FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6373, 270 aa 1>>>pF1KB6373 270 - 270 aa - 270 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9683+/-0.000303; mu= 17.1972+/- 0.019 mean_var=70.2067+/-14.038, 0's: 0 Z-trim(117.5): 172 B-trim: 170 in 1/50 Lambda= 0.153068 statistics sampled from 29300 (29495) to 29300 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.346), width: 16 Scan time: 6.640 The best scores are: opt bits E(85289) NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid de ( 270) 1776 400.8 1.4e-111 XP_005259026 (OMIM: 612832) PREDICTED: 17-beta-hyd ( 212) 1174 267.7 1.2e-71 XP_005259027 (OMIM: 612832) PREDICTED: 17-beta-hyd ( 140) 625 146.4 2.8e-35 NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl ( 303) 389 94.5 2.5e-19 NP_065715 (OMIM: 615839) peroxisomal 2,4-dienoyl-C ( 292) 384 93.4 5.1e-19 XP_016868636 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 355 87.0 4.7e-17 XP_011515182 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 355 87.0 4.7e-17 XP_016868637 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 355 87.0 4.7e-17 NP_001317504 (OMIM: 222745) 2,4-dienoyl-CoA reduct ( 326) 355 87.0 4.7e-17 NP_001350 (OMIM: 222745) 2,4-dienoyl-CoA reductase ( 335) 355 87.0 4.8e-17 NP_066284 (OMIM: 611596) dehydrogenase/reductase S ( 278) 337 83.0 6.6e-16 NP_005785 (OMIM: 615194) dehydrogenase/reductase S ( 280) 324 80.1 4.8e-15 XP_005267306 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 324 80.1 4.8e-15 XP_006720064 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 324 80.1 4.8e-15 NP_057370 (OMIM: 260800,608347) L-xylulose reducta ( 244) 320 79.2 8e-15 NP_878912 (OMIM: 615194) dehydrogenase/reductase S ( 300) 303 75.5 1.3e-13 NP_001182147 (OMIM: 260800,608347) L-xylulose redu ( 242) 293 73.2 5e-13 XP_005250865 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 243) 279 70.2 4.3e-12 NP_000851 (OMIM: 119900,259100,601688) 15-hydroxyp ( 266) 277 69.7 6.2e-12 NP_002144 (OMIM: 109685) estradiol 17-beta-dehydro ( 387) 275 69.4 1.1e-11 XP_011508777 (OMIM: 612131) PREDICTED: dehydrogena ( 319) 274 69.1 1.1e-11 NP_001135743 (OMIM: 612131) dehydrogenase/reductas ( 319) 274 69.1 1.1e-11 NP_954674 (OMIM: 612131) dehydrogenase/reductase S ( 319) 274 69.1 1.1e-11 NP_001135742 (OMIM: 612131) dehydrogenase/reductas ( 319) 274 69.1 1.1e-11 NP_001276692 (OMIM: 612131) dehydrogenase/reductas ( 379) 274 69.2 1.3e-11 NP_055049 (OMIM: 601417) estradiol 17-beta-dehydro ( 261) 272 68.6 1.3e-11 XP_016862499 (OMIM: 603063) PREDICTED: D-beta-hydr ( 324) 265 67.2 4.5e-11 XP_016862498 (OMIM: 603063) PREDICTED: D-beta-hydr ( 324) 265 67.2 4.5e-11 XP_016862500 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 265 67.2 4.6e-11 XP_016862501 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 265 67.2 4.6e-11 XP_016862497 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 265 67.2 4.6e-11 NP_976060 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 265 67.2 4.7e-11 NP_004042 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 265 67.2 4.7e-11 XP_005269409 (OMIM: 603063) PREDICTED: D-beta-hydr ( 343) 265 67.2 4.7e-11 XP_016862496 (OMIM: 603063) PREDICTED: D-beta-hydr ( 343) 265 67.2 4.7e-11 NP_976059 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 265 67.2 4.7e-11 XP_011511369 (OMIM: 603063) PREDICTED: D-beta-hydr ( 347) 265 67.2 4.8e-11 NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289) 257 65.4 1.4e-10 NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339) 257 65.4 1.6e-10 XP_016876857 (OMIM: 612833) PREDICTED: dehydrogena ( 404) 257 65.5 1.8e-10 XP_011534641 (OMIM: 615194) PREDICTED: dehydrogena ( 204) 249 63.5 3.7e-10 XP_011534640 (OMIM: 615194) PREDICTED: dehydrogena ( 204) 249 63.5 3.7e-10 NP_001032900 (OMIM: 300220,300256,300438) 3-hydrox ( 252) 243 62.2 1.1e-09 NP_001139288 (OMIM: 119900,259100,601688) 15-hydro ( 178) 233 59.9 3.8e-09 NP_932349 (OMIM: 615196) dehydrogenase/reductase S ( 232) 233 60.0 