FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6389, 275 aa 1>>>pF1KB6389 275 - 275 aa - 275 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1399+/-0.000827; mu= 15.9888+/- 0.050 mean_var=67.3985+/-13.390, 0's: 0 Z-trim(107.0): 22 B-trim: 7 in 1/51 Lambda= 0.156224 statistics sampled from 9273 (9290) to 9273 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.285), width: 16 Scan time: 2.310 The best scores are: opt bits E(32554) CCDS11657.1 ICAM2 gene_id:3384|Hs108|chr17 ( 275) 1835 422.3 1.8e-118 CCDS12235.1 ICAM3 gene_id:3385|Hs108|chr19 ( 547) 419 103.4 3.7e-22 CCDS12233.1 ICAM5 gene_id:7087|Hs108|chr19 ( 924) 388 96.5 7.2e-20 CCDS12231.1 ICAM1 gene_id:3383|Hs108|chr19 ( 532) 366 91.4 1.4e-18 CCDS12232.1 ICAM4 gene_id:3386|Hs108|chr19 ( 271) 289 73.9 1.4e-13 CCDS82290.1 ICAM3 gene_id:3385|Hs108|chr19 ( 470) 288 73.8 2.6e-13 CCDS42500.1 ICAM4 gene_id:3386|Hs108|chr19 ( 237) 280 71.8 5.1e-13 >>CCDS11657.1 ICAM2 gene_id:3384|Hs108|chr17 (275 aa) initn: 1835 init1: 1835 opt: 1835 Z-score: 2240.3 bits: 422.3 E(32554): 1.8e-118 Smith-Waterman score: 1835; 100.0% identity (100.0% similar) in 275 aa overlap (1-275:1-275) 10 20 30 40 50 60 pF1KB6 MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTAD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 REDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 REDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVT 190 200 210 220 230 240 250 260 270 pF1KB6 SVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP ::::::::::::::::::::::::::::::::::: CCDS11 SVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP 250 260 270 >>CCDS12235.1 ICAM3 gene_id:3385|Hs108|chr19 (547 aa) initn: 449 init1: 302 opt: 419 Z-score: 511.2 bits: 103.4 E(32554): 3.7e-22 Smith-Waterman score: 419; 36.0% identity (63.1% similar) in 214 aa overlap (16-225:18-226) 10 20 30 40 50 pF1KB6 MSSFGYRTLTVALFTLICC---PGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQP :.:: :: . . : ..:.:.. .. ::: ::::: : . CCDS12 MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 EVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQV : .:::::.: :. : . .::.. .. . : :.:.: . .::..::. :..: CCDS12 EKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 ILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATF :. : ::..::..:.: : :::. :.: .: : . :. : :.::: CCDS12 ELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQ---PAVEEPAEVTATV 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 NSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE-PVSDSQMVIIVTVVSVL :.:.: ::: . ::.. .: ..: . :::..:. . ::. ..: CCDS12 --LASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVET 180 190 200 210 220 230 240 250 260 270 pF1KB6 LSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP CCDS12 SWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCN 240 250 260 270 280 290 >>CCDS12233.1 ICAM5 gene_id:7087|Hs108|chr19 (924 aa) initn: 355 init1: 223 opt: 388 Z-score: 470.2 bits: 96.5 E(32554): 7.2e-20 Smith-Waterman score: 388; 35.8% identity (58.6% similar) in 215 aa overlap (9-222:19-230) 10 20 30 40 50 pF1KB6 MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCST : ..:: : . ... : . ..:. :: ::: .:::: CCDS12 MPGPSPGLRRALLGLWAALGLGLFGL---SAVSQEPFWADLQPRVAFVERGGSLWLNCST 10 20 30 40 50 60 70 80 90 100 pF1KB6 TCNQPEVGGLETSLDKILLDEQAQW-KHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVY .: .:: ::::::: . .. .: . ::. .: : : :. . . . . .. CCDS12 NCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTF 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB6 QPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQ : : .: : : ::..::. :::: . : :::: :.:: . : ..:. : . CCDS12 QRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRAR 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB6 EATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVT :. : . : ::: :::: : ::: .: ..:.. :::. :. . :. CCDS12 GAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPR 180 190 200 210 220 230 230 240 250 260 270 pF1KB6 VVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP CCDS12 LLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGA 240 250 260 270 280 290 >>CCDS12231.1 ICAM1 gene_id:3383|Hs108|chr19 (532 aa) initn: 326 init1: 170 opt: 366 Z-score: 446.8 bits: 91.4 E(32554): 1.4e-18 Smith-Waterman score: 366; 35.0% identity (62.7% similar) in 220 aa overlap (9-225:13-222) 10 20 30 40 50 pF1KB6 MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPE : : : .:. ::. . . : :.:. . ::. :.:::.:.::. CCDS12 MAPSSPRPALPALLVLLGALFPGPGNAQ----TSVSPSKVILPRGGSVLVTCSTSCDQPK 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 