Result of FASTA (omim) for
pF1KB6391
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6391, 276 aa
1>>>pF1KB6391 276 - 276 aa - 276 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1518+/-0.000328; mu= 15.7477+/- 0.020
mean_var=59.4760+/-11.978, 0's: 0 Z-trim(115.0): 30 B-trim: 226 in 1/52
Lambda= 0.166304
statistics sampled from 25141 (25170) to 25141 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.295), width: 16
Scan time: 6.600
The best scores are: opt bits E(85289)
NP_852480 (OMIM: 606019,616081) exosome complex co ( 276) 1821 445.0 7.2e-125
XP_006719826 (OMIM: 606019,616081) PREDICTED: exos ( 313) 1702 416.5 3.2e-116
XP_011530337 (OMIM: 606180) PREDICTED: exosome com ( 392) 412 107.0 5.7e-23
NP_005024 (OMIM: 606180) exosome complex component ( 439) 412 107.0 6.2e-23
NP_001029366 (OMIM: 606180) exosome complex compon ( 456) 412 107.0 6.4e-23
NP_055819 (OMIM: 606488) exosome complex component ( 291) 375 98.1 2.1e-20
XP_016861419 (OMIM: 606488) PREDICTED: exosome com ( 210) 218 60.3 3.4e-09
>>NP_852480 (OMIM: 606019,616081) exosome complex compon (276 aa)
initn: 1821 init1: 1821 opt: 1821 Z-score: 2362.8 bits: 445.0 E(85289): 7.2e-125
Smith-Waterman score: 1821; 100.0% identity (100.0% similar) in 276 aa overlap (1-276:1-276)
10 20 30 40 50 60
pF1KB6 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 KEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 KEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 LKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 LKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGG
190 200 210 220 230 240
250 260 270
pF1KB6 SGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
::::::::::::::::::::::::::::::::::::
NP_852 SGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
250 260 270
>>XP_006719826 (OMIM: 606019,616081) PREDICTED: exosome (313 aa)
initn: 1702 init1: 1702 opt: 1702 Z-score: 2207.6 bits: 416.5 E(85289): 3.2e-116
Smith-Waterman score: 1702; 100.0% identity (100.0% similar) in 258 aa overlap (19-276:56-313)
10 20 30 40
pF1KB6 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGS
::::::::::::::::::::::::::::::
XP_006 RVESAAAEQARRRGAAQAQTRGREDGGWVQKENCRPDGRELGEFRTTTVNIGSISTADGS
30 40 50 60 70 80
50 60 70 80 90 100
pF1KB6 ALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQF
90 100 110 120 130 140
110 120 130 140 150 160
pF1KB6 IADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEV
150 160 170 180 190 200
170 180 190 200 210 220
pF1KB6 TINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDE
210 220 230 240 250 260
230 240 250 260 270
pF1KB6 EGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
270 280 290 300 310
>>XP_011530337 (OMIM: 606180) PREDICTED: exosome complex (392 aa)
initn: 227 init1: 142 opt: 412 Z-score: 533.4 bits: 107.0 E(85289): 5.7e-23
Smith-Waterman score: 412; 29.2% identity (64.0% similar) in 264 aa overlap (15-272:11-271)
10 20 30 40 50
pF1KB6 MAAGFKTVEPLEYYRRFL----KENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNT
:::: .:. : :::. ..:. ...: : : .:.::.:
XP_011 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFG---TDYGCCIVELGKT
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 TVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENS
:. :. :...:. . .: . :..: . . :. : .. .... ..::
XP_011 RVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 QIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTIN-EETA
. :. :.::. :. :: . :: :..::::.:: ..: ..:: . . :.:... .:..
XP_011 KCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 LAEVNLKKKSYLNIRTHPVATSFAVFDD-TLLIVDPTGEEEHLATGTLTIVMDEEGKLCC
: . . :.:. :. .::: :.. : :.:::. .::.. : :.:.:... ..:
XP_011 LYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICT
180 190 200 210 220 230
240 250 260 270
pF1KB6 LHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
... :: : .. : . : .. :. .:. .....
XP_011 IQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRI
240 250 260 270 280 290
XP_011 TAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDS
300 310 320 330 340 350
>>NP_005024 (OMIM: 606180) exosome complex component RRP (439 aa)
initn: 227 init1: 142 opt: 412 Z-score: 532.7 bits: 107.0 E(85289): 6.2e-23
Smith-Waterman score: 412; 29.2% identity (64.0% similar) in 264 aa overlap (15-272:11-271)
10 20 30 40 50
pF1KB6 MAAGFKTVEPLEYYRRFL----KENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNT
:::: .:. : :::. ..:. ...: : : .:.::.:
NP_005 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFG---TDYGCCIVELGKT
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 TVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENS
:. :. :...:. . .: . :..: . . :. : .. .... ..::
NP_005 RVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 QIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTIN-EETA
. :. :.::. :. :: . :: :..::::.:: ..: ..:: . . :.:... .:..