4.7e-09 XP_016862503 (OMIM: 603063) PREDICTED: D-beta-hydr ( 206) 231 59.5 5.8e-09 XP_005269412 (OMIM: 603063) PREDICTED: D-beta-hydr ( 206) 231 59.5 5.8e-09 XP_016862504 (OMIM: 603063) PREDICTED: D-beta-hydr ( 206) 231 59.5 5.8e-09 NP_835236 (OMIM: 612127) 17-beta-hydroxysteroid de ( 300) 228 59.0 1.2e-08 NP_683695 (OMIM: 609769) short-chain dehydrogenase ( 313) 228 59.0 1.3e-08 >>NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid dehydr (270 aa) initn: 1776 init1: 1776 opt: 1776 Z-score: 2124.2 bits: 400.8 E(85289): 1.4e-111 Smith-Waterman score: 1776; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270) 10 20 30 40 50 60 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 CISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 CISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTG 190 200 210 220 230 240 250 260 270 pF1KB6 IELLVTGGAELGYGCKASRSTPVDAPDIPS :::::::::::::::::::::::::::::: NP_057 IELLVTGGAELGYGCKASRSTPVDAPDIPS 250 260 270 >>XP_005259026 (OMIM: 612832) PREDICTED: 17-beta-hydroxy (212 aa) initn: 1172 init1: 1172 opt: 1174 Z-score: 1407.1 bits: 267.7 E(85289): 1.2e-71 Smith-Waterman score: 1174; 90.8% identity (91.7% similar) in 206 aa overlap (1-205:1-204) 10 20 30 40 50 60 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 CISPGNIW-TPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCT : : .:: : :. : XP_005 C--HWAAWASPLRSGLRQCSWPPKPTSARALNCS 190 200 210 >>XP_005259027 (OMIM: 612832) PREDICTED: 17-beta-hydroxy (140 aa) initn: 662 init1: 625 opt: 625 Z-score: 754.4 bits: 146.4 E(85289): 2.8e-35 Smith-Waterman score: 625; 94.1% identity (95.1% similar) in 102 aa overlap (1-102:1-102) 10 20 30 40 50 60 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT :::::::::::::::::::::::::::::::: :: ::. XP_005 CDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHPRPPLPAEESRECHQHLQPGGGNRPGPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN XP_005 SSLCGHQGGSNSHDQSFGPG 130 140 >>NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl-CoA (303 aa) initn: 312 init1: 142 opt: 389 Z-score: 468.1 bits: 94.5 E(85289): 2.5e-19 Smith-Waterman score: 389; 32.8% identity (63.3% similar) in 256 aa overlap (9-251:18-267) 10 20 30 40 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKD----ESGGR :.:..::::. ::: .::. ... :. ::: .. .:.. NP_060 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 ALEQELPGA-----VFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAG-HHPPPQRPEE :. .:: . . : :.. .:..:..::. :. ::... .:::.: . : :. NP_060 ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSP--AEH 70 80 90 100 110 110 120 130 140 150 160 pF1KB6 TSAQGFRQLLELNLLGTYTLTKLALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGA :..:.. .:: :: ::. . : . .... :...:: . : : :: :.... NP_060 ISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKA-GFPLAVHSGAARAG 120 130 140 150 160 170 170 180 190 200 210 pF1KB6 VTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQ-PLGRMG : .::.:::. . :.:.::..:: :.. : . . .. :: . . : :.: NP_060 VYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQ---SFFEGSFQKIPAKRIG 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB6 QPAEVGAAAVFLASEA-NFCTGIELLVTGGAELGYGCKASRSTPVDAPDIPS : ::.... :: : : .: :: . : :: : NP_060 VPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMK 240 250 260 270 280 290 NP_060 ETFKEKAKL 300 >>NP_065715 (OMIM: 615839) peroxisomal 2,4-dienoyl-CoA r (292 aa) initn: 318 init1: 152 opt: 384 Z-score: 462.4 bits: 93.4 E(85289): 5.1e-19 Smith-Waterman score: 384; 32.1% identity (61.9% similar) in 252 aa overlap (10-253:29-275) 10 20 30 40 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDK ::. .:::: ::: :.. :. : ..:: .. NP_065 MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR 10 20 30 40 50 60 50 60 70 80 90 pF1KB6 DESGGRALEQELPGAVFILC-----DVTQEDDVKTLVSETIRRFGRLDCVVN-NAGHHPP . . ..: ::. : :: : . :......:::.: ..: ::. NP_065 SLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 