FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6394, 303 aa 1>>>pF1KB6394 303 - 303 aa - 303 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8442+/-0.000383; mu= 18.0428+/- 0.024 mean_var=62.2846+/-12.630, 0's: 0 Z-trim(112.4): 149 B-trim: 301 in 1/50 Lambda= 0.162511 statistics sampled from 21192 (21358) to 21192 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.25), width: 16 Scan time: 7.160 The best scores are: opt bits E(85289) NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl ( 303) 1994 476.1 3.7e-134 XP_011509780 (OMIM: 605843) PREDICTED: peroxisomal ( 157) 1049 254.3 1.1e-67 XP_016868636 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 536 134.3 3.2e-31 NP_001317504 (OMIM: 222745) 2,4-dienoyl-CoA reduct ( 326) 536 134.3 3.2e-31 XP_016868637 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 536 134.3 3.2e-31 XP_011515182 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 536 134.3 3.2e-31 NP_001350 (OMIM: 222745) 2,4-dienoyl-CoA reductase ( 335) 536 134.3 3.2e-31 NP_065715 (OMIM: 615839) peroxisomal 2,4-dienoyl-C ( 292) 523 131.2 2.4e-30 XP_005250865 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 243) 394 100.9 2.6e-21 NP_066284 (OMIM: 611596) dehydrogenase/reductase S ( 278) 394 100.9 2.9e-21 NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid de ( 270) 389 99.8 6.5e-21 XP_005267306 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 378 97.2 4e-20 NP_005785 (OMIM: 615194) dehydrogenase/reductase S ( 280) 378 97.2 4e-20 XP_006720064 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 378 97.2 4e-20 NP_878912 (OMIM: 615194) dehydrogenase/reductase S ( 300) 317 82.9 8.5e-16 XP_005259026 (OMIM: 612832) PREDICTED: 17-beta-hyd ( 212) 306 80.2 3.9e-15 NP_055049 (OMIM: 601417) estradiol 17-beta-dehydro ( 261) 303 79.6 7.4e-15 NP_000851 (OMIM: 119900,259100,601688) 15-hydroxyp ( 266) 288 76.1 8.6e-14 NP_077284 (OMIM: 616159) dehydrogenase/reductase S ( 260) 276 73.3 5.9e-13 XP_011534641 (OMIM: 615194) PREDICTED: dehydrogena ( 204) 268 71.3 1.8e-12 XP_011534640 (OMIM: 615194) PREDICTED: dehydrogena ( 204) 268 71.3 1.8e-12 NP_001207422 (OMIM: 616161) dehydrogenase/reductas ( 312) 265 70.7 4.1e-12 NP_001099041 (OMIM: 616161) dehydrogenase/reductas ( 311) 261 69.8 7.8e-12 NP_932349 (OMIM: 615196) dehydrogenase/reductase S ( 232) 248 66.7 5.1e-11 NP_000405 (OMIM: 233400,261515,601860) peroxisomal ( 736) 247 66.8 1.5e-10 NP_001139288 (OMIM: 119900,259100,601688) 15-hydro ( 178) 237 64.0 2.5e-10 NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339) 240 64.9 2.5e-10 XP_016876857 (OMIM: 612833) PREDICTED: dehydrogena ( 404) 240 65.0 2.9e-10 XP_011522088 (OMIM: 616160) PREDICTED: dehydrogena ( 334) 231 62.8 1.1e-09 NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289) 230 62.5 1.1e-09 NP_612461 (OMIM: 610410) dehydrogenase/reductase S ( 313) 229 62.3 1.4e-09 NP_001129522 (OMIM: 610410) dehydrogenase/reductas ( 313) 229 62.3 1.4e-09 XP_005257715 (OMIM: 616159) PREDICTED: dehydrogena ( 229) 227 61.7 1.5e-09 XP_006720309 (OMIM: 615195) PREDICTED: putative de ( 244) 227 61.8 1.6e-09 XP_005266734 (OMIM: 136440) PREDICTED: 3-ketodihyd ( 298) 226 61.6 2.2e-09 NP_002026 (OMIM: 136440) 3-ketodihydrosphingosine ( 332) 226 61.6 2.4e-09 NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310) 225 61.4 2.7e-09 NP_056325 (OMIM: 616160) dehydrogenase/reductase S ( 325) 225 61.4 2.8e-09 XP_016879915 (OMIM: 616160) PREDICTED: dehydrogena ( 325) 225 61.4 2.8e-09 XP_005256652 (OMIM: 616160) PREDICTED: dehydrogena ( 372) 225 61.4 3.1e-09 XP_016879914 (OMIM: 616160) PREDICTED: dehydrogena ( 372) 225 61.4 3.1e-09 XP_006720068 (OMIM: 611596) PREDICTED: dehydrogena ( 233) 219 59.9 5.7e-09 NP_001243234 (OMIM: 119900,259100,601688) 15-hydro ( 143) 215 58.8 7.5e-09 XP_011530209 (OMIM: 119900,259100,601688) PREDICTE ( 176) 215 58.8 8.8e-09 NP_004484 (OMIM: 300220,300256,300438) 3-hydroxyac ( 261) 215 59.0 1.2e-08 XP_016870160 (OMIM: 264300,605573) PREDICTED: test ( 310) 208 57.4 4.3e-08 NP_000188 (OMIM: 