FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6391, 276 aa 1>>>pF1KB6391 276 - 276 aa - 276 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1722+/-0.000722; mu= 15.4137+/- 0.043 mean_var=59.1434+/-11.706, 0's: 0 Z-trim(108.4): 20 B-trim: 0 in 0/53 Lambda= 0.166771 statistics sampled from 10169 (10182) to 10169 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.313), width: 16 Scan time: 2.120 The best scores are: opt bits E(32554) CCDS31958.1 EXOSC8 gene_id:11340|Hs108|chr13 ( 276) 1821 446.2 1.2e-125 CCDS3722.2 EXOSC9 gene_id:5393|Hs108|chr4 ( 439) 412 107.2 2.1e-23 CCDS34057.1 EXOSC9 gene_id:5393|Hs108|chr4 ( 456) 412 107.3 2.1e-23 CCDS2725.1 EXOSC7 gene_id:23016|Hs108|chr3 ( 291) 375 98.3 6.9e-21 >>CCDS31958.1 EXOSC8 gene_id:11340|Hs108|chr13 (276 aa) initn: 1821 init1: 1821 opt: 1821 Z-score: 2369.1 bits: 446.2 E(32554): 1.2e-125 Smith-Waterman score: 1821; 100.0% identity (100.0% similar) in 276 aa overlap (1-276:1-276) 10 20 30 40 50 60 pF1KB6 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 KEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 LKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGG 190 200 210 220 230 240 250 260 270 pF1KB6 SGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK :::::::::::::::::::::::::::::::::::: CCDS31 SGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK 250 260 270 >>CCDS3722.2 EXOSC9 gene_id:5393|Hs108|chr4 (439 aa) initn: 227 init1: 142 opt: 412 Z-score: 533.8 bits: 107.2 E(32554): 2.1e-23 Smith-Waterman score: 412; 29.2% identity (64.0% similar) in 264 aa overlap (15-272:11-271) 10 20 30 40 50 pF1KB6 MAAGFKTVEPLEYYRRFL----KENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNT :::: .:. : :::. ..:. ...: : : .:.::.: CCDS37 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFG---TDYGCCIVELGKT 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 TVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENS :. :. :...:. . .: . :..: . . :. : .. .... ..:: CCDS37 RVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 QIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTIN-EETA . :. :.::. :. :: . :: :..::::.:: ..: ..:: . . :.:... .:.. CCDS37 KCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 LAEVNLKKKSYLNIRTHPVATSFAVFDD-TLLIVDPTGEEEHLATGTLTIVMDEEGKLCC : . . :.:. :. .::: :.. : :.:::. .::.. : :.:.:... ..: CCDS37 LYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICT 180 190 200 210 220 230 240 250 260 270 pF1KB6 LHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK ... :: : .. : . : .. :. .:. ..... CCDS37 IQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRI 240 250 260 270 280 290 CCDS37 TAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDS 300 310 320 330 340 350 >>CCDS34057.1 EXOSC9 gene_id:5393|Hs108|chr4 (456 aa) initn: 227 init1: 142 opt: 412 Z-score: 533.6 bits: 107.3 E(32554): 2.1e-23 Smith-Waterman score: 412; 29.2% identity (64.0% similar) in 264 aa overlap (15-272:11-271) 10 20 30 40 50 pF1KB6 MAAGFKTVEPLEYYRRFL----KENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNT :::: .:. : :::. ..:. ...: : : .:.::.: CCDS34 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFG---TDYGCCIVELGKT 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 TVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENS :. :. :...:. . .: . :..: . . :. : .. .... ..:: CCDS34 RVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 QIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTIN-EETA . :. :.::. :. :: . :: :..::::.:: ..: ..:: . . :.:... .:.. CCDS34 KCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 LAEVNLKKKSYLNIRTHPVATSFAVFDD-TLLIVDPTGEEEHLATGTLTIVMDEEGKLCC : . . :.:. :. .::: :.. : :.:::. .::.. : :.:.:... ..: CCDS34 LYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICT 180 190 200 210 220 230 240 250 260 270 pF1KB6 LHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK ... :: : .. : . : .. :. .:. ..... CCDS34 IQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRI 240 250 260 270 280 290 CCDS34 TAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDS 300 310 320 330 340 350 >>CCDS2725.1 EXOSC7 gene_id:23016|Hs108|chr3 (291 aa) initn: 391 init1: 316 opt: 375 Z-score: 488.5 bits: 98.3 E(32554): 6.9e-21 Smith-Waterman score: 375; 28.6% identity (62.5% similar) in 269 aa overlap (18-276:18-283) 10 20 30 40 50 60 pF1KB6 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC ..:. : ::: ..: . :. .:...::: ::::.: .. CCDS27 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEE--AQVASQFIADVIENSQI :::::...:. . :..::. :: . .:. : :.. ...:. . ...:.. CCDS27 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFE-GRGGDDLGTEIANTLYR-IFNNKSS 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 IQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINE-ETALA .. . ::::: . :::: :.. :. ::..:: ..:. ::: :...:.: . : : . CCDS27 VDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 EVNLKKKSY----LNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLC ...:. : :.... : ... . .:: : .:: . ..: . . .: . CCDS27 DIELSDDPYDCIRLSVENVPCIVTLCKIGYRH-VVDATLQEEACSLASLLVSVTSKGVVT 180 190 200 210 220 230 240 250 260 270 pF1KB6 CLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVI---KSMKPK :..: : ..: .. . : . : .. .. :. .:. :: CCDS27 CMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG 240 250 260 270 280 290 276 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:46:13 2016 done: Fri Nov 4 20:46:13 2016 Total Scan time: 2.120 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]