VGGLETSLDKI-LLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQV . :.:: : : :: . : : .::...:. .:. .: : . .. ..:: :..: CCDS12 LLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 ILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATF :. :. :::..:..:.: : .::. :.::.. :. : :. : :.:.: CCDS12 ELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREP---AVGEPAEVTTT- 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 NSTADREDGH-RNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE-PVSDSQMVIIVTVVSV . :.: : :::: . ::: .: ..:.. ::: .:. . :.. :.: CCDS12 --VLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVD 180 190 200 210 220 230 240 250 260 270 pF1KB6 LLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP CCDS12 TQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTC 240 250 260 270 280 290 >>CCDS12232.1 ICAM4 gene_id:3386|Hs108|chr19 (271 aa) initn: 196 init1: 95 opt: 289 Z-score: 357.3 bits: 73.9 E(32554): 1.4e-13 Smith-Waterman score: 289; 27.0% identity (62.2% similar) in 230 aa overlap (20-245:41-262) 10 20 30 40 pF1KB6 MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCS :.. : :.. :. .::.: :...::: CCDS12 FFLAAAYPGVGSALGRRTKRAQSPKGSPLAPSGTSVPFWVRMSPEFVAVQPGKSVQLNCS 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB6 TTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNI-SHDTVLQCHFTCSGKQESMNSNVSV ..: ::. ..:.: : . . : : . .. . ... .: ::.:: . .: ... CCDS12 NSCPQPQNSSLRTPLRQGKTLRGPGWVSYQLLDVRAWSSLAHCLVTCAGKTRWATSRITA 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB6 YQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAP :.::..::: .: .. :...:..:.: : :. :.. : .:..... :.. . . CCDS12 YKPPHSVIL--EPPVLK-GRKYTLRCHVTQVFPVGYLVVTLRHGSRVIYSESLERFTGLD 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 -QEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVI- ..: :.. .: .: . : : :.: : . .. ::: : . . . .. CCDS12 LANVTLTYEFAAGPRDFWQPVICHARLNL---DGLVVRNSSAPITLMLAWSPAPTALASG 190 200 210 220 230 240 230 240 250 260 270 pF1KB6 -IVTVVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP :...:..::. : .. :: CCDS12 SIAALVGILLT--VGAAYLCKCLAMKSQA 250 260 270 >>CCDS82290.1 ICAM3 gene_id:3385|Hs108|chr19 (470 aa) initn: 303 init1: 177 opt: 288 Z-score: 352.6 bits: 73.8 E(32554): 2.6e-13 Smith-Waterman score: 288; 34.2% identity (63.2% similar) in 152 aa overlap (75-225:3-149) 50 60 70 80 90 100 pF1KB6 EVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNS : . .::.. .. . : :.:.: . .: CCDS82 MGWAAFNLSNVTGNSRILCSVYCNGSQITGSS 10 20 30 110 120 130 140 150 160 pF1KB6 NVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKA :..::. :..: :. : ::..::..:.: : :::. :.: .: : . : CCDS82 NITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQP---A 40 50 60 70 80 170 180 190 200 210 220 pF1KB6 APAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYE-PVSDSQ . : :.::: :.:.: ::: . ::.. .: ..: . :::..:. . ::. . CCDS82 VEEPAEVTATV--LASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPR 90 100 110 120 130 140 230 240 250 260 270 pF1KB6 MVIIVTVVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP .: CCDS82 LVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARA 150 160 170 180 190 200 >>CCDS42500.1 ICAM4 gene_id:3386|Hs108|chr19 (237 aa) initn: 196 init1: 95 opt: 280 Z-score: 347.1 bits: 71.8 E(32554): 5.1e-13 Smith-Waterman score: 280; 28.0% identity (62.5% similar) in 200 aa overlap (20-217:41-234) 10 20 30 40 pF1KB6 MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCS :.. : :.. :. .::.: :...::: CCDS42 FFLAAAYPGVGSALGRRTKRAQSPKGSPLAPSGTSVPFWVRMSPEFVAVQPGKSVQLNCS 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB6 TTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNI-SHDTVLQCHFTCSGKQESMNSNVSV ..: ::. ..:.: : . . : : . .. . ... .: ::.:: . .: ... CCDS42 NSCPQPQNSSLRTPLRQGKTLRGPGWVSYQLLDVRAWSSLAHCLVTCAGKTRWATSRITA 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB6 YQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAP :.::..:: :.: .. :...:..:.: : :. :.. : .:..... :.. . . CCDS42 YKPPHSVI--LEPPVLK-GRKYTLRCHVTQVFPVGYLVVTLRHGSRVIYSESLERFTGLD 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 -QEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVII ..: :.. .: .: . : : :.: : . .. ::: : . : CCDS42 LANVTLTYEFAAGPRDFWQPVICHARLNL---DGLVVRNSSAPITLMLGEAPL 190 200 210 220 230 230 240 250 260 270 pF1KB6 VTVVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP 275 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:33:21 2016 done: Sat Nov 5 00:33:22 2016 Total Scan time: 2.310 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]