264300,605573) testosterone 17-be ( 310) 208 57.4 4.3e-08 XP_011516920 (OMIM: 264300,605573) PREDICTED: test ( 310) 208 57.4 4.3e-08 XP_016870161 (OMIM: 264300,605573) PREDICTED: test ( 310) 208 57.4 4.3e-08 XP_011516921 (OMIM: 264300,605573) PREDICTED: test ( 310) 208 57.4 4.3e-08 >>NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl-CoA (303 aa) initn: 1994 init1: 1994 opt: 1994 Z-score: 2529.5 bits: 476.1 E(85289): 3.7e-134 Smith-Waterman score: 1994; 100.0% identity (100.0% similar) in 303 aa overlap (1-303:1-303) 10 20 30 40 50 60 pF1KB6 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEK 250 260 270 280 290 300 pF1KB6 AKL ::: NP_060 AKL >>XP_011509780 (OMIM: 605843) PREDICTED: peroxisomal tra (157 aa) initn: 1049 init1: 1049 opt: 1049 Z-score: 1336.1 bits: 254.3 E(85289): 1.1e-67 Smith-Waterman score: 1049; 100.0% identity (100.0% similar) in 157 aa overlap (147-303:1-157) 120 130 140 150 160 170 pF1KB6 EHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARA :::::::::::::::::::::::::::::: XP_011 MKEHGGSIVNIIVPTKAGFPLAVHSGAARA 10 20 30 180 190 200 210 220 230 pF1KB6 GVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVP 40 50 60 70 80 90 240 250 260 270 280 290 pF1KB6 EEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKET 100 110 120 130 140 150 300 pF1KB6 FKEKAKL ::::::: XP_011 FKEKAKL >>XP_016868636 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 499 init1: 168 opt: 536 Z-score: 681.6 bits: 134.3 E(85289): 3.2e-31 Smith-Waterman score: 536; 35.2% identity (69.3% similar) in 261 aa overlap (8-264:40-293) 10 20 30 pF1KB6 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKE ...: :. .::.::..:::.::.::... XP_016 LLMGEFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 LLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDT : ::.. ::::::.. ::..:...... .: :::..:. . :.: :. . . XP_016 LSSLGAQCVIASRKMDVLKATAEQISSQTG----NKVHAIQCDVRDPDMVQNTVSELIKV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 FGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGG----S :. :...::..:.:.::.:..: ..:... . :.:: .. . .. .: . : : XP_016 AGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB6 IVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENY :..: . : .:: .: :..:.::: ..:::: ::. :.:.: . :: : .. : XP_016 ITTIYAETGSGF--VVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB6 GSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYE : .: . . .:: :.:. ::..... :: : ::.:.: . ::: XP_016 DPTG-TFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEF 250 260 270 280 290 300 280 290 300 pF1KB6 VPDHDNWPKGAGDLSVVKKMKETFKEKAKL XP_016 NDLRKVTKEQWDTIEELIRKTKGS 310 320 >>NP_001317504 (OMIM: 222745) 2,4-dienoyl-CoA reductase, (326 aa) initn: 499 init1: 168 opt: 536 Z-score: 681.6 bits: 134.3 E(85289): 3.2e-31 Smith-Waterman score: 536; 35.2% identity (69.3% similar) in 261 aa overlap (8-264:40-293) 10 20 30 pF1KB6 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKE ...: :. .::.::..:::.::.::... NP_001 LLMGEFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 LLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDT : ::.. ::::::.. ::..:...... .: :::..:. . :.: :. . . NP_001 LSSLGAQCVIASRKMDVLKATAEQISSQTG----NKVHAIQCDVRDPDMVQNTVSELIKV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 FGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGG----S :. :...::..:.:.::.:..: ..:... . :.:: .. . .. .: . : : NP_001 AGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB6 IVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENY :..: . : .:: .: :..:.::: ..:::: ::. :.:.: . :: : .. : NP_001 ITTIYAETGSGF--VVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB6 GSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYE : .: . . .:: :.:. ::..... :: : ::.:.: . ::: NP_001 DPTG-TFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEF 250 260 270 280 290 300 280 290 300 pF1KB6 VPDHDNWPKGAGDLSVVKKMKETFKEKAKL NP_001 NDLRKVTKEQWDTIEELIRKTKGS 310 320 >>XP_016868637 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 499 init1: 168 opt: 536 Z-score: 681.6 bits: 134.3 