ENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQ : .::.. ..: .. . ::::::: .:... .:. : ::::::.:::: . : NP_001 QIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 RAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKID : ..::: .: ::.::. .:. :.: :::.. .: : .. :.: : :::..: NP_001 R-RVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEIT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 VHWTRAGE--VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVP . : : :: .:. :: .. :.::.:.:..:.:: . :.::::: .: .::.. NP_001 LTWQRDGEDQTQDTELV-ETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLR 240 250 260 270 280 290 pF1KB6 WEAS :: : NP_001 WELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSD 300 310 320 330 340 350 >>NP_002107 (OMIM: 142800,608579) HLA class I histocompa (365 aa) initn: 425 init1: 204 opt: 679 Z-score: 791.2 bits: 154.7 E(85289): 2.5e-37 Smith-Waterman score: 679; 39.0% identity (64.0% similar) in 308 aa overlap (1-298:1-301) 10 20 30 40 50 60 pF1KB6 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFR :. :.: : :::: : . .. : .:. :..:..:. . : : :.: ..: :: : NP_002 MAVMAPRTL-LLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVR 10 20 30 40 50 70 80 90 100 110 pF1KB6 YNSKDRKSQ---PMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSN-GSHV ..: : :: : . : . :: : : :... ::. . : . :::.:. :::. NP_002 FDS-DAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 LQGRFGCEIENNRSSGAFWKYY----YDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEP .: .::.. :.: : . : ::::::: .:... .:. : ::::::.:::: NP_002 IQIMYGCDVG---SDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 VYVQRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYP ... .:::. : ::.::. .:. :.: :::.. .: : .. :.: : ::: NP_002 -EAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 GKIDVHWTRAGE--VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQP ..: . : : :: .:. :: .. :.::.:.:..:.:: . :.::::: .: .: NP_002 AEITLTWQRDGEDQTQDTELV-ETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKP 240 250 260 270 280 290 pF1KB6 LVVPWEAS :.. :: : NP_002 LTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSA 300 310 320 330 340 350 >>XP_011512866 (OMIM: 143110) PREDICTED: HLA class I his (343 aa) initn: 529 init1: 214 opt: 663 Z-score: 773.0 bits: 151.3 E(85289): 2.6e-36 Smith-Waterman score: 663; 37.2% identity (65.4% similar) in 301 aa overlap (4-298:1-298) 10 20 30 40 50 60 pF1KB6 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFR :.: : :::: : . .. : .:: :. :..:. . : . :. ..: ::.: XP_011 MAPRSL-LLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLR 10 20 30 40 50 70 80 90 100 110 pF1KB6 YNSKDR--KSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSN-GSHVL ..: . .: : . :: . :. . :: . .:..... ::.:. :::.: XP_011 FDSDAAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 QGRFGCEI-ENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQ :: ::.. ..: .. .. ::::::: .:... .:. : .::::.. .::: :.. XP_011 QGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEE-YAE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 RAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKID . ..::: :: ::.::. .:. :.: :::.. :. : .. :.: : :::..: XP_011 EFRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEIT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 VHWTRAGE--VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVP . : : :: .:. :: .. :.::.:.:..:.::: . :.::::: .: :::.. XP_011 LTWQRDGEEQTQDTELV-ETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILR 240 250 260 270 280 290 pF1KB6 WEAS :: : XP_011 WEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSGKLTHTGVQ 300 310 320 330 340 >>NP_061823 (OMIM: 143110) HLA class I histocompatibilit (346 aa) initn: 529 init1: 214 opt: 663 Z-score: 773.0 bits: 151.3 E(85289): 2.6e-36 Smith-Waterman score: 663; 37.2% identity (65.4% similar) in 301 aa overlap (4-298:1-298) 10 20 30 40 50 60 pF1KB6 MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFR :.: : :::: : . .. : .:: :. :..:. . : . :. ..: ::.: NP_061 MAPRSL-LLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLR 10 20 30 40 50 70 80 90 100 110 pF1KB6 YNSKDR--KSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSN-GSHVL ..: . .: : . :: . :. . :: . .:..... ::.:. :::.: NP_061 FDSDAAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 QGRFGCEI-ENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQ :: ::.. ..: .. .. ::::::: .:... .:. : .::::.. .::: :.. NP_061 QGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEE-YAE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 RAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKID . ..::: :: ::.::. .:. :.: :::.. :. : .. :.: : :::..: NP_061 EFRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEIT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 VHWTRAGE--VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVP . : : :: .:. :: .. :.::.:.:..:.::: . :.::::: .: :::.. NP_061 LTWQRDGEEQTQDTELV-ETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILR 240 250 260 270 280 290 pF1KB6 WEAS :: : NP_061 WEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSDRNRGSYSQAAV 300 310 320 330 340 298 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:40:59 2016 done: Fri Nov 4 20:41:00 2016 Total Scan time: 7.620 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]