NP_005 KCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 LAEVNLKKKSYLNIRTHPVATSFAVFDD-TLLIVDPTGEEEHLATGTLTIVMDEEGKLCC
: . . :.:. :. .::: :.. : :.:::. .::.. : :.:.:... ..:
NP_005 LYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICT
180 190 200 210 220 230
240 250 260 270
pF1KB6 LHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
... :: : .. : . : .. :. .:. .....
NP_005 IQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRI
240 250 260 270 280 290
NP_005 TAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDS
300 310 320 330 340 350
>>NP_001029366 (OMIM: 606180) exosome complex component (456 aa)
initn: 227 init1: 142 opt: 412 Z-score: 532.4 bits: 107.0 E(85289): 6.4e-23
Smith-Waterman score: 412; 29.2% identity (64.0% similar) in 264 aa overlap (15-272:11-271)
10 20 30 40 50
pF1KB6 MAAGFKTVEPLEYYRRFL----KENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNT
:::: .:. : :::. ..:. ...: : : .:.::.:
NP_001 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFG---TDYGCCIVELGKT
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 TVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENS
:. :. :...:. . .: . :..: . . :. : .. .... ..::
NP_001 RVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 QIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTIN-EETA
. :. :.::. :. :: . :: :..::::.:: ..: ..:: . . :.:... .:..
NP_001 KCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 LAEVNLKKKSYLNIRTHPVATSFAVFDD-TLLIVDPTGEEEHLATGTLTIVMDEEGKLCC
: . . :.:. :. .::: :.. : :.:::. .::.. : :.:.:... ..:
NP_001 LYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICT
180 190 200 210 220 230
240 250 260 270
pF1KB6 LHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
... :: : .. : . : .. :. .:. .....
NP_001 IQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRI
240 250 260 270 280 290
NP_001 TAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDS
300 310 320 330 340 350
>>NP_055819 (OMIM: 606488) exosome complex component RRP (291 aa)
initn: 391 init1: 316 opt: 375 Z-score: 487.4 bits: 98.1 E(85289): 2.1e-20
Smith-Waterman score: 375; 28.6% identity (62.5% similar) in 269 aa overlap (18-276:18-283)
10 20 30 40 50 60
pF1KB6 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC
..:. : ::: ..: . :. .:...::: ::::.: ..
NP_055 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
10 20 30 40 50 60
70 80 90 100 110
pF1KB6 GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEE--AQVASQFIADVIENSQI
:::::...:. . :..::. :: . .:. : :.. ...:. . ...:..
NP_055 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFE-GRGGDDLGTEIANTLYR-IFNNKSS
70 80 90 100 110
120 130 140 150 160 170
pF1KB6 IQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINE-ETALA
.. . ::::: . :::: :.. :. ::..:: ..:. ::: :...:.: . : : .
NP_055 VDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 EVNLKKKSY----LNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLC
...:. : :.... : ... . .:: : .:: . ..: . . .: .
NP_055 DIELSDDPYDCIRLSVENVPCIVTLCKIGYRH-VVDATLQEEACSLASLLVSVTSKGVVT
180 190 200 210 220 230
240 250 260 270
pF1KB6 CLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVI---KSMKPK
:..: : ..: .. . : . : .. .. :. .:. ::
NP_055 CMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
240 250 260 270 280 290
>>XP_016861419 (OMIM: 606488) PREDICTED: exosome complex (210 aa)
initn: 228 init1: 153 opt: 218 Z-score: 286.0 bits: 60.3 E(85289): 3.4e-09
Smith-Waterman score: 218; 26.6% identity (60.7% similar) in 173 aa overlap (112-276:31-202)
90 100 110 120 130 140
pF1KB6 NVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLIC
...:.. .. . ::::: . :::: :..
XP_016 MASSSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLL
10 20 30 40 50 60
150 160 170 180 190
pF1KB6 LDYDGNILDACTFALLAALKNVQLPEVTINE-ETALAEVNLKKKSY----LNIRTHPVAT
:. ::..:: ..:. ::: :...:.: . : : . ...:. : :.... : .
XP_016 LECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIV
70 80 90 100 110 120
200 210 220 230 240 250
pF1KB6 SFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAV
.. . .:: : .:: . ..: . . .: . :..: : ..: .. . : .
XP_016 TLCKIGYRH-VVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGK
130 140 150 160 170
260 270
pF1KB6 TRHKEVKKLMDEVI---KSMKPK
: .. .. :. .:. ::
XP_016 RVGKVLHASLQSVVHKEESLGPKRQKVGFLG
180 190 200 210
276 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:46:14 2016 done: Fri Nov 4 20:46:15 2016
Total Scan time: 6.600 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]