E(85289): 3.2e-31 Smith-Waterman score: 536; 35.2% identity (69.3% similar) in 261 aa overlap (8-264:40-293) 10 20 30 pF1KB6 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKE ...: :. .::.::..:::.::.::... XP_016 LLMGEFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 LLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDT : ::.. ::::::.. ::..:...... .: :::..:. . :.: :. . . XP_016 LSSLGAQCVIASRKMDVLKATAEQISSQTG----NKVHAIQCDVRDPDMVQNTVSELIKV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 FGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGG----S :. :...::..:.:.::.:..: ..:... . :.:: .. . .. .: . : : XP_016 AGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB6 IVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENY :..: . : .:: .: :..:.::: ..:::: ::. :.:.: . :: : .. : XP_016 ITTIYAETGSGF--VVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB6 GSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYE : .: . . .:: :.:. ::..... :: : ::.:.: . ::: XP_016 DPTG-TFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEF 250 260 270 280 290 300 280 290 300 pF1KB6 VPDHDNWPKGAGDLSVVKKMKETFKEKAKL XP_016 NDLRKVTKEQWDTIEELIRKTKGS 310 320 >>XP_011515182 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 499 init1: 168 opt: 536 Z-score: 681.6 bits: 134.3 E(85289): 3.2e-31 Smith-Waterman score: 536; 35.2% identity (69.3% similar) in 261 aa overlap (8-264:40-293) 10 20 30 pF1KB6 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKE ...: :. .::.::..:::.::.::... XP_011 LWKEMFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 LLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDT : ::.. ::::::.. ::..:...... .: :::..:. . :.: :. . . XP_011 LSSLGAQCVIASRKMDVLKATAEQISSQTG----NKVHAIQCDVRDPDMVQNTVSELIKV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 FGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGG----S :. :...::..:.:.::.:..: ..:... . :.:: .. . .. .: . : : XP_011 AGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB6 IVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENY :..: . : .:: .: :..:.::: ..:::: ::. :.:.: . :: : .. : XP_011 ITTIYAETGSGF--VVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB6 GSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYE : .: . . .:: :.:. ::..... :: : ::.:.: . ::: XP_011 DPTG-TFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEF 250 260 270 280 290 300 280 290 300 pF1KB6 VPDHDNWPKGAGDLSVVKKMKETFKEKAKL XP_011 NDLRKVTKEQWDTIEELIRKTKGS 310 320 >>NP_001350 (OMIM: 222745) 2,4-dienoyl-CoA reductase, mi (335 aa) initn: 499 init1: 168 opt: 536 Z-score: 681.4 bits: 134.3 E(85289): 3.2e-31 Smith-Waterman score: 536; 35.2% identity (69.3% similar) in 261 aa overlap (8-264:49-302) 10 20 30 pF1KB6 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKE ...: :. .::.::..:::.::.::... NP_001 LAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTL 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 LLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDT : ::.. ::::::.. ::..:...... .: :::..:. . :.: :. . . NP_001 LSSLGAQCVIASRKMDVLKATAEQISSQTG----NKVHAIQCDVRDPDMVQNTVSELIKV 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB6 FGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGG----S :. :...::..:.:.::.:..: ..:... . :.:: .. . .. .: . : : NP_001 AGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB6 IVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENY :..: . : .:: .: :..:.::: ..:::: ::. :.:.: . :: : .. : NP_001 ITTIYAETGSGF--VVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRL 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB6 GSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYE : .: . . .:: :.:. ::..... :: : ::.:.: . ::: NP_001 DPTG-TFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEF 260 270 280 290 300 310 280 290 300 pF1KB6 VPDHDNWPKGAGDLSVVKKMKETFKEKAKL NP_001 NDLRKVTKEQWDTIEELIRKTKGS 320 330 >>NP_065715 (OMIM: 615839) peroxisomal 2,4-dienoyl-CoA r (292 aa) initn: 306 init1: 179 opt: 523 Z-score: 665.8 bits: 131.2 E(85289): 2.4e-30 Smith-Waterman