PQRPEETSAQGFRQLLELNLLGTYTLTK-LALPYLRKSQGNVINISSLVGAIGQAQAVPY : : ..:. ..... ::..... : ..: : ..::.. .: ::: : NP_065 PAG--ALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHA 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 VATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQP ..:.:: :::. ::.. .: ..::: ..:: : : : : :.:.. . :.: NP_065 GSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGT--EGLRRL-GGPQASLSTKVTASP 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB6 LGRMGQPAEVGAAAVFLASE-ANFCTGIELLVTGGAELGYGCKASRSTPVDAPDIPS : :.:. .:.. ....::: :.. :: :.. ::: : . NP_065 LQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL 240 250 260 270 280 290 >>XP_016868636 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 312 init1: 123 opt: 355 Z-score: 427.1 bits: 87.0 E(85289): 4.7e-17 Smith-Waterman score: 355; 29.9% identity (61.7% similar) in 261 aa overlap (1-251:42-296) 10 20 30 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFV : . . :::. .:::: :.: :.. . XP_016 MGEFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLS 20 30 40 50 60 70 40 50 60 70 80 pF1KB6 NSGARVVICDKDESGGRALEQELPGAV-----FILCDVTQEDDVKTLVSETIRRFGRLDC . ::. :: .. . .: ... . . : ::: . : :.. ::: :. :. . XP_016 SLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNI 80 90 100 110 120 130 90 100 110 120 130 140 pF1KB6 VVNNA-GHHPPPQRPEETSAQGFRQLLELNLLGTYTLT-KLALPYLRKSQGNV-INISSL :.::: :. : :. : .... . .. : :: .: ... .. ..: . ..:... XP_016 VINNAAGNFISPT--ERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTI 140 150 160 170 180 150 160 170 180 190 200 pF1KB6 VGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDP . :.. .:: ...:..: ::.:.:: . . ::.: : :.:: :. . : :: XP_016 YAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPG----PIKTKGAFSRLDP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB6 RATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIELLVTGGAELGYGCKASRS .:... :... : ::.: :.. :.:: :. :.. .: . :: :. XP_016 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 250 260 270 280 290 300 270 pF1KB6 TPVDAPDIPS XP_016 RKVTKEQWDTIEELIRKTKGS 310 320 >>XP_011515182 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 312 init1: 123 opt: 355 Z-score: 427.1 bits: 87.0 E(85289): 4.7e-17 Smith-Waterman score: 355; 29.9% identity (61.7% similar) in 261 aa overlap (1-251:42-296) 10 20 30 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFV : . . :::. .:::: :.: :.. . XP_011 KEMFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLS 20 30 40 50 60 70 40 50 60 70 80 pF1KB6 NSGARVVICDKDESGGRALEQELPGAV-----FILCDVTQEDDVKTLVSETIRRFGRLDC . ::. :: .. . .: ... . . : ::: . : :.. ::: :. :. . XP_011 SLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNI 80 90 100 110 120 130 90 100 110 120 130 140 pF1KB6 VVNNA-GHHPPPQRPEETSAQGFRQLLELNLLGTYTLT-KLALPYLRKSQGNV-INISSL :.::: :. : :. : .... . .. : :: .: ... .. ..: . ..:... XP_011 VINNAAGNFISPT--ERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTI 140 150 160 170 180 150 160 170 180 190 200 pF1KB6 VGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDP . :.. .:: ...:..: ::.:.:: . . ::.: : :.:: :. . : :: XP_011 YAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPG----PIKTKGAFSRLDP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB6 RATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIELLVTGGAELGYGCKASRS .:... :... : ::.: :.. :.:: :. :.. .: . :: :. XP_011 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 250 260 270 280 290 300 270 pF1KB6 TPVDAPDIPS XP_011 RKVTKEQWDTIEELIRKTKGS 310 320 >>XP_016868637 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 312 init1: 123 opt: 355 Z-score: 427.1 bits: 87.0 E(85289): 4.7e-17 Smith-Waterman score: 355; 29.9% identity (61.7% similar) in 261 aa overlap (1-251:42-296) 10 20 30 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFV : . . :::. .:::: :.: :.. . XP_016 MGEFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLS 20 30 40 50 60 70 40 50 60 70 80 pF1KB6 NSGARVVICDKDESGGRALEQELPGAV-----FILCDVTQEDDVKTLVSETIRRFGRLDC . ::. :: .. . .: ... . . : ::: . : :.. ::: :. :. . XP_016 SLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNI 80 90 100 110 120 130 90 100 110 120 130 140 pF1KB6 VVNNA-GHHPPPQRPEETSAQGFRQLLELNLLGTYTLT-KLALPYLRKSQGNV-INISSL :.::: :. : :. : .... . .. : :: .: ... .. ..: . ..:... XP_016 VINNAAGNFISPT--ERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTI 140 150 160 170 180 150 160 170 180 190 200 pF1KB6 VGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDP . :.. .:: ...:..: ::.:.:: . . ::.: : :.:: :. . : :: XP_016 YAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPG----PIKTKGAFSRLDP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB6 RATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIELLVTGGAELGYGCKASRS .:... :... : ::.: :.. :.:: :. :.. .: . :: :. XP_016 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 250 260 270 280 290 300 270 pF1KB6 TPVDAPDIPS XP_016 RKVTKEQWDTIEELIRKTKGS 310 320 >>NP_001317504 (OMIM: 222745) 2,4-dienoyl-CoA reductase, (326 aa) initn: 312 init1: 123 opt: 355 Z-score: 427.1 bits: 87.0 E(85289): 4.7e-17 Smith-Waterman score: 355; 29.9% identity (61.7% similar) in 261 aa overlap (1-251:42-296) 10 20 30 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFV : . . :::. .:::: :.: :.. . NP_001 MGEFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLS 20 30 40 50 60 70 40 50 60 70 80 pF1KB6 NSGARVVICDKDESGGRALEQELPGAV-----FILCDVTQEDDVKTLVSETIRRFGRLDC . ::. :: .. . .: ... . . : ::: . : :.. ::: :. :. . NP_001 SLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNI 80 90 100 110 120 130 90 100 110 120 130 140 pF1KB6 VVNNA-GHHPPPQRPEETSAQGFRQLLELNLLGTYTLT-KLALPYLRKSQGNV-INISSL :.::: :. : :. : .... . .. : :: .: ... .. ..: . ..:... NP_001 VINNAAGNFISPT--ERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTI 140 150 160 170 180 150 160 170 180 190 200 pF1KB6 VGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDP . :.. .:: ...:..: ::.:.:: . . ::.: : :.:: :. . : :: NP_001 YAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPG----PIKTKGAFSRLDP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB6 RATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIELLVTGGAELGYGCKASRS .:... :... : ::.: :.. :.:: :. :.. .: . :: :. NP_001 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 250 260 270 280 290 300 270 pF1KB6 TPVDAPDIPS NP_001 RKVTKEQWDTIEELIRKTKGS 310 320 >>NP_001350 (OMIM: 222745) 2,4-dienoyl-CoA reductase, mi (335 aa) initn: 277 init1: 123 opt: 355 Z-score: 427.0 bits: 87.0 E(85289): 4.8e-17 Smith-Waterman score: 355; 29.9% identity (61.7% similar) in 261 aa overlap (1-251:51-305) 10 20 30 pF1KB6 MATGTRYAGKVVVVTGGGRGIGAGIVRAFV : . . :::. .:::: :.: :.. . NP_001 PRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLS 30 40 50 60 70 80 40 50 60 70 80 pF1KB6 NSGARVVICDKDESGGRALEQELPGAV-----FILCDVTQEDDVKTLVSETIRRFGRLDC . ::. :: .. . .: ... . . : ::: . : :.. ::: :. :. . NP_001 SLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNI 90 100 110 120 130 140 90 100 110 120 130 140 pF1KB6 VVNNA-GHHPPPQRPEETSAQGFRQLLELNLLGTYTLT-KLALPYLRKSQGNV-INISSL :.::: :. : :. : .... . .. : :: .: ... .. ..: . ..:... NP_001 VINNAAGNFISPT--ERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTI 150 160 170 180 190 150 160 170 180 190 200 pF1KB6 VGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDP . :.. .:: ...:..: ::.:.:: . . ::.: : :.:: :. . : :: NP_001 YAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPG----PIKTKGAFSRLDP 200 210 220 230 240 250 210 220 230 240 250 260 pF1KB6 RATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIELLVTGGAELGYGCKASRS .:... :... : ::.: :.. :.:: :. :.. .: . :: :. NP_001 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 260 270 280 290 300 310 270 pF1KB6 TPVDAPDIPS NP_001 RKVTKEQWDTIEELIRKTKGS 320 330 270 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:28:22 2016 done: Fri Nov 4 18:28:23 2016 Total Scan time: 6.640 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]