score: 523; 34.9% identity (67.4% similar) in 258 aa overlap (8-264:18-270) 10 20 30 40 50 pF1KB6 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASR : . : ::. .::..:::..::: :.. ... : ..::::: NP_065 MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 KLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGG .: :. .:: .: . . : .:.. ..: : : ..: ::.:..:.: ..: NP_065 SLPRVLTAARKLAG----ATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAG 70 80 90 100 110 120 130 140 150 160 pF1KB6 QFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPT-KAGFPLAV .:: :: .: .....:.. . .::: . ...: .....::: :::: . . : : : NP_065 NFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB6 HSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIP :.:.:.:.: .:. ::.::. ..::.: .::: : . ... :. :. . . : NP_065 HAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGG-PQASLSTKVTASP 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB6 AKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSV .:.: :.. : .: :: ::..:: . .::: NP_065 LQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL 240 250 260 270 280 290 290 300 pF1KB6 VKKMKETFKEKAKL >>XP_005250865 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (243 aa) initn: 367 init1: 163 opt: 394 Z-score: 503.5 bits: 100.9 E(85289): 2.6e-21 Smith-Waterman score: 394; 32.3% identity (66.4% similar) in 217 aa overlap (52-264:1-210) 30 40 50 60 70 80 pF1KB6 IVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNI .. ::..:...... .: :::.. XP_005 MDVLKATAEQISSQT----GNKVHAIQCDV 10 20 90 100 110 120 130 140 pF1KB6 RNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKA :. . :.: :. . . :. :...::..:.:.::.:..: ..:... . :.:: .. XP_005 RDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLE 30 40 50 60 70 80 150 160 170 180 190 pF1KB6 VYSSWMKEHGG----SIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRIN . .. .: . : ::..: . : .:: .: :..:.::: ..:::: ::. :.:.: XP_005 IGKQLIKAQKGAAFLSITTIYAETGSGF--VVPSASAKAGVEAMSKSLAAEWGKYGMRFN 90 100 110 120 130 140 200 210 220 230 240 250 pF1KB6 CVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQ . :: : .. : : .: . . .:: :.:. ::..... :: : ::.:.: XP_005 VIQPGPIKTKGAFSRLDPTG-TFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGA 150 160 170 180 190 200 260 270 280 290 300 pF1KB6 SVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEKAKL . ::: XP_005 VIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS 210 220 230 240 >>NP_066284 (OMIM: 611596) dehydrogenase/reductase SDR f (278 aa) initn: 330 init1: 114 opt: 394 Z-score: 502.6 bits: 100.9 E(85289): 2.9e-21 Smith-Waterman score: 394; 33.1% identity (63.2% similar) in 269 aa overlap (1-264:19-273) 10 20 30 40 pF1KB6 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELG ::: .: . : : ..::.::... ::: ::...: . : NP_066 MHKAGLLGLCARAWNSVRMAS--SGMTRRDP--LANKVALVTASTDGIGFAIARRLAQDG 10 20 30 40 50 50 60 70 80 90 100 pF1KB6 SNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKIN ..::..::: . . .:. ::. . : :.. . :. . :: ... : :. NP_066 AHVVVSSRKQQNVDQAVATLQG-----EGLSVTGTVCHVGKAEDRERLVATAVKLHGGID 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB6 FLVNNGG-GQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPT .::.:.. . :.. .. . : .:. :. . : ::: :. :::.: :: . NP_066 ILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVV--IVSS 120 130 140 150 160 170 180 190 200 210 pF1KB6 KAGF---PLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQ :.: : ....... .:::.::.: : .::.::.:::.: .:. . : . NP_066 IAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLI--KTSFSRM-LWMD 170 180 190 200 210 220 220 230 240 250 260 270 pF1KB6 SFFEGSFQK-IPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDH . : :... . .:.: ::. ...: :: : ::.:::..: : :: NP_066 KEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 230 240 250 260 270 280 290 300 pF1KB6 DNWPKGAGDLSVVKKMKETFKEKAKL 303 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:52:04 2016 done: Fri Nov 4 22:52:05 2016 Total Scan time: 